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Journal Articles

A Phase 1b Study of ELA026, a Monoclonal Antibody Targeting Signal Regulatory Protein-α/β1/γ, in Patients with Newly Diagnosed and Previously Treated Secondary Hemophagocytic Lymphohistiocytosis

Abhishek Maiti, Naval Daver, Swami P. Iyer, David McCall, Satyen H Gohil, Javier Lopez Jimenez, Hayley Lane, Benjamin Kim, Kim-Hien Dao, Gary Patou, Sandip Panicker, Kelly Covert, Graham Carl Parry, Carl E Allen
Journal: Blood
Blood (2023) 142 (Supplement 1): 1162.
https://doi.org/10.1182/blood-2023-177795
Published: 2023
Journal Articles

Trial in Progress: A Phase 1b Study of ELA026 in Patients with Secondary Hemophagocytic Lymphohistiocytosis

Timothy S. Leach, Hayley Lane, Benjamin Kim, Stephen J. Moore, Sandip Panicker, Gary Patou
Journal: Blood
Blood (2022) 140 (Supplement 1): 8336–8337.
https://doi.org/10.1182/blood-2022-167961
Published: 2022
Journal Articles

Pre-Clinical Characterization of VGA039, an Anti-Protein S Monoclonal Antibody Being Developed As a Universal Hemostatic Agent for Various Bleeding Disorders

Lilley Leong, Tony Byun, Benjamin Kim, Ian Huck, Abel Silva, Joanne Chan, Young Cho, John Liu, Christopher J. Horvath, Stephen J. Moore, Sandip Panicker
Journal: Blood
Blood (2022) 140 (Supplement 1): 1666–1667.
https://doi.org/10.1182/blood-2022-170245
Published: 2022
Journal Articles

Characterization of ELA026, a Clinical-Stage Monoclonal Antibody That Rapidly and Potently Depletes Myeloid Cells and T Lymphocytes

Eileen Rose, Stephen J. Moore, Allen Cai, Alina He, Ian Huck, Jen Razo, Laurie Wong, Joanne Chan, Christopher J. Horvath, John Liu, Sandip Panicker
Journal: Blood
Blood (2022) 140 (Supplement 1): 8318–8319.
https://doi.org/10.1182/blood-2022-168013
Published: 2022
Journal Articles

Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial

Clinical Trials & Observations
Ulrich Jäger, Shirley D’Sa, Christian Schörgenhofer, Johann Bartko, Ulla Derhaschnig, Christian Sillaber, Petra Jilma-Stohlawetz, Michael Fillitz, Thomas Schenk, Gary Patou, Sandip Panicker, Graham C. Parry, James C. Gilbert, Bernd Jilma
Journal: Blood
Blood (2019) 133 (9): 893–901.
https://doi.org/10.1182/blood-2018-06-856930
Published: 2019
Includes: Supplemental data
Journal Articles

Long Term Efficacy, Safety and PK/PD Profile of the Anti-C1s Antibody (BIVV009) in Primary Cold Agglutinin Disease Patients

Ulrich Jaeger, MD, Shirley D'Sa, MD FRCP, FRCPath, Christian Schoergenhofer, MD, Johann Bartko, MD, Christian Sillaber, MD, Petra Jilma-Stohlawetz, MD, Michael Fillitz, MD, Thomas Schenk, MD, Gary Patou, MD, Sandip Panicker, PhD, Graham C Parry, PhD, James C Gilbert, MD, Bernd Jilma, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 703.
https://doi.org/10.1182/blood.V130.Suppl_1.703.703
Published: 2017
Journal Articles

Chronic Inhibition of Complement C1s By TNT009 Produces Sustained, Complete Remission in Patients with Severe, Transfusion-Dependent Cold Agglutinin Disease (CAD)

Bernd Jilma, MD, James C Gilbert, MD, Sandip Panicker, PhD, Graham C Parry, PhD, Michael Fillitz, MD, Schenk Thomas, Christian Sillaber, MD, Johann Bartko, MD, Ulrich Jaeger, MD
Journal: Blood
Blood (2016) 128 (22): 2435.
https://doi.org/10.1182/blood.V128.22.2435.2435
Published: 2016
Journal Articles

TNT009 Prevents Erythrocyte C3 Fragment Opsonization and Rescues Reticulocytes from Destruction in Patients with Cold Agglutinin Disease

Sandip Panicker, PhD, Christa Drucker, Sami Hussain, Graham C Parry, PhD, James C Gilbert, MD, Bernd Jilma, MD, Ulrich Jaeger, MD
Journal: Blood
Blood (2016) 128 (22): 94.
https://doi.org/10.1182/blood.V128.22.94.94
Published: 2016
Journal Articles

Therapeutic Rationale and Clinical Development of TNT009, an Upstream Classical Pathway Inhibitor, for Cold Agglutinin Disease

Ulrich Jaeger, MD, Eileen L Rose, Andrew Singh, Sebastian H A Feickert, Simon Panzer, Bernd Jilma, MD, James C. Gilbert, MD, Sandip Panicker, PhD
Journal: Blood
Blood (2015) 126 (23): 3560.
https://doi.org/10.1182/blood.V126.23.3560.3560
Published: 2015
Journal Articles

Classical Pathway of Complement Activation in ITP: Inhibition By TNT003, a Novel C1s Inhibitor

Ellinor I.B. Peerschke, PhD, Sandip Panicker, PhD, Alexa M. Sughroue, James B. Bussel, MD
Journal: Blood
Blood (2014) 124 (21): 1453.
https://doi.org/10.1182/blood.V124.21.1453.1453
Published: 2014
Journal Articles

TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins

Ju Shi, Eileen L. Rose, Andrew Singh, Sami Hussain, Nancy E. Stagliano, Graham C. Parry, Sandip Panicker
Journal: Blood
Blood (2014) 123 (26): 4015–4022.
https://doi.org/10.1182/blood-2014-02-556027
Published: 2014
Includes: Supplemental data
Journal Articles

TNT009, a Classical Complement Pathway Specific Inhibitor, Prevents Complement Dependent Hemolysis Induced By Cold Agglutinin Disease Patient Autoantibodies

Sandip Panicker, Ph.D., Ju Shi, Ph.D., Eileen Rose, Sami Hussain, Susan Tom, William Strober, Steven R. Sloan, M.D., Ph.D., Graham Parry, Ph.D., Nancy Stagliano, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 42.
https://doi.org/10.1182/blood.V122.21.42.42
Published: 2013