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Journal Articles

Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents

Rudolf Hartmann, PhD, Tjerk Feenstra, MSc, Sabine Knappe, PhD, Michael Dockal, PhD, Friedrich Scheiflinger, PhD

Blood (2017) 130 (Supplement 1): 90.

https://doi.org/10.1182/blood.V130.Suppl_1.90.90

Published: 2017

Journal Articles

A Bispecific Antibody Lacks Measurability in Routine Coagulation Assays and Comparability to Factor VIII

Rudolf Hartmann, PhD, Tjerk Feenstra, MSc, Sabine Knappe, PhD, Gerald Schrenk, PhD, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2017) 130 (Supplement 1): 1080.

https://doi.org/10.1182/blood.V130.Suppl_1.1080.1080

Published: 2017

Journal Articles

Bispecific Antibodies with Native Human IgG Structure As Mimetics for FVIII Activity

Sabine Knappe, PhD, Nicolas Fischer, Patrice Robert Douillard, Rudolf Hartmann, PhD, Gerald Schrenk, PhD, Ulla Ravn, Giovanni Magistrelli, Franck Gueneau, Gerard Didelot, Krzysztof Masternak, Marie Kosco-Vilbois, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2017) 130 (Supplement 1): 1083.

https://doi.org/10.1182/blood.V130.Suppl_1.1083.1083

Published: 2017

Journal Articles

Synergistic Effects of a Procoagulant Bispecific Antibody and Rescue Therapies on Thrombin Generation- a Potential Safety Risk

Sabine Knappe, Rudolf Hartmann, Brahm Goldstein, MD, Bruce M. Ewenstein, Leonard Valentino, Friedrich Scheiflinger, PhD

Blood (2016) 128 (22): 4952.

https://doi.org/10.1182/blood.V128.22.4952.4952

Published: 2016

Journal Articles

Lethality of Mouse Tissue Factor Pathway Inhibitor Gene Disruption Is Rescued By Transgenic Human Tissue Factor Pathway Inhibitor Knock in

Robert Pachlinger, Rudolf Hartmann, Andrea Kolm, Erwin Panholzer, Nadja Ullrich, Fabian Knofl, Maria Schuster, Werner Hoellriegl, DVM, Friedrich Scheiflinger, PhD, Michael Dockal

Blood (2015) 126 (23): 3495.

https://doi.org/10.1182/blood.V126.23.3495.3495

Published: 2015

Journal Articles

A TFPI Inhibitory Half Life Extended Fusion Peptide Proves Efficacy in FVIII Knock out Mice and Marmoset Monkeys

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Erwin Panholzer, Willibald Kammlander, Frank Osterkamp, PhD, Ulrich Reineke, PhD, Alexandra Schiviz, PhD, Werner Hoellriegl, PhD, Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 1469.

https://doi.org/10.1182/blood.V124.21.1469.1469

Published: 2014

Journal Articles

Molecular Characterization of the Synergistic Effect on TFPI Inhibition By Fusion of Two Inhibitory Peptides

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Christoph Redl, Erwin Panholzer, Willibald Kammlander, Frank Osterkamp, PhD, Ulrich Reineke, PhD, Hans Brandstetter, Prof., Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 1484.

https://doi.org/10.1182/blood.V124.21.1484.1484

Published: 2014

Journal Articles

TFPI Expresses Anticoagulant Activity Independent Of TF-FVIIa

Stella Thomassen, PhD, Alexandra Heinzmann, PhD, Linda Herfs, Jan Rosing, PhD, Tilman M. Hackeng, PhD, Rudolf Hartmann, PhD, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2013) 122 (21): 3563.

https://doi.org/10.1182/blood.V122.21.3563.3563

Published: 2013

Journal Articles

Design Of a Most Efficient Inhibitor Of TFPI By Molecular Fusion Of Two Inhibitory Peptides

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Johannes Brandstetter, PhD, Willibald Kammlander, Erwin Panholzer, Christoph Redl, Frank Osterkamp, PhD, Jan Rosing, PhD, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 3564.

https://doi.org/10.1182/blood.V122.21.3564.3564

Published: 2013

Journal Articles

Crystal Structure Of Tissue Factor Pathway Inhibitor (TFPI) Kunitz Domain 1 and 2 In Complex With An Inhibitory Cyclic Peptide,

Michael Dockal, PhD, Rudolf Hartmann, PhD, Markus Fries, PhD, Katerina Prohaska, Robert Pachlinger, PhD, Thomas Polakowski, PhD, Johannes Brandstetter, PhD, Jan Rosing, PhD, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 453.

https://doi.org/10.1182/blood.V122.21.453.453

Published: 2013

Journal Articles

Effect of Increased Tissue Factor Pathway Inhibitor (TFPI) Levels On Factor Xa Inhibition and Global Hemostasis in the Presence of TFPI-Antagonistic Aptamer BAX 499.

