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Journal Articles

Preclinical Characterization of the Anti-Leukemia Activity of the CD33/CD16/NKG2D Immune Modulating TriNKET ® BMS-986357 (CC-96191)

Margaret C. Lunn, George S. Laszlo, Sarah Eraiss, Mark T. Orr, Heidi K. Jessup, Henry Chan, Heather J. Thomas, Ann F. Cheung, Gregory P. Chang, Asya Grinberg, Eduardo Rodríguez-Arbolí, Sheryl Y. T. Lim, Allie R. Kehret, Jenny Huo, Frances M. Cole, Samuel C. Scharffenberger, Roland B. Walter
Journal: Blood
Blood (2023) 142 (Supplement 1): 1431.
https://doi.org/10.1182/blood-2023-185432
Published: 2023
Journal Articles

Optimizing Siglec-8-Directed Immunotherapy for Eosinophilic and Mast Cell Disorders

Jenny Huo, George S. Laszlo, Sheryl Y. T. Lim, Frances M. Cole, Allie R. Kehret, Junyang Li, Margaret C. Lunn, Jasmyn L. Persicke, Peter B. Rupert, Roland K. Strong, Roland B. Walter
Journal: Blood
Blood (2023) 142 (Supplement 1): 1781.
https://doi.org/10.1182/blood-2023-181476
Published: 2023
Journal Articles

Targeting the Membrane-Proximal C2-Set Domain of CD33 for Improved CD33-Directed CAR T Cell Therapy

Salvatore Fiorenza, George S. Laszlo, Tinh-Doan Phi, Margaret C. Lunn, Delaney R. Kirchmeier, Colin D. Godwin, Erik L. Kimble, Cameron J. Turtle, Roland B. Walter
Journal: Blood
Blood (2021) 138 (Supplement 1): 2776.
https://doi.org/10.1182/blood-2021-149642
Published: 2021
Journal Articles

Development of Astatine-211 ( 211 At)-Based Anti-CD123 Radioimmunotherapy for Acute Leukemias and Other CD123+ Hematologic Malignancies

George S. Laszlo, Johnnie J. Orozco, Allie R. Kehret, Margaret C. Lunn, Donald K. Hamlin, D. Scott Wilbur, Shannon L. Dexter, Melissa C. Comstock, Shyril O'Steen, Damian J. Green, Roland B. Walter
Journal: Blood
Blood (2021) 138 (Supplement 1): 3341.
https://doi.org/10.1182/blood-2021-152105
Published: 2021
Journal Articles

CRISPR/Cas9-Mediated Protection of Normal Hematopoiesis Combined with the CD33/CD3 Bispecific T-Cell Engager (BiTE) Antibody AMG330 for Improved AML Therapy

Olivier Humbert, PhD, Mallory J Llewellyn, George S. Laszlo, PhD, Roland B. Walter, MD PhD MS, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4427.
https://doi.org/10.1182/blood-2019-129399
Published: 2019
Journal Articles

Anti-Apoptotic BCL-2 Family Members Confer Resistance to Calicheamicin-Based Antibody-Drug Conjugate Therapy of Acute Leukemia

Colin D. Godwin, MDMPhil, Olivia M. Bates, BA, Sae Rin Jean, PhD, George S. Laszlo, PhD, Eliotte E. Garling, BA, Mary E. Beddoe, BS, Michael H. Cardone, PhD, Roland B. Walter, MD PhD MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2561.
https://doi.org/10.1182/blood-2019-126110
Published: 2019
Journal Articles

Engineering Resistance to CD33-Targeted Immunotherapy in Normal Hematopoiesis By CRISPR/Cas9-Deletion of CD33 Exon 2

Roland B. Walter, MD PhD MS, Olivier Humbert, PhD, George S. Laszlo, PhD, Sophie R. Sichel, BS, Christina M. Ironside, BS, Kevin G. Haworth, PhD, Olivia M. Bates, BA, Mary E. Beddoe, BS, Ray R. Carillo, BS, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2200.
https://doi.org/10.1182/blood-2018-99-117856
Published: 2018
Journal Articles

