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Journal Articles

MALT1 Protease Inhibition Overcomes BTK Inhibitor Resistance and Shows Synergistic Activity with Venetoclax in Models of B Cell Lymphoma and Leukemia

Joshua Plotnik, Velitchka Bontcheva, Colleen Dowell, Christine Will, Jun Chen, Adam Richardson, Ryan McClure, Paul Jung, Lan Pham, Andrew Souers, Jonathan Meulbroek, William Pappano

Blood (2023) 142 (Supplement 1): 5009.

https://doi.org/10.1182/blood-2023-189061

Published: 2023

Journal Articles

Single-Cell-Multiomics Demonstrates Molecular Efficacy of a Clinical Lentiviral Vector for Gene Therapy of RPS19-Deficient Diamond-Blackfan Anemia

Sofia Freiman, Jun Chen, Johan Flygare, Chayenne Kampman, Karin Pike-Overzet, Alexander Mohseny, Teng-Cheong Ha, Mathias Lidgren, Shamit Soneji, Stefan Karlsson, Dagmar Pospíšilová, Frank Staal, Axel Schambach, Johan Flygare

Blood (2023) 142 (Supplement 1): 943.

https://doi.org/10.1182/blood-2023-185802

Published: 2023

Journal Articles

A Novel Platform to Manufacture High-Efficient "Off-the-Shelf" CAR-NK Products from Peripheral Blood Mononuclear Cells (PBMC)

Blood (2022) 140 (Supplement 1): 7409–7410.

https://doi.org/10.1182/blood-2022-162937

Published: 2022

Journal Articles

Characterization of JNJ-80948543, a Novel CD79bxCD20xCD3 Trispecific T-Cell Redirecting Antibody for the Treatment of B-Cell Non-Hodgkin Lymphoma

Blood (2022) 140 (Supplement 1): 3105–3106.

https://doi.org/10.1182/blood-2022-168739

Published: 2022

Journal Articles

RVU120 (SEL120) CDK8/19 Inhibitor - a Drug Candidate for the Treatment of MDS Can Induce Erythroid Differentiation

Blood (2021) 138 (Supplement 1): 1518.

https://doi.org/10.1182/blood-2021-150662

Published: 2021

Journal Articles

Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

Mark C Wilkes, PhD, Kavitha Siva, PhD, Jacqueline D Mercado, Ethan Patrick Wentworth, Mallika Saxena, Jun Chen, MD PhD, Anupama Narla, MD, Bertil Glader, MD PhD, Shuo Lin, PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD

Blood (2020) 136 (Supplement 1): 7.

https://doi.org/10.1182/blood-2020-137170

Published: 2020

Journal Articles

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171

Agatheeswaran Subramaniam, Kristijonas Žemaitis, Mehrnaz Safaee Talkhoncheh, David Yudovich, Alexandra Bäckström, Shubhranshu Debnath, Jun Chen, Mayur Vilas Jain, Roman Galeev, Massimiliano Gaetani, Roman A. Zubarev, Jonas Larsson

Blood (2020) 136 (19): 2151–2161.

https://doi.org/10.1182/blood.2020005827

Published: 2020

Includes: Supplemental data

Journal Articles

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, PhD, Jacqueline D Mercado, Mallika Saxena, Jun Chen, MD PhD, Kavitha Siva, PhD, Hee-Don Chae, PhD, Minyoung Youn, PhD, Ethan Patrick Wentworth, Kevin Jung, Ryan Sathianathen, Hiral Patel, Bertil Glader, MD PhD, Anupama Narla, MD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD

Blood (2019) 134 (Supplement_1): 455.

https://doi.org/10.1182/blood-2019-129570

Published: 2019

Journal Articles

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Lorena Nunez Villacis, Sheren J Al-Obaidi, Piyush Madhamshettiwar, PhD, Nadine Hein, PhD, Jun Chen, MD PhD, Priscilla Soo, Perlita Poh, Megan Pavy, Kaylene J Simpson, PhD, Thomas John Gonda, PhD BSc, Richard B Pearson, PhD, Johan Flygare, MD PhD, Katherine M Hannan, PhD, Amee J George, PhD, Ross Hannan, PhD

Blood (2018) 132 (Supplement 1): 3859.

