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Journal Articles

Cxcr4 low FLT3/ITD + Cells Exhibit Enhanced Resistance to the FLT3 Inhibitor Quizartinib Compared to Cxcr4 high FLT3/ITD + Cells By Elevating Runx1 Expression

Seiji Fukuda, MD PhD, Chie Onishi, MD PhD, Takeshi Taketani, MD

Blood (2019) 134 (Supplement_1): 2558.

https://doi.org/10.1182/blood-2019-129513

Published: 2019

Journal Articles

Flt3/ITD Enhances Hematopoietic Cell Migration Towards Chemokine CCL2 Independent of Blocking the Negative Feedback Mechanism on Rho-Associated Kinase

Seiji Fukuda, MD PhD, Chie Onishi, MD, Tomohiro Hirade, MD, Mariko Abe, MD, Takeshi Taketani, MD PhD, Seiji Yamaguchi, MD PhD

Blood (2014) 124 (21): 3597.

https://doi.org/10.1182/blood.V124.21.3597.3597

Published: 2014

Journal Articles

Myeloid Cells Having NUP98-HOX Fusion Genes with Simultaneous FLT3 , NRAS , or WT1 Mutations Confer Growth Advantage, Inhibit Differeniation/Apoptosis, and Augment Self-Renewal

Takeshi Taketani, MD PhD, Miho Hattori, Mariko Abe, MD, Tomohiro Hirade, MD, Seiji Fukuda, MD PhD, Seiji Yamaguchi, MD PhD

Blood (2014) 124 (21): 5199.

https://doi.org/10.1182/blood.V124.21.5199.5199

Published: 2014

Journal Articles

Flt3/ITD Confers Resistance to FLT3 Inhibitor AC220 By up-Regulating Runx1

Tomohiro Hirade, MD, Mariko Abe, MD, Chie Onishi, MD, Seiji Yamaguchi, MD PhD, Seiji Fukuda, MD PhD

Blood (2014) 124 (21): 2223.

https://doi.org/10.1182/blood.V124.21.2223.2223

Published: 2014

Journal Articles

Survivin Is a Master Regulator of Mesenchymal Stem Cell Functions and Potential Therapeutic Target for Mesenchymal Stem Cell Expansion

Pratibha Singh, PhD, Seiji Fukuda, MD PhD, Mary R. Saunders, PhD, Louis M. Pelus, PhD

Blood (2014) 124 (21): 774.

https://doi.org/10.1182/blood.V124.21.774.774

Published: 2014

Journal Articles

Flt3/ITD Blocks Myeloid Differentiation Of Hematopoietic Cells By Up-Regulating Runx1

Tomohiro Hirade, MD, Mariko Abe, MD, Chie Onishi, MD, Seiji Yamaguchi, MD, Seiji Fukuda, MD, PhD

Blood (2013) 122 (21): 3808.

https://doi.org/10.1182/blood.V122.21.3808.3808

Published: 2013

Journal Articles

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Sarah C Nabinger, PhD, Xing Jun Li, MD, PhD, Baskar Ramdas, Ph.D., Yantao He, PhD, Xian Zhang, Ph.D., Briana Richine, Joshua Bowling, Seiji Fukuda, MD, PhD, Shreevrat Goenka, Ph.D., Ziyue Liu, Ph.D., Gen-Sheng Feng, PhD, Menggang Yu, Ph.D., George Sandusky, MD, H. Scott Boswell, MD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2012) 120 (21): 2420.

https://doi.org/10.1182/blood.V120.21.2420.2420

Published: 2012

Journal Articles

The Internal-Tandem-Duplication of Flt3 Mutation Generates Growth Inhibitory Signals in Mouse Hematopoietic Progenitor Cells by Down-Regulating Pbx1 Expression Via P21 cdkn1a .

Seiji Fukuda, MD, PhD, Mariko Abe, MD, Tomohiro Hirade, MD, Chie Onishi, MD, Louis M. Pelus, PhD, Seiji Yamaguchi, MD

Blood (2012) 120 (21): 2340.

https://doi.org/10.1182/blood.V120.21.2340.2340

Published: 2012

Journal Articles

The Internal-Tandem-Duplication of Flt3 Mutations Augment Chemotaxis in Hematopoietic Cells by Blocking the Down-Regulation of Rho-Associated Kinase That Is Induced by SDF1/CXCR4 Signaling

Chie Onishi, MD, Satomi Mori, MD, Tomohiro Hirade, MD, Mariko Abe, MD, Seiji Yamaguchi, MD, Reuben Kapur, PhD, Seiji Fukuda, MD, PhD

Blood (2012) 120 (21): 1319.

