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Journal Articles

Both permissive and nonpermissive HLA-DPB1 mismatches can induce polyclonal HLA-DPB1 specific immune responses in vivo and in vitro

Caroline E. Rutten, Simone A. P. van Luxemburg-Heijs, Edith D. van der Meijden, Marieke Griffioen, Machteld Oudshoorn, Roel Willemze, J. H. Frederik Falkenburg

Blood (2010) 115 (1): 151–153.

https://doi.org/10.1182/blood-2009-10-249821

Published: 2010

Journal Articles

Myeloid Chimerism Reflects Engraftment of Donor Hematopoiesis, Whereas T Cell Chimerism Reflects Survival and Expansion of Donor and Recipient Residual Mature T Cells Early After T Cell Depleted Allogeneic Stem Cell Transplantation.

Jessica C. Harskamp, Esther H.M. van Egmond, Hans L. Vos, PhD, Stijn J.M. Halkes, MD, PhD, Roel Willemze, MD, PhD, J.H. Frederik Falkenburg, MD, PhD, Erik W.A. Marijt, MD, PhD

Blood (2009) 114 (22): 4475.

https://doi.org/10.1182/blood.V114.22.4475.4475

Published: 2009

Journal Articles

Diversity of HLA Class I and Class II Restricted Minor Histocompatibility Antigens in Graft-Versus-Leukemia Reactivity.

Marieke Griffioen, M. Willy Honders, Anita N. Stumpf, Edith D. van der Meijden, Cornelis A.M. van Bergen, Simone A.P. van Luxemburg-Heijs, Elisabeth G.A. Lurvink, Roel Willemze, J.H. Frederik Falkenburg

Blood (2009) 114 (22): 4084.

https://doi.org/10.1182/blood.V114.22.4084.4084

Published: 2009

Journal Articles

Identification of 4 new HLA-DR–restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity

Anita N. Stumpf, Edith D. van der Meijden, Cornelis A. M. van Bergen, Roel Willemze, J. H. Frederik Falkenburg, Marieke Griffioen

Blood (2009) 114 (17): 3684–3692.

https://doi.org/10.1182/blood-2009-03-208017

Published: 2009

Journal Articles

Leukemic Blasts Acting as Host Antigen Presenting Cells Trigger a Combined CD4 and CD8 Allo-Immune Response Directed against Mismatched HLA Class I

Avital L. Amir, MD, Renate S. Hagedoorn, MSC, W.A. Eric Marijt, MD, PhD, Roel Willemze, MD, PhD, J.H. Frederik Falkenburg, MD, PhD, Mirjam H.M. Heemskerk, PhD

Blood (2008) 112 (11): 4607.

https://doi.org/10.1182/blood.V112.11.4607.4607

Published: 2008

Journal Articles

High Avidity HLA-A2-Restricted CD8+ T Cells against the Wilms Tumor Protein (WT1) Can Be Isolated Only from HLA-A2 Negative Donors Not Subjected to HLA-A2-Mediated Thymic Deletion

Inge Jedema, PhD, Marian van de Meent, Willem J.J. Falkenburg, Michel G.D. Kester, Roel Willemze, J.H. Frederik Falkenburg

Blood (2008) 112 (11): 3895.

https://doi.org/10.1182/blood.V112.11.3895.3895

Published: 2008

Journal Articles

Both the Activation Kinetics and the Frequency of Regulatory T Cells Determine the Ability to Generate Primary Anti-Tumor and Pathogen- Specific Immune Responses from a Naïve Donor T Cell Repertoire

Inge Jedema, PhD, Jeanette Pots, Marian van de Meent, Roel Willemze, J.H. Frederik Falkenburg

Blood (2008) 112 (11): 3898.

https://doi.org/10.1182/blood.V112.11.3898.3898

Published: 2008

Journal Articles

Vigorous Priming of Minor Histocompatibility Antigen Specific T Cells by Frequent High Dose Peptide Vaccination May Lead to Prolonged T Cell Receptor Downregulation, Impaired T Cell Functionality, and Promotion of Tumor Escape.

Inge Jedema, Linda van Dreunen, Marleen M. van Loenen, Mirjam Heemskerk, Roel Willemze, J.H. Frederik Falkenburg

Blood (2007) 110 (11): 1809.

https://doi.org/10.1182/blood.V110.11.1809.1809

Published: 2007

Journal Articles

Donor Lymphocyte Infusion for Mixed Chimerism or Residual Disease after Reduced-Intensity T Cell Depleted Stem Cell Transplantation Results in Conversion to Full Donor Chimerism Combined with Graft Versus Tumor Responses and Limited GVHD.

