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Journal Articles

PYGO2-MDR1 Axis in Multiple Myeloma Patients with 1q21 Amplification As Promising Target to Overcome Carfilzomib Resistance

Nicolas Thomas Iannozzi, Jessica Burroughs Garcia, Valentina Marchica, Valentina Franceschi, Denise Toscani, Rosanna Vescovini, Vincenzo Raimondi, Oxana Lungu, Giannalisa Todaro, Gabriella Sammarelli, Matteo Scita, Federica Librale, Anna Benedetta Dalla Palma, Gaetano Donofrio, Paola Storti, Luca Agnelli, Giancarlo Pruneri, Nicola Giuliani

Blood (2023) 142 (Supplement 1): 6575.

https://doi.org/10.1182/blood-2023-181685

Published: 2023

Journal Articles

Identification of the Proteasome Subunits PSMB4 and PSMD4 As Novel Targets in Multiple Myeloma Patients Carrying 1q21 Amplification

Jessica Burroughs Garcia, Paola Storti, Nicolas Thomas Iannozzi, Laura Notarfranchi, Denise Toscani, Valentina Marchica, Vincenzo Raimondi, Luca Agnelli, Valentina Franceschi, Giannalisa Todaro, Oxana Lungu, Matia Bernardi, Matteo Scita, Gabriella Sammarelli, Gaetano Donofrio, Anna Benedetta Dalla Palma, Nicola Giuliani

Blood (2022) 140 (Supplement 1): 6750–6751.

https://doi.org/10.1182/blood-2022-165974

Published: 2022

Journal Articles

Glutamate Metabolism Shapes Osteoclast Differentiation: New Potential Therapeutic Target to Block Osteoclastic Bone Resorption in Multiple Myeloma Patients

Denise Toscani, Oxana Lungu, Vincenzo Raimondi, Martina Chiu, Nicolas Thomas Iannozzi, Jessica Burroughs Garcia, Anna Benedetta Dalla Palma, Matteo Scita, Matia Bernardi, Valentina Marchica, Paola Storti, Ovidio Bussolati, Nicola Giuliani

Blood (2022) 140 (Supplement 1): 4217–4218.

https://doi.org/10.1182/blood-2022-166654

Published: 2022

Journal Articles

PSMB4 and PSMD4 Are Correlated with 1q21 Amplification in CD138 + Plasma Cells: New Potential Druggable Targets in Myeloma Patients

Jessica Burroughs-Garcia, Paola Storti, Luca Agnelli, Denise Toscani, Valentina Marchica, Gabriella Sammarelli, Giannalisa Todaro, Vincenzo Raimondi, Valentina Franceschi, Naomi Soressi, Anna Benedetta Dalla Palma, Laura Notarfranchi, Gaetano Donofrio, Nicola Giuliani

Blood (2021) 138 (Supplement 1): 2657.

https://doi.org/10.1182/blood-2021-150198

Published: 2021

Journal Articles

Development and Validation of [ 18 f](2 S ,4 R )-4-Fluoroglutamine in Multiple Myeloma Mouse Models

Denise Toscani, Silvia Valtorta, Martina Chiu, Andrea Sartori, Angela Coliva, Arianna Brevi, Giuseppe Taurino, Matteo Grioni, Vincenzo Raimondi, Jessica Burroughs-Garcia, Paola Storti, Livia Ruffini, Federica Vacondio, Franca Zanardi, Matteo Bellone, Rosa Maria Moresco, Ovidio Bussolati, Nicola Giuliani

Blood (2021) 138 (Supplement 1): 2674.

https://doi.org/10.1182/blood-2021-147721

Published: 2021

Journal Articles

PD-L1/PD-1 Pattern of Distribution within Bone Marrow Microenvironment Cells in Patients with Smoldering Myeloma and Active Multiple Myeloma

Federica Costa, Rosanna Vescovini, PhD, Laura Notarfranchi, Paola Storti, PhD, Valentina Marchica, MS, Anna Benedetta Dalla Palma, MD, Cristina Manferdini, BS, Denise Toscani, PhD, Rosalba Eufemiese, MS, Jessica Burroughs, PhD, Gina Lisignoli, PhD, Nicola Giuliani

