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Journal Articles

Etavopivat, an Allosteric Activator of Pyruvate Kinase-R, Improves Sickle RBC Functional Health and Survival and Reduces Systemic Markers of Inflammation and Hypercoagulability in Patients with Sickle Cell Disease: An Analysis of Exploratory Studies in a Phase 1 Study

Theodosia A. Kalfa, Marilyn J. Telen, Santosh L. Saraf, R. Clark Clark Brown, Katie Giger Seu, Sandra K. Larkin, Maria D. Ribadeneira, Patricia Schroeder, Eric Wu, Patrick Kelly, Frans A. Kuypers

Blood (2021) 138 (Supplement 1): 8.

https://doi.org/10.1182/blood-2021-147078

Published: 2021

Journal Articles

The Effect of Voxelotor on Exercise Capacity of Youths with Sickle Cell Anemia

Vivian Phan, Laura Caldarera, Ana Lucia Cortez, Kari Wheeler, Sandra K. Larkin, Sangah Nancy Park, Robin Yates Dulman, Noravy Briere, Angela Lewis, Frans A. Kuypers, Jared Hershenson, Elizabeth Yang

Blood (2021) 138 (Supplement 1): 2045.

https://doi.org/10.1182/blood-2021-149163

Published: 2021

Journal Articles

Differential Acetone Extraction of Total and Hemoprotein-Unbound Heme to Quantify Heme Binding Capacity of Plasma in Patients with Sickle Cell Disease: The Role of Heme Scavengers

Madhav Vissa, Eric Soupene, PhD, Sandra K. Larkin, MS, Lynne D. Neumayr, MD, Elliott P. Vichinsky, MD, Frans A. Kuypers, PhD

Blood (2020) 136 (Supplement 1): 15.

https://doi.org/10.1182/blood-2020-134717

Published: 2020

Journal Articles

Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis

Ted Wun, MD, Marilyn J. Telen, MD, Lakshmanan Krishnamurti, MD, Timothy L. McCavit, MD, Laura M DeCastro, MD, Henry Flanner, ME, Frans A. Kuypers, PhD, Sandra K. Larkin, MS, Seungshin Rhee, MS, John L. Magnani, PhD, Helen M. Thackray, MD

Blood (2014) 124 (21): 2704.

https://doi.org/10.1182/blood.V124.21.2704.2704

Published: 2014

Journal Articles

Citrate Synthase Activity Is Increased In Children With Sickle Cell Disease (SCD) On Hydroxyurea (HU) Therapy

Claudia R. Morris, MD, Cornelia Latronica, MD, Frans A Kuypers, PhD, Howard Rosenfeld, MD, Sandra K Larkin, MS, Stephanie Doniger, MD, Elliott Vichinsky, MD, Sruti Shiva, PhD

Blood (2013) 122 (21): 4690.

https://doi.org/10.1182/blood.V122.21.4690.4690

Published: 2013

Journal Articles

Tricuspid Regurgitant Jet Velocity (TRV), Biomarkers of Hemolysis, and Impact of Oxygen Therapy in Children with Sickle Cell Disease (SCD) and Vaso-Occlusive Pain Episodes (VOE)

Cornelia Latronica, MD, Frans A Kuypers, PhD, Howard Rosenfeld, MD, Sandra K Larkin, MS, Stephanie Doniger, MD, Elliott Vichinsky, MD, Claudia R. Morris, MD

Blood (2012) 120 (21): 4752.

https://doi.org/10.1182/blood.V120.21.4752.4752

Published: 2012

Journal Articles

Pan-Selectin Antagonist GMI-1070 Affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults At Steady State

John L. Magnani, PhD, Frans A Kuypers, PhD, John T. Patton, PhD, Sandra K Larkin, MS, Lori Styles, MD, Laura M DeCastro, MD, Marilyn J. Telen, MD, Ted Wun, MD, Helen Thackray, MD

Blood (2012) 120 (21): 87.

https://doi.org/10.1182/blood.V120.21.87.87

Published: 2012

Journal Articles

Treatment with a Novel Dinitroazetidine, Abdnaz, Improves Nitrite Reductase Activity of Sickle Red Blood Cells

Marcel H.A.M. Fens, PhD, Sandra K Larkin, MS, William L Fitch, PhD, Jan Scicinski, PhD, Bryan Oronsky, MD, Frans A Kuypers, PhD

Blood (2012) 120 (21): 3246.

https://doi.org/10.1182/blood.V120.21.3246.3246

Published: 2012

Journal Articles

Cardiopulmonary and Laboratory Profiling of Patients with Thalassemia At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network.

