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Journal Articles

Genomic Profiling Identifies Novel Mutations and Fusion Genes in Newly Diagnosed and Relapsed Pediatric FLT3-ITD-Positive AML

Daelynn R Buelow, PhD, Stanley Pounds, PhD, Yong-Dong Wang, Lei Shi, PhD, Yongjin Li, PhD, David Finkelstein, Sheila A Shurtleff, PhD, Geoffrey A. Neale, PhD, Hiroto Inaba, MD PhD, Raul C. Ribeiro, MD, Dominique Garrison, Shelley Orwick, BS, James S. Blachly, MD, John C. Byrd, MD, Karl Kroll, Tanja A. Gruber, MD PhD, Jeffrey E Rubnitz, MD PhD, Sharyn D Baker, PharmD, PhD

Blood (2016) 128 (22): 2838.

https://doi.org/10.1182/blood.V128.22.2838.2838

Published: 2016

Journal Articles

Expression of an Oncogenic ERG isoform Characterizes a Distinct Subtype of B-Progenitor Acute Lymphoblastic Leukemia

Jinghui Zhang, PhD, Kelly McCastlain, Chunxu Qu, PhD, Gang Wu, PhD, Michael Edmonson, PhD, Yongjin Li, PhD, Lei Wei, PhD, Debbie Payne-Turner, BS, Hiroki Yoshihara, MDPhD, Michelle L. Churchman, PhD, Esmé Waanders, PhD, Panagiotis Ntziachristos, PhD, Iannis Aifantis, PhD, Kathryn G. Roberts, Jing Ma, PhD, Guangchun Song, PhD, John Easton, PhD, Heather L. Mulder, BS, Xiang Chen, PhD, Michael Rusch, BA, Kristy Boggs, PhD, Bhavin Vadodaria, BS, James Dalton, BS, Marcus L Valentine, PhD, Li Ding, PhD, Charles Lu, PhD, Robert S. Fulton, PhD, Lucinda Fulton, PhD, Yashodan Tabib, PhD, Kerri Ochoa, Meenakshi Devidas, PhD, Deqing Pei, Cheng Cheng, PhD, William E. Evans, PharmD, Ching-Hon Pui, MD, Sima Jeha, MD, Richard C. Harvey, PhD, I-Ming L Chen, DVM, MS, Cheryl L. Willman, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD, Jessica Kohlschmidt, PhD BS, MS, Krzysztof Mrozek, MD PhD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Wendy Stock, MD, Peter M. Voorhees, MD, Janis Racevskis, MD, Jacob M. Rowe, MD, Selina Luger, MD, Steven M. Kornblau, MD, Sheila A Shurtleff, PhD, Susana C. Raimondi, PhD, Elaine R Mardis, PhD, Richard K Wilson, PhD, Stephen P Hunger, MD, Mignon L. Loh, MD, James R. Downing, MD, Charles G. Mullighan

Blood (2015) 126 (23): 693.

https://doi.org/10.1182/blood.V126.23.693.693

Published: 2015

Journal Articles

Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project

Blood (2014) 124 (21): 127.

https://doi.org/10.1182/blood.V124.21.127.127

Published: 2014

Journal Articles

Prognostic Factors For Children With Acute Myeloid Leukemia Who Achieve Minimal Residual Disease-Negative Status After Induction Therapy

Seth E Karol, MD, Elaine Coustan-Smith, MS, Xueyuan Cao, PhD, Sheila A Shurtleff, PhD, Susana C Raimondi, PhD, John K Choi, MD, PhD, Raul C Ribeiro, MD, Gary V Dahl, MD, W Paul Bowman, MD, Jeffrey W Taub, MD, Barbara Degar, MD, Wing Leung, MD, PhD, James R Downing, MD, Ching-Hon Pui, MD, Jeffrey E Rubnitz, MD, PhD, Dario Campana, MD, PhD, Hiroto Inaba, MD, PhD

Blood (2013) 122 (21): 490.