https://doi.org/10.1182/blood-2018-99-114303

Published: 2018

Journal Articles

Pharmacological Inhibition of Nlk (Nemo-like Kinase) Rescues Erythropoietic Defects in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, Jun Chen, MD PhD, Kavitha Siva, PhD, Gianluca Veretti, PhD, Daniel P. Dever, PhD, Minyoung Youn, PhD, Hee-Don Chae, PhD, Jacqueline D Mercado, Mallika Saxena, Anupama Narla, MD, Bertil Glader, MD, Matthew Porteus, MD PhD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD

Blood (2018) 132 (Supplement 1): 754.

https://doi.org/10.1182/blood-2018-99-119954

Published: 2018

Journal Articles

Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs

Blood (2018) 132 (Supplement 1): 753.

https://doi.org/10.1182/blood-2018-99-114570

Published: 2018

Journal Articles

Inhibition of Lysine-Specific Demethylase 1A (LSD1) Supports Human HSCs in Culture By Preserving Their Immature State

Agatheeswaran Subramaniam, PhD, Mehrnaz Safaee Talkhoncheh, Kristijonas Zemaitis, Shubhranshu Debnath, PhD, Jun Chen, MD PhD, Mayur Jain, PhD, Roman Galeev, MD, Jonas Larsson, MD PhD

Blood (2018) 132 (Supplement 1): 194.

https://doi.org/10.1182/blood-2018-194

Published: 2018

Journal Articles

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

Blood (2018) 132 (Supplement 1): 1520.

https://doi.org/10.1182/blood-2018-99-111859

Published: 2018

Journal Articles

Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models

Lina Han, MD PhD, Qi Zhang, MD PhD, Ce Shi, MD PhD, Antonio Cavazos, MS, Vivian Ruvolo, MS, Joel Leverson, Dail Monique, PhD, Darren C. Phillips, PhD, Jun Chen, MD PhD, Sha S Jin, Rodrigo Omar Jacamo, PhD, Naval Daver, MD, Elias J. Jabbour, MD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Deepak Sampath, PhD, Marina Konopleva, MD PhD

Blood (2016) 128 (22): 97.

https://doi.org/10.1182/blood.V128.22.97.97

Published: 2016

Journal Articles

Concomitantly Targeting BCL-2 with Venetoclax (ABT-199/GDC-0199) and MAPK Signaling with Cobimetinib (GDC-0973) in Acute Myeloid Leukemia Models

Lina Han, PhD, Qi Zhang, Ce Shi, PhD, Joel Leverson, PhD, Monique Dail, Darren C. Phillips, PhD, Jun Chen, MDPhD, Sha S Jin, Rodrigo Omar Jacamo, PhD, Naval Daver, MD, Elias J Jabbour, MD, Hagop M Kantarjian, MD, Michael Andreeff, MD PhD, Deepak Sampath, PhD, Marina Konopleva, MD PhD

Blood (2015) 126 (23): 2544.

https://doi.org/10.1182/blood.V126.23.2544.2544

Published: 2015

Journal Articles

CDK9 Inhibition Reverses Resistance to ABT-199 (GDC-0199) By Down-Regulating MCL-1

Jun Chen, MDPhD, Sha Jin, MS, Paul Tapang, Stephen K Tahir, PhD, Morey Smith, John Xue, Haichao Zhang, PhD, Wenqing Gao, PhD, Yunsong Tong, PhD, Richard Clark, Justin L. Ricker, MD PhD, Thomas D Penning, PhD, Daniel H Albert, PhD, Darren C Phillips, PhD, Andrew J Souers, PhD, Joel D. Leverson, PhD

Blood (2014) 124 (21): 2161.

https://doi.org/10.1182/blood.V124.21.2161.2161

Published: 2014

Journal Articles

Expression of Bcl-2 Pro-Survival Family Proteins Predicts Pharmacological Responses to ABT-199, a Novel and Selective Bcl-2 Antagonist, in Multiple Myeloma Models

Deepak Sampath, PhD, Elizabeth Punnoose, PhD, Erwin R. Boghaert, PhD, Lisa Belmont, PhD, Jun Chen, PhD, Franklin Peale, MD, PhD, Nguyen Tan, Walter Darbonne, Peng Yue, PhD, Jason Oeh, Leslie Lee, Wayne J. Fairbrother, PhD, Andrew J. Souers, PhD, Steve W. Elmore, PhD, Joel D. Leverson, PhD

