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Shuling Guo, PhD
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Journal Articles

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Valentina Ghiaccio, PhD, Alisa Dong, PhD, Irene Motta, MD, Shuling Guo, PhD, Raechel Peralta, MS, Susan M Freier, Andy Watt, Yasuhiro Ikawa, MD PhD, Maxwell Chappell, MS, Coralea Stephanou, PhD, Paola Delbini, PhD, Connie Chen, Soteroula Christou, MD, Marina Kleanthous, PhD, Kim Smith-Whitley, MD, Deepa Manwani, MD, Carla Casu, PhD, Maria Domenica Cappellini, MD, Osheiza Abdulmalik, DVM, Stefano Rivella, PhD, Laura Breda, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2244.
https://doi.org/10.1182/blood-2019-127017
Published: 2019
Journal Articles

Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models

Mariateresa Pettinato, Mariam Aghajan, PhD, Violante Olivari, MSc, Alessandro Dulja, MSc, Antonella Nai, PhD, Jessica Bordini, PhD, Alessandro Campanella, PhD, Alessia Pagani, PhD, Shuling Guo, PhD, Clara Camaschella, MD, Laura Silvestri, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 955.
https://doi.org/10.1182/blood-2019-126496
Published: 2019
Journal Articles

Potential Therapeutic Applications of Jak2 Inhibitors and Hif2a-ASO for the Treatment of β-Thalassemia Intermedia and Major

Carla Casu, Paraskevi Rea Oikonomidou, MD, Vania Lo Presti, Mariam Aghajan, PhD, Shuling Guo, PhD, Abdulmalik Osheiza, Luca Melchiori, Pedro Ramos, Stefano Rivella, PhD
Journal: Blood
Blood (2016) 128 (22): 1012.
https://doi.org/10.1182/blood.V128.22.1012.1012
Published: 2016
Journal Articles

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Mariam Aghajan, PhD, Carla Casu, PhD, Vania lo Presti, Sheri Booten, Brett P. Monia, PhD, Stefano Rivella, PhD, Shuling Guo, PhD
Journal: Blood
Blood (2016) 128 (22): 1013.
https://doi.org/10.1182/blood.V128.22.1013.1013
Published: 2016
Journal Articles

Adult Hemoglobin Production, Chain Rebalance, and Splice Correction in IVS2-745 Beta-Thalassemia Patient Cells Using 2'-O-Methoxyethyl Splice-Switching Oligos

Alisa Cheung Dong, Valentina Ghiaccio, Irene Motta, MD, Shuling Guo, PhD, Raechel Peralta, MS, Coralea Stephanou, PhD, Paola Delbini, PhD, Connie Chen, Soteroula Christou, Marina Kleanthous, PhD, Maria Domenica Cappellini, MD, Osheiza Abdulmalik, DVM, MS, Laura Breda, PhD, Stefano Rivella, PhD
Journal: Blood
Blood (2016) 128 (22): 1014.
https://doi.org/10.1182/blood.V128.22.1014.1014
Published: 2016
Journal Articles

Targeting TMPRSS6 Using Antisense Technology for the Treatment of Beta-Thalassemia

Shuling Guo, PhD, Mariam Aghajan, PhD, Carla Casu, PhD, Sara Gardenghi, PhD, Sheri Booten, Stefano Rivella, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2015) 126 (23): 753.
https://doi.org/10.1182/blood.V126.23.753.753
Published: 2015
Journal Articles

Combination of Tmprss6 -ASO and the Iron Chelator Deferiprone Improves Erythropoiesis and Reduces Iron Overload in a Mouse Model of Beta-Thalassemia

Carla Casu, PhD, Mariam Aghajan, PhD, Rea Oikonomidau, MD, Shuling Guo, PhD, Brett P. Monia, PhD, Stefano Rivella, PhD
Journal: Blood
Blood (2014) 124 (21): 4024.
https://doi.org/10.1182/blood.V124.21.4024.4024
Published: 2014
Journal Articles

Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugates

Noriko Satake, MD, Connie Duong, BS, Michael Oestergaard, Sakiko Yoshida, MDPhD, Cathy Chen, Jan A. Nolta, PhD, Shuling Guo, PhD, Punit Seth, PhD, Nitin Nitin, PhD, Joseph Tuscano, MD
Journal: Blood
Blood (2014) 124 (21): 3719.
https://doi.org/10.1182/blood.V124.21.3719.3719
Published: 2014
Journal Articles

Targeting KLF1 for the Treatment of Sickle Cell Disease Using Antisense Oligonucleotides

Raechel Peralta, MS, Audrey Low, Sheri Booten, Dewang Zhou, Aneeza Kim, Sue Freier, Shuling Guo, PhD, Sue Murray, Tim M. Townes, PhD, Gene Hung
Journal: Blood
Blood (2014) 124 (21): 4038.
https://doi.org/10.1182/blood.V124.21.4038.4038
Published: 2014
Journal Articles

Targeting BCL11A and KLF1 For The Treatment Of Sickle Cell Disease and β-Thalassemia In Vitro using Antisense Oligonucleotides

Raechel Peralta, Audrey Low, Aneeza Kim, Sue Murray, Shuling Guo, PhD, Sue Freier, Tim M. Townes, PhD, Gene Hung
Journal: Blood
Blood (2013) 122 (21): 1022.
https://doi.org/10.1182/blood.V122.21.1022.1022
Published: 2013
Journal Articles

Target TMPRSS6 Using Antisense Technology for the Treatment of Hereditary Hemochromatosis and β-Thalassemia

Shuling Guo, PhD, Carla Casu, Sara Gardenghi, PhD, Sheri Booten, Andy Watt, Susan Freier, Ph.D, Stefano Rivella, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2012) 120 (21): 481.
https://doi.org/10.1182/blood.V120.21.481.481
Published: 2012
Journal Articles

Target TMPRSS6 for the Treatment of Hereditary Hemochromatosis

Sheri Booten, Daniel Knox, Luis Alvarado, Shuling Guo, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2011) 118 (21): 1047.
https://doi.org/10.1182/blood.V118.21.1047.1047
Published: 2011