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Journal Articles

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

Amy M. Cook, Liang Li, Yinwei Ho, Allen Lin, Ling Li, Anthony Stein, Stephen Forman, Danilo Perrotti, Richard Jove, Ravi Bhatia

Blood (2014) 123 (18): 2826–2837.

https://doi.org/10.1182/blood-2013-05-505735

Published: 2014

Includes: Supplemental data

Journal Articles

Combination Therapy with the Histone Deacetylase Inhibitor Vorinostat Plus the Novel Aurora Kinase A Inhibitor MK-5108 Leads to Enhanced Lymphoma Cell Death Due to Acetylation of p53 and Repression of c-Myc, hTERT, and miRNA Levels.

Leo Kretzner, Anna Scuto, Kowolik Claudia, Richard Jove, Stephen J Forman, MD, Yun Yen, MD, PhD, Mark Kirschbaum, MD

Blood (2009) 114 (22): 1690.

https://doi.org/10.1182/blood.V114.22.1690.1690

Published: 2009

Journal Articles

Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph − Acute Lymphoblastic Leukemia Cells Alone and in Combination with the HDAC Inhibitor LBH589..

Anna Scuto, Mark Kirschbaum, MD, Jennifer M Cermak, Peter Atadja, Richard Jove

Blood (2009) 114 (22): 3083.

https://doi.org/10.1182/blood.V114.22.3083.3083

Published: 2009

Journal Articles

STAT3 Silencing as a Novel Therapeutic Strategy for Activated B Cell-Type Diffuse Large B-Cell Lymphoma.

Anna Scuto, Maciej Kujawski, Claudia Kowolik, Hua Yu, Stephen Forman, Richard Jove

Blood (2009) 114 (22): 926.

https://doi.org/10.1182/blood.V114.22.926.926

Published: 2009

Journal Articles

Combination Therapy with Histone Deacetylase Inhibitor Vorinostat Plus Aurora Kinase Inhibitor MK-0457 Leads to Enhanced Lymphoma Cell Killing with Stabilization of p53 and Repression of C-Myc, hTERT, and Myc-Responsive miRNAs

Leo Kretzner, Anna Scuto, Richard Jove, Stephen J. Forman, MD, Yun Yen, MD, PhD, Mark Kirschbaum, MD

Blood (2008) 112 (11): 3628.

https://doi.org/10.1182/blood.V112.11.3628.3628

Published: 2008

Journal Articles

The HMGA1a-STAT3 axis: an “Achilles Heel” for Hematopoietic Malignancies Overexpressing HMGA1a?

Linda Resar, MD, Joelle Hillion, Ph.D., Surajit Dhara, Ph.D., Takita Felder Sumter, Ph.D., Mita Mukherjee, Ph.D., Francescopaolo Di Cello, Ph.D., Amy Belton, Ph.D., James Turkson, Ph.D., Souyma Jaganathan, Ph.D., Linzhao Cheng, Ph.D., Zhaohui Ye, B.S., Yingwei Lin, MD, PhD, Peter D. Aplan, MD, Richard Jove, Jeanne Kowalski, Kelsey Wertzler, B.S., Ray Reeves, Ph.D., Ossama Elbahlouh, M.D., Raka Bhattacharya, Ph.D.

Blood (2008) 112 (11): 3810.

https://doi.org/10.1182/blood.V112.11.3810.3810

Published: 2008

Journal Articles

The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph − acute lymphoblastic leukemia cells

Anna Scuto, Mark Kirschbaum, Claudia Kowolik, Leo Kretzner, Agnes Juhasz, Peter Atadja, Vinod Pullarkat, Ravi Bhatia, Stephen Forman, Yun Yen, Richard Jove

Blood (2008) 111 (10): 5093–5100.

https://doi.org/10.1182/blood-2007-10-117762

Published: 2008

Includes: Supplemental data

Journal Articles

Effect of Dasatinib on BCR-ABL and Src Mediated Growth Signaling in Primary CML Hematopoietic Progenitors.

