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Journal Articles

IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias

Blood (2021) 137 (9): 1208–1218.

https://doi.org/10.1182/blood.2020005944

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

How I treat hypoxia in adults with hemoglobinopathies and hemolytic disorders

Evans M. Machogu, Roberto F. Machado

Blood (2018) 132 (17): 1770–1780.

https://doi.org/10.1182/blood-2018-03-818195

Published: 2018

Journal Articles

HMOX1 and acute kidney injury in sickle cell anemia

Santosh L. Saraf, Maya Viner, Ariel Rischall, Rasha Raslan, Binal N. Shah, Xu Zhang, Jin Han, Michel Gowhari, Shivi Jain, Robert E. Molokie, Roberto F. Machado, James P. Lash, Victor R. Gordeuk

Blood (2018) 132 (15): 1621–1625.

https://doi.org/10.1182/blood-2018-05-853929

Published: 2018

Includes: Supplemental data

Journal Articles

HMOX1 and Acute Kidney Injury in Sickle Cell Anemia

Santosh L. Saraf, MD, Maya Viner, MD, Ariel Rischall, MD, Binal Shah, PhD, Xu Zhang, PhD, Jin Han, PharmD, PhD, Michel Gowhari, DO, Shivi Jain, MD, Robert E. Molokie, MD, Roberto F. Machado, MD, James P. Lash, MD, Victor R. Gordeuk, MD

Blood (2017) 130 (Supplement 1): 686.

https://doi.org/10.1182/blood.V130.Suppl_1.686.686

Published: 2017

Journal Articles

Biomarker Discovery: Novel Insights into Red Blood Cell Metabolomics in Patients with Sickle Cell Disease at Risk for Early Mortality

Claudia R. Morris, MD, Chunyu Ma, Shuzhao Li, Dean Jones, Lou Ann Brown, PhD, Roberto F. Machado, MD, Gregory J. Kato, MD, Yingze Zhang, PhD, Seyed Mehdi Nouraie, PhD MD, Mark T Gladwin, MD

Blood (2017) 130 (Supplement 1): 4772.

https://doi.org/10.1182/blood.V130.Suppl_1.4772.4772

Published: 2017

Journal Articles

Reduced Hemolysis and Related Complications in Females with Sickle Cell Disease

Santosh L. Saraf, MD, Tamir Kanias, PhD, Xu Zhang, PhD, Binal Shah, PhD, Rasha Raslan, MD, Jin Han, PharmD, PhD, Roberto F. Machado, MD, Mark T Gladwin, MD, Victor R. Gordeuk, MD

Blood (2017) 130 (Supplement 1): 3530.

https://doi.org/10.1182/blood.V130.Suppl_1.3530.3530

Published: 2017

Journal Articles

Association of circulating transcriptomic profiles with mortality in sickle cell disease

Ankit A. Desai, Zhengdeng Lei, Neil Bahroos, Mark Maienschein-Cline, Santosh L. Saraf, Xu Zhang, Binal N. Shah, Seyed M. Nouraie, Taimur Abbasi, Amit R. Patel, Roberto M. Lang, Yves Lussier, Joe G. N. Garcia, Victor R. Gordeuk, Roberto F. Machado

Blood (2017) 129 (22): 3009–3016.

https://doi.org/10.1182/blood-2016-11-752279

Published: 2017

Includes: Supplemental data

Journal Articles

Genetic Modifiers Identify a High Risk Group for Stroke in Three Independent Cohorts of Sickle Cell Anemia Patients

Santosh L. Saraf, MD, Titilola S. Akingbola, MBBS, FWACP, Binal N. Shah, PhD, Xu Zhang, PhD, Lewis L. Hsu, MD PhD, Mark T. Gladwin, MD, Roberto F. Machado, MD, Richard S. Cooper, MD, Victor R. Gordeuk, MD, Bamidele O. Tayo, PhD

Blood (2016) 128 (22): 1015.

https://doi.org/10.1182/blood.V128.22.1015.1015

Published: 2016

Journal Articles

Progressive Glomerular Damage in Sickle Cell Trait and Sickle Cell Anemia Mouse Models

Santosh L. Saraf, MD, Justin R. Sysol, PhD, Alexandru Susma, Suman Setty, MD PhD, Xu Zhang, PhD, Krishnamurthy P. Gudehithlu, PhD, Jose A.L. Arruda, MD, Ashok K. Singh, PhD, Roberto F. Machado, MD, Victor R. Gordeuk, MD

Blood (2016) 128 (22): 3637.

