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Robert MacLeod
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Journal Articles

Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited antitumor activity

Antonio Sacco, Cinzia Federico, Katia Todoerti, Bachisio Ziccheddu, Valentina Palermo, Arianna Giacomini, Cosetta Ravelli, Federica Maccarinelli, Giada Bianchi, Angelo Belotti, Rossella Ribolla, Vanessa Favasuli, Alexey S. Revenko, A. Robert Macleod, Brandon Willis, Hongbo Cai, Joana Hauser, Claire Rooney, Sophie E. Willis, Philip Lloyd Martin, Anna Staniszewska, Helen Ambrose, Lyndsey Hanson, Chiara Cattaneo, Alessandra Tucci, Giuseppe Rossi, Roberto Ronca, Antonino Neri, Stefania Mitola, Niccolò Bolli, Marco Presta, Michele Moschetta, Sarah Ross, Aldo M. Roccaro
Journal: Blood
Blood (2021) 138 (18): 1705–1720.
https://doi.org/10.1182/blood.2020010572
Published: 2021
Includes: Supplemental data
Journal Articles

Mechanisms Regulating Myeloma Cell Responsiveness to Antisense Oligonucleotides Targeting IRF4

Ryosuke Shirasaki, MD PhD, Esperanza M Algarín, PhD, Ricardo De Matos Simoes, PhD, Sondra L. Downey-Kopyscinski, PhD, Shizuka Yamano, Xiaolin Luo, Youngsoo Kim, PhD, Robert MacLeod, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-142518
Published: 2020
Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Maria E Balasis, Alexis Vedder, BS, Lei Sun, Ariel Quintana, PhD, Abhishek Dhawan, Hannah Newman, BS, Jane Merlevede, Kathy McGraw, PhD, Traci Kruer, PhD, Nana Ben-Crentsil, Jeffrey S Painter, BS, Nathalie Droin, PhD, Thomas Cluzeau, MD PhD, Christopher Letson, BS, Sheng Wei, MD, Rami S. Komrokji, MD, Hailing Zhang, MD, A. Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD PhD, Pearlie K. Epling-Burnette, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1692.
https://doi.org/10.1182/blood-2019-128573
Published: 2019
Journal Articles

Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma

Antonio Sacco, RN, Cinzia Federico, PhD, Katia Todoerti, PhD, Bachisio Ziccheddu, PhD, Arianna Giacomini, PhD, Cosetta Ravelli, PhD, Federica Maccarinelli, PhD, Giada Bianchi, MD, Angelo Belotti, Rossella Ribolla, MD, Vanessa Favasuli, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brandon Willis, PhD, Hongoo Cai, PhD, Joana Hauser, RN, Claire Rooney, PhD, Helen Ambrose, PhD, Anna Staniszewska, PhD, Lyndsey Hanson, PhD, Giuseppe Rossi, Roberto Ronca, PhD, Antonino Neri, MD, Stefania Mitola, PhD, Niccolò Bolli, MD PhD, Marco Presta, PhD, Michele Moschetta, MD PhD, Sarah Ross, PhD, Aldo M. Roccaro, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3104.
https://doi.org/10.1182/blood-2019-124391
Published: 2019
Journal Articles

Therapeutic Targeting of Interferon Regulatory Factor 4 with Next Generation Antisense Oligonucleotides Produces Robust In Vivo Antitumor Activity in Preclinical Models of Multiple Myeloma

Tianyuan Zhou, PhD, Joanna Schmidt, Youngsoo Kim, PhD, A. Robert MacLeod, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3078.
https://doi.org/10.1182/blood.V130.Suppl_1.3078.3078
Published: 2017
Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 364.
https://doi.org/10.1182/blood.V130.Suppl_1.364.364
Published: 2017
Journal Articles

Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice

Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland
Journal: Blood
Blood (2017) 129 (18): 2547–2556.
https://doi.org/10.1182/blood-2016-11-753202
Published: 2017
Includes: Supplemental data
Journal Articles

Molecular Characterization of SRSF2 Mutation Identifies a Clinically Relevant Lncrna (MALAT1) in Chronic Myelomonocytic Leukemia (CMML)

Maria E. Balasis, Jane Merelvede, Sateesh Kunigal, Xiaoyi Ren, Yan Ma, Qing Zhang, PhD, Jeff Painter, Nathalie M. Droin, PhD, Joseph Johnson, Sean Yoder, M.S, Rami S. Komrokji, MD, Ling Zhang, MD, Sheng Wei, MD, Torsten Haferlach, Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD Prof, P.K. Epling-Burnette, PhD, Eric Padron, MD
Journal: Blood
Blood (2015) 126 (23): 1641.
https://doi.org/10.1182/blood.V126.23.1641.1641
Published: 2015
Journal Articles

Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death

Mark B Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, MS, Liang Nong, MD, Ismael Rosado-Lopez, Tuan Nguyen, Jennifer E. Ring, William Matsui, MD, Robert MacLeod, PhD, David T. Weaver, PhD, Jonathan A. Pachter, PhD, Lori A. Hazlehurst, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3008.
https://doi.org/10.1182/blood.V126.23.3008.3008
Published: 2015
Journal Articles

Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death

Kenneth H. Shain, MD PhD, Mark B Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, Liang Nong, MD, Ismael Rosado-Lopez, BS, Jennifer E. Ring, Robert MacLeod, PhD, Lori Hazlehurst, PhD, Conor Lynch, PhD, Jonathan A. Pachter, PhD, William Matsui, MD, John Koomen, PhD, Tuan Nguyen
Journal: Blood
Blood (2014) 124 (21): 2081.
https://doi.org/10.1182/blood.V124.21.2081.2081
Published: 2014
Journal Articles

PYK2 Mediates Microenvironment-Specific Myeloma Survival

Mark Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, Liang Nong, M.D., Lori A Hazlehurst, Ph.D, Robert MacLeod, PhD, John Koomen, Ph.D., Kenneth Shain, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4443.
https://doi.org/10.1182/blood.V122.21.4443.4443
Published: 2013
Journal Articles

Pyk2 Mediates Enhanced STAT3 Phosphorylation Following Collaborative Signaling Between gp130 and beta1 Integrins in Adhered Myeloma Cells

Kenneth Shain, MD, PhD, Mark Meads, PhD, Liang Nong, M.D., Jennifer Gemmer, Linda Mathews, Bin Fang, PhD, Robert MacLeod, Ph.D., John Koomen, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 4021.
https://doi.org/10.1182/blood.V120.21.4021.4021
Published: 2012
Journal Articles

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

Jeff R. Crosby, PhD, Ulla M Marzec, MS, Chenguang Zhao, Dacao Gao, Alexey S Revenko, PhD, Anton Matafonov, MD, David Gailani, MD, Robert MacLeod, Ph.D., Andras Gruber, MD, Stephen Hanson, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2011) 118 (21): 2250.
https://doi.org/10.1182/blood.V118.21.2250.2250
Published: 2011
Journal Articles

ISIS-FXI Rx , a Potent Antisense Inhibitor of Factor XI, Suppresses FXI Activity and Elevates Aptt without Increased Risk of Bleeding in Cynomolgus Monkeys Following 13 Weeks of Treatment

Husam Younis, Jeff R. Crosby, PhD, Chenguang Zhao, Robert MacLeod, Ph.D., Brett P. Monia, PhD, Scott Henry
Journal: Blood
Blood (2011) 118 (21): 2255.
https://doi.org/10.1182/blood.V118.21.2255.2255
Published: 2011
Journal Articles

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Brian K. Turpin, DO, Whitney M Miller, Eric S. Mullins, MD, Jay L. Degen, PhD, Matthew J. Flick, PhD, Brett P. Monia, PhD, Robert MacLeod, Ph.D., Alexey S Revenko, PhD, Joseph S. Palumbo, MD
Journal: Blood
Blood (2011) 118 (21): 2237.
https://doi.org/10.1182/blood.V118.21.2237.2237
Published: 2011
Journal Articles

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

Alexey S. Revenko, Dacao Gao, Jeff R. Crosby, Gourab Bhattacharjee, Chenguang Zhao, Chris May, David Gailani, Brett P. Monia, A. Robert MacLeod
Journal: Blood
Blood (2011) 118 (19): 5302–5311.
https://doi.org/10.1182/blood-2011-05-355248
Published: 2011
Includes: Supplemental data
Journal Articles

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

Hong Zhang, Ester C. Löwenberg, Jeffrey R. Crosby, A. Robert MacLeod, Chenguang Zhao, Dacao Gao, Chris Black, Alexey S. Revenko, Joost C. M. Meijers, Erik S. Stroes, Marcel Levi, Brett P. Monia
Journal: Blood
Blood (2010) 116 (22): 4684–4692.
https://doi.org/10.1182/blood-2010-04-277798
Published: 2010
Includes: Multimedia, Supplemental data
Journal Articles

FXII Antisense Oligonucleotide Mediated Depletion Results In Effective Anticoagulation without Bleeding Risk.

Jeff R. Crosby, PhD, Dacao Gao, Chenguang Zhao, Chris May, Robert MacLeod, Ph.D., Brett P. Monia, PhD
Journal: Blood
Blood (2010) 116 (21): 1149.
https://doi.org/10.1182/blood.V116.21.1149.1149
Published: 2010
Journal Articles

Combination of FXI Antisense Oligonucleotide and Plavix® Treatment Results in Enhanced Antithrombotic Activity without Increased Risk of Bleeding in Mouse Models of Thrombosis.

Dacao Gao, Jeff Crosby, PhD, Robert MacLeod, PhD, Gourab Bhattacharjee, PhD, Ester C Lowenberg, MD, Marcel Levi, MD, PhD, Prof., Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 4173.
https://doi.org/10.1182/blood.V114.22.4173.4173
Published: 2009
Journal Articles

Systematic Evaluation of Coagulation Factors as Targets for Anti-Thrombotic Therapy Using Antisense Technology.

Jeff Crosby, PhD, Dacao Gao, Chenguang Zhao, Gourab Bhattacharjee, PhD, Chris May, Hong Zhang, MD, Robert MacLeod, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 4181.
https://doi.org/10.1182/blood.V114.22.4181.4181
Published: 2009