Peter A. von dem Borne, MD, PhD, Ingrid Starrenburg, Erik W.A. Marijt, Stijn Halkes, J.H. Frederik Falkenburg, Roel Willemze

Blood (2007) 110 (11): 1652.

https://doi.org/10.1182/blood.V110.11.1652.1652

Published: 2007

Journal Articles

Rituximab and Alemtuzumab in Combination, but Not Alone, Induce Complete Remissions in a Preclinical Animal Model of Primary Human ALL: Rationale for Combination Treatment.

Bart Nijmeijer, PhD, Marianke L.J. van Schie, Roel Willemze, PhD, J.H. Frederik Falkenburg, PhD

Blood (2007) 110 (11): 2833.

https://doi.org/10.1182/blood.V110.11.2833.2833

Published: 2007

Journal Articles

Proliferation of Acute Lymphoblastic Leukemic (ALL) Cells Is Dependent on Exogenous Purine Administration.

Henriette M. Goselink, BS, Bart A. Nijmeijer, Cornelis H. Hokke, Rob van der Heijden, Roel Willemze, J.H. Frederik Falkenburg

Blood (2007) 110 (11): 3466.

https://doi.org/10.1182/blood.V110.11.3466.3466

Published: 2007

Journal Articles

Efficient Induction and Isolation of CMV-Specific CD8+ T Cells from CMV Seronegative Donors for the Treatment of CMV Reactivation in CMV Seropositive Patients Transplanted with a CMV Seronegative Donor.

Inge Jedema, Marian van de Meent, Pim L.J. van der Heiden, Erik W.A. Marijt, Pauline Meij, Roel Willemze, J.H. Frederik Falkenburg

Blood (2007) 110 (11): 1053.

https://doi.org/10.1182/blood.V110.11.1053.1053

Published: 2007

Journal Articles

Multiple myeloma–reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene

Cornelis A. M. van Bergen, Michel G. D. Kester, Inge Jedema, Mirjam H. M. Heemskerk, Simone A. P. van Luxemburg-Heijs, Freke M. Kloosterboer, W. A. Erik Marijt, Arnoud H. de Ru, M. Ron Schaafsma, Roel Willemze, Peter A. van Veelen, J. H. Frederik Falkenburg

Blood (2007) 109 (9): 4089–4096.

https://doi.org/10.1182/blood-2006-08-043935

Published: 2007

Journal Articles

Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting

Alma J. Nauta, Geert Westerhuis, Alwine B. Kruisselbrink, Ellie G. A. Lurvink, Roel Willemze, Willem E. Fibbe

Blood (2006) 108 (6): 2114–2120.

https://doi.org/10.1182/blood-2005-11-011650

Published: 2006

Journal Articles

Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

Mirjam H. M. Heemskerk, Renate S. Hagedoorn, Menno A. W. G. van der Hoorn, Lars T. van der Veken, Manja Hoogeboom, Michel G. D. Kester, Roel Willemze, J. H. Frederik Falkenburg

Blood (2006) 109 (1): 235–243.

https://doi.org/10.1182/blood-2006-03-013318

Published: 2006

Journal Articles

Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer

Elisabeth H. Slager, M. Willy Honders, Edith D. van der Meijden, Simone A. P. van Luxemburg-Heijs, Freke M. Kloosterboer, Michel G. D. Kester, Inge Jedema, W. A. Erik Marijt, M. Ron Schaafsma, Roel Willemze, J. H. Frederik Falkenburg

Blood (2006) 107 (12): 4954–4960.

https://doi.org/10.1182/blood-2005-09-3883

Published: 2006

Journal Articles

Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia

Freke M. Kloosterboer, Simone A. P. van Luxemburg-Heijs, Ronald A. van Soest, H. M. Esther van Egmond, Roel Willemze, J. H. Frederik Falkenburg

Blood (2005) 106 (12): 3955–3957.

https://doi.org/10.1182/blood-2004-09-3749

Published: 2005

Journal Articles

CD97 Is Differentially Expressed on Murine Hematopoietic Stem Cells and Progenitor Cells.