https://doi.org/10.1182/blood.V128.22.3637.3637

Published: 2016

Journal Articles

Pathophysiology and treatment of pulmonary hypertension in sickle cell disease

Victor R. Gordeuk, Oswaldo L. Castro, Roberto F. Machado

Blood (2016) 127 (7): 820–828.

https://doi.org/10.1182/blood-2015-08-618561

Published: 2016

Journal Articles

Hydroxyurea Treatment Is Associated with Elevated Serum Erythropoietin Concentration but Suppressed Global Hypoxic Transcriptional Responses in Sickle Cell Disease

Xu Zhang, PhD, Wei Zhang, PhD, Binal Shah, PhD, Galina Miasnikova, MD, Adelina Sergueeva, MD, Tatiana Ammosova, PhD, Xiaomei Niu, Mehdi Nouraie, MD PhD, Sergei Nekhai, PhD, Roberto F. Machado, MD, Joe G.N. Garcia, Mark T. Gladwin, MD, Oswaldo L Castro, MD, Victor R. Gordeuk, MD

Blood (2015) 126 (23): 3380.

https://doi.org/10.1182/blood.V126.23.3380.3380

Published: 2015

Journal Articles

Chronic Opioid Use Pattern in Adult Patients with Sickle Cell Disease

Jin Han, PharmD, PhD, Santosh L. Saraf, MD, Xu Zhang, PhD, Michel Gowhari, DO, Robert E. Molokie, MD, Johara Hassan, MD, Chaher Alhandalous, MD, Jewel Younge, MA, Taimur Abbasi, MD, Roberto F. Machado, MD, Victor R. Gordeuk, MD

Blood (2015) 126 (23): 3400.

https://doi.org/10.1182/blood.V126.23.3400.3400

Published: 2015

Journal Articles

Age As an Independent Clinical Predictor for Vitamin D Deficiency in Sickle Cell Disease

Jin Han, PharmD, PhD, Santosh L. Saraf, MD, Taimur Abbasi, MD, Xu Zhang, PhD, Robert E. Molokie, MD, Johara Hassan, MD, Michel Gowhari, DO, Chaher Alhandalous, MD, Roberto F. Machado, MD, Victor R. Gordeuk, MD

Blood (2014) 124 (21): 1385.

https://doi.org/10.1182/blood.V124.21.1385.1385

Published: 2014

Journal Articles

Cell-Free Hemoglobin, HMOX1 and APOL1 in Sickle Cell Nephropathy

Santosh L. Saraf, MD, Xu Zhang, PhD, Binal Shah, PhD, Krishnamurthy P. Gudehithlu, PhD, Rick Kittles, PhD, Michel Gowhari, DO, Jose Arruda, MD, Roberto F. Machado, MD, Mark T Gladwin, MD, Ashok Singh, PhD, Victor R. Gordeuk, MD

Blood (2014) 124 (21): 4056.

https://doi.org/10.1182/blood.V124.21.4056.4056

Published: 2014

Journal Articles

European Ancestry Is Associated with Acute Chest Syndrome in Sickle Cell Disease

Ken Batai, PhD, Taimur Abbasi, MD, Maggie Parker, BS, Xu Zhang, PhD, Wei Zhang, PhD, Yingze Zhang, PhD, Mark T Gladwin, MD, Joe G. N. Garcia, MD, Victor R. Gordeuk, MD, Rick Kittles, PhD, Roberto F. Machado, MD

Blood (2014) 124 (21): 4051.

https://doi.org/10.1182/blood.V124.21.4051.4051

Published: 2014

Journal Articles

Use Of Hydroxyurea For Sickle Cell Disease In An Academic Center

Michel Gowhari, DO, Taimur Abbasi, MD, Roberto F Machado, MD, Victor R. Gordeuk, MD

Blood (2013) 122 (21): 4697.

https://doi.org/10.1182/blood.V122.21.4697.4697

Published: 2013

Journal Articles

Mechanistic Insights Into Ventricular Arrhythmias Associated With Sickle Cell Disease: Role Of Abnormal Repolarization

I D Greener, Ph.D., C A Rutledge, BS, T Abassi, BS, K Yadav, BS, A B Desai, MD, M Oberoi, MD, P Chunduru, MD, D P Parikh, MD, J GN Garcia, MD, Victor R. Gordeuk, MD, Cheryl A. Hillery, MD, S c Dudley, Jr., MD, Roberto F Machado, MD, A A Desai, MD

Blood (2013) 122 (21): 980.

