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Journal Articles

Induction of CABLES1 by the TKI Inhibits the Cell Cycle Progression and Induces Apoptosis In CML Cell.

Tomonari Takemura, Satoki Nakamura, Yasuyuki Nagata, Daisuke Yokota, Isao Hirano, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kazunori Ohnishi, MD, PhD

Blood (2010) 116 (21): 1199.

https://doi.org/10.1182/blood.V116.21.1199.1199

Published: 2010

Journal Articles

Bcr-Abl Mediated-Depletion of Dual-Specificity MAP Kinase Phosphatase, DUSP1, Expression Promotes the Cell Proliferation.

Yasuyuki Nagata, Satoki Nakamura, Tomonari Takemura, Daisuke Yokota, Isao Hirano, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kazunori Ohnishi

Blood (2010) 116 (21): 3381.

https://doi.org/10.1182/blood.V116.21.3381.3381

Published: 2010

Journal Articles

Activation of Raf-1 through the Depletion of RKIP by Bcr-Abl Promotes CML Cell Proliferation

Satoki Nakamura, Tomonari Takemura, Yasuyuki Nagata, Daisuke Yokota, Isao Hirano, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kazunori Ohnishi

Blood (2010) 116 (21): 5105.

https://doi.org/10.1182/blood.V116.21.5105.5105

Published: 2010

Journal Articles

Regulation of c-Myc Expression through the Depletion of THAP11 and Fbw7 by Bcr-Abl Promotes CML Cell Proliferation

Daisuke Yokota, Satoki Nakamura, Tomonari Takemura, Yasuyuki Nagata, Isao Hirano, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kazunori Ohnishi

Blood (2010) 116 (21): 4463.

https://doi.org/10.1182/blood.V116.21.4463.4463

Published: 2010

Journal Articles

Downregulation of THAP11 by Bcr-Abl Promotes c-Myc-Mediated CML Cell Proliferation.

Daisuke Yokota, Satoki Nakamura, Tomonari Takemura, Isao Hirano, Shinya Fujisawa, Kaori Takeshita, Takaaki Ono, Kazuyuki Shigeno, Kazunori Ohnishi, MD, PhD

Blood (2009) 114 (22): 3255.

https://doi.org/10.1182/blood.V114.22.3255.3255

Published: 2009

Journal Articles

Identification of Target Molecules and Anti-Leukemic Effects of Novel Phospha Sugar Derivative, TMPP.

Satoki Nakamura, Mitsuji Yamashita, Tomonari Takemura, Daisuke Yokota, Isao Hirano, Takaaki Ono, Kazuyuki Shigeno, Kiyoshi Shibata, Michio Fujie, Shinya Fujisawa, Kaori Shinjo, Kazunori Ohnishi

Blood (2009) 114 (22): 4814.

https://doi.org/10.1182/blood.V114.22.4814.4814

Published: 2009

Journal Articles

Depletion of PHLPP1 and 2 by Bcr-Abl Promotes CML Cell Proliferation through the Continuous Phosphorylation of Akt.

Isao Hirano, Satoki Nakamura, Tomonari Takemura, Daisuke Yokota, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kaori Shinjo, Kazunori Ohnishi

Blood (2009) 114 (22): 2182.

https://doi.org/10.1182/blood.V114.22.2182.2182

Published: 2009

Journal Articles

Bcr-Abl Promotes CML Cell Proliferation through the Suppression of PHLPP Expression.

Isao Hirano, Satoki Nakamura, Daisuke Yokota, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kaori Shinjo, Kazunori Ohnishi, MD, PhD

Blood (2008) 112 (11): 1085.

https://doi.org/10.1182/blood.V112.11.1085.1085

Published: 2008

Journal Articles

Development and Characterization of Phospha Sugar Derivatives, DMPP and TMPP, with Anti-Leukemic Effects

Satoki Nakamura, Mitsuji Yamashita, Daisuke Yokota, Isao Hirano, Takaaki Ono, Michio Fujie, Kiyoshi Shibata, Taishi Niimi, Takuya Suyama, Kasthuraiah Maddali, Kazuhide Asai, Junko Yamashita, Yukiko Iguchi, Kazunori Ohnishi, MD

Blood (2008) 112 (11): 5057.

https://doi.org/10.1182/blood.V112.11.5057.5057

Published: 2008

Journal Articles

Development as Anti-Leukemic Agents, a Novel Synthesis of Phospha Sugar Derivatives in Therapy for Leukemias, and Analysis of Their Characterizations.

