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Journal Articles

ITK Inhibitor Induces Dose-Dependent Th1 Skewing in Normal T Cells and Is Active in Refractory T Cell Lymphomas

Yuqin Song, Ning Ding, Dok Hyun Yoon, John C. Reneau, Ryan A. Wilcox, Won Seog Kim, Youn H. Kim, Michael S. Khodadoust, Tatyana A. Feldman, Costas K. Yannakou, Pratyush Giri, Jonathan E Brammer, Lih-Yun Hsu, Hongwei Yuan, Erik Verner, Suresh Mahabhashyam, Richard A. Miller

Blood (2022) 140 (Supplement 1): 8857–8859.

https://doi.org/10.1182/blood-2022-159177

Published: 2022

Journal Articles

Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, Is Well-Tolerated and Active in Patients with T-Cell Lymphoma

Michael S. Khodadoust, MD PhD, Tatyana A. Feldman, MD, Dok Hyun Yoon, Costas K. Yannakou, MBBS (Hons), FRACP, FRCPA, Dejan Radeski, MBBS, FRACP, FRCPA, Youn H. Kim, MD, Neha Mehta-Shah, MD, Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Ryan A. Wilcox, MD, Won Seog Kim, MD PhD, Steven M. Horwitz, MD, Joseph J. Buggy, PhD, Andrew Hotson, PhD, Craig M. Hill, PhD, Brian Munneke, PhD, Suresh Mahabhashyam, MD, Richard A. Miller, MD, James W. Janc, PhD, Mehrdad Mobasher, MDMPH

Blood (2020) 136 (Supplement 1): 19–20.

https://doi.org/10.1182/blood-2020-137782

Published: 2020

Journal Articles

The ITK Inhibitor Cpi-818 Blocks Activation of T Cells from Autoimmune Lymphoproliferative Syndrome (ALPS) Patients and Is Active in a Murine Model of ALPS

V. Koneti Koneti Rao, MD FRCPA, Patrick P. Ng, PhD, Craig M. Hill, PhD, Richard A. Miller, MD, Joseph J. Buggy, PhD, James W. Janc, PhD

Blood (2020) 136 (Supplement 1): 36–37.

https://doi.org/10.1182/blood-2020-137631

Published: 2020

Journal Articles

Preliminary Clinical Data from a Phase 1 Trial with CPI-818, a Selective ITK Inhibitor That Preferentially Blocks the Growth of T Lymphoma Cells

Patrick P. Ng, PhD, Mehrdad Mobasher, MD MPH, Kitman S. Yeung, MS, Andrew N. Hotson, PhD, Craig M. Hill, PhD, Antonett Madriaga, MS, Trang P. Dao-Pick, MA, Erik Verner, PhD, Dejan Radeski, MBBS, FRACP, FRCPA, Michael S. Khodadoust, MD PhD, Youn H. Kim, MD, Richard A. Miller, MD, Joseph J. Buggy, PhD, James W. Janc, PhD

Blood (2019) 134 (Supplement_1): 1571.

https://doi.org/10.1182/blood-2019-127338

Published: 2019

Journal Articles

A Phase 1/1b Dose-Escalation Trial Evaluating Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, in Subjects with Relapsed/Refractory T-Cell Lymphoma

Mehrdad Mobasher, MD MPH, Richard A. Miller, MD, James W. Janc, PhD, Long Kwei, PhD, Joseph J. Buggy, PhD, Gabriel Luciano, Anahita Mohammady, PharmD, Won Seog Kim, MD PhD, Youn H. Kim, MD, Michael S. Khodadoust, MD PhD, Steven M. Horwitz, MD, Dejan Radeski, MBBS, FRACP, FRCPA

Blood (2019) 134 (Supplement_1): 4030.

https://doi.org/10.1182/blood-2019-124958

Published: 2019

Journal Articles

Microrna Mediated Regulation of Hematopoietic Stem Cell Aging

Safak Yalcin, PhD, Mark Carty, Joseph Yusup Shin, Richard A Miller, PhD, Christina Leslie, PhD, Christopher Y. Park, MD PhD

Blood (2014) 124 (21): 602.

https://doi.org/10.1182/blood.V124.21.602.602

Published: 2014

Journal Articles

Longevity Promoting Interventions Inhibit Molecular and Functional Changes In Aging Hematopoietic Stem Cells

Safak Yalcin, PhD, Wenhuo Hu, PhD, Richard A Miller, PhD, Yusup Shin, Christopher Y. Park, MD, PhD

Blood (2013) 122 (21): 1168.

https://doi.org/10.1182/blood.V122.21.1168.1168

Published: 2013

Journal Articles

Histone Deacetylase Inhibitor (HDACi) PCI-24781 and Bortezomib Result in Synergistic Apoptosis in Hodgkin Lymphoma (HL) and Non-Hodgkin’s Lymphoma (NHL) Cell Lines: Investigation of Cell Death and NFKB-Mediated Pathways.