https://doi.org/10.1182/blood.V122.21.980.980

Published: 2013

Journal Articles

Genetic Association Of a MAPK8 Expression Quantitative Trait Locus With Pre-Capillary Pulmonary Hypertension In Sickle Cell Disease

Xu Zhang, PhD, Wei Zhang, PhD, Shwu-Fan Ma, PhD, Ankit A. Desai, MD, Galina Y. Miasnikova, MD, Adelina Sergueeva, MD, Tatiana Ammosova, PhD, Min Xu, Sergei A. Nekhai, PhD, Taimur Abbasi, MD, Nancy G. Casanova, MD, Martin H. Steinberg, MD, Clinton T. Baldwin, PhD, Paola Sebastiani, PhD, Josef Prchal, MD, Rick Kittles, PhD, Joe GN Garcia, MD, Roberto F. Machado, MD, Victor R. Gordeuk, MD

Blood (2013) 122 (21): 991.

https://doi.org/10.1182/blood.V122.21.991.991

Published: 2013

Journal Articles

Iron Deficiency Modifies Gene Expression Variation Induced by Augmented Hypoxia Sensing

Victor R. Gordeuk, MD, Xu Zhang, PhD, Wei Zhang, PhD, Shwu-Fan Ma, PhD, Galina Miasniakova, MD, Adelina Sergueeva, MD, Tatiana Ammosova, PhD, Min Xu, PhD, Sergei Nekhai, PhD, Josef T. Prchal, MD, Michael Wade, MS, Joe GN Garcia, MD, Roberto F Machado, MD

Blood (2012) 120 (21): 1765.

https://doi.org/10.1182/blood.V120.21.1765.1765

Published: 2012

Journal Articles

Integration of Genomic and Genetic Approaches Highlight a Novel Validated Gene Signature for Pulmonary Hypertension Associated with Sickle Cell Disease

Ankit A Desai, MD, Homaa Ahmad, MD, Tong Zhou, PhD, Wei Zhang, PhD, Sharon Trevino, RN, Michael Wade, MS, Nalini Raghavachari, PhD, Gregory J. Kato, MD, Tejasi Thiruvoipati, MD, Kristin Turner, BS, Nicole Artz, MD, Amit R Patel, MD, Jason × Yuan, MD PhD, Victor R. Gordeuk, MD, Roberto M Lang, MD, Joe GN Garcia, MD, Roberto F. Machado, MD

Blood (2011) 118 (21): 511.

https://doi.org/10.1182/blood.V118.21.511.511

Published: 2011

NARROW

IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias

How I treat hypoxia in adults with hemoglobinopathies and hemolytic disorders

HMOX1 and acute kidney injury in sickle cell anemia

HMOX1 and Acute Kidney Injury in Sickle Cell Anemia

Biomarker Discovery: Novel Insights into Red Blood Cell Metabolomics in Patients with Sickle Cell Disease at Risk for Early Mortality

Reduced Hemolysis and Related Complications in Females with Sickle Cell Disease

Association of circulating transcriptomic profiles with mortality in sickle cell disease

Genetic Modifiers Identify a High Risk Group for Stroke in Three Independent Cohorts of Sickle Cell Anemia Patients

Progressive Glomerular Damage in Sickle Cell Trait and Sickle Cell Anemia Mouse Models

Pathophysiology and treatment of pulmonary hypertension in sickle cell disease

Hydroxyurea Treatment Is Associated with Elevated Serum Erythropoietin Concentration but Suppressed Global Hypoxic Transcriptional Responses in Sickle Cell Disease

Chronic Opioid Use Pattern in Adult Patients with Sickle Cell Disease

Age As an Independent Clinical Predictor for Vitamin D Deficiency in Sickle Cell Disease

Cell-Free Hemoglobin, HMOX1 and APOL1 in Sickle Cell Nephropathy

European Ancestry Is Associated with Acute Chest Syndrome in Sickle Cell Disease

Use Of Hydroxyurea For Sickle Cell Disease In An Academic Center

Mechanistic Insights Into Ventricular Arrhythmias Associated With Sickle Cell Disease: Role Of Abnormal Repolarization

Genetic Association Of a MAPK8 Expression Quantitative Trait Locus With Pre-Capillary Pulmonary Hypertension In Sickle Cell Disease

Iron Deficiency Modifies Gene Expression Variation Induced by Augmented Hypoxia Sensing

Integration of Genomic and Genetic Approaches Highlight a Novel Validated Gene Signature for Pulmonary Hypertension Associated with Sickle Cell Disease

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