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Journal Articles

Intensification of Chemotherapeutic Regimens and Hematopoietic Stem Cell Transplantation Are Responsible for Improved Overall Survival in Adult Acute Lymphoblastic Leukemia in a Single Center Over the Last Forty Years

Estrella Carrillo, MD, Nancy Rodriguez, Juan Francisco Dominguez, Jose Gonzalez, MD, Jose Francisco Falantes, MD, Isabel Montero, MD, M. Luz Martino, MD, Francisco Márquez-Malaver, Ricardo Parody, MD, Estefania Garcia-Guerrero, Jose Antonio Perez-Simón, Sr., MD, PhD, Ildefonso Espigado, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4227.
https://doi.org/10.1182/blood.V118.21.4227.4227
Published: 2011
Journal Articles

Differentiation syndrome in patients with acute promyelocytic leukemia treated with all- trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors

Clinical Trials & Observations
Pau Montesinos, Juan M. Bergua, Edo Vellenga, Chelo Rayón, Ricardo Parody, Javier de la Serna, Angel León, Jordi Esteve, Gustavo Milone, Guillermo Debén, Concha Rivas, Marcos González, Mar Tormo, Joaquín Díaz-Mediavilla, Jose D. González, Silvia Negri, Elena Amutio, Salut Brunet, Bob Lowenberg, Miguel A. Sanz
Journal: Blood
Blood (2009) 113 (4): 775–783.
https://doi.org/10.1182/blood-2008-07-168617
Published: 2009
Journal Articles

Treatment of High-Risk (HR) Philadelphia Chromosome-Negative (Ph-) Adult Acute Lymphoblastic Leukemia (ALL) According to Baseline Risk Factors and Minimal Residual Disease (MRD). Results of the PETHEMA ALL-AR-03 Trial.

Josep-Maria Ribera, Albert Oriol, Mireia Morgades, Josep Sarra, Pau Montesinos, Salut Brunet, Ramon Guardia, Pascual Fernández-Abellan, Teresa Bernal, MD, Arancha Bermudez, Maria-Jose Moreno, Ricardo Parody, Mar Tormo, Eloy Del Potro, Andreu Llorente, Raimundo Garcia-Boyero, Jordi Esteve, Maria-Jose Rabuñal, Emilia Pardal, Carlos Grande, Javier Bueno, Antonia Cladera, Concepcion Bethencourt, Victoria Martin-Reina, Maria-Luz Amigo, Jesus-Maria Hernandez-Rivas, Miguel-Angel Sanz, Evarist Feliu
Journal: Blood
Blood (2008) 112 (11): 3291.
https://doi.org/10.1182/blood.V112.11.3291.3291
Published: 2008
Journal Articles

Risk-adapted treatment of acute promyelocytic leukemia with all- trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group

Brief Report
Miguel A. Sanz, Pau Montesinos, Edo Vellenga, Consuelo Rayón, Javier de la Serna, Ricardo Parody, Juan M. Bergua, Angel León, Silvia Negri, Marcos González, Concha Rivas, Jordi Esteve, Gustavo Milone, José D. González, Elena Amutio, Salut Brunet, J. García-Laraña, Dolors Colomer, María J. Calasanz, Carmen Chillón, Eva Barragán, Pascual Bolufer, Bob Lowenberg
Journal: Blood
Blood (2008) 112 (8): 3130–3134.
https://doi.org/10.1182/blood-2008-05-159632
Published: 2008
Journal Articles

Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin

Clinical Trials & Observations
Javier de la Serna, Pau Montesinos, Edo Vellenga, Chelo Rayón, Ricardo Parody, Angel León, Jordi Esteve, Juan M. Bergua, Gustavo Milone, Guillermo Debén, Concha Rivas, Marcos González, Mar Tormo, Joaquín Díaz-Mediavilla, Jose D. González, Silvia Negri, Elena Amutio, Salut Brunet, Bob Lowenberg, Miguel A. Sanz
Journal: Blood
Blood (2008) 111 (7): 3395–3402.
https://doi.org/10.1182/blood-2007-07-100669
Published: 2008
Journal Articles

Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results

Clinical Trials & Observations
Lionel Adès, Miguel A. Sanz, Sylvie Chevret, Pau Montesinos, Patrice Chevallier, Emmanuel Raffoux, Edo Vellenga, Agnès Guerci, Arnaud Pigneux, Francoise Huguet, Consuelo Rayon, Anne Marie Stoppa, Javier de la Serna, Jean-Yves Cahn, Sandrine Meyer-Monard, Thomas Pabst, Xavier Thomas, Stéphane de Botton, Ricardo Parody, Juan Bergua, Thierry Lamy, Anne Vekhoff, Silvia Negri, Norbert Ifrah, Hervé Dombret, Augustin Ferrant, Dominique Bron, Laurent Degos, Pierre Fenaux
Journal: Blood
Blood (2008) 111 (3): 1078–1084.
https://doi.org/10.1182/blood-2007-07-099978
Published: 2008
Journal Articles

The Prognostic Significance of Complex Karyotype in Philadelphia Chromosome-Negative (Ph−) Acute Lymphoblastic Leukemia (ALL) in Adults Is Related with Risk Group.

Isabel Granada, MD, Juan-Manuel Sancho, MD, Albert Oriol, MD, Mireia Morgades, MD, Concepción Bethencourt, MD, Ricardo Parody, MD, Jesús-María Hernández-Rivas, PhD, Maria-José Moreno, MD, Eloy Del-Potro, MD, Mar Tormo, MD, Concepción Rivas, MD, Miguel-Angel Sanz, PhD, Carlos Grande, MD, Javier Bueno, MD, Eugenia Abella, MD, Juan-José Ortega, PhD, Josep-Maria Ribera, PhD
Journal: Blood
Blood (2007) 110 (11): 3501.
https://doi.org/10.1182/blood.V110.11.3501.3501
Published: 2007
Journal Articles

Risk-Adapted Treatment of Acute Promyelocytic Leukemia: Updated Results of the Spanish PETHEMA LPA99 Trial Using ATRA and Anthracycline Monochemotherapy.

Miguel A. Sanz, PhD, Pau Montesinos, MD, Edo Vellenga, PhD, Chelo Rayon, PhD, Ricardo Parody, PhD, Javier de la Serna, PhD, Juan Bergua, PhD, Angel Leon, PhD, Silvia Negri, PhD, Concha Rivas, PhD, Salut Brunet, PhD, Marcos Gonzalez, PhD, Jordi Esteve, PhD, Bob Lowenberg, PhD
Journal: Blood
Blood (2007) 110 (11): 590.
https://doi.org/10.1182/blood.V110.11.590.590
Published: 2007
Journal Articles

Central Nervous System Relapse in Patients with Acute Promyelocytic Leukemia Treated with All-Trans Retinoic Acid and Reinforced Anthracycline Monochemotherapy.

Pau Montesinos, MD, Jose D. Gonzalez, PHD, Edo Vellenga, PHD, Chelo Rayon, PHD, Ricardo Parody, PHD, Angel Leon, PHD, Jordi Esteve, PHD, Juan Bergua, PHD, Gustavo Milone, PHD, Miguel A. Sanz, PHD
Journal: Blood
Blood (2007) 110 (11): 592.
https://doi.org/10.1182/blood.V110.11.592.592
Published: 2007
Journal Articles

Incidence and Risk Factors for Thrombosis in Patients with Acute Promyelocytic Leukemia. Experience of the PETHEMA LPA96 and LPA99 Protocols.

