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Journal Articles

Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

Hiroto Horiguchi, MD, Masayoshi Kobune, MD PhD, Shohei Kikuchi, MD PhD, Wataru Jomen, MD, Kazuyuki Murase, MD PhD, Soushi Ibata, MD, Satoshi Iyama, MD PhD, Tsutomu Sato, MD PhD, Yusuke Kamihara, MD, Koji Miyanishi, MD PhD, Yasushi Sato, MD PhD, Tsuyoshi Hayashi, MD PhD, Rishu Takimoto, MD PhD, Junji Kato, MD PhD

Blood (2014) 124 (21): 4627.

https://doi.org/10.1182/blood.V124.21.4627.4627

Published: 2014

Journal Articles

Myelodysplastic Syndrome-Derived Stromal Cells Support Leukemia-Initiating Cells and Contradirectly Eliminate Normal CD34+ Clonogenic Cells

Hiroto Horiguchi, MD, Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Yusuke Kamihara, MD, Akari Hashimoto, MD, Ayumi Tatekoshi, MD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2013) 122 (21): 1219.

https://doi.org/10.1182/blood.V122.21.1219.1219

Published: 2013

Journal Articles

Iron Chelation Therapy Could Rapidly Reduce Oxidative DNA Damage In CD34+ Hematopoietic Cells Before Decrease Of Serum Ferritin Level

Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Hiroto Horiguchi, MD, Yusuke Kamihara, MD, Akari Hashimoto, MD, Ayumi Tatekoshi, MD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2013) 122 (21): 959.

https://doi.org/10.1182/blood.V122.21.959.959

Published: 2013

Journal Articles

Stromal Cells Expressing Hedgehog-Interacting Protein Are One of the Main Regulators of the Hedgehog Signaling System in Myeloid Neoplasms

Masayoshi Kobune, MD, PhD, Hiroto Horiguchi, MD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Yusuke Kamihara, MD, Yutaka Kawano, MD, PhD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2012) 120 (21): 3840.

https://doi.org/10.1182/blood.V120.21.3840.3840

Published: 2012

Journal Articles

Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells

Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2010) 116 (21): 3211.

https://doi.org/10.1182/blood.V116.21.3211.3211

Published: 2010

Journal Articles

Central Nervous System Events In Patients with Diffuse Large B-Cell Lymphoma In the Rituximab Era

Blood (2010) 116 (21): 3948.

https://doi.org/10.1182/blood.V116.21.3948.3948

Published: 2010

Journal Articles

CD34+ Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

Shohei Kikuchi, MD., Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Yutaka Kawano, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2009) 114 (22): 1439.

https://doi.org/10.1182/blood.V114.22.1439.1439

Published: 2009

Journal Articles

Cyclopamine Induced Apoptosis in Primary CD34+ Acute Leukemic Cells.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Rishu Takimoto, MD, PhD, Yutaka Kawano, MD, PhD, Shohei Kikuchi, MD., Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Junji Kato, MD, PhD

Blood (2009) 114 (22): 3768.

https://doi.org/10.1182/blood.V114.22.3768.3768

Published: 2009

Journal Articles

Hedgehog Inhibitors Reduce the Survival and Drug Resistance in CD34+ Leukemic Cells.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Yutaka Kawano, MD, PhD, Shohei Kikuchi, MD, PhD, Koji Miyanishi, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2008) 112 (11): 1611.

https://doi.org/10.1182/blood.V112.11.1611.1611

Published: 2008

Journal Articles

Wnt3 Signaling Augments integrinβ1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner.

Blood (2008) 112 (11): 1698.

https://doi.org/10.1182/blood.V112.11.1698.1698

Published: 2008

Journal Articles

Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Wnt Signaling.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Shohei Kikuchi, MD, PhD, Yutaka Kawano, MD, PhD, Kohichi Takada, MD, PhD, Koji Miyanishi, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2008) 112 (11): 2325.

https://doi.org/10.1182/blood.V112.11.2325.2325

Published: 2008

Journal Articles

Adenoviral Vector-Mediated Transfer of the Indian Hedgehog Gene Modulates Lymphomyelopoiesis In Vivo .

Masayoshi Kobune, MD, PhD, Yutaka Kawano, MD, PhD, Katsunori Sasaki, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD, Hirofumi Hamada, MD, PhD, Yoshiro Niitsu, MD, PhD

Blood (2007) 110 (11): 2205.

https://doi.org/10.1182/blood.V110.11.2205.2205

Published: 2007

Journal Articles

Wnt3 / RhoA / ROCK Signaling Pathway Is Involved in VLA6-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma.

Masayoshi Kobune, MD, PhD, Yutaka Kawano, MD, PhD, Rishu Takimoto, MD, PhD, Takuya Matsunaga, MD, PhD, Junji Kato, MD, PhD, Hirofumi Hamada, MD, PhD, Yoshiro Niitsu, MD, PhD

Blood (2007) 110 (11): 2518.

https://doi.org/10.1182/blood.V110.11.2518.2518

Published: 2007

Journal Articles

TGFβ Activates p53 Via PP2A in Hematopoietic Cells.

Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD, Koichi Takada, MD, PhD, Daisuke Takahari, MD, Yoshiro Niitsu

Blood (2006) 108 (11): 4335.

https://doi.org/10.1182/blood.V108.11.4335.4335

Published: 2006

Journal Articles

Wnt3 Augments Adhesion Mediated Drug Resistance of Myeloma Cells Via Wnt/RhoA Pathway.

