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Journal Articles

Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells

Uri Rozovski, MD, David M. Harris, PhD, Ping Li, PhD, Zhiming Liu, BS, Taghi Manshouri, PhD, Ivo Veletic, MD, Preetesh Jain, MBBS,MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, Srdan Verstovsek, MD PhD, William G. Wierda, MD PhD, Michael J Keating, MBBS, Zeev E. Estrov, MD

Blood (2019) 134 (Supplement_1): 3018.

https://doi.org/10.1182/blood-2019-124014

Published: 2019

Journal Articles

STAT3-Induced Gli1 Promotes the Differentiation and Maturation of Myelofibrosis Fibrocytes

Taghi Manshouri, PhD, Ivo Veletic, MD, Ying Zhang, MD MS, Joseph E. Bove, IV, BS, Ping Li, PhD, David M. Harris, PhD, Zhiming Liu, BS, Evan N. Cohen, PhD, Srdan Verstovsek, MD PhD, Zeev E. Estrov, MD

Blood (2019) 134 (Supplement_1): 2961.

https://doi.org/10.1182/blood-2019-132054

Published: 2019

Journal Articles

Constitutively Activated STAT3 Induces the Production of PTX3 That Contributes to the Induction of Bone Marrow Reticulin Fibrosis in Patient with CLL

Blood (2019) 134 (Supplement_1): 3024.

https://doi.org/10.1182/blood-2019-124183

Published: 2019

Journal Articles

FT-2102, an IDH1m Inhibitor, in Combination with Azacitidine in Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Ayndrome (MDS): Results from a Phase 1 Study

Blood (2018) 132 (Supplement 1): 1452.

https://doi.org/10.1182/blood-2018-99-114126

Published: 2018

Journal Articles

Phase 1 Study of the IDH1m Inhibitor FT-2102 As a Single Agent in Patients with IDH1 m Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

Justin Watts, MD, Maria R. Baer, MD, Jay Yang, MD, Shira Dinner, MD, Sangmin Lee, MD, Karen Seiter, MD, Thomas Prebet, MD PhD, Gary J. Schiller, MD, Paul Brent Ferrell, Jr., MD, Kim-Hien Dao, DO, PhD, Hagop M. Kantarjian, MD, Patrick Kelly, MD, Ping Li, PhD, Jennifer Sweeney, Courtney Watson, Hesham Mohamed, MD, Jorge E. Cortes, MD

Blood (2018) 132 (Supplement 1): 1453.

https://doi.org/10.1182/blood-2018-99-114263

Published: 2018

Journal Articles

Endogenous STAT3-Activated Wnt5a Provides CLL Cells with Survival Advantage

Uri Rozovski, Ping Li, PhD, David M. Harris, Zhiming Liu, Preetesh Jain, MBBS, MDDM, PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, William G. Wierda, MD PhD, Michael J. Keating, MD, Zeev E. Estrov, MD

Blood (2018) 132 (Supplement 1): 4398.

https://doi.org/10.1182/blood-2018-99-111960

Published: 2018

Journal Articles

CLL Cells with 13q- Are Characterized By High BCL2 Levels and CLL Cells with Trisomy-12 By Increased Activation of STAT3 and NF-κB

Uri Rozovski, David M. Harris, Ping Li, PhD, Zhiming Liu, Preetesh Jain, MBBS, MDDM, PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, William G. Wierda, MD PhD, Michael J. Keating, MD, Zeev E. Estrov, MD

Blood (2018) 132 (Supplement 1): 4411.

https://doi.org/10.1182/blood-2018-99-114909

Published: 2018

Journal Articles

CLL Cell-Derived Exosomes Promote Bone Marrow Fibrosis and Inhibit Normal Hematopoietic Colony Proliferation

Uri Rozovski, MD, David M. Harris, Ping Li, PhD, Zhiming Liu, Taghi Manshouri, Ivo Veletic, MD, Carlos Bueso-Ramos, MD PhD, Preetesh Jain, MBBS,MDDM,PhD, Srdan Verstovsek, MD PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A Thompson, MBBS, Nitin Jain, MD, William G Wierda, MD PhD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2017) 130 (Supplement 1): 1728.