Satoki Nakamura, MD, PhD, Keiji Okinaka, MD, Isao Hirano, MD, Takaaki Ono, MD, Kazuyuki Shigeno, MD, Kaori Shinjo, MD,PhD, Michio Fujie, Yukiko Iguchi, PhD, Taishi Niimi, PhD, Satoru Ito, PhD, Takuya Suyama, PhD, Kazuhide Asai, PhD, Mitsuji Yamashita, PhD, Kazunori Ohnishi, MD, PhD

Blood (2007) 110 (11): 4174.

https://doi.org/10.1182/blood.V110.11.4174.4174

Published: 2007

Journal Articles

Expression Analysis and Prognostic Significance of the PHLPP Gene in Acute Leukemias and Myelodysplastic Syndromes.

Takaaki Ono, Satoki Nakamura, Shigeno Kazuyuki, Kaori Takeshita, Okinaka Keiji, Isao Hirano, Shinya Fujisawa, Kazunori Ohnishi

Blood (2007) 110 (11): 4234.

https://doi.org/10.1182/blood.V110.11.4234.4234

Published: 2007

Journal Articles

Cell Cycle Features and Quantitative Alteration of Target Molecules of Malignant B Cells Treated with Inotuzumab Ozogamicin (CMC544) Alone or in Combination with Rituximab.

Nozomi Yamakage, MA, Akihiro Takeshita, PhD, MD, Kaori Shinjo, MD, Takaaki Ono, MD, Hirotaka Matsui, MD, Satoki Nakamura, MD, Kazuyuki Shigeno, MD, Masato Maekawa, PhD, MD, Kazunori Ohnishi, PhD, MD, Ryuzo Ohno, PhD, MD

Blood (2007) 110 (11): 2362.

https://doi.org/10.1182/blood.V110.11.2362.2362

Published: 2007

Journal Articles

Reduced Effect of Inotuzumab Ozogamicin (CMC544) on P-Glycoprotein Positive Malignant B Cells and Its Restoration by Multidrug Resistance Modifiers.

Akihiro Takeshita, PhD, MD, Kaori Shinjo, PhD, MD, Nozomi Yamakage, MA, Takaaki Ono, MD, Isao Hirano, MD, Kenji Okinaka, MD, Hirotaka Matsui, PhD, MD, Satoki Nakamura, MD, Kazuyuki Shigeno, MD, Masato Maekawa, PhD, MD, Kazunori Ohnishi, PhD, MD, Ryuzo Ohno, PhD, MD

Blood (2007) 110 (11): 2378.

https://doi.org/10.1182/blood.V110.11.2378.2378

Published: 2007

Journal Articles

HOXA10 Expression Induces by Abl Kinase Inhibitors Enhanced Apoptosis through PI3K Pathway in CML Cells.

Isao Hirano, Yuya Sugimoto, Keiji Okinaka, Takaaki Ono, Kaori Shinjo, Kazuyuki Shigeno, Satoki Nakamura, Kazunori Ohnishi

Blood (2007) 110 (11): 4529.

https://doi.org/10.1182/blood.V110.11.4529.4529

Published: 2007

Journal Articles

Elevated FoxM1 Expression Promotes Cell Cycle Progression by Induction of KIS Expression and Contributes to the Development of Leukemia Cells.

Okinaka Keiji, Satoki Nakamura, Isao Hirano, Takaaki Ono, Shinya Fujisawa, Kazuyuki Shigeno, Kaori Shinjo, Kazunori Ohnishi

Blood (2007) 110 (11): 888.

https://doi.org/10.1182/blood.V110.11.888.888

Published: 2007

Journal Articles

Bcr-Abl Inhibitors Induce Expression of HoxA10, Playing a Role as an Inhibitor of the Proliferation through PI3K/PKB Pathway in Chronic Myelogenous Leukemia Cells.

Yuya Sugimoto, MD, Satoki Nakamura, MD,PhD, Takaaki Ono, MD, Miki Kobayashi, MD,PhD, Naohi Sahara, MD,PhD, Kaori Shinjo, MD,PhD, Kazuyuki Shigeno, MD,PhD, Kazunori Ohnishi, MD,PhD

Blood (2006) 108 (11): 1363.

https://doi.org/10.1182/blood.V108.11.1363.1363

Published: 2006

Journal Articles

Analysis of Aurora Kinase Expressions and Cell Cycle Regulation by Aurora-C in Leukemia Cells.

Miki Kobayashi, MD, PhD, Satoki Nakamura, MD, PhD, Takaaki Ono, MD, Yuya Sugimoto, MD, Naohi Sahara, MD, PhD, Kaori Shinjo, MD, PhD, Kazuyuki Shigeno, MD, PhD, Kazunori Ohnishi, MD, PhD

Blood (2006) 108 (11): 1366.

https://doi.org/10.1182/blood.V108.11.1366.1366

Published: 2006

Journal Articles

Analysis of the Expression of an Endogenous Tumor Suppressor Gene, PHLPP, and Elevation of PHLPP as an Ideal Target for MRD Monitoring in Leukemia.