Hiroki Chiba, MD, Masayoshi Kobune, MD, PhD, Kazunori Kato, PhD, Kiminori Nakamura, PhD, Yutaka Kawano, MD, PhD, Rishu Takimoto, MD, PhD, Takuya Matsunaga, MD, PhD, Junji Kato, MD, PhD, Yoshiro Niitsu, MD, PhD, Hirofumi Hamada, MD, PhD

Blood (2005) 106 (11): 5075.

https://doi.org/10.1182/blood.V106.11.5075.5075

Published: 2005

Journal Articles

Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion

Yasushi Sato, Hironobu Araki, Junji Kato, Kiminori Nakamura, Yutaka Kawano, Masayoshi Kobune, Tsutomu Sato, Koji Miyanishi, Tetsuji Takayama, Minoru Takahashi, Rishu Takimoto, Satoshi Iyama, Takuya Matsunaga, Seiji Ohtani, Akihiro Matsuura, Hirofumi Hamada, Yoshiro Niitsu

Blood (2005) 106 (2): 756–763.

https://doi.org/10.1182/blood-2005-02-0572

Published: 2005

Journal Articles

Indian Hedgehog Stimulates Proliferation of Short-Term NOD/SCID-ß2m null Repopulating Cells on Coculture with Human Stromal Cells.

Masayoshi Kobune, MD, PhD, Yutaka Kawano, MD, PhD, Junji Kato, MD, PhD, Yoshinori Ito, MD, Hiroki Chiba, MD, Kageaki Kuribayashi, MD, PhD, Rishu Takimoto, MD, PhD, Takuya Matsunaga, MD, PhD, Hirofumi Hamada, MD, PhD, Yoshiro Niitsu, MD, PhD

Blood (2004) 104 (11): 1300.

https://doi.org/10.1182/blood.V104.11.1300.1300

Published: 2004

Journal Articles

Impaired Expression of the DNA Repair Factor DDB2 in Human Myeloid Leukemias.

Rishu Takimoto, MD/PhD, Junji Kato, MD/PhD, Koichi Takada, MD/PhD, Takuya Matsunaga, MD/PhD, Yoshiro Niitsu, MD/PhD

Blood (2004) 104 (11): 2046.

https://doi.org/10.1182/blood.V104.11.2046.2046

Published: 2004

Journal Articles

A Novel p53-PP2A Signaling Pathway Is Responsible for Regulation of Hematopoiesis Induced by TGFß.

Rishu Takimoto, MD/PhD, Junji Kato, MD/PhD, Koichi Takada, MD/PhD, Daisuke Takahari, MD, Yoshiro Niitsu, MD/PhD

Blood (2004) 104 (11): 4327.

https://doi.org/10.1182/blood.V104.11.4327.4327

Published: 2004

Journal Articles

Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID– ß 2 m –/– repopulating cells.

Masayoshi Kobune, Yoshinori Ito, Yutaka Kawano, Katsunori Sasaki, Hiroaki Uchida, Kiminori Nakamura, Hironari Dehari, Hiroki Chiba, Rishu Takimoto, Takuya Matsunaga, Takeshi Terui, Junji Kato, Yoshiro Niitsu, Hirofumi Hamada

Blood (2004) 104 (4): 1002–1009.

https://doi.org/10.1182/blood-2003-09-3347

Published: 2004

NARROW

Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

Myelodysplastic Syndrome-Derived Stromal Cells Support Leukemia-Initiating Cells and Contradirectly Eliminate Normal CD34+ Clonogenic Cells

Iron Chelation Therapy Could Rapidly Reduce Oxidative DNA Damage In CD34+ Hematopoietic Cells Before Decrease Of Serum Ferritin Level

Stromal Cells Expressing Hedgehog-Interacting Protein Are One of the Main Regulators of the Hedgehog Signaling System in Myeloid Neoplasms

Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells

Central Nervous System Events In Patients with Diffuse Large B-Cell Lymphoma In the Rituximab Era

CD34+ Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

Cyclopamine Induced Apoptosis in Primary CD34+ Acute Leukemic Cells.

Hedgehog Inhibitors Reduce the Survival and Drug Resistance in CD34+ Leukemic Cells.

Wnt3 Signaling Augments integrinβ1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner.

Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Wnt Signaling.

Adenoviral Vector-Mediated Transfer of the Indian Hedgehog Gene Modulates Lymphomyelopoiesis In Vivo .

Wnt3 / RhoA / ROCK Signaling Pathway Is Involved in VLA6-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma.

TGFβ Activates p53 Via PP2A in Hematopoietic Cells.

Wnt3 Augments Adhesion Mediated Drug Resistance of Myeloma Cells Via Wnt/RhoA Pathway.

Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion

Indian Hedgehog Stimulates Proliferation of Short-Term NOD/SCID-ß2m null Repopulating Cells on Coculture with Human Stromal Cells.

Impaired Expression of the DNA Repair Factor DDB2 in Human Myeloid Leukemias.

A Novel p53-PP2A Signaling Pathway Is Responsible for Regulation of Hematopoiesis Induced by TGFß.

Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID– ß 2 m –/– repopulating cells.

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American Society of Hematology

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American Society of Hematology

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