Blood (2020) 136 (Supplement 1): 49–50.

https://doi.org/10.1182/blood-2020-139275

Published: 2020

Journal Articles

Short-Term Risk for Progression in Patients with Smoldering Multiple Myeloma: The Impact of CD56 Expression

Laura Notarfranchi, Rosanna Vescovini, PhD, Roberta Segreto, MS, Sabrina Bonomini, MS, Paola Storti, PhD, Valentina Marchica, MS, Federica Costa, Gabriella Sammarelli, PhD, Giannalisa Todaro, PhD, Maria Teresa Catarozzo, MS, Dario De Giovanni, MD, Vincenza Fabiano, MD, Anna Benedetta Dalla Palma, MD, Nicola Giuliani

Blood (2020) 136 (Supplement 1): 11.

https://doi.org/10.1182/blood-2020-139214

Published: 2020

Journal Articles

Short-Term Risk of Progression of Patients with Asymptomatic Monoclonal Gammopathies to Active Multiple Myeloma: The Critical Impact of the Tumoral Mass

Anna Benedetta Dalla Palma, MD, Laura Notarfranchi, MD, Jessica Crosara, MD, Mario Pedrazzoni, MD, Fabrizio Accardi, MD, Valentina Marchica, MS, Denise Toscani, PhD, Emanuela Vicario, PhD, Paola Storti, PhD, Nicola Giuliani

Blood (2019) 134 (Supplement_1): 1795.

https://doi.org/10.1182/blood-2019-128252

Published: 2019

Journal Articles

Glutamine Depletion By Addicted Myeloma Cells Inhibits Osteoblastic Differentiation of Bone Marrow Mesenchymal Stromal Cells Limiting Asparagine Availability: A Possible New Mechanism for Myeloma Bone Disease

Martina Chiu, PhD, Denise Toscani, PhD, Emanuela Vicario, PhD, Roberta Andreoli, PhD, Giuseppe Taurino, MS, Valentina Marchica, MS, Paola Storti, PhD, Massimiliano Bianchi, PhD, Ovidio Bussolati, MD PhD, Nicola Giuliani

Blood (2019) 134 (Supplement_1): 4339.

https://doi.org/10.1182/blood-2019-128034

Published: 2019

Journal Articles

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

Denise Toscani, PhD, Martina Chiu, PhD, Giuseppe Taurino, MS, Emanuela Vicario, MS, Valentina Marchica, MS, Fabrizio Accardi, MD, Anna Benedetta Dalla Palma, MD, Paola Storti, PhD, Gaetano Donofrio, PhD, Franco Aversa, MD, Ovidio Bussolati, MD PhD, Nicola Giuliani, MD PhD

Blood (2018) 132 (Supplement 1): 4481.

https://doi.org/10.1182/blood-2018-99-111337

Published: 2018

Journal Articles

CD14 + CD16 + Monocyte Binding to Myeloma Cells Is Required for Daratumumab Dependent Killing in Multiple Myeloma Patients

Paola Storti, PhD, Rosanna Vescovini, PhD, Valentina Marchica, MS, Marina Bolzoni, PhD, Federica Costa, MS, Emanuela Vicario, MS, Denise Toscani, PhD, Anna Benedetta Dalla Palma, MD, Fabrizio Accardi, MD, Fabio Malavasi, MD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2018) 132 (Supplement 1): 3200.

https://doi.org/10.1182/blood-2018-99-112873

Published: 2018

Journal Articles

Relationship between Bone Marrow PD-1 and PD-L1 Expression and the Presence of Osteolytic Bone Disease in Multiple Myeloma Patients

Federica Costa, MS, Marina Bolzoni, PhD, Rosanna Vescovini, PhD, Fabrizio Accardi, MD, Anna Benedetta Dalla Palma, MD, Federica De Luca, PhD, Valentina Marchica, MS, Denise Toscani, PhD, Emanuela Vicario, MS, Paola Storti, PhD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2018) 132 (Supplement 1): 3183.