Melissa van Pel, PhD, Henny Hagoort, Roel Willemze, MD, PhD, Jorg Hamann, PhD, Willem E. Fibbe, MD, PhD

Blood (2005) 106 (11): 2281.

https://doi.org/10.1182/blood.V106.11.2281.2281

Published: 2005

Journal Articles

Successful Generation of Mature Professional Acute Myeloid Leukemia (AML) – Antigen Presenting Cells (APC) Does Not Predict Successful Induction of AML Reactive T Cells for Adoptive Immunotherapy.

Pauline Meij, Marian van de Meent, Inge Jedema, Roel Willemze, J.H. Frederik Falkenburg

Blood (2005) 106 (11): 2789.

https://doi.org/10.1182/blood.V106.11.2789.2789

Published: 2005

Journal Articles

Identification of the Angiogenic Endothelial Cell Growth Factor-1/Thymidine Phosphorylase as a Target for Immunotherapy of Cancer.

Elisabeth H. Slager, PhD, M. Willy Honders, Edith D. van der Meijden, Simone A.P. van Luxemburg-Heijs, Freke M. Kloosterboer, PhD, Michel G.D. Kester, Inge Jedema, PhD, W.A. Erik Marijt, PhD, MD, M. Ronald Schaafsma, PhD, MD, J.H. Frederik Falkenburg, PhD, MD, Roel Willemze, PhD, MD

Blood (2005) 106 (11): 3094.

https://doi.org/10.1182/blood.V106.11.3094.3094

Published: 2005

NARROW

Both permissive and nonpermissive HLA-DPB1 mismatches can induce polyclonal HLA-DPB1 specific immune responses in vivo and in vitro

Myeloid Chimerism Reflects Engraftment of Donor Hematopoiesis, Whereas T Cell Chimerism Reflects Survival and Expansion of Donor and Recipient Residual Mature T Cells Early After T Cell Depleted Allogeneic Stem Cell Transplantation.

Diversity of HLA Class I and Class II Restricted Minor Histocompatibility Antigens in Graft-Versus-Leukemia Reactivity.

Identification of 4 new HLA-DR–restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity

Leukemic Blasts Acting as Host Antigen Presenting Cells Trigger a Combined CD4 and CD8 Allo-Immune Response Directed against Mismatched HLA Class I

High Avidity HLA-A2-Restricted CD8+ T Cells against the Wilms Tumor Protein (WT1) Can Be Isolated Only from HLA-A2 Negative Donors Not Subjected to HLA-A2-Mediated Thymic Deletion

Both the Activation Kinetics and the Frequency of Regulatory T Cells Determine the Ability to Generate Primary Anti-Tumor and Pathogen- Specific Immune Responses from a Naïve Donor T Cell Repertoire

Vigorous Priming of Minor Histocompatibility Antigen Specific T Cells by Frequent High Dose Peptide Vaccination May Lead to Prolonged T Cell Receptor Downregulation, Impaired T Cell Functionality, and Promotion of Tumor Escape.

Donor Lymphocyte Infusion for Mixed Chimerism or Residual Disease after Reduced-Intensity T Cell Depleted Stem Cell Transplantation Results in Conversion to Full Donor Chimerism Combined with Graft Versus Tumor Responses and Limited GVHD.

Rituximab and Alemtuzumab in Combination, but Not Alone, Induce Complete Remissions in a Preclinical Animal Model of Primary Human ALL: Rationale for Combination Treatment.

Proliferation of Acute Lymphoblastic Leukemic (ALL) Cells Is Dependent on Exogenous Purine Administration.

Efficient Induction and Isolation of CMV-Specific CD8+ T Cells from CMV Seronegative Donors for the Treatment of CMV Reactivation in CMV Seropositive Patients Transplanted with a CMV Seronegative Donor.

Multiple myeloma–reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene

Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting

Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer

Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia

CD97 Is Differentially Expressed on Murine Hematopoietic Stem Cells and Progenitor Cells.

Successful Generation of Mature Professional Acute Myeloid Leukemia (AML) – Antigen Presenting Cells (APC) Does Not Predict Successful Induction of AML Reactive T Cells for Adoptive Immunotherapy.

Identification of the Angiogenic Endothelial Cell Growth Factor-1/Thymidine Phosphorylase as a Target for Immunotherapy of Cancer.

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American Society of Hematology

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American Society of Hematology

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