https://doi.org/10.1182/blood.V120.21.1319.1319

Published: 2012

Journal Articles

Cyclin Dependent Kinase Inhibitor P21 Negatively Regulates PBX-1 Via Internal Tandem Duplication of Flt3 Dependent Manner, a Novel Mechanism That Does Not Exist in Normal Hematopoietic Progenitor Cells

Mariko Abe, MD, Seiji Yamaguchi, MD, Takeshi Taketani, MD, PhD, Seiji Fukuda, MD, PhD

Blood (2011) 118 (21): 1310.

https://doi.org/10.1182/blood.V118.21.1310.1310

Published: 2011

Journal Articles

The Concurrent Mutations in Hematological Malignancies with NUP98 -Fusion Genes Are Associated with Clinical Prognosis

Takeshi Taketani, MD, PhD, Tomohiko Taki, MD, PhD, Seiji Fukuda, MD, PhD, Mizuki Hyuga, Chie Onishi, MD, Seiji Yamaguchi, MD, Yasuhide Hayashi, MD, PhD

Blood (2011) 118 (21): 1480.

https://doi.org/10.1182/blood.V118.21.1480.1480

Published: 2011

Journal Articles

Survivin Modulates Gene Expression That Connects through An Extensive Functional Signaling Network and Regulates Proliferation of Hematopoietic Stem Cells through Evi-1

Seiji Fukuda, MD, PhD, Pratibha Singh, PhD, Jonathan Hoggatt, PhD, Jennifer Speth, MS, Mariko Abe, MD, Edward M. Conway, MD, PhD, FRCPC, MBA, John Crispino, PhD, Giuseppina Nucifora, Seiji Yamaguchi, MD, Louis M. Pelus, PhD

Blood (2010) 116 (21): 87.

https://doi.org/10.1182/blood.V116.21.87.87

Published: 2010

Journal Articles

p21 WAF1/CDKN1 Function In Hematopoietic Progenitor Cell Proliferation Is Inversely Regulated by Wild-Type Flt3 and Internal Tandem Duplication Mutation of Flt3

Mariko Abe, MD, Louis M. Pelus, PhD, Pratibha Singh, PhD, Seiji Yamaguchi, MD, Takeshi Taketani, MD, PhD, Seiji Fukuda, MD, PhD

Blood (2010) 116 (21): 4175.

https://doi.org/10.1182/blood.V116.21.4175.4175

Published: 2010

Journal Articles

Transplantation of Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells with Bone Marrow Improved Osteogenesis and Bone Formation In Patients with Perinatal Hypophosphatasia

Takeshi Taketani, MD, PhD, Rie Kanai, MD, Aya Mihara, MD, Chigusa Oyama, MD, Seiji Fukuda, MD, PhD, Seiji Yamaguchi, MD, Koji Hattori, MD, PhD, Yoshihiro Katsube, MD, PhD, Hiroko Machida, PhD, Hiroe Ohnishi, MD, PhD, Hajime Ohgushi, MD, PhD

Blood (2010) 116 (21): 4690.

https://doi.org/10.1182/blood.V116.21.4690.4690

Published: 2010

Journal Articles

High Frequencies of Simultaneous FLT3-ITD, WT1, and KIT mutations in NUP98 -Related Hematologic Malignancies.

Takeshi Taketani, Tomohiko Taki, Seiji Fukuda, MD, PhD, Chie Onishi, MD, Mariko Abe, MD, Seiji Yamaguchi, MD, Yasuhide Hayashi

Blood (2009) 114 (22): 2620.

https://doi.org/10.1182/blood.V114.22.2620.2620

Published: 2009

Journal Articles

ITD-Flt3 Enhances Migration of Hematopoietic Cells through Aberrant CXCR4 Signaling Pathways Overlapping but Functionally Distinct From SDF1/CXCR4 Signaling Axis in Normal Hematopoietic Cells.

Seiji Fukuda, MD, PhD, Satomi Mori, MS, Mariko Abe, MD, Seiji Yamaguchi, MD, Louis M. Pelus, PhD

Blood (2009) 114 (22): 2383.

https://doi.org/10.1182/blood.V114.22.2383.2383

Published: 2009

Journal Articles

Internal Tandem Duplication Mutations of Flt3 (ITD-Flt3) up-Regulate p21 WAF1/CDKN1 Protein That Negatively Regulates Aberrant Proliferation of Hematopoietic Cells Induced by ITD-Flt3.

Mariko Abe, MD, Louis M. Pelus, PhD, Takeshi Taketani, MD, Seiji Yamaguchi, MD, Seiji Fukuda, MD, PhD

Blood (2009) 114 (22): 5037.

https://doi.org/10.1182/blood.V114.22.5037.5037

Published: 2009

Journal Articles

Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors.

