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Journal Articles

Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

Clinical Trials & Observations
Ruth Namazzi, Caitlin Bond, Andrea L. Conroy, Dibyadyuti Datta, Abner Tagoola, Michael J. Goings, Jeong Hoon Jang, Russell E. Ware, Robert Opoka, Chandy C. John
Journal: Blood
Blood (2024) 143 (14): 1425–1428.
https://doi.org/10.1182/blood.2023021575
Published: 2024
Includes: Supplemental data
Journal Articles

Neurocognitive Improvement with Hydroxyurea Therapy in Children with Sickle Cell Anemia in Uganda: Interim Analysis at Month 18

Shubaya Kasule Naggayi, Dennis Kalibala, Robert Opoka, Caterina Rosano, Deogratias Munube, Phillip Kasirye, Ezekiel Mupere, Vincent Mboizi, John Ssenkusu, Nancy S. Green, Richard Idro, Paul Bangirana
Journal: Blood
Blood (2023) 142 (Supplement 1): 275.
https://doi.org/10.1182/blood-2023-190687
Published: 2023
Journal Articles

Malaria in Children with Sickle Cell Anaemia in Areas with Low, Moderate and High Transmission in Uganda

Ruth Namazzi, Richard Idro, Dennis Kalibala, John Ssenkusu, Pamela Akun, Vincent Mboizi, Thandile Nkosi Gondwe, Deogratias Munube, Philip Kasirye, Catherine Nabaggala, Chandy C. John, Nancy S. Green, Bjarne Robberstat, Boele van Hensbroek, Feiko ter Kuile, Kamija S. Phiri, Robert Opoka
Journal: Blood
Blood (2023) 142 (Supplement 1): 5327.
https://doi.org/10.1182/blood-2023-189066
Published: 2023
Journal Articles

Pharmacokinetic-Guided Hydroxyurea to Reduce Transfusion Requirements in Ugandan Children with Sickle Cell Anemia: Baseline Data from the Alternative Dosing and Prevention of Transfusions (ADAPT) Trial

Alexandra Power-Hays, Ruth Namazzi, Charles Kato, Andrea Conroy, Heather Ann Hume, Chandy C. John, Susan E. Stuber, Adam C. Lane, Teresa S. Latham, Robert Opoka, Russell E. Ware
Journal: Blood
Blood (2023) 142 (Supplement 1): 1156.
https://doi.org/10.1182/blood-2023-181058
Published: 2023
Journal Articles

Effect of Hydroxyurea Treatment on Body Composition in Children with Sickle Cell Anemia in Uganda Using Bioelectrical Impedance Analysis (BIA)

Dennis Kalibala, Catherine Nabaggala, Lynnth Turyagyenda, Vincent Mboizi, Shubaya Kasule Naggayi, Maxencia Kabatabaazi, Caterina Rosano, Deogratias Munube, Phillip Kasirye, John Ssenkusu, Robert Opoka, Paul Bangirana, Nancy S. Green, Richard Idro, Ezekiel Mupere
Journal: Blood
Blood (2023) 142 (Supplement 1): 1136.
https://doi.org/10.1182/blood-2023-190181
Published: 2023
Journal Articles

Novel Genetic Loci That Influence Fetal Hemoglobin Expression in Children with Sickle Cell Anemia

Anu Marahatta, PhD, Thad A. Howard, MS, Susan E. Stuber, MA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Jasmine Baker, PhD, Teresa Latham, MA, Jonathan M. Flanagan, PhD, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-143025
Published: 2020
Journal Articles

Genetic Variants That Influence Fetal Hemoglobin Expression from Hydroxyurea Treatment

Anu Marahatta, PhD, Jonathan M. Flanagan, PhD, Thad A. Howard, MS, Nicole Mortier, MHS, PA-C, William Schultz, MHS, PA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Marvin E Reid, MB, BS, PhD, Angela Rankine-Mullings, MBBS, Jasmine Baker, PhD, Patrick T. McGann, MD MS, Banu Aygun, MD, Adam Lane, PhD, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Susan E. Stuber, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-143139
Published: 2020
Journal Articles