Blood (2012) 120 (21): 5028.

https://doi.org/10.1182/blood.V120.21.5028.5028

Published: 2012

Journal Articles

Activity of Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 in Mantle Cell Lymphoma (MCL) Identifies Btk As a Novel Therapeutic Target,

Sabine Ponader, PhD, Sriram Balasubramanian, PhD, Lan V Pham, PhD, Jun Chen, PhD, Archito T. Tamayo, MS, Michael Wang, MD, Susan O'Brien, MD, William G. Wierda, MD, PhD, Michael J Keating, MD, Richard J. Ford, MD, PhD, Jan A. Burger, MD, PhD

Blood (2011) 118 (21): 3688.

https://doi.org/10.1182/blood.V118.21.3688.3688

Published: 2011

Journal Articles

The Bruton's Tyrosine Kinase (BTK) Inhibitor PCI-32765 Inhibits Growth of ABC DLBCL Tumors In Vivo and in Vitro by Preventing Activation of Pro-Survival NF-κB pathways

Sriram Balasubramanian, PhD, Richard Crowley, MS, Mint Sirisawad, MS, Patti Thiemann, MS, Jun Chen, PhD, Joseph J. Buggy, PhD

Blood (2011) 118 (21): 4969.

https://doi.org/10.1182/blood.V118.21.4969.4969

Published: 2011

Journal Articles

Identification of MicroRNA Markers of Sensitivity to the Novel Bruton’s Tyrosine Kinase (BTK) Inhibitor PCI-32765 in Non-Hodgkin’s Lymphoma.

Sriram Balasubramanian, PhD, Jun Chen, Ph.D., Lee Honigberg, Ph.D., Lillian Tee, Hannah Mamuszka

Blood (2008) 112 (11): 3366.

https://doi.org/10.1182/blood.V112.11.3366.3366

Published: 2008

NARROW

MALT1 Protease Inhibition Overcomes BTK Inhibitor Resistance and Shows Synergistic Activity with Venetoclax in Models of B Cell Lymphoma and Leukemia

Single-Cell-Multiomics Demonstrates Molecular Efficacy of a Clinical Lentiviral Vector for Gene Therapy of RPS19-Deficient Diamond-Blackfan Anemia

A Novel Platform to Manufacture High-Efficient "Off-the-Shelf" CAR-NK Products from Peripheral Blood Mononuclear Cells (PBMC)

Characterization of JNJ-80948543, a Novel CD79bxCD20xCD3 Trispecific T-Cell Redirecting Antibody for the Treatment of B-Cell Non-Hodgkin Lymphoma

RVU120 (SEL120) CDK8/19 Inhibitor - a Drug Candidate for the Treatment of MDS Can Induce Erythroid Differentiation

Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Pharmacological Inhibition of Nlk (Nemo-like Kinase) Rescues Erythropoietic Defects in Pre-Clinical Models of Diamond Blackfan Anemia

Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs

Inhibition of Lysine-Specific Demethylase 1A (LSD1) Supports Human HSCs in Culture By Preserving Their Immature State

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models

Concomitantly Targeting BCL-2 with Venetoclax (ABT-199/GDC-0199) and MAPK Signaling with Cobimetinib (GDC-0973) in Acute Myeloid Leukemia Models

CDK9 Inhibition Reverses Resistance to ABT-199 (GDC-0199) By Down-Regulating MCL-1

Expression of Bcl-2 Pro-Survival Family Proteins Predicts Pharmacological Responses to ABT-199, a Novel and Selective Bcl-2 Antagonist, in Multiple Myeloma Models

Activity of Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 in Mantle Cell Lymphoma (MCL) Identifies Btk As a Novel Therapeutic Target,

The Bruton's Tyrosine Kinase (BTK) Inhibitor PCI-32765 Inhibits Growth of ABC DLBCL Tumors In Vivo and in Vitro by Preventing Activation of Pro-Survival NF-κB pathways

Identification of MicroRNA Markers of Sensitivity to the Novel Bruton’s Tyrosine Kinase (BTK) Inhibitor PCI-32765 in Non-Hodgkin’s Lymphoma.

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American Society of Hematology

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American Society of Hematology

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