https://doi.org/10.1182/blood.V122.21.490.490

Published: 2013

Journal Articles

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Jinghui Zhang, PhD, Li Ding, PhD, Linda Holmfeldt, PhD, Gang Wu, PhD, Susan L. Heatley, Ph.D., Debbie Payne-Turner, John Easton, PhD, Xiang Chen, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Charles Lu, PhD, Shann-Ching Chen, PhD, Racquel Collins-Underwood, PhD, Jing Ma, PhD, Kathryn G. Roberts, PhD, Stanley Pounds, PhD, Lei Wei, PhD, Anatoly Ulyanov, PhD, Jared Becksfort, Pankaj Gupta, Robert Huether, PhD, Richard Kriwacki, PhD, Daniel McGoldrick, David Zhao, Daniel Alford, Stephen Espy, Kiran Chand Bobba, Guangchun Song, Deqing Pei, MS, Cheng Cheng, PhD, Stefan Roberts, Michael Barbato, Dario Campana, MD, PhD, Elaine Coustan-Smith, MS, William E. Evans, PharmD, Sheila A Shurtleff, PhD, Maria Kleppe, Jan Cools, PhD, Kristin Shimano, Michelle L. Hermiston, MD, PhD, Sergei Doulatov, PhD, Kolja Eppert, PhD, Elisa Laurenti, PhD, Faiyaz Notta, PhD, John E Dick, PhD, Giuseppe Basso, MD PhD, Stephen P. Hunger, MD, Mignon L Loh, MD, Meenakshi Devidas, PhD, Brent L. Wood, MD, PhD, Stuart S. Winter, MD, Kimberly Dunsmore, MD, Robert S. Fulton, MS, Lucinda A. Fulton, MS, Xin Hong, PhD, Christopher C. Harris, BS, David J. Dooling, PhD, Kerri Ochoa, Kimberly J Johnson, John C Obenauer, Ching-Hon Pui, MD, Susana C. Raimondi, PhD, Clayton W Naeve, PhD, Timothy J Ley, MD, Elaine R Mardis, PhD, Richard K Wilson, PhD, James R Downing, MD, Charles G Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2011) 118 (21): 68.

https://doi.org/10.1182/blood.V118.21.68.68

Published: 2011

Journal Articles

Whole Genome Sequence Analysis of 22 MLL Rearranged Infant Acute Lymphoblastic Leukemias Reveals Remarkably Few Somatic Mutations: A Report From the St Jude Children‘s Research Hospital - Washington University Pediatric Cancer Genome Project

Blood (2011) 118 (21): 69.

https://doi.org/10.1182/blood.V118.21.69.69

Published: 2011

Journal Articles

Clinical Activity, Pharmacokinetics, and Pharmacodynamics of Sorafenib In Pediatric Acute Myeloid Leukemia.

Hiroto Inaba, MD, PhD, Jeffrey E Rubnitz, MD, PhD, Elaine Coustan-Smith, MS, Lie Li, Brian D Furmanski, PhD, Gerard P Mascara, Sheila A Shurtleff, PhD, Stanley B Pounds, PhD, Ching-Hon Pui, MD, Raul C Ribeiro, MD, Dario Campana, MD, PhD, Sharyn D Baker, PharmD, PhD

Blood (2010) 116 (21): 1073.

https://doi.org/10.1182/blood.V116.21.1073.1073

Published: 2010

Journal Articles

The Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Sub-Classification of Leukemia: Final Report on 3252 Cases from the International MILE Study Group

Blood (2008) 112 (11): 753.

https://doi.org/10.1182/blood.V112.11.753.753

Published: 2008

Journal Articles

Deletion of IKZF1 (Ikaros) Predicts Poor Outcome and Impaired Maturation in B-Progenitor Acute Lymphoblastic Leukemia

Blood (2008) 112 (11): 427.

https://doi.org/10.1182/blood.V112.11.427.427

Published: 2008

Journal Articles

Genome-Wide Analysis of Genetic Alterations in Chronic Myelogenous Leukemia.

Charles G Mullighan, MBBS(Hons), MSC, MD, Ina Radtke, PhD, Jinghui Zhang, Ph.D., Letha A. Phillips, BS, Xiaoping Su, PhD, Jing Ma, PhD, Zhongling Cai, Timothy P. Hughes, MBBS, PhD, Deborah L White, PhD, Andrew W. Roberts, MBBS, PhD, Lynda J. Campbell, MBBS, FRCPA, Sheila A. Shurtleff, James R. Downing, MD

Blood (2008) 112 (11): 1089.

https://doi.org/10.1182/blood.V112.11.1089.1089

Published: 2008

Journal Articles

Ultra-High Resolution Analysis of Genomic Alterations in High-Risk Acute Lymphoblastic Leukemia.

Charles G Mullighan, MBBS(Hons), MSc, MD, Letha A. Phillips, BS, Lesli A. Kiedrowski, Jing Ma, PhD, Richard T. Williams, MD, PhD, Sheila A. Shurtleff, Charles J. Sherr, MD, PhD, James R. Downing, MD

Blood (2008) 112 (11): 2053.

https://doi.org/10.1182/blood.V112.11.2053.2053

Published: 2008

Journal Articles

High-Resolution Genome-Wide Profiling of DNA Copy Number Abnormalities and Gene Resequencing in Pediatric Acute Myeloid Leukemia (AML).