Savita Bhalla, PhD, Kevin David, MD, Lauren Mauro, MD, Sheila Prachand, MS, Mint Sirisawad, Sriram Balasubramanian, PhD, Richard A. Miller, MD, Joseph Buggy, PhD, Leo I. Gordon, MD, Andrew M. Evens, DO, MS

Blood (2007) 110 (11): 3589.

https://doi.org/10.1182/blood.V110.11.3589.3589

Published: 2007

Journal Articles

A Phase I/II Trial of Radioimmunotherapy (RIT) with 90 Yttrium-Ibritumomab Tiuxetan (Zevalin®; 90 Y-Zevalin) Combined with the Redox-Active Agent Motexafin Gadolinium (MGd): Prompt and High Remission Rates in Patients with Rituximab-Refractory Non-Hodgkin’s Lymphoma (NHL).

Andrew M. Evens, DO, MS, Stewart Spies, MD, David Patton, MS, Irene Helenowski, MS, Borko Jovanovic, PhD, Sarah Miyata, RN, ACNP, Elizabeth Hamilton, RN, CNP, M. Wayne Saville, MD, Richard A. Miller, MD, Jane N. Winter, MD, Leo I. Gordon, MD

Blood (2007) 110 (11): 2558.

https://doi.org/10.1182/blood.V110.11.2558.2558

Published: 2007

Journal Articles

Motexafin Gadolinium and Other Metallotexaphyrins Upregulate Heme Oxygenase-1.

Mint Sirisawad, Jun Chen, Jason Ramos, Richard A. Miller, Louie Naumovski

Blood (2005) 106 (11): 4468.

https://doi.org/10.1182/blood.V106.11.4468.4468

Published: 2005

Journal Articles

Motexafin Gadolinium (MGd) Has Clinical Activity in Relapsed/Refractory Low Grade Lymphomas (LG) and Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL).

Brad S. Kahl, MD, Ranjana Advani, MD, Neil Kay, MD, Izidore S. Lossos, MD, Andrew Evens, DO, Leo Gordon, MD, Richard A. Miller, MD, See-Chun Phan, MD

Blood (2005) 106 (11): 4758.

https://doi.org/10.1182/blood.V106.11.4758.4758

Published: 2005

Journal Articles

Motexafin Gadolinium Upregulates pAkt Levels and Synergizes with Inhibitors of Akt Phosphorylation.

Jason Ramos, PhD, Mint Sirisawad, BS, Richard A. Miller, Louie Naumovski, MD-PhD

Blood (2005) 106 (11): 4275.

https://doi.org/10.1182/blood.V106.11.4275.4275

Published: 2005

Journal Articles

Growth Inhibition or Apoptosis after Treatment with Motexafin Gadolinium and Celecoxib Is Cell Line Dependent and Correlates with p27 Levels.

Jason Ramos, PhD, Mint Sirisawad, BS, Jun Chen, PhD, Richard A. Miller, MD, Louie Naumovski, MD-PhD

Blood (2005) 106 (11): 4296.

https://doi.org/10.1182/blood.V106.11.4296.4296

Published: 2005

Journal Articles

Motexafin Gadolinium Causes Apoptosis in Lymphoma Cells by Increasing Intracellular Free Zinc and Disrupting Redox Balance.

Darren Magda, PhD, Philip Lecane, PhD, Mazen W. Karaman, PhD, Mint Sirisawad, PhD, Louie Naumovski, MD, PhD, Richard A. Miller, MD, Joseph G. Hacia, PhD

Blood (2005) 106 (11): 4827.

https://doi.org/10.1182/blood.V106.11.4827.4827

Published: 2005

Journal Articles

Motexafin Gadolinium Enhances Rituximab-Induced Cytotoxicity Against B-Cell Lymphoma Cell Lines: Role of Elevated Intracellular Calcium.

Jun Chen, PhD, Jason Ramos, PhD, Mint Sirisawad, BS, Richard A. Miller, MD, Louie Naumovski, MD-PhD

Blood (2005) 106 (11): 4829.

https://doi.org/10.1182/blood.V106.11.4829.4829

Published: 2005

Journal Articles

Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells

Andrew M. Evens, Philip Lecane, Darren Magda, Sheila Prachand, Seema Singhal, Jeff Nelson, Richard A. Miller, Ronald B. Gartenhaus, Leo I. Gordon

Blood (2005) 105 (3): 1265–1273.

https://doi.org/10.1182/blood-2004-03-0964

Published: 2005

Journal Articles

Motexafin Gadolinium Mobilizes Zinc and Inhibits Thioredoxin Reductase in Human Lymphoma Cell Lines.

Darren Magda, Ph.D., Philip Lecane, Ph.D., Lepp Cheryl, M.S., Richard A. Miller, M.D.

Blood (2004) 104 (11): 4316.

https://doi.org/10.1182/blood.V104.11.4316.4316

Published: 2004

Journal Articles

Effects of the Redox Mediator Motexafin Gadolinium in a Pilot Phase I Trial in Refractory Chronic Lymphocytic Leukemia (CLL).

