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Journal Articles

T follicular helper cells are mis-localized in idiopathic multicentric castleman disease

Free
Melanie Mumau, Katherine Forsyth, Michael Gonzalez, Joseph Zinski, Abiola Irvine, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 1236.
https://doi.org/10.1182/blood-2025-1236
Published: 2025
Journal Articles

Xgboost profiling of quantitative lymph-node and symptom signatures distinguishes idiopathic multicentric castleman disease and its clinical subtypes

Free
Joseph Zinski, Larissa Borys, Michael Gonzalez, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 1234.
https://doi.org/10.1182/blood-2025-1234
Published: 2025
Journal Articles

Quantitative measures of imcd lymph nodes reveal distinguishing characteristics of imcd lymph nodes and clinical subtypes

Free
Michael Gonzalez, Joseph Zinski, Ira Miller, Abiola Irvine, Melanie Mumau, Sheila Pierson, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 6568.
https://doi.org/10.1182/blood-2025-6568
Published: 2025
Journal Articles

Transcriptomic and pathological insights into PI3K–Akt pathway activation in idiopathic multicentric castleman disease, tafro and NOS subtypes

Free
Tomoka Haratake, Midori Filiz Nishimura, Asami Nishikori, Yoshito Nishimura, Michael Gonzalez, Daisuke Ennishi, Manaka Tsunoda, David Fajgenbaum, Frits van Rhee, Shuji Momose, Yasuharu Sato
Journal: Blood
Blood (2025) 146 (Supplement 1): 4782.
https://doi.org/10.1182/blood-2025-4782
Published: 2025
Journal Articles

Somatic mutation discovery in idiopathic multicentric castleman disease (iMCD) lymph node tissue identifies dysregulated intracellular calcium signaling as a potential disease mechanism and therapeutic target

Free
Michael Gonzalez, Melanie Mumau, Joseph Zinski, Vikas Arige, Flore Castellan, Abiola Irvine, Katherine Forsyth, Ira Miller, Bridget Austin, Criswell Lavery, David Wu, David Yule, David Beck, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 4789.
https://doi.org/10.1182/blood-2025-4789
Published: 2025
Journal Articles

Increased type I interferon signaling is a hallmark of idiopathic multicentric castleman disease

Free
Katherine Forsyth, Michael Gonzalez, Joseph Zinski, Melanie Mumau, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 4786.
https://doi.org/10.1182/blood-2025-4786
Published: 2025
Journal Articles

A Novel Cryopreservation and Biobanking Strategy to Study Lymphoid Tissue Stromal Cells in Lymphoproliferative Disorders

Free
Joshua D Brandstadter, Angelina De Martin, Mechthild Lϋetge, Antonio Ferreira, Brian T. Gaudette, Michael Gonzalez, Yves Stanossek, Edward Camiolo, Gerald Wertheim, David Allman, David C Fajgenbaum, Jon C. Aster, Burkhard Ludewig, Ivan Maillard
Journal: Blood
Blood (2022) 140 (Supplement 1): 3562–3563.
https://doi.org/10.1182/blood-2022-159835
Published: 2022
Journal Articles

Serum Proteomics Identifies Interferon Gamma Signaling in Idiopathic Multicentric Castleman Disease

Free
Melanie Mumau, Sheila K Pierson, Michael Gonzalez, Scott Canna, David C Fajgenbaum
Journal: Blood
Blood (2022) 140 (Supplement 1): 5500–5501.
https://doi.org/10.1182/blood-2022-167829
Published: 2022
Journal Articles

RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells

Free
Brian Estevez, Sara Borst, Danuta Jarocha, Varun Sudunagunta, Michael Gonzalez, James Garifallou, Hakon Hakonarson, Peng Gao, Kai Tan, Paul Liu, Sumedha Bagga, Nicholas Holdreith, Wei Tong, Nancy Speck, Deborah L. French, Paul Gadue, Mortimer Poncz
Journal: Blood
Blood (2021) 137 (19): 2662–2675.
https://doi.org/10.1182/blood.2020006389
Published: 2021
Includes: Supplemental data
Journal Articles

Type I Interferon Response Identified through Phenotypic and Transcriptional Profiling of Circulating Immune Cells during Idiopathic Multicentric Castleman Disease Flare

Free
Ruth-Anne Langan, BA, Alberto Japp, PhD, Michael Gonzalez, PhD, Rozena Rasheed, BS, Sheila K Pierson, MS, Charlly Kao, PhD, Hakon Hakonarson, MD PhD, Frits van Rhee, MD PhD, Michael Betts, PhD, Taku Kambayashi, MD PhD, David C Fajgenbaum, MDMBA,MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1046.
https://doi.org/10.1182/blood-2019-128994
Published: 2019
Journal Articles

The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction

Free
Brian Estevez, PhD, Sara Borst, BS, Danuta Jadwiga Jarocha, PhD, Varun Sudunagunta, Michael Gonzalez, PhD, Peng Gao, Kai Tan, Deborah L French, PhD, Paul Gadue, PhD, Mortimer Poncz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 220.
https://doi.org/10.1182/blood-2019-124851
Published: 2019
Journal Articles

Single-Cell RNA-Sequencing of Peripheral Blood Mononuclear Cells Reveals Changes in Immune Cell Composition and Distinct Inflammatory Gene Expression Profiles during Idiopathic Multicentric Castleman Disease Flare

Free
Ruth-Anne Langan, BA, Dustin Shilling, PhD, Michael Gonzalez, PhD, Charlly Kao, PhD, Hakon Hakonarson, MD PhD, Taku Kambayashi, MD PhD, David C Fajgenbaum, MD MBA, MSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 2406.
https://doi.org/10.1182/blood-2018-99-110461
Published: 2018