Sarah C Nabinger, Yantao He, Fuqin Yin, Xian Zhang, Linda Senbanjo, Seiji Fukuda, MD, PhD, Menggang Yu, Gen-Sheng Feng, Zhong-Yin Zhang, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2009) 114 (22): 827.

https://doi.org/10.1182/blood.V114.22.827.827

Published: 2009

Journal Articles

Overlapping but Distinct Role of p21 WAF1/CDKN1 and Survivin in Hematopoietic Progenitor Cell Proliferation.

Seiji Fukuda, MD, PhD, Mariko Abe, MD, Seiji Yamaguchi, MD, Louis M. Pelus, PhD

Blood (2008) 112 (11): 1334.

https://doi.org/10.1182/blood.V112.11.1334.1334

Published: 2008

Journal Articles

G-CSF Mediated Decrease in Bone-Marrow SDF-1 Level Is Neutrophil Dependent but CD26 Independent

Pratibha Singh, PhD, Seiji Fukuda, MD, PhD, Janardhan Sampath, PhD, Louis M. Pelus, PhD

Blood (2008) 112 (11): 3469.

https://doi.org/10.1182/blood.V112.11.3469.3469

Published: 2008

NARROW

Cxcr4 low FLT3/ITD + Cells Exhibit Enhanced Resistance to the FLT3 Inhibitor Quizartinib Compared to Cxcr4 high FLT3/ITD + Cells By Elevating Runx1 Expression

Flt3/ITD Enhances Hematopoietic Cell Migration Towards Chemokine CCL2 Independent of Blocking the Negative Feedback Mechanism on Rho-Associated Kinase

Myeloid Cells Having NUP98-HOX Fusion Genes with Simultaneous FLT3 , NRAS , or WT1 Mutations Confer Growth Advantage, Inhibit Differeniation/Apoptosis, and Augment Self-Renewal

Flt3/ITD Confers Resistance to FLT3 Inhibitor AC220 By up-Regulating Runx1

Survivin Is a Master Regulator of Mesenchymal Stem Cell Functions and Potential Therapeutic Target for Mesenchymal Stem Cell Expansion

Flt3/ITD Blocks Myeloid Differentiation Of Hematopoietic Cells By Up-Regulating Runx1

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

The Internal-Tandem-Duplication of Flt3 Mutation Generates Growth Inhibitory Signals in Mouse Hematopoietic Progenitor Cells by Down-Regulating Pbx1 Expression Via P21 cdkn1a .

The Internal-Tandem-Duplication of Flt3 Mutations Augment Chemotaxis in Hematopoietic Cells by Blocking the Down-Regulation of Rho-Associated Kinase That Is Induced by SDF1/CXCR4 Signaling

Cyclin Dependent Kinase Inhibitor P21 Negatively Regulates PBX-1 Via Internal Tandem Duplication of Flt3 Dependent Manner, a Novel Mechanism That Does Not Exist in Normal Hematopoietic Progenitor Cells

The Concurrent Mutations in Hematological Malignancies with NUP98 -Fusion Genes Are Associated with Clinical Prognosis

Survivin Modulates Gene Expression That Connects through An Extensive Functional Signaling Network and Regulates Proliferation of Hematopoietic Stem Cells through Evi-1

p21 WAF1/CDKN1 Function In Hematopoietic Progenitor Cell Proliferation Is Inversely Regulated by Wild-Type Flt3 and Internal Tandem Duplication Mutation of Flt3

Transplantation of Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells with Bone Marrow Improved Osteogenesis and Bone Formation In Patients with Perinatal Hypophosphatasia

High Frequencies of Simultaneous FLT3-ITD, WT1, and KIT mutations in NUP98 -Related Hematologic Malignancies.

ITD-Flt3 Enhances Migration of Hematopoietic Cells through Aberrant CXCR4 Signaling Pathways Overlapping but Functionally Distinct From SDF1/CXCR4 Signaling Axis in Normal Hematopoietic Cells.

Internal Tandem Duplication Mutations of Flt3 (ITD-Flt3) up-Regulate p21 WAF1/CDKN1 Protein That Negatively Regulates Aberrant Proliferation of Hematopoietic Cells Induced by ITD-Flt3.

Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors.

Overlapping but Distinct Role of p21 WAF1/CDKN1 and Survivin in Hematopoietic Progenitor Cell Proliferation.

G-CSF Mediated Decrease in Bone-Marrow SDF-1 Level Is Neutrophil Dependent but CD26 Independent

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American Society of Hematology

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American Society of Hematology

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