Pau Montesinos, MD, Javier de la Serna, PhD, Edo Vellenga, PhD, Consuelo Rayon, PhD, Juan Bergua, PhD, Ricardo Parody, PhD, Jordi Esteve, PhD, Marcos Gonzalez, PhD, Salud Brunet, PhD, Miguel Sanz, PhD
Journal: Blood
Blood (2006) 108 (11): 1503.
https://doi.org/10.1182/blood.V108.11.1503.1503
Published: 2006
Journal Articles

Treatment of High-Risk (HR) Philadelphia Chromosome-Negative (Ph-) Adult Acute Lymphoblastic Leukemia (ALL) According to Classical Risk Factors and Minimal Residual Disease (MRD). Interim Results of the PETHEMA ALL-AR-03 Trial.

Josep Ribera, MD, Albert Oriol, MD, Mireia Morgades, MD, Josep Sarrá, MD, Salut Brunet, MD, Andreu Llorente, MD, Ramon Guardia, MD, Ricardo Parody, MD, Teresa Bernal, MD, Jordi Esteve, MD, Miguel Sanz, MD, Eloy Del Potro, MD, Juan Bergua, MD, Maria-Jose Moreno, MD, Carlos Grande, MD, Javier Bueno, MD, Antonia Cladera, MD, María-Carmen Fernández, MD, Raimundo García-Boyero, MD, Arancha Bermúdez, MD, Evarist Feliu, MD
Journal: Blood
Blood (2006) 108 (11): 1872.
https://doi.org/10.1182/blood.V108.11.1872.1872
Published: 2006
Journal Articles

Prognostic Value of Immunophenotype Analysis in Patients with Acute Promyelocytic Leukemia (APL) Treated with All-Transretinoic Acid and Anthracyclin Monochemotherapy.

Pau Montesinos, MD, Concepcion Rivas, PhD, Consuelo Rayon, PhD, Edo Vellenga, PhD, Javier de la Serna, PhD, Juan Bergua, PhD, Ricardo Parody, PhD, Salud Brunet, PhD, Gustavo Milone, PhD, Miguel Sanz, PhD
Journal: Blood
Blood (2006) 108 (11): 2345.
https://doi.org/10.1182/blood.V108.11.2345.2345
Published: 2006
Journal Articles

Retinoic Acid Syndrome in Patients with Acute Promyelocytic Leukemia Treated with All-Trans Retinoic Acid and Anthracycline Monochemotherapy.

Pau Montesinos, MD, Juan Bergua, PhD, Guillermo Martin, PhD, Javier de la Serna, PhD, Edo Vellenga, PhD, Consuelo Rayon, PhD, Ricardo Parody, PhD, Jordi Esteve, PhD, Marcos Gonzalez, PhD, Jose Gonzalez, PhD, Miguel Sanz, PhD
Journal: Blood
Blood (2006) 108 (11): 2010.
https://doi.org/10.1182/blood.V108.11.2010.2010
Published: 2006
Journal Articles

Central Nervous System (CNS) Relapse in Adult Patients with Acute Lymphoblastic Leukemia (ALL): Frequency and Prognosis in 467 Patients without Cranial Irradiation for CNS Prophylaxis.

Juan-Manuel Sancho, MD, Josep-Maria Ribera, PhD, Albert Oriol, MD, Jesus-Maria Hernandez-Rivas, PhD, Concepcion Rivas, MD, Concepcion Bethencourt, MD, Javier Fernández-Calvo, MD, Ricardo Parody, MD, Guillermo Deben, MD, Jose-Luis Bello, MD, Josep-Maria Marti, MD, Eugenia Abella, PhD, Eloy Del-Potro, MD, Maria-Jose Terol, MD, Evarist Feliu, PhD
Journal: Blood
Blood (2005) 106 (11): 1841.
https://doi.org/10.1182/blood.V106.11.1841.1841
Published: 2005
Journal Articles

Efficacy and Safety of Fludarabine/Cyclophosphamide (FC) as Front-Line Treatment of CLL. Final Results of a Phase II Clinical Trial in a Single Center.

