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Christine Will
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Journal Articles

Abbv-101, a Highly Potent and Selective Clinical Stage Bruton Tyrosine Kinase Degrader for the Treatment of B-Cell Malignancies

Chin Pan, Tarikere L Gururaja, Haiyan Li, Henry Nguyen, Yongjiao Zhai, Xiaoping Xie, Rong-Xian Ding, Rebecca Mathew, Hana Y Hoh, Zhaozhong J Jia, Bo Liu, Cassandra Shu, Wissam Assaily, Lloyd T Lam, Jacob J Riehm, Claudina Stevenson, Christine Will, Federico Innocenti, Alexey Rivkin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1887.
https://doi.org/10.1182/blood-2023-184835
Published: 2023
Journal Articles

A First-in-Human Phase 1 Study of ABBV-525, a Small-Molecule MALT1 Inhibitor, in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Andrew L. Sochacki, Jan A. Burger, Carrianne Ludwig, Wissam Assaily, Wijith Munasinghe, William Pappano, Edward Greenberg, Christine Will, Meghan C. Thompson
Journal: Blood
Blood (2023) 142 (Supplement 1): 3101.
https://doi.org/10.1182/blood-2023-181671
Published: 2023
Journal Articles

MALT1 Protease Inhibition Overcomes BTK Inhibitor Resistance and Shows Synergistic Activity with Venetoclax in Models of B Cell Lymphoma and Leukemia

Joshua Plotnik, Velitchka Bontcheva, Colleen Dowell, Christine Will, Jun Chen, Adam Richardson, Ryan McClure, Paul Jung, Lan Pham, Andrew Souers, Jonathan Meulbroek, William Pappano
Journal: Blood
Blood (2023) 142 (Supplement 1): 5009.
https://doi.org/10.1182/blood-2023-189061
Published: 2023
Journal Articles

NSD2-E1099K Mutation Leads to Glucocorticoid-Resistant B Cell Lymphocytic Leukemia in Mice

Jianping Li, MD, Crissandra Piper, LATG, Daphne Dupere-Richer, PhD, Heidi Casellas Roman, MS, Alok Swaroop, PhD, Catalina Troche, PhD, Jon Oyer, PhD, Christine Will, MS, Alberto Riva, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-141295
Published: 2020
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Jianping Li, MD, Catalina Troche, PhD, Julia Hlavka Zhang, BS, Jonathan Shrimp, PhD, Jacob S. Roth, PhD, Duohui Jing, PhD, Alok Swaroop, PhD, Marta Kulis, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Amin Sobn, PhD, Sharon Norton, MS, Richard Lynn Bennett, PhD, Min Shen, PhD, Matthew D. Hall, PhD, Richard B. Lock, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3758.
https://doi.org/10.1182/blood-2019-126910
Published: 2019
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance of Acute Lymphoblastic Leukemia

Jianping Li, MD, Catalina Troche, PhD, Alok Swaroop, PhD, Marta Kulis, PhD, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Sharon Norton, MS, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 653.
https://doi.org/10.1182/blood-2018-99-116309
Published: 2018
Journal Articles

Allele-Specific Crispr Targeting Reveals Epigenetic and Phenotypic Effects of a MMSET Gain of Function Mutation Found in Relapsed Acute Lymphoblastic Leukemia

Jon Oyer, PhD, Christine Will, M.S., Xiaoxiao Huang, Teresa Ezponda, PhD, Relja Popovic, PhD, Yupeng Zheng, PhD, Neil L Kelleher, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2015) 126 (23): 437.
https://doi.org/10.1182/blood.V126.23.437.437
Published: 2015
Journal Articles

Loss of the Histone Demethylase UTX Contributes to Multiple Myeloma and Sensitizes Cells to EZH2 Inhibitors

Teresa Ezponda, PhD, Relja Popovic, PhD, Yupeng Zheng, PhD, Behnam Nabet, Christine Will, MS, Eliza C Small, PhD, Manuela Occhionorelli, PhD, Giovanni Tonon, MDPhD, Jonathan J. Keats, PhD, Neil L Kelleher, PhD, Jonathan D. Licht
Journal: Blood
Blood (2014) 124 (21): 611.
https://doi.org/10.1182/blood.V124.21.611.611
Published: 2014
Journal Articles

MMSET/WHSC1 Enhances DNA Damage Repair Leading To An Increase In Resistance To Chemotherapeutic Agents

Mrinal Y. Shah, PhD, Eva Martinez, PhD, Relja Popovic, PhD, Teresa Ezponda, PhD, Eliza C. Small, PhD, Christine Will, MS, Paola Neri, MD, PhD, Nizar J. Bahlis, MD, Jonathan D. Licht, MD
Journal: Blood
Blood (2013) 122 (21): 808.
https://doi.org/10.1182/blood.V122.21.808.808
Published: 2013
Journal Articles

MMSET Dysregulates Gene Expression in Myeloma Through Global and Focal Changes in H3K36 and H3K27 Methylation

Relja Popovic, PhD, Eva Martinez, PhD, Quanwei Zhang, PhD, Teresa Ezponda, PhD, Yanwen Jiang, PhD, Mrinal Y. Shah, PhD, Christine Will, M.S., Eliza C. Small, PhD, Olivier Elemento, PhD, Ji-Ping Wang, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2012) 120 (21): 523.
https://doi.org/10.1182/blood.V120.21.523.523
Published: 2012
Journal Articles

MMSET Stimulates Myeloma Cell Growth Through MicroRNA-Mediated Modulation of c-MYC

Dong-Joon Min, PhD, Marianne Kim, PhD, Teresa Ezponda, PhD, Christine Will, M.S., Eva Martinez-Garcia, PhD, Relja Popovic, PhD, Kojo S.J. Elenitoba-Johnson, MD, Basrur Venkatesha, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2011) 118 (21): 469.
https://doi.org/10.1182/blood.V118.21.469.469
Published: 2011
Journal Articles

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

Eva Martinez-Garcia, Relja Popovic, Dong-Joon Min, Steve M. M. Sweet, Paul M. Thomas, Leonid Zamdborg, Aaron Heffner, Christine Will, Laurence Lamy, Louis M. Staudt, David L. Levens, Neil L. Kelleher, Jonathan D. Licht
Journal: Blood
Blood (2011) 117 (1): 211–220.
https://doi.org/10.1182/blood-2010-07-298349
Published: 2011
Includes: Supplemental data
Journal Articles

The MMSET Histone Methyl Transferase Alters Chromatin Structure and Gene Expression in t(4;14) Multiple Myeloma Cells.

Eva Martinez-Garcia, PhD, Relja Popovic, PhD, Dong-Joon Min, PhD, Christine Will, MS, Julia Meyer, BS, Louis M. Staudt, MD, PhD, Laurence Lamy, PhD, Josh Lauring, MD, PhD, Zhongjun Cheng, PhD, Dinshaw Patel, PhD, Jonathan D. Licht, M.D.
Journal: Blood
Blood (2009) 114 (22): 675.
https://doi.org/10.1182/blood.V114.22.675.675
Published: 2009