Michael Dockal, PhD, Rudolf Hartmann, PhD, Sabine Knappe, PhD, Michael Palige, PhD, Willibald Kammlander, PhD, Klara Kunckova, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2012) 120 (21): 2207.

https://doi.org/10.1182/blood.V120.21.2207.2207

Published: 2012

Journal Articles

Biological Explanation of Clinically Observed Elevation of TFPI Plasma Levels After Treatment with TFPI-Antagonistic Aptamer BAX 499

Michael Dockal, PhD, Robert Pachlinger, Rudolf Hartmann, PhD, Sabine Knappe, PhD, Benny Sorensen, Wing Yen Wong, Maureen Conlan, Michael Cecerle, Bruce M. Ewenstein, MD PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2012) 120 (21): 1104.

https://doi.org/10.1182/blood.V120.21.1104.1104

Published: 2012

Journal Articles

Peptides Inhibiting Tissue Factor Pathway Inhibitor Improve Hemostasis in Mice

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, MBA, Osterkamp Frank, Hartmut J. Ehrlich, MD, Alexandra Schiviz, Werner Hoellriegl, Eva-Maria Muchitsch, Ulrich Reinecke, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 24.

https://doi.org/10.1182/blood.V118.21.24.24

Published: 2011

Journal Articles

Peptides Binding to Kunitz Domain 1 of Tissue Factor Pathway Inhibitor (TFPI) Inhibit All Functions of TFPI and Improve Thrombin Generation of Hemophilia Plasma

Michael Dockal, PhD, Johannes Brandstetter, PhD, Martin Ludwiczek, Georg Kontaxis, PhD, Markus Fries, PhD, M C L G D Thomassen, PhD, A Heinzmann, PhD, Hartmut J. Ehrlich, MD, Katerina Prohaska, Rudolf Hartmann, PhD, Jan Rosing, Professor, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 2245.

https://doi.org/10.1182/blood.V118.21.2245.2245

Published: 2011

Journal Articles

A New Procoagulant Mechanism Mediated by Fucoidans

Michael Dockal, PhD, Erwin Panholzer, Rudolf Hartmann, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2010) 116 (21): 4420.

https://doi.org/10.1182/blood.V116.21.4420.4420

Published: 2010

Journal Articles

Variants of Recombinant Factor IX with Enhanced Functional Properties.

Rudolf Hartmann, PhD, Michael Dockal, PhD, Willibald Kammlander, Erwin Panholzer, Friedrich Scheiflinger, PhD

Blood (2007) 110 (11): 2694.

https://doi.org/10.1182/blood.V110.11.2694.2694

Published: 2007

NARROW

Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents

A Bispecific Antibody Lacks Measurability in Routine Coagulation Assays and Comparability to Factor VIII

Bispecific Antibodies with Native Human IgG Structure As Mimetics for FVIII Activity

Synergistic Effects of a Procoagulant Bispecific Antibody and Rescue Therapies on Thrombin Generation- a Potential Safety Risk

Lethality of Mouse Tissue Factor Pathway Inhibitor Gene Disruption Is Rescued By Transgenic Human Tissue Factor Pathway Inhibitor Knock in

A TFPI Inhibitory Half Life Extended Fusion Peptide Proves Efficacy in FVIII Knock out Mice and Marmoset Monkeys

Molecular Characterization of the Synergistic Effect on TFPI Inhibition By Fusion of Two Inhibitory Peptides

TFPI Expresses Anticoagulant Activity Independent Of TF-FVIIa

Design Of a Most Efficient Inhibitor Of TFPI By Molecular Fusion Of Two Inhibitory Peptides

Crystal Structure Of Tissue Factor Pathway Inhibitor (TFPI) Kunitz Domain 1 and 2 In Complex With An Inhibitory Cyclic Peptide,

Effect of Increased Tissue Factor Pathway Inhibitor (TFPI) Levels On Factor Xa Inhibition and Global Hemostasis in the Presence of TFPI-Antagonistic Aptamer BAX 499.

Biological Explanation of Clinically Observed Elevation of TFPI Plasma Levels After Treatment with TFPI-Antagonistic Aptamer BAX 499

Peptides Inhibiting Tissue Factor Pathway Inhibitor Improve Hemostasis in Mice

Peptides Binding to Kunitz Domain 1 of Tissue Factor Pathway Inhibitor (TFPI) Inhibit All Functions of TFPI and Improve Thrombin Generation of Hemophilia Plasma

A New Procoagulant Mechanism Mediated by Fucoidans

Variants of Recombinant Factor IX with Enhanced Functional Properties.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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