Ina Radtke, PhD, Charles G. Mullighan, MD, PhD, Masami Ishii, MD, PhD, Jing Ma, PhD, Xiaoping Su, PhD, Salil Goorha, MD, Ramapriya Ganti, PhD, Zhongling Cai, Letha A. Phillips, Stanley B. Pounds, PhD, James Dalton, Susana C. Raimondi, PhD, Jeffrey E. Rubnitz, MD, PhD, Raul C. Ribeiro, MD, Sheila A. Shurtleff, PhD, James R. Downing, MD

Blood (2007) 110 (11): 103.

https://doi.org/10.1182/blood.V110.11.103.103

Published: 2007

Journal Articles

High-Resolution SNP Array Profiling of Relapsed Acute Leukemia Identifies Genomic Abnormalities Distinct from Those Present at Diagnosis.

Charles G. Mullighan, MBBS, MD, Ina Radtke, MD, PhD, Jing Ma, PhD, Sheila A. Shurtleff, PhD, James R. Downing, MD

Blood (2007) 110 (11): 234.

https://doi.org/10.1182/blood.V110.11.234.234

Published: 2007

Journal Articles

IKZF1 (Ikaros) Deletions Are a Hallmark of BCR-ABL1 Positive Acute Lymphoblastic Leukemia.

Charles G. Mullighan, MBBS, MD, Christopher B. Miller, BS, Letha A. Phillips, BS, James Dalton, BS, Jing Ma, PhD, Ina Radtke, MD, PhD, Deborah White, BSc(Hons), Timothy P. Hughes, MBBS, PhD, Michelle M. Le Beau, MD, PhD, Sheila A. Shurtleff, PhD, James R. Downing, MD

Blood (2007) 110 (11): 721.

https://doi.org/10.1182/blood.V110.11.721.721

Published: 2007

Journal Articles

ERG Deletions Define a Novel Subtype of B-Progenitor Acute Lymphoblastic Leukemia.

Charles G. Mullighan, MBBS, MD, Christopher B. Miller, BS, Xiaoping Su, PhD, Ina Radtke, MD, PhD, James Dalton, BS, Guanchung Song, PhD, Xiaodong Zhou, MS, Ching-Hon Pui, MD, Sheila A. Shurtleff, PhD, James R. Downing, MD

Blood (2007) 110 (11): 691.

https://doi.org/10.1182/blood.V110.11.691.691

Published: 2007

Journal Articles

Rapid Immune Reconstitution after a Reduced-Intensity Conditioning Regimen and a CD3-Depleted Haploidentical Stem Cell Graft for Pediatric Refractory Hematologic Malignancies.

Xiaohua Chen, MD, PhD, Gregory A. Hale, MD, Raymond C. Barfield, MD PhD, Ely Benaim, MD, Wing H. Leung, MD PhD, James Knowles, MS, Edwin M. Horwitz, MD PhD, Paul Woodard, MD, Kimberly A. Kasow, MD, Usman Yusuf, MD, Fred G. Behm, MD, Randall T. Hayden, MD, Sheila A. Shurtleff, PhD, Victoria Turner, PhD, Deo Kumar Srivastava, PhD, Rupert Handgretinger, MD PhD

Blood (2006) 108 (11): 5311.

https://doi.org/10.1182/blood.V108.11.5311.5311

Published: 2006

Journal Articles

Genome-Wide Profiling of DNA Copy Number Abnormalities and Loss-Of-Heterozygosity in Pediatric Acute Myeloid Leukemia Using High-Resolution Single Nucleotide Polymorphism Microarrays.

Ina Radtke, PhD, Charles G. Mullighan, MBBS, MSc, MD, Salil Goorha, MD, Jing Ma, PhD, Stanley B. Pounds, PhD, Xiaoping Su, PhD, Alyssa L. Kennedy, Susanna M. Downing, Jeffrey E. Rubnitz, MD, PhD, Raul C. Ribeiro, MD, Sheila A. Shurtleff, PhD, James R. Downing, MD

Blood (2006) 108 (11): 106.

https://doi.org/10.1182/blood.V108.11.106.106

Published: 2006

Journal Articles

Genes Regulating B-Cell Development and Differentiation Are Mutated in 40% of Pediatric Acute Lymphoblastic Leukemia.