Heiko Konig, MD, Mhairi Copland, MD, Richard Jove, PhD, Tessa L. Holyoake, MD, PhD, Ravi Bhatia, MD

Blood (2007) 110 (11): 2944.

https://doi.org/10.1182/blood.V110.11.2944.2944

Published: 2007

Journal Articles

The Novel Histone Deacetylase Inhibitor, LBH589, Induces Expression of DNA Damage Response Genes and Apoptosis in Ph-Acute Lymphoblastic Leukemia Cells.

Scuto Anna, PhD, Mark H. Kirschbaum, MD, Peter Atadja, Agnes Juhasz, Vinod Pullarkat, MD, Ravi Bhatia, MD, Stephen J. Forman, MD, Yun Yen, MD, PhD, Richard Jove, PhD

Blood (2007) 110 (11): 2796.

https://doi.org/10.1182/blood.V110.11.2796.2796

Published: 2007

Journal Articles

Combination of the Histone Deacetylase Inhibitor Vorinostat and Dasatinib Increases Apoptosis in Bcr-abl+ Cells and Reverses Changes Associated with CML Progression.

Leo Kretzner, PhD, Anna Scuto, PhD, Agnes Juhasz, PhD, Richard Jove, PhD, Yun Yen, MD, Stephen J. Forman, MD, Mark Kirschbaum

Blood (2006) 108 (11): 2165.

https://doi.org/10.1182/blood.V108.11.2165.2165

Published: 2006

Journal Articles

Regulation of Signal Transducers and Activators of Transcription by Src Family Kinase in AML.

Yukiyasu Ozawa, MD, PhD, Ann H. Williams, Ph.D, Myka Estes, Lubomir Sokol, MD, Richard Jove, PhD, Alan F. List, MD

Blood (2005) 106 (11): 2766.

https://doi.org/10.1182/blood.V106.11.2766.2766

Published: 2005

Journal Articles

Oxidative Stress Induces Binding of FANCD2 to STAT5 and Facilitates STAT5-Dependent Survival Signals.

Grover Bagby, MD, Winifred Keeble, MS, Tara Koretsky, Dylan Zodrow, Richard Jove, PhD, Laura Hays, PhD, Hanqian Carlson, PhD

Blood (2004) 104 (11): 33.

https://doi.org/10.1182/blood.V104.11.33.33

Published: 2004

Journal Articles

In Vivo Visualization of Stat3 Activation in Myeloid Cells during Inflammation and Tumor Growth.

Pedro Horna, MD, Fengdong Cheng, MD, Richard Jove, PhD, Linda Mora, MD, Eduardo M. Sotomayor, MD

Blood (2004) 104 (11): 3434.

https://doi.org/10.1182/blood.V104.11.3434.3434

Published: 2004

Journal Articles

β1 Integrin Activation Via FN Adhesion Enhances IL-6 Response in Myeloma Cells.

Kenneth H. Shain, PhD, Danielle N. Kelsch, BS, Mei Huang, PhD, Melissa Alsina, MD, Richard Jove, PhD, William S. Dalton, MD, PhD

Blood (2004) 104 (11): 2352.

https://doi.org/10.1182/blood.V104.11.2352.2352

Published: 2004

Journal Articles

Disruption of STAT3 Signaling in Antigen Presenting Cells Represents a Novel Strategy To Overcome Tumor-Induced Antigen-Specific CD4+ T-Cell Tolerance.

Fengdong Cheng, M.D., Hongwei Wang, M.D., Alex G. Cuenca, Pedro Horna, M.D., Lldefonso Suarez, Jason Brayer, Ph.D., James Turkson, Ph.D., Richard Jove, Ph.D., Eduardo M. Sotomayor, M.D.

