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Quinlan Sievers
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Journal Articles

UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability

Jonathan M Tsai, Jacob D Aguirre, Jared Brown, Vivian Focht, Yen-Der Li, Georg Kempf, Lukas Kater, Pius Galli, Simone Cavadini, Brittany E Sandoval, Charles Zou, Justine Rutter, Katherine Donovan, Quinlan Sievers, Paul Park, Jevon A. Cutler, Charlie Hatton, Elizabeth Ener, Micah T Sperling, Mikolaj Slabicki, Peter G. Miller, Roger Belizaire, Adam S. Sperling, Scott A. Armstrong, Eric S. Fischer, Nicolas Thomä, Benjamin L. Ebert
Journal: Blood
Blood (2022) 140 (Supplement 1): 2968–2969.
https://doi.org/10.1182/blood-2022-167615
Published: 2022
Journal Articles

Using an in-Vivo Degron-Based Approach to Interrogate Dependencies of Serially Acquired Mutations - Including DNMT3a-R882 and NPM1c - in Acute Myeloid Leukemia

Andrew A Guirguis, MD PhD, Alexander Tepper, Max Jan, MD PhD, Quinlan Sievers, MD PhD, Benjamin L. Ebert, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-142566
Published: 2020
Journal Articles

Exploiting the Zinc Finger Degrome Targeted By Lenalidomide to Engineer Reversible Off-Switch Degradable Chimeric Antigen Receptors

Max Jan, MD PhD, Ana Castano, MD, Amanda Walker, BA, Andrew A Guirguis, MD PhD, Jessica A Gasser, PhD, Amanda A Bouffard, Mikolaj Slabicki, PhD, Alexander Tepper, Daniel E Grinshpun, Taeyoon Kyung, PhD, Quinlan Sievers, MD PhD, Michael E Birnbaum, PhD, Marcela V Maus, MD PhD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 866.
https://doi.org/10.1182/blood-2019-124210
Published: 2019
Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Dennis Buckley, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Johanna B Bruggenthies, Quinlan Sievers, BA, Haley Poarch, Nicholas P Kwiatkowski, PhD, Tinghu Zhang, PhD, Jacob Laubach, MD, Robert L. Schlossman, MD, Paul Richardson, Aedin Culhane, PhD, Richard WJ Groen, PhD, Eric S. Fischer, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, Daniel Auclair, PhD, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, Benjamin L. Ebert, MDPhD, James Bradner, MD, Nathanae Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1367.
https://doi.org/10.1182/blood-2018-99-116232
Published: 2018
Journal Articles

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Ryosuke Shirasaki, MD PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Paul Hengeveld, Johanna Bruggenthies, Eugen Dhimolea, PhD, Huihui Tang, PhD, Megan Bariteau, Andrew Aguirre, MD PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Brian Glassner, PhD, Christopher J. Ott, PhD, Dennis Buckley, Nicholas P Kwiatkowski, PhD, Jonathan D. Licht, MD, Nathanael Gray, PhD, Joshua Dempster, PhD, Richard WJ Groen, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1212.
https://doi.org/10.1182/blood.V130.Suppl_1.1212.1212
Published: 2017
Journal Articles

Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing

Geoffrey M. Matthews, PhD, Ricardo De Matos Simoes, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Paul J. Hengeveld, B.Sc., Megan A. Bariteau, BSc, Brian Glassner, PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Sara Gandolfi, MD, Pallavi Awate, MSc, Huihui Tang, PhD, Franciska Vazquez, PhD, Aedin Culhane, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 119.
https://doi.org/10.1182/blood.V128.22.119.119
Published: 2016
Journal Articles

Genome-Scale Screen Reveals Genes Required for Lenalidomide-Mediated Degradation of Aiolos By CRL4-CRBN

Quinlan Sievers, BA, Jessica Gasser, PhD, Glenn Cowley, PhD, John G Doench, PhD, Eric Fischer, PhD, Benjamin L Ebert, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5139.
https://doi.org/10.1182/blood.V128.22.5139.5139
Published: 2016
Journal Articles

Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering

Zuzana Tothova, MD PhD, John M Krill-Burger, MCS, Katerina D Popova, BA, Quinlan Sievers, BA, David Yudovich, BSc, Roger Belizaire, MD PhD, Jon C. Aster, MD PhD, Elizabeth A. Morgan, MD, Aviad Tsherniak, MSc, Benjamin L Ebert, MD PhD
Journal: Blood
Blood (2016) 128 (22): 741.
https://doi.org/10.1182/blood.V128.22.741.741
Published: 2016