Charles G. Mullighan, MBBS, MSc, MD, Salil Goorha, MD, Ina Radtke, MD, Christopher B. Miller, Elaine Coustan-Smith, James D. Dalton, Kevin Girtman, Susan Mathew, PhD, Jing Ma, PhD, Stanley B. Pounds, PhD, Xiaoping Su, PhD, Ching-Hon Pui, MS, Mary V. Relling, PharmD, William E. Evans, PharmD, Sheila A. Shurtleff, PhD, James R. Downing, MD

Blood (2006) 108 (11): 217.

https://doi.org/10.1182/blood.V108.11.217.217

Published: 2006

Journal Articles

Pediatric Acute Myeloid Leukemia with Nucleophosmin Mutations Is Characterized by a Gene Expression Signature with Dysregulated HOX Gene Expression Distinct from MLL -Rearranged Leukemias.

Charles G. Mullighan, MBBS, MSc, MD, Alyssa L. Kennedy, BS, Xiaodong Zhou, MS, Sheila A. Shurtleff, PhD, James R. Downing, MD

Blood (2005) 106 (11): 2993.

https://doi.org/10.1182/blood.V106.11.2993.2993

Published: 2005

Journal Articles

Molecular Characterization of a Novel Subtype of Pediatric Acute Lymphoblastic Leukemia.

Charles G. Mullighan, MBBS, MSc, MD, Mary E. Ross, MD, PhD, Xiaodong Zhou, MS, James Dalton, BS, Fred G. Behm, MD, Sheila A. Shurtleff, PhD, James R. Downing, MD

Blood (2005) 106 (11): 482.

https://doi.org/10.1182/blood.V106.11.482.482

Published: 2005

NARROW

Genomic Profiling Identifies Novel Mutations and Fusion Genes in Newly Diagnosed and Relapsed Pediatric FLT3-ITD-Positive AML

Expression of an Oncogenic ERG isoform Characterizes a Distinct Subtype of B-Progenitor Acute Lymphoblastic Leukemia

Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project

Prognostic Factors For Children With Acute Myeloid Leukemia Who Achieve Minimal Residual Disease-Negative Status After Induction Therapy

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Whole Genome Sequence Analysis of 22 MLL Rearranged Infant Acute Lymphoblastic Leukemias Reveals Remarkably Few Somatic Mutations: A Report From the St Jude Children‘s Research Hospital - Washington University Pediatric Cancer Genome Project

Clinical Activity, Pharmacokinetics, and Pharmacodynamics of Sorafenib In Pediatric Acute Myeloid Leukemia.

The Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Sub-Classification of Leukemia: Final Report on 3252 Cases from the International MILE Study Group

Deletion of IKZF1 (Ikaros) Predicts Poor Outcome and Impaired Maturation in B-Progenitor Acute Lymphoblastic Leukemia

Genome-Wide Analysis of Genetic Alterations in Chronic Myelogenous Leukemia.

Ultra-High Resolution Analysis of Genomic Alterations in High-Risk Acute Lymphoblastic Leukemia.

High-Resolution Genome-Wide Profiling of DNA Copy Number Abnormalities and Gene Resequencing in Pediatric Acute Myeloid Leukemia (AML).

High-Resolution SNP Array Profiling of Relapsed Acute Leukemia Identifies Genomic Abnormalities Distinct from Those Present at Diagnosis.

IKZF1 (Ikaros) Deletions Are a Hallmark of BCR-ABL1 Positive Acute Lymphoblastic Leukemia.

ERG Deletions Define a Novel Subtype of B-Progenitor Acute Lymphoblastic Leukemia.

Rapid Immune Reconstitution after a Reduced-Intensity Conditioning Regimen and a CD3-Depleted Haploidentical Stem Cell Graft for Pediatric Refractory Hematologic Malignancies.

Genome-Wide Profiling of DNA Copy Number Abnormalities and Loss-Of-Heterozygosity in Pediatric Acute Myeloid Leukemia Using High-Resolution Single Nucleotide Polymorphism Microarrays.

Genes Regulating B-Cell Development and Differentiation Are Mutated in 40% of Pediatric Acute Lymphoblastic Leukemia.

Pediatric Acute Myeloid Leukemia with Nucleophosmin Mutations Is Characterized by a Gene Expression Signature with Dysregulated HOX Gene Expression Distinct from MLL -Rearranged Leukemias.

Molecular Characterization of a Novel Subtype of Pediatric Acute Lymphoblastic Leukemia.

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American Society of Hematology

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American Society of Hematology

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