Blood (2004) 104 (11): 109.

https://doi.org/10.1182/blood.V104.11.109.109

Published: 2004

Journal Articles

Co-Administration of SAHA and 17-AAG Synergistically Induces Apoptosis in Bcr-Abl + Cells Sensitive and Resistant to STI-571 in Association with Down-Regulation of Bcr-Abl, Abrogation of STAT5 Activity, and Bax Conformational Change.

Mohamed Rahmani, Erin Reese, Yun Dai, Cheryl Bauer, Lora Kramer, Mei Huang, Richard Jove, Paul Dent, Steven Grant

Blood (2004) 104 (11): 1995.

https://doi.org/10.1182/blood.V104.11.1995.1995

Published: 2004

Journal Articles

STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells

Rolf P. de Groot, Jan A.M. Raaijmakers, Jan-Willem J. Lammers, Richard Jove, Leo Koenderman

Blood (1999) 94 (3): 1108–1112.

https://doi.org/10.1182/blood.V94.3.1108.415k07_1108_1112

Published: 1999

Journal Articles

Constitutive Activation of the JAK2/STAT5 Signal Transduction Pathway Correlates With Growth Factor Independence of Megakaryocytic Leukemic Cell Lines

Richard Y. Liu, Chun Fan, Roy Garcia, Richard Jove, Kenneth S. Zuckerman

Blood (1999) 93 (7): 2369–2379.

https://doi.org/10.1182/blood.V93.7.2369

Published: 1999

NARROW

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

Combination Therapy with the Histone Deacetylase Inhibitor Vorinostat Plus the Novel Aurora Kinase A Inhibitor MK-5108 Leads to Enhanced Lymphoma Cell Death Due to Acetylation of p53 and Repression of c-Myc, hTERT, and miRNA Levels.

Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph − Acute Lymphoblastic Leukemia Cells Alone and in Combination with the HDAC Inhibitor LBH589..

STAT3 Silencing as a Novel Therapeutic Strategy for Activated B Cell-Type Diffuse Large B-Cell Lymphoma.

Combination Therapy with Histone Deacetylase Inhibitor Vorinostat Plus Aurora Kinase Inhibitor MK-0457 Leads to Enhanced Lymphoma Cell Killing with Stabilization of p53 and Repression of C-Myc, hTERT, and Myc-Responsive miRNAs

The HMGA1a-STAT3 axis: an “Achilles Heel” for Hematopoietic Malignancies Overexpressing HMGA1a?

The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph − acute lymphoblastic leukemia cells

Effect of Dasatinib on BCR-ABL and Src Mediated Growth Signaling in Primary CML Hematopoietic Progenitors.

The Novel Histone Deacetylase Inhibitor, LBH589, Induces Expression of DNA Damage Response Genes and Apoptosis in Ph-Acute Lymphoblastic Leukemia Cells.

Combination of the Histone Deacetylase Inhibitor Vorinostat and Dasatinib Increases Apoptosis in Bcr-abl+ Cells and Reverses Changes Associated with CML Progression.

Regulation of Signal Transducers and Activators of Transcription by Src Family Kinase in AML.

Oxidative Stress Induces Binding of FANCD2 to STAT5 and Facilitates STAT5-Dependent Survival Signals.

In Vivo Visualization of Stat3 Activation in Myeloid Cells during Inflammation and Tumor Growth.

β1 Integrin Activation Via FN Adhesion Enhances IL-6 Response in Myeloma Cells.

Disruption of STAT3 Signaling in Antigen Presenting Cells Represents a Novel Strategy To Overcome Tumor-Induced Antigen-Specific CD4+ T-Cell Tolerance.

Co-Administration of SAHA and 17-AAG Synergistically Induces Apoptosis in Bcr-Abl + Cells Sensitive and Resistant to STI-571 in Association with Down-Regulation of Bcr-Abl, Abrogation of STAT5 Activity, and Bax Conformational Change.

STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells

Constitutive Activation of the JAK2/STAT5 Signal Transduction Pathway Correlates With Growth Factor Independence of Megakaryocytic Leukemic Cell Lines

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American Society of Hematology

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American Society of Hematology

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