Bispecific Anti-CD123 x Anti-CD3 Adaptir™ Molecules APVO436 and APVO437 Have Broad Activity Against Primary Human AML Cells In Vitro

Colin D. Godwin, MD MPhil, Olivia M. Bates, BA, George S. Laszlo, PhD, Rebecca Gottschalk, Michael R. Comeau, Gabriela H. Hoyos, Roland B. Walter, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2639.
https://doi.org/10.1182/blood.V130.Suppl_1.2639.2639
Published: 2017
Journal Articles

High Expression of Myocyte Enhancer Factor 2C ( MEF2C ) Is Associated with Adverse Risk Features and Poor Outcome in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group

George S. Laszlo, PhD, Todd A. Alonzo, PhD, Chelsea J. Gudgeon, BS, Kimberly H. Harrington, BS, Alex Kentsis, MD PhD, Robert B. Gerbing, MA, Yi-Cheng Wang, MS, Rhonda E. Ries, MA, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, Alan S. Gamis, MD MPH, Soheil Meshinchi, MD PhD, Roland B. Walter, MD PhD MS
Journal: Blood
Blood (2015) 126 (23): 2570.
https://doi.org/10.1182/blood.V126.23.2570.2570
Published: 2015
Journal Articles

The Broad Activity of the CD33/CD3 Bispecific BiTE® Antibody AMG 330 in Primary Human AML Is Impacted By Disease Stage and Cytogenetic/Molecular Risk

Kimberly H. Harrington, BS, Chelsea J. Gudgeon, BS, George S. Laszlo, PhD, Kathryn J. Newhall, PhD, Angus M. Sinclair, PhD, Stanley R. Frankel, MD, Roman Kischel, MD, Guang Chen, PhD, Roland B. Walter, MD PhD MS
Journal: Blood
Blood (2014) 124 (21): 266.
https://doi.org/10.1182/blood.V124.21.266.266
Published: 2014
Journal Articles

Multimerin-1 (MMRN1) As Novel Adverse Prognostic Marker in Acute Myeloid Leukemia: A Report from the Children’s Oncology Group

George S. Laszlo, PhD, Todd A. Alonzo, PhD, Chelsea J. Gudgeon, BS, Kimberly H. Harrington, BS, Robert B. Gerbing, MA, Yi-Cheng Wang, MS, Rhonda E. Ries, MA, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, Alan S. Gamis, MD MPH, Soheil Meshinchi, MD PhD, Roland B. Walter, MD PhD MS
Journal: Blood
Blood (2014) 124 (21): 2330.
https://doi.org/10.1182/blood.V124.21.2330.2330
Published: 2014
Journal Articles

Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML

George S. Laszlo, Chelsea J. Gudgeon, Kimberly H. Harrington, Justine Dell’Aringa, Kathryn J. Newhall, Gary D. Means, Angus M. Sinclair, Roman Kischel, Stanley R. Frankel, Roland B. Walter
Journal: Blood
Blood (2014) 123 (4): 554–561.
https://doi.org/10.1182/blood-2013-09-527044
Published: 2014
Includes: Supplemental data
Journal Articles

Novel Long-Term Co-Culture Approach Identifies Prognostically Important Heterogeneity Of Stem/Progenitor Cell Involvement In Human Acute Myeloid Leukemia

George S. Laszlo, PhD, Jack M. Lionberger, MD, PhD, Kimberly H. Harrington, BS, Chelsea J. Gudgeon, BS, Megan Othus, PhD, Frederick R. Appelbaum, MD, Irwin D. Bernstein, MD, Roland B. Walter, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1318.
https://doi.org/10.1182/blood.V122.21.1318.1318
Published: 2013
Journal Articles

Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

AA Cardoso, JL Schultze, VA Boussiotis, GJ Freeman, MJ Seamon, S Laszlo, A Billet, SE Sallan, JG Gribben, LM Nadler
Journal: Blood
Blood (1996) 88 (1): 41–48.
https://doi.org/10.1182/blood.V88.1.41.41
Published: 1996