Claudia R. Morris, MD, Hae-Young Kim, DrPH, John C Wood, MD, Ph.D, Felicia Trachtenberg, PhD, Elizabeth S Klings, MD, John B. Porter, MD, Nancy Sweeters, RN, PNP, Nancy F Olivieri, MD, Janet L. Kwiatkowski, MD, Sylvia Titi Singer, MD, Ali T Taher, MD, Ellis J. Neufeld, MD, PhD, Alexis A. Thompson, MD, MPH, Sandra K Larkin, MS, Jung H Suh, PhD, Elliott Vichinsky, MD, Frans A Kuypers, PhD

Blood (2012) 120 (21): 2122.

https://doi.org/10.1182/blood.V120.21.2122.2122

Published: 2012

Journal Articles

Sildenafil Therapy in Patients with Thalassemia and an Elevated Tricuspid Regurgitant Jet Velocity (TRV) On Doppler Echocardiography At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network

Claudia R. Morris, MD, Hae-Young Kim, DrPH, John C Wood, MD, Felicia Trachtenberg, PhD, Elizabeth S Klings, MD, John B. Porter, MD, Nancy Sweeters, RN, PNP, Nancy F Olivieri, MD, Janet L. Kwiatkowski, MD, Sylvia Titi Singer, MD, Ali T Taher, MD, Ellis J. Neufeld, MD, PhD, Alexis A. Thompson, MD, MPH, Vandana Sachdev, M.D., Sandra K Larkin, MS, Jung H Suh, PhD, Frans A Kuypers, PhD, Elliott Vichinsky, MD

Blood (2012) 120 (21): 1023.

https://doi.org/10.1182/blood.V120.21.1023.1023

Published: 2012

Journal Articles

NO or No NO, Increased Reduction of Nitrite to Nitric Oxide by Modified Red Blood Cells

Marcel H.A.M. Fens, PhD, Sandra K Larkin, Claudia R. Morris, MD, Bill Fitch, PhD, Jan Scicinski, PhD, Bryan Oronsky, MD, Frans A Kuypers, PhD

Blood (2011) 118 (21): 2125.

https://doi.org/10.1182/blood.V118.21.2125.2125

Published: 2011

Journal Articles

Effect of Short-Term Simvastatin Treatment on Endothelial Adhesion Molecules in Sickle Cell Disease: A Pilot Study

Carolyn Hoppe, MD, Frans A Kuypers, PhD, Sandra K Larkin, Robert Hagar, MD, Elliott Vichinsky, MD, Lori A Styles, MD

Blood (2011) 118 (21): 1070.

https://doi.org/10.1182/blood.V118.21.1070.1070

Published: 2011

Journal Articles

Augmented Regulatory T Cell Response After Photochemical Treatment Alleviates Acute Graft-Versus-Host Disease and Improves Survival.

Bindu Kanathezhath, M.D., Sandra K Larkin, Senior, Research, Associate, Julika Kaplan, Mark C. Walters, MD, Frans Kuypers, PhD

Blood (2010) 116 (21): 3740.

https://doi.org/10.1182/blood.V116.21.3740.3740

Published: 2010

Journal Articles

Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: Preliminary Pharmacokinetics Results

Claudia R. Morris, MD, Frans Kuypers, PhD, Robert W Hagar, MD, Michael Ansari, Sandra K Larkin, Senior, Research, Associate, Lisa Lavrisha, Meghan Wardlaw, Alicia Zhou, Elliott Vichinsky, MD, Jung H Suh, PhD

Blood (2010) 116 (21): 1636.

https://doi.org/10.1182/blood.V116.21.1636.1636

Published: 2010

Journal Articles

The Effect of Thalassemia and Other RBC Hemolytic Disorders and Splenectomy on the Frequency of Pulmonary Hypertension

Sylvia T Singer, MD, Frans Kuypers, PhD, Jeffrey Fineman, MD, Sandra K Larkin, Michael Jeng, MD, Cynthia Harmon, Nancy Sweeters, PNP, Ann Higa, Elliott Vichinsky, MD

Blood (2010) 116 (21): 2077.

https://doi.org/10.1182/blood.V116.21.2077.2077

Published: 2010

Journal Articles

Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes In Sickle Cell Patients Not In Crisis