Takaaki Ono, MD, Satoki Nakamura, MD,PhD, Yuya Sugimoto, MD, Miki Kobayashi, MD,PhD, Naohi Sahara, MD,PhD, Kaori Shinjo, MD,PhD, Kazuyuki Shigeno, MD,PhD, Shinya Fujisawa, MD, Kazunori Ohnishi, MD,PhD

Blood (2006) 108 (11): 4327.

https://doi.org/10.1182/blood.V108.11.4327.4327

Published: 2006

Journal Articles

Arsenic Trioxide Inhibited Bacterial Growth but Increased the Incidence of Herpes Zoster among Patients with APL; Results from In Vitro and Clinical Studies.

Akihiro Takeshita, MD, PhD, Kaori Shinjo, MD, Kazuyuki Shigeno, MD, Naohi Sahara, MD, Takaaki Ono, MD, Satoki Nakamura, MD, Masato Maekawa, MD, Kazunori Ohnishi, MD,PhD, Ryuzo Ohno, MD,PhD

Blood (2006) 108 (11): 4559.

https://doi.org/10.1182/blood.V108.11.4559.4559

Published: 2006

Journal Articles

Analysis of FoxM1 Expression and Regulation of Cell Cycle, and Anti-Leukemic Effectss by FoxM1 Knockdown on Leukemia Cells Transfected with siRNA FoxM1.

Satoki Nakamura, MD, PhD, Takaaki Ono, MD, Yuya Sugimoto, MD, Miki Kobayashi, MD,PhD, Naohi Sahara, MD,PhD, Kazuyuki Shigeno, MD,PhD, Kaori Shinjo, MD,PhD, Shinya Fujisawa, MD,PhD, Kazunori Ohnishi, MD,PhD

Blood (2006) 108 (11): 4320.

https://doi.org/10.1182/blood.V108.11.4320.4320

Published: 2006

NARROW

Induction of CABLES1 by the TKI Inhibits the Cell Cycle Progression and Induces Apoptosis In CML Cell.

Bcr-Abl Mediated-Depletion of Dual-Specificity MAP Kinase Phosphatase, DUSP1, Expression Promotes the Cell Proliferation.

Activation of Raf-1 through the Depletion of RKIP by Bcr-Abl Promotes CML Cell Proliferation

Regulation of c-Myc Expression through the Depletion of THAP11 and Fbw7 by Bcr-Abl Promotes CML Cell Proliferation

Downregulation of THAP11 by Bcr-Abl Promotes c-Myc-Mediated CML Cell Proliferation.

Identification of Target Molecules and Anti-Leukemic Effects of Novel Phospha Sugar Derivative, TMPP.

Depletion of PHLPP1 and 2 by Bcr-Abl Promotes CML Cell Proliferation through the Continuous Phosphorylation of Akt.

Bcr-Abl Promotes CML Cell Proliferation through the Suppression of PHLPP Expression.

Development and Characterization of Phospha Sugar Derivatives, DMPP and TMPP, with Anti-Leukemic Effects

Development as Anti-Leukemic Agents, a Novel Synthesis of Phospha Sugar Derivatives in Therapy for Leukemias, and Analysis of Their Characterizations.

Expression Analysis and Prognostic Significance of the PHLPP Gene in Acute Leukemias and Myelodysplastic Syndromes.

Cell Cycle Features and Quantitative Alteration of Target Molecules of Malignant B Cells Treated with Inotuzumab Ozogamicin (CMC544) Alone or in Combination with Rituximab.

Reduced Effect of Inotuzumab Ozogamicin (CMC544) on P-Glycoprotein Positive Malignant B Cells and Its Restoration by Multidrug Resistance Modifiers.

HOXA10 Expression Induces by Abl Kinase Inhibitors Enhanced Apoptosis through PI3K Pathway in CML Cells.

Elevated FoxM1 Expression Promotes Cell Cycle Progression by Induction of KIS Expression and Contributes to the Development of Leukemia Cells.

Bcr-Abl Inhibitors Induce Expression of HoxA10, Playing a Role as an Inhibitor of the Proliferation through PI3K/PKB Pathway in Chronic Myelogenous Leukemia Cells.

Analysis of Aurora Kinase Expressions and Cell Cycle Regulation by Aurora-C in Leukemia Cells.

Analysis of the Expression of an Endogenous Tumor Suppressor Gene, PHLPP, and Elevation of PHLPP as an Ideal Target for MRD Monitoring in Leukemia.

Arsenic Trioxide Inhibited Bacterial Growth but Increased the Incidence of Herpes Zoster among Patients with APL; Results from In Vitro and Clinical Studies.

Analysis of FoxM1 Expression and Regulation of Cell Cycle, and Anti-Leukemic Effectss by FoxM1 Knockdown on Leukemia Cells Transfected with siRNA FoxM1.

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American Society of Hematology

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American Society of Hematology

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