Impact of a National Lockdown for COVID-19 on Morbidity and Mortality Among Children with Sickle Cell Anaemia at a Tertiary Care Hospital in Uganda

Ruth Namazzi, MD, Robert Opoka, MMED, Andrea L Conroy, PhD, Dibyadyuti Datta, PhD, Micheal Goings, MPH, Chandy C. John, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-142417
Published: 2020
Journal Articles

Optimizing Hydroxyurea Dosing in Sickle Cell Anemia: The Uganda MTD Study

Chandy C. John, MDMS, Robert Opoka, MMED, Teresa Latham, MA, Heather Hume, MDFRCPC, Maria Nakafeero, Phillip Kasirye, Christopher Ndugwa, Adam Lane, PhD, Russell E. Ware, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 520.
https://doi.org/10.1182/blood-2019-125128
Published: 2019
Journal Articles

Profound Alteration of Host Response in Severe Malarial Anemia By Sickle Cell Disease: Reduction of Parasite Sequestration and Inflammation, Upregulation of Angiopoietin-2

Ryan C Henrici, PhD BS, Casey Sautter, MDMS, Robert Opoka, MMED, Ruth Namazzi, MD, Gregory S Park, Dibyadyuti John, PhD, Andrea L Conroy, PhD, Russell E. Ware, MD PhD, Chandy C. John, MDMS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2283.
https://doi.org/10.1182/blood-2019-129566
Published: 2019
Journal Articles

Association between Inflammatory Markers and Abnormal Neurological, Neurocognitive and Magnetic Resonance Imaging (MRI) Findings in Children with Sickle Cell Anemia in Uganda

Amelia Boehme, PhD MSPH, Adiba Ashrafi, MS, Richard Idro, MMED, PhD, Paul Bangirana, MS, PhD, Deogratias Munube, MD, Robert Opoka, MMED, Philip Kasirye, MMED, Margaret T. Lee, MD, Nancy S. Green, MD, Mady Hornig, MA, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2300.
https://doi.org/10.1182/blood-2019-131560
Published: 2019
Journal Articles

Frequent Impaired Overall Neurocognitive and Executive Function in Children Ages 1-12 Years of Age with Sickle Cell Anemia in Uganda

Amelia Boehme, PhD MSPH, Paul Bangirana, MS, PhD, Annet Birabwa, MS, Deogratias Munube, MD, Ezekiel Mupere, MMed, MS, PhD, Robert Opoka, MMED, Philip Kasirye, MMED, Philip LaRussa, MD, Nancy S. Green, MD, Richard Idro, MMED, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1015.
https://doi.org/10.1182/blood-2019-131509
Published: 2019
Journal Articles

Long Term Haematological Recovery of Children with Severe Malaria Anaemia in Uganda

Ruth Namazzi, MD, Andrea L Conroy, PhD, Dibyadyuti Datta, PhD, Chandy C. John, MDMS, Robert Opoka, MMED
Journal: Blood
Blood (2019) 134 (Supplement_1): 4698.
https://doi.org/10.1182/blood-2019-132170
Published: 2019
Journal Articles

Radiological Findings By Magnetic Resonance (MRI) and Arteriography (MRA) Brain Imaging Compared to Neurological, Stroke and TCD Assessment in Children with Sickle Cell Anemia in Uganda

Amelia Boehme, PhD MSPH, Richard Idro, MMED, PhD, Deogratias Munube, MD, Paul Bangirana, MS, PhD, Ezekiel Mupere, MMed, MS, PhD, Robert Opoka, MMED, Michael Kawooya, MMed, Samson K. Lubowa, MMed, Angela Lignelli, MD, Philip Kasirye, MMED, Philip LaRussa, MD, Nancy S. Green, MD, Frank Minja, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2304.
https://doi.org/10.1182/blood-2019-130707
Published: 2019
Journal Articles

Burden and Risk of Neurological and Cognitive Impairment in Pediatric Sickle Cell Anemia in Uganda (BRAIN SAFE): Final Results of the Cross-Sectional Analysis