https://doi.org/10.1182/blood-2018-99-118200

Published: 2018

Journal Articles

Effect of Continuous Lenalidomide Treatment on Copy Number Alteration and Cytogenetic Abnormalities in Multiple Myeloma Cells

Paola Storti, PhD, Marina Bolzoni, PhD, Francesca Novara, PhD, Giannalisa Todaro, PhD, Valentina Marchica, Federica Costa, PhD, Tania Maldacena, PhD, Laura Notarfranchi, MD, Fabrizio Accardi, MD, Orsetta Zuffardi, PhD, Franco Aversa, MD, Nicola Giuliani, MD PhD, Gabriella Sammarelli, PhD

Blood (2017) 130 (Supplement 1): 3039.

https://doi.org/10.1182/blood.V130.Suppl_1.3039.3039

Published: 2017

Journal Articles

ILF2-YB1 Protein Interaction Modulates RNA Splicing to Induce Resistance to Chemotherapy in High Risk Multiple Myeloma

Matteo Marchesini, PhD, Yamini Ogoti, MS, Elena Fiorini, MS, Marianna D'anca, PhD, Paola Storti, PhD, Luigi Nezi, PhD, Mehmet K. Samur, PhD, Irene Gañán-Gómez, PhD, Mariateresa Fulciniti, PhD, Zachary S. Bohannan, MA, Karen Clise-Dwyer, PhD, Nicola Giuliani, MD PhD, Nikhil C Munshi, MD, Robert Z. Orlowski, PhD, MD, Guillermo Garcia-Manero, MD, Ronald A. DePinho, Simona Colla, PhD

Blood (2016) 128 (22): 359.

https://doi.org/10.1182/blood.V128.22.359.359

Published: 2016

Journal Articles

Oncolytic Virotherapy in Multiple Myeloma: A Possible Alternative Role of Bovine Viruses.

Valentina Marchica, Gaetano Donofrio, PhD, Rosanna Vescovini, PhD, Giulia Tebaldi, Alfonso Rosamilia, Daniela Guasco, Paola Storti, PhD, Marina Bolzoni, PhD, Federica Costa, Chiara Schifano, MSc, Sabrina Bonomini, MSc, Fabrizio Accardi, MD, Francesco Piazza, MD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2016) 128 (22): 2093.

https://doi.org/10.1182/blood.V128.22.2093.2093

Published: 2016

Journal Articles

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Blood (2016) 128 (5): 667–679.

https://doi.org/10.1182/blood-2016-01-690743

Published: 2016

Includes: Supplemental data

Journal Articles

Expression Profile of CD38 and Related Ectoenzymes in Myeloma Bone Niche: A Rational Basis for the Use of Daratumumab to Inhibit Osteoclast Formation and Activity

Denise Toscani, PhD, Marina Bolzoni, PhD, Federica Costa, Valeria Quarona, Valentina Marchica, Cristina Mancini, MD, Eugenia Martella, MD, Sabrina Bonomini, Paola Storti, PhD, Antonella Chillemi, PhD, Fabrizio Accardi, MD, Benedetta Dalla Palma, MD, Luisa Craviotto, MD, Fabio Malavasi, MD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2015) 126 (23): 2959.

https://doi.org/10.1182/blood.V126.23.2959.2959

Published: 2015

Journal Articles

The Myeloma Cells Escape from Bone Marrow to Skin Extramedullary Localization upon Bortezomib Resistance: Role of CXCR4

Valentina Marchica, Fabrizio Accardi, MD, Paola Storti, PhD, Cristina Mancini, MD, Eugenia Martella, MD, Marina Bolzoni, PhD, Katia Todoerti, Chiara Schifano, Sabrina Bonomini, Benedetta Dalla Palma, MD, Magda Marcatti, MD, Maurilio Ponzoni, MD, Antonino Neri, MD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2015) 126 (23): 5315.