Ana Marin-Niebla, MD, Eduardo Rios-Herranz, MD, Juan M. Rodriguez, PhD, Ramiro Nunez, MD, Ascension Herrera, MD, Ricardo Parody, MD, Ildefonso Espigado, PhD.
Journal: Blood
Blood (2004) 104 (11): 4826.
https://doi.org/10.1182/blood.V104.11.4826.4826
Published: 2004
Journal Articles

Comparison of Intensive Chemotherapy (CHT), Allogeneic (ALLO) or Autologous (AUTO) Stem Cell Transplantation (SCT) as Post-Remission Treatment for Adult Patients with High-Risk Acute Lymphoblastic Leukemia (HR-ALL). Final Results of the PETHEMA ALL-93 Trial.

Josep-Maria Ribera, MD, Albert Oriol, MD, Concepcion Bethencourt, MD, Ricardo Parody, MD, Jesus-Maria Hernandez-Rivas, MD, Maria-Jose Moreno, MD, Eloy Del Potro, MD, Mar Tormo, MD, Concepcion Rivas, MD, Joan Besalduch, MD, Miguel-Angel Sanz, MD, Jesus Arias, MD, Javier Fernandez-Calvo, MD, Jose-Maria Moraleda, MD, Javier Bueno, MD, Evarist Feliu, MD, Juan-Jose Ortega, MD
Journal: Blood
Blood (2004) 104 (11): 2731.
https://doi.org/10.1182/blood.V104.11.2731.2731
Published: 2004
Journal Articles

Causes of Induction Failure in Newly Diagnosed Acute Promyelocytic Leukemia Patients Treated with Simultaneous ATRA and Idarubicin (AIDA).

Javier de la Serna, MD, Guillermo Martin, MD, Edo Vellenga, MD, Chelo Rayon, MD, Concha Rivas, MD, Guillermo Deben, MD, Marcos Gonzalez, MD, Mar Tormo, MD, Juan Bergua, MD, Jaoquin Diaz-Mediavilla, MD, Angel Leon, MD, Jordi Esteve, MD, Ricardo Parody, MD, Elena Amutio, MD, Jose D. Gonzalez, MD, Silvia Negri, MD, Francisco J. Capote, MD, Javier Bueno, MD, Manuel Perez-Encina, MD, Andres Novo, MD, Antonia Rodriguez, MD, Miguel A. Sanz, MD
Journal: Blood
Blood (2004) 104 (11): 887.
https://doi.org/10.1182/blood.V104.11.887.887
Published: 2004
Journal Articles

Treatment of Philadelphia Chromosome (Ph)-Positive Acute Lymphoblastic Leukemia (ALL) with Concurrent Chemotherapy and Imatinib Mesylate.

Josep-Maria Ribera, MD, Albert Oriol, MD, Marcos Gonzalez, MD, Maria-Belen Vidriales, MD, Blanca Xicoy, MD, Javier Grau, MD, Jordi Esteve, MD, Salut Brunet, MD, Eloy Del Potro, MD, Maria-Jose Moreno, MD, Mar Tormo, MD, Maria-Victoria Martin-Reina, MD, Guillermo Deben, MD, Ricardo Parody, MD, Juan-Jose Lahuerta, MD, Jesus-Fernando San Miguel, MD
Journal: Blood
Blood (2004) 104 (11): 4483.
https://doi.org/10.1182/blood.V104.11.4483.4483
Published: 2004
Journal Articles

Risk-adapted treatment of acute promyelocytic leukemia with all- trans -retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group

Clinical Trials & Observations
Miguel A. Sanz, Guillermo Martín, Marcos González, Angel León, Chelo Rayón, Concha Rivas, Dolors Colomer, Elena Amutio, Francisco J. Capote, Gustavo A. Milone, Javier de la Serna, José Román, Eva Barragán, Juan Bergua, Lourdes Escoda, Ricardo Parody, Silvia Negri, María J. Calasanz, Pascual Bolufer
Journal: Blood
Blood (2004) 103 (4): 1237–1243.
https://doi.org/10.1182/blood-2003-07-2462
Published: 2004