https://doi.org/10.1182/blood.V130.Suppl_1.1728.1728

Published: 2017

Journal Articles

Overexpression of CD36, Driven By STAT3, Mediates Free Fatty Acid Uptake in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping Li, PhD, Zhiming Liu, Preetesh Jain, MBBS,MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A Thompson, MBBS, Nitin Jain, MD, William G Wierda, MD PhD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2017) 130 (Supplement 1): 4301.

https://doi.org/10.1182/blood.V130.Suppl_1.4301.4301

Published: 2017

Journal Articles

Ibrutinib Disrupts the Metabolic Program of CLL Cells in-Vivo

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Preetesh Jain, MBBS, MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Susan M. O'Brien, MD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, William G. Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD

Blood (2016) 128 (22): 4348.

https://doi.org/10.1182/blood.V128.22.4348.4348

Published: 2016

Journal Articles

Casein Kinase-2 Induces Constitutive Phosphorylation of STAT3 in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Preetesh Jain, MBBS, MDDM, PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Susan M. O'Brien, MD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, William G. Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD

Blood (2016) 128 (22): 4374.

https://doi.org/10.1182/blood.V128.22.4374.4374

Published: 2016

Journal Articles

Stimulation of the B-Cell Receptor (BCR) Induces Successive Activation of STAT3 and Nuclear Factor-Kappa-B in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Alessandra Ferrajoli, MD, Jan A Burger, MD PhD, Philip Thompson, MBBS, Nitin Jain, MD, William Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD

Blood (2015) 126 (23): 4125.

https://doi.org/10.1182/blood.V126.23.4125.4125

Published: 2015

Journal Articles

P300 Acetylates STAT3 and Increases Its Constitutive Transcriptional Activity in CLL Cells

Blood (2015) 126 (23): 4143.

https://doi.org/10.1182/blood.V126.23.4143.4143

Published: 2015

Journal Articles

STAT3-Driven, Aberrantly Expressed Lipoprotein Lipase Mediates Free Fatty Acid Metabolism in Chronic Lymphocytic Leukemia Cells

Uri Rozovski, MD, Srdana Grgurevic, Carlos E. Bueso-Ramos, MD PhD, David M. Harris, Ping Li, PhD, Zhiming Liu, JI Yuan Wu, MD, William Wierda, MD PhD, Jan A. Burger, MD PhD, Susan O'Brien, MD, Nitin Jain, MD, Alessandra Ferrajoli, MD, Michael Keating, MBBS, Zeev Estrov, MD

Blood (2014) 124 (21): 3304.

https://doi.org/10.1182/blood.V124.21.3304.3304

Published: 2014

Journal Articles

Signal Transducer and Activator Of Transcription 3 Activates and Deregulates Micro RNA Expression In Chronic Lymphocytic Leukemia Cells

Rozovski Uri, MD, George Calin, MD PhD, Tetsoro Setoyama, Abundu Lucilla, Harris David, Ping Li, PhD, Lui Zhiming, Grugurevic Srdana, Alessandra Ferrajoli, MD, Stefan H. Faderl, MD, Jan A. Burger, MD, PhD, Susan O'Brien, MD, William G. Wierda, MD, PhD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2013) 122 (21): 4152.

https://doi.org/10.1182/blood.V122.21.4152.4152

Published: 2013

Journal Articles

STAT3 Activates Anti-Apoptotic Genes But When In Access Induces Apoptosis Of CLL Cells

Rozovski Uri, MD, David Harris, Ping Li, PhD, Zhiming Liu, Ji Yuan, Srdana Grugurevic, Susan Lerner, MS, William G. Wierda, MD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2013) 122 (21): 5294.

https://doi.org/10.1182/blood.V122.21.5294.5294

Published: 2013

Journal Articles

STAT3-Activated GM-CSFRα Shuttles To The Nucleus and Protects CLL Cells From Apoptosis

Ping Li, PhD, Uri Rozovski, MD, David Harris, Lui Zhiming, Alessandra Ferrajoli, MD, Carlos E. Bueso-Ramos, MD, PhD, Inbal Hazan-Halevy, Srdana Grugurevic, William G. Wierda, MD, PhD, Jan A. Burger, MD, PhD, Susan O'Brien, MD, Stefan H. Faderl, MD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2013) 122 (21): 4118.

https://doi.org/10.1182/blood.V122.21.4118.4118

Published: 2013

Journal Articles

Signal Transducer and Activator of Transcription (STAT)-3 Induces the Expression of Microrna-155 in Chronic Lymphocytic Leukemia (CLL) Cells.