Thomas S. Lin, MD, PhD, Sabyasachi Biswas, PhD, Louie Naumovski, MD, PhD, Phillip Lecane, PhD, Margaret S. Lucas, PA-C, Mollie E. Moran, CRNP, Andrew P. Mone, MD, PhD, David M. Lucas, PhD, See-Chun Phan, MD, Richard A. Miller, MD, John C. Byrd, MD

Blood (2004) 104 (11): 3486.

https://doi.org/10.1182/blood.V104.11.3486.3486

Published: 2004

Journal Articles

Motexafin Gadolinium Induces Apoptosis in Lymphoid Cell Lines and Demonstrates Enhanced Biological Activity with Akt Kinase Inhibitors.

Louie Naumovski, MD-PhD, Jason Ramos, PhD, Jun Chen, PhD, Mint Sirisawad, BA, David Lucas, PhD, John C. Byrd, MD, Richard A. Miller, MD

Blood (2004) 104 (11): 3406.

https://doi.org/10.1182/blood.V104.11.3406.3406

Published: 2004

Journal Articles

Sapphyrins Exhibit Tumor Selectivity and Efficacy in Animal Models of Hematologic Malignancies.

Louie Naumovski, MD-PhD, Mint Sirisawad, BA, Philip Lecane, PhD, Jason Ramos, PhD, Darren Magda, PhD, Zhong Wang, PhD, Patti Thiemann, BS, Garry Boswell, PharmD, Dong-Gyu Cho, BS, Jonathan Sessler, PhD, Richard A. Miller, MD

Blood (2004) 104 (11): 2501.

https://doi.org/10.1182/blood.V104.11.2501.2501

Published: 2004

NARROW

ITK Inhibitor Induces Dose-Dependent Th1 Skewing in Normal T Cells and Is Active in Refractory T Cell Lymphomas

Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, Is Well-Tolerated and Active in Patients with T-Cell Lymphoma

The ITK Inhibitor Cpi-818 Blocks Activation of T Cells from Autoimmune Lymphoproliferative Syndrome (ALPS) Patients and Is Active in a Murine Model of ALPS

Preliminary Clinical Data from a Phase 1 Trial with CPI-818, a Selective ITK Inhibitor That Preferentially Blocks the Growth of T Lymphoma Cells

A Phase 1/1b Dose-Escalation Trial Evaluating Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, in Subjects with Relapsed/Refractory T-Cell Lymphoma

Microrna Mediated Regulation of Hematopoietic Stem Cell Aging

Longevity Promoting Interventions Inhibit Molecular and Functional Changes In Aging Hematopoietic Stem Cells

Histone Deacetylase Inhibitor (HDACi) PCI-24781 and Bortezomib Result in Synergistic Apoptosis in Hodgkin Lymphoma (HL) and Non-Hodgkin’s Lymphoma (NHL) Cell Lines: Investigation of Cell Death and NFKB-Mediated Pathways.

A Phase I/II Trial of Radioimmunotherapy (RIT) with 90 Yttrium-Ibritumomab Tiuxetan (Zevalin®; 90 Y-Zevalin) Combined with the Redox-Active Agent Motexafin Gadolinium (MGd): Prompt and High Remission Rates in Patients with Rituximab-Refractory Non-Hodgkin’s Lymphoma (NHL).

Motexafin Gadolinium and Other Metallotexaphyrins Upregulate Heme Oxygenase-1.

Motexafin Gadolinium (MGd) Has Clinical Activity in Relapsed/Refractory Low Grade Lymphomas (LG) and Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL).

Motexafin Gadolinium Upregulates pAkt Levels and Synergizes with Inhibitors of Akt Phosphorylation.

Growth Inhibition or Apoptosis after Treatment with Motexafin Gadolinium and Celecoxib Is Cell Line Dependent and Correlates with p27 Levels.

Motexafin Gadolinium Causes Apoptosis in Lymphoma Cells by Increasing Intracellular Free Zinc and Disrupting Redox Balance.

Motexafin Gadolinium Enhances Rituximab-Induced Cytotoxicity Against B-Cell Lymphoma Cell Lines: Role of Elevated Intracellular Calcium.

Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells

Motexafin Gadolinium Mobilizes Zinc and Inhibits Thioredoxin Reductase in Human Lymphoma Cell Lines.

Effects of the Redox Mediator Motexafin Gadolinium in a Pilot Phase I Trial in Refractory Chronic Lymphocytic Leukemia (CLL).

Motexafin Gadolinium Induces Apoptosis in Lymphoid Cell Lines and Demonstrates Enhanced Biological Activity with Akt Kinase Inhibitors.

Sapphyrins Exhibit Tumor Selectivity and Efficacy in Animal Models of Hematologic Malignancies.

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American Society of Hematology

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American Society of Hematology

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