Nancy S. Green, MD, Deogratias Munube, MD, Paul Bangirana, MS, PhD, Robert Opoka, MMED, Edward Kayongo, BSc, Ezekiel Mupere, MMed, MS, PhD, Linda Rosset Buluma, MD, Bridget Kebirungi, BSc, Rogers Sekibira, BSc, Sarah Kiguli, MMed, Michael Kawooya, MMed, Samson Kamya Lubowa, MD, Mitchell S.V. Elkind, MDMS, MPhil, Gen Li, PhD, Philip LaRussa, MD, Richard Idro, MMED, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2375.
https://doi.org/10.1182/blood-2018-99-117392
Published: 2018
Journal Articles

Brain Magnetic Resonance Imaging and Angiography Findings in Ugandan Children with Sickle Cell Anemia; A Cross Sectional Study

Richard Idro, MMED, PhD, Nancy S. Green, MD, Deogratias Munube, MD, Linda Rosset Buluma, MD, Bridget Kebirungi, BSc, Robert Opoka, MMED, Paul Bangirana, MS, PhD, Ezekiel Mupere, MMed, MS, PhD, Edward Kayongo, BSc, Rogers Sekibira, BSc, Philip Kasirye, MD, Samson K. Lubowa, MMed, Michael Kawooya, MMed, Phillip LaRussa, MD, Frank Minja, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2376.
https://doi.org/10.1182/blood-2018-99-112462
Published: 2018
Journal Articles

Novel Use of Hydroxyurea in an African Region with Malaria (NOHARM): A Randomized Controlled Trial

Robert Opoka, Christopher Ndugwa, MMED, Teresa S. Latham, Adam Lane, Heather Ann Hume, MDFRCPC, Philip Kasirye, MD, James L Hodges, PhD, Russell E. Ware, MD PhD, Chandy C John, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 759.
https://doi.org/10.1182/blood.V130.Suppl_1.759.759
Published: 2017
Journal Articles

Burden and Risk of Neurological and Cognitive Impairment in Pediatric Sickle Cell Anemia in Uganda (BRAIN SAFE): Interim Overall Results

Nancy S. Green, MD, Deogratias Munube, MD, Ezekiel Mupere, MMed, MS, PhD, Robert Opoka, MPH, MMed, Phillip Kasirye, MD, Paul Bangirana, MS, PhD, Linda Rosset Buluma, MD, Sarah Kiguli, MMed, Michael Kawooya, MMed, Samson K. Lubowa, MMed, Heather Ann Hume, MDFRCPC, Jose Gutierrez, MD MPH, Philip LaRussa, MD, Frank Minja, MD, Richard Idro, MMed, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 979.
https://doi.org/10.1182/blood.V130.Suppl_1.979.979
Published: 2017
Journal Articles

Pharmacokinetics of Hydroxyurea Therapy in African Children with Sickle Cell Anemia:Â Noharm Ancillary PK Study

Anu Marahatta, PhD, Min Dong, PhD, Robert Opoka, Kathryn E. McElhinney, Teresa S. Latham, Chandy C. John, MDMS, Alexander A. Vinks, Russell E. Ware, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2252.
https://doi.org/10.1182/blood.V130.Suppl_1.2252.2252
Published: 2017
Journal Articles

Tissue Oxygenation By Transfusion in Severe Anemia with Lactic Acidosis (TOTAL): A Prospective, Randomized, Non-Inferiority Trial of Blood Storage Duration

Aggrey Dhabangi, MD, Brenda Ainomugisha, MD, Christine M. Cserti-Gazdewich, MD, Henry Ddungu, MBCHB, M.MD(Int. MD, Dorothy Kyeyune, MD, Ezra Musisi, Robert Opoka, MD, Christopher P. Stowell, MD PhD, Walter H. Dzik, MD
Journal: Blood
Blood (2015) 126 (23): 769.
https://doi.org/10.1182/blood.V126.23.769.769
Published: 2015