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Stephen Connelly
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Journal Articles

Blocking the CD6-Alcam Pathway Prevents Trans Endothelial Migration of Pathogenic Effector T Cells

Valeria Marrocco, Jeanette Ampudia, Cherie Ng, Stephen Connelly
Journal: Blood
Blood (2022) 140 (Supplement 1): 12657–12658.
https://doi.org/10.1182/blood-2022-170294
Published: 2022
Journal Articles

CD6 Is a Modulator of Treg Differentiation and Activity

Jeanette Ampudia, Dalena Chu, Stephen Connelly, Cherie Ng
Journal: Blood
Blood (2022) 140 (Supplement 1): 12653–12654.
https://doi.org/10.1182/blood-2022-170268
Published: 2022
Journal Articles

Antigenic Modulation of CD6 By Itolizumab Is a New Mechanism for Effector T Cell Inhibition

Dalena Chu, Valeria Marrocco, Phoi Tiet, Jeanette Ampudia, Stephen Connelly, Cherie Ng
Journal: Blood
Blood (2021) 138 (Supplement 1): 995.
https://doi.org/10.1182/blood-2021-148805
Published: 2021
Journal Articles

Itolizumab, a Novel Targeted Anti-CD6 Therapy, in Combination with Corticosteroids, Is Well-Tolerated, with Rapid Pharmacodynamic and Clinical Response in Newly Diagnosed Acute Graft-Versus-Host Disease

John Koreth, Jerome Ritz, Leslie Chinn, Cherie Ng, Lisette M Acevedo, Dalena Chu, Maple Fung, Joel Rothman, Stephen Connelly, Dolca Thomas, Corey Cutler
Journal: Blood
Blood (2021) 138 (Supplement 1): 2891.
https://doi.org/10.1182/blood-2021-145721
Published: 2021
Journal Articles

Impact of Itolizumab on the Expression of CD6 and the Function of Effector T Cells

Jeanette Ampudia, Dalena Chu, MS, Jana Badrani, MS, Taylor Doherty, MD, Stephen Connelly, PhD MBA, Cherie Tracy Ng, PhD MPH
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-141638
Published: 2020
Journal Articles

Early Reconstitution of CD6+ T Cells after Hematopoietic Cell Transplantation Identifies a Suitable Target for Acute Graft Versus Host Disease Treatment Using Anti-CD6 Monoclonal Antibody Itolizumab

Benedetta Rambaldi, MD, Haesook T. Kim, PhD, Carol Reynolds, PhD, Sharmila Chamling Rai, BSc, Takeru Asano, MD PhD, Yohei Arihara, MD PhD, Mahasweta Gooptu, MD, John Koreth, MBBS, DPhil, Corey Cutler, MD MPH, FRCPC, Sarah Nikiforow, MD PhD, Vincent T. Ho, MD, Joseph H. Antin, MD, Rizwan Romee, MD, Robert J. Soiffer, MD, Jeanette Ampudia, Cherie Tracy Ng, PhD MPH, Stephen Connelly, PhD MBA, Jerome Ritz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-138710
Published: 2020
Journal Articles

Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizumab, in Subjects with Newly Diagnosed Acute Graft Versus Host Disease

John Koreth, MBBS, DPhil, Saurabh Chhabra, MD, Joseph Pidala, MD, Thomas C. Shea, MD, Madan Jagasia, MBBS, MS, MMHC, Edmund K. Waller, PhDMD, Ryotaro Nakamura, MD, Marco Mielcarek, MD, George L. Chen, MD, Gabrielle Meyers, MD, Daanish Hoda, MD, Betty K. Hamilton, MD, Cherie Tracy Ng, PhD MPH, Mark Sonnemann, Susan Light, MD, Nuwan Nanayakkara, PhD, David Essayan, MD, Joel Rothman, BS, Stephen Connelly, PhD MBA, Krishna Polu, MD, Leslie Kean, MD PhD, Jerome Ritz, MD, Robert J. Soiffer, MD, Corey Cutler, MD MPH, FRCPC
Journal: Blood
Blood (2019) 134 (Supplement_1): 4516.
https://doi.org/10.1182/blood-2019-127325
Published: 2019
Journal Articles

Anti-CD6 Monoclonal Antibody Itolizumab Efficiently Inhibits T Cell Proliferation after in Vitro TCR Stimulation in the Setting of Acute Graft Versus Host Disease

Benedetta Rambaldi, MD, Carol Reynolds, PhD, Sharmila Chamling Rai, BSc, Takeru Asano, MD PhD, Yohei Arihara, MD PhD, Mahasweta Gooptu, MD, John Koreth, MBBS, DPhil, Corey Cutler, MD MPH, FRCPC, Sarah Nikiforow, MD PhD, Vincent T. Ho, MD, Edwin P. Alyea, III, MD, Joseph H. Antin, MD, Rizwan Romee, MD PhD, Robert J. Soiffer, MD, Domenico Russo, MD, Jeanette Ampudia, BSc, Cherie Tracy Ng, PhD MPH, Stephen Connelly, PhD MBA, Jerome Ritz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4517.
https://doi.org/10.1182/blood-2019-125721
Published: 2019
Journal Articles

Itolizumab As a Potential Therapeutic for the Prevention and Treatment of Graft Vs Host Disease

Cherie Tracy Ng, PhD MPH, Jeanette Ampudia, BSc, Robert J. Soiffer, MD, Jerome Ritz, MD, Stephen Connelly, PhD MBA
Journal: Blood
Blood (2019) 134 (Supplement_1): 5603.
https://doi.org/10.1182/blood-2019-122787
Published: 2019