Ping Li, PhD, Srdana Grgurevic, MS, Zhiming Liu, MS, David Harris, BS, Uri Rozovski, MD, Michael J. Keating, MD, George Calin, MD PhD, Zeev Estrov, MD

Blood (2012) 120 (21): 2885.

https://doi.org/10.1182/blood.V120.21.2885.2885

Published: 2012

Journal Articles

Spontaneous Apoptosis of Chronic Lymphocytic Leukemia (CLL) Cells Correlates with Disease Burden and Inversely Correlates with Intracellular Levels of Signal Transducer and Activator of Transcription-3 (STAT3)

Rozovski Uri, MD, David Harris, Ping Li, PhD, Zhiming Liu, Srdana Grgurevic, Susan Lerner, MS, Matthew Martinez, William G. Wierda, MD, Ph.D., Michael Keating, MD, Zeev Estrov, MD, PhD

Blood (2012) 120 (21): 3910.

https://doi.org/10.1182/blood.V120.21.3910.3910

Published: 2012

Journal Articles

Signal Transducer and Activator of Transcription (STAT)-3 Induces Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) Receptor-α Expression in Chronic Lymphocytic Leukemia (CLL) Cells,

Ping Li, PhD, Zhiming Liu, MS, David Harris, BS, Alessandra Ferrajoli, MD, Yongtao Wang, MD, Inbal Hazan-Halevy, PhD, Srdana Grgurevic, MS, William G. Wierda, MD, PhD, Jan A. Burger, MD, PhD, Susan O'Brien, MD, Stefan Faderl, MD, Michael J Keating, MD, Zeev Estrov

Blood (2011) 118 (21): 3879.

https://doi.org/10.1182/blood.V118.21.3879.3879

Published: 2011

NARROW

Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells

STAT3-Induced Gli1 Promotes the Differentiation and Maturation of Myelofibrosis Fibrocytes

Constitutively Activated STAT3 Induces the Production of PTX3 That Contributes to the Induction of Bone Marrow Reticulin Fibrosis in Patient with CLL

FT-2102, an IDH1m Inhibitor, in Combination with Azacitidine in Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Ayndrome (MDS): Results from a Phase 1 Study

Phase 1 Study of the IDH1m Inhibitor FT-2102 As a Single Agent in Patients with IDH1 m Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

Endogenous STAT3-Activated Wnt5a Provides CLL Cells with Survival Advantage

CLL Cells with 13q- Are Characterized By High BCL2 Levels and CLL Cells with Trisomy-12 By Increased Activation of STAT3 and NF-κB

CLL Cell-Derived Exosomes Promote Bone Marrow Fibrosis and Inhibit Normal Hematopoietic Colony Proliferation

Overexpression of CD36, Driven By STAT3, Mediates Free Fatty Acid Uptake in CLL Cells

Ibrutinib Disrupts the Metabolic Program of CLL Cells in-Vivo

Casein Kinase-2 Induces Constitutive Phosphorylation of STAT3 in CLL Cells

Stimulation of the B-Cell Receptor (BCR) Induces Successive Activation of STAT3 and Nuclear Factor-Kappa-B in CLL Cells

P300 Acetylates STAT3 and Increases Its Constitutive Transcriptional Activity in CLL Cells

STAT3-Driven, Aberrantly Expressed Lipoprotein Lipase Mediates Free Fatty Acid Metabolism in Chronic Lymphocytic Leukemia Cells

Signal Transducer and Activator Of Transcription 3 Activates and Deregulates Micro RNA Expression In Chronic Lymphocytic Leukemia Cells

STAT3 Activates Anti-Apoptotic Genes But When In Access Induces Apoptosis Of CLL Cells

STAT3-Activated GM-CSFRα Shuttles To The Nucleus and Protects CLL Cells From Apoptosis

Signal Transducer and Activator of Transcription (STAT)-3 Induces the Expression of Microrna-155 in Chronic Lymphocytic Leukemia (CLL) Cells.

Spontaneous Apoptosis of Chronic Lymphocytic Leukemia (CLL) Cells Correlates with Disease Burden and Inversely Correlates with Intracellular Levels of Signal Transducer and Activator of Transcription-3 (STAT3)

Signal Transducer and Activator of Transcription (STAT)-3 Induces Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) Receptor-α Expression in Chronic Lymphocytic Leukemia (CLL) Cells,

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American Society of Hematology

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American Society of Hematology

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