Scott I Simon, PhD, Shannon Chase, Sandra K Larkin, Frans Kuypers, Ph.D., Lori Styles, MD, Ted Wun, MD, FACP, Helen Thackray, MD, John L Magnani, PhD

Blood (2010) 116 (21): 2672.

https://doi.org/10.1182/blood.V116.21.2672.2672

Published: 2010

Journal Articles

Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of Tropomodulin 3 in red blood cells and disruption of the membrane skeleton

Jeannette D. Moyer, Roberta B. Nowak, Nancy E. Kim, Sandra K. Larkin, Luanne L. Peters, John Hartwig, Frans A. Kuypers, Velia M. Fowler

Blood (2010) 116 (14): 2590–2599.

https://doi.org/10.1182/blood-2010-02-268458

Published: 2010

Includes: Supplemental data

Journal Articles

Elevated Plasma Arginase Levels in Hemoglobinopathies.

Sandra K. Larkin, MS, Claudia R. Morris, MD, Lori A. Styles, MD, Frans A. Kuypers, PhD

Blood (2005) 106 (11): 2346.

https://doi.org/10.1182/blood.V106.11.2346.2346

Published: 2005

Journal Articles

Serum C-reactive protein parallels secretory phospholipase A 2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome

Emilee M. Bargoma, Joyce K. Mitsuyoshi, Sandra K. Larkin, Lori A. Styles, Frans A. Kuypers, Samuel T. Test

Blood (2005) 105 (8): 3384–3385.

https://doi.org/10.1182/blood-2004-12-4676

Published: 2005

Journal Articles

Di-Annexin, a Novel Tool To Identify and Protect Phosphatidylserine Exposing Cells.

Frans A. Kuypers, PhD, Sandra K. Larkin, MS, Renee K. Emerson, Anthony C. Allison, PhD

Blood (2004) 104 (11): 1581.

https://doi.org/10.1182/blood.V104.11.1581.1581

Published: 2004

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Etavopivat, an Allosteric Activator of Pyruvate Kinase-R, Improves Sickle RBC Functional Health and Survival and Reduces Systemic Markers of Inflammation and Hypercoagulability in Patients with Sickle Cell Disease: An Analysis of Exploratory Studies in a Phase 1 Study

The Effect of Voxelotor on Exercise Capacity of Youths with Sickle Cell Anemia

Differential Acetone Extraction of Total and Hemoprotein-Unbound Heme to Quantify Heme Binding Capacity of Plasma in Patients with Sickle Cell Disease: The Role of Heme Scavengers

Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis

Citrate Synthase Activity Is Increased In Children With Sickle Cell Disease (SCD) On Hydroxyurea (HU) Therapy

Tricuspid Regurgitant Jet Velocity (TRV), Biomarkers of Hemolysis, and Impact of Oxygen Therapy in Children with Sickle Cell Disease (SCD) and Vaso-Occlusive Pain Episodes (VOE)

Pan-Selectin Antagonist GMI-1070 Affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults At Steady State

Treatment with a Novel Dinitroazetidine, Abdnaz, Improves Nitrite Reductase Activity of Sickle Red Blood Cells

Cardiopulmonary and Laboratory Profiling of Patients with Thalassemia At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network.

Sildenafil Therapy in Patients with Thalassemia and an Elevated Tricuspid Regurgitant Jet Velocity (TRV) On Doppler Echocardiography At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network

NO or No NO, Increased Reduction of Nitrite to Nitric Oxide by Modified Red Blood Cells

Effect of Short-Term Simvastatin Treatment on Endothelial Adhesion Molecules in Sickle Cell Disease: A Pilot Study

Augmented Regulatory T Cell Response After Photochemical Treatment Alleviates Acute Graft-Versus-Host Disease and Improves Survival.

Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: Preliminary Pharmacokinetics Results

The Effect of Thalassemia and Other RBC Hemolytic Disorders and Splenectomy on the Frequency of Pulmonary Hypertension

Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes In Sickle Cell Patients Not In Crisis

Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of Tropomodulin 3 in red blood cells and disruption of the membrane skeleton

Elevated Plasma Arginase Levels in Hemoglobinopathies.

Serum C-reactive protein parallels secretory phospholipase A 2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome

Di-Annexin, a Novel Tool To Identify and Protect Phosphatidylserine Exposing Cells.

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