https://doi.org/10.1182/blood.V126.23.5315.5315

Published: 2015

Journal Articles

Hypoxia-Inducible Factor (HIF)-1alpha Inhibitionin Myeloma Cells Significantly Increases the Anti-Myeloma Effect of Lenalidomide in Vivo

Paola Storti, PhD, Valentina Marchica, Denise Toscani, PhD, Irma Airoldi, PhD, Sophie Maiga, PhD, Marina Bolzoni, PhD, Nicoletta Campanini, Eugenia Martella, MD, Cristina Mancini, MD, Valentina Ferri, Gaetano Donofrio, PhD, Martine Amiot, PhD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2015) 126 (23): 3012.

https://doi.org/10.1182/blood.V126.23.3012.3012

Published: 2015

Journal Articles

Ammonium Production and Glutamine-Addiction of Myeloma Cells: New Attractive Targets in Multiple Myeloma

Fabrizio Accardi, MD, Martina Chiu, Marina Bolzoni, Paola Storti, PhD, Katia Todoerti, PhD, Luca Agnelli, Massimiliano Ferrari, MD, Gabriele Missale, MD, Franco Aversa, MD, Ovidio Bussolati, MD PhD, Nicola Giuliani, MD PhD

Blood (2014) 124 (21): 2067.

https://doi.org/10.1182/blood.V124.21.2067.2067

Published: 2014

NARROW

PYGO2-MDR1 Axis in Multiple Myeloma Patients with 1q21 Amplification As Promising Target to Overcome Carfilzomib Resistance

Identification of the Proteasome Subunits PSMB4 and PSMD4 As Novel Targets in Multiple Myeloma Patients Carrying 1q21 Amplification

Glutamate Metabolism Shapes Osteoclast Differentiation: New Potential Therapeutic Target to Block Osteoclastic Bone Resorption in Multiple Myeloma Patients

PSMB4 and PSMD4 Are Correlated with 1q21 Amplification in CD138 + Plasma Cells: New Potential Druggable Targets in Myeloma Patients

Development and Validation of [ 18 f](2 S ,4 R )-4-Fluoroglutamine in Multiple Myeloma Mouse Models

PD-L1/PD-1 Pattern of Distribution within Bone Marrow Microenvironment Cells in Patients with Smoldering Myeloma and Active Multiple Myeloma

Short-Term Risk for Progression in Patients with Smoldering Multiple Myeloma: The Impact of CD56 Expression

Short-Term Risk of Progression of Patients with Asymptomatic Monoclonal Gammopathies to Active Multiple Myeloma: The Critical Impact of the Tumoral Mass

Glutamine Depletion By Addicted Myeloma Cells Inhibits Osteoblastic Differentiation of Bone Marrow Mesenchymal Stromal Cells Limiting Asparagine Availability: A Possible New Mechanism for Myeloma Bone Disease

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

CD14 + CD16 + Monocyte Binding to Myeloma Cells Is Required for Daratumumab Dependent Killing in Multiple Myeloma Patients

Relationship between Bone Marrow PD-1 and PD-L1 Expression and the Presence of Osteolytic Bone Disease in Multiple Myeloma Patients

Effect of Continuous Lenalidomide Treatment on Copy Number Alteration and Cytogenetic Abnormalities in Multiple Myeloma Cells

ILF2-YB1 Protein Interaction Modulates RNA Splicing to Induce Resistance to Chemotherapy in High Risk Multiple Myeloma

Oncolytic Virotherapy in Multiple Myeloma: A Possible Alternative Role of Bovine Viruses.

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Expression Profile of CD38 and Related Ectoenzymes in Myeloma Bone Niche: A Rational Basis for the Use of Daratumumab to Inhibit Osteoclast Formation and Activity

The Myeloma Cells Escape from Bone Marrow to Skin Extramedullary Localization upon Bortezomib Resistance: Role of CXCR4

Hypoxia-Inducible Factor (HIF)-1alpha Inhibitionin Myeloma Cells Significantly Increases the Anti-Myeloma Effect of Lenalidomide in Vivo

Ammonium Production and Glutamine-Addiction of Myeloma Cells: New Attractive Targets in Multiple Myeloma

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American Society of Hematology

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