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Seyed Alireza Hasheminasab
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Journal Articles

Phase 1 study of ktx-1001, a first-in-class oral MMSET/NSD2 inhibitor, demonstrates clinical activity in relapsed/refractory multiple myeloma

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Saad Usmani, Pierre Bories, Cristina Gasparetto, David Dingli, Sagar Lonial, David Siegel, Andrew Yee, Cindy Varga, Suzanne Trudel, Laura Rosiñol Dachs, Paula Rodriguez-Otero, Salomon Manier, Jesús Berdeja, Aimaz Afrough, Warren Baker, Seyed Alireza Hasheminasab, Anjan Thakurta, Vinidhra Sridharan, Erin Flynt, Miriam Barnett, Laura Versmee, María-Victoria Mateos, Cyrille Touzeau, Alfred Chung, Vivek Roy, Edward Stadtmauer
Journal: Blood
Blood (2025) 146 (Supplement 1): 250.
https://doi.org/10.1182/blood-2025-250
Published: 2025
Journal Articles

AI-based analysis reveals novel blood protein biomarkers for predicting cardiac amyloidosis approximately a decade early: A UK biobank study

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Seyed Alireza Hasheminasab, Berrin Balik, Joshua Fieggen, Lei Clifton, Nikant Sabharwal, Karthik Ramasamy, Ashutosh Wechalekar, Anjan Thakurta
Journal: Blood
Blood (2025) 146 (Supplement 1): 580.
https://doi.org/10.1182/blood-2025-580
Published: 2025
Journal Articles

A Novel Segmentation-Based Purity-Informed Approach Accurately Detects Total Copy Number and Its Subclonal Fraction in Myeloma Targeted Panel Sequencing Data

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Naser Ansari-Pour, Mohammad Kazeroun, Seyed Alireza Hasheminasab, Emma J Lyon, Bethan Hudson-Lund, Evie Fitzsimons, Gaurav Agarwal, Kara-Louise Royle, Matthew W. Jenner, Martin F Kaiser, Karthik Ramasamy, Kwee Yong, Eileen M Boyle, Sarah Gooding, Angela Hamblin, Anjan Thakurta
Journal: Blood
Blood (2024) 144 (Supplement 1): 1909.
https://doi.org/10.1182/blood-2024-207973
Published: 2024
Journal Articles

A Mass Cytometry-Based Clinical Pharmacodynamic Assay for Histone 3 Lysine 36 Dimethyl (H3K36me2) Levels in Myeloma Cells and Peripheral Blood for Implementation in NSD2 Inhibitor Ktx-1001 First in Human Trial in Relapsed and Refractory Multiple Myeloma

Free
Joao Lourenco, Erin Flynt, Warren Baker, Edmund Watson, Udo Oppermann, Seyed Alireza Hasheminasab, Vicki Gamble, Benjamin Winograd, Anjan Thakurta
Journal: Blood
Blood (2024) 144 (Supplement 1): 6814.
https://doi.org/10.1182/blood-2024-201554
Published: 2024