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Journal Articles

Improved Outcomes of Budd-Chiari Syndrome in Paroxysmal Nocturnal Hemoglobinuria with Eculizumab Therapy

Joanna Haughton, MBChB, Richard J Kelly, MBChB, Stephen J Richards, PhD, Louise M Arnold, RN, BSc, Alexandra Wood, RN, BSc, Tracy Downing, Claire McKinley, BSc, Mervyn Davies, MBChB, Peter Hillmen, MBChB, PhD, Anita Hill, MBChB, PhD

Blood (2012) 120 (21): 3478.

https://doi.org/10.1182/blood.V120.21.3478.3478

Published: 2012

Journal Articles

Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival

Richard J. Kelly, Anita Hill, Louise M. Arnold, Gemma L. Brooksbank, Stephen J. Richards, Matthew Cullen, Lindsay D. Mitchell, Dena R. Cohen, Walter M. Gregory, Peter Hillmen

Blood (2011) 117 (25): 6786–6792.

https://doi.org/10.1182/blood-2011-02-333997

Published: 2011

Journal Articles

A “pathogenetic” role for CMV in CD4 + LGL proliferations

Stephen J. Richards

Blood (2008) 112 (12): 4367–4368.

https://doi.org/10.1182/blood-2008-09-180257

Published: 2008

Journal Articles

Successful Pregnancy Outcomes in Paroxysmal Nocturnal Hemoglobinuria with Long-Term Eculizumab Treatment

Richard Kelly, MD, Louise Arnold, BSc, MA, Stephen J. Richards, PhD, Anita Hill, MD, Charlotte Bomken, MD, John Hanley, MD, Andrew Loughney, MD, PhD, Gus Khursigara, PhD, Russell P. Rother, PhD, Elizabeth Chalmers, MD, Edward Fitzsimons, MD, Ryotaro Nakamura, MD, Anna Gaya, MD, Bruno Rotoli, MD, Antonio M. Risitano, MD, PhD, Joerg Schubert, MD, Peter Hillmen, MB, PhD

Blood (2008) 112 (11): 4576.

https://doi.org/10.1182/blood.V112.11.4576.4576

Published: 2008

Journal Articles

Eculizumab Reduces Pulmonary Hypertension through Inhibition of Hemolysis-Associated Nitric Oxide Consumption in Patients with Paroxysmal Nocturnal Hemoglobinuria

Anita Hill, MD, Russell P. Rother, PhD, Xunde Wang, MD, Robert J Sapsford, MD, Paul O Collinson, MD, David C Gaze, PhD, Sidney M Morris, Jr., PhD, Andrew Scally, Kerry Quinn-Senger, PhD, Stephen J Richards, PhD, Monica Bessler, MD, PhD, Richard Kelly, MD, Peter Hillmen, MBChB, PhD, Mark Gladwin, MD

Blood (2008) 112 (11): 486.

https://doi.org/10.1182/blood.V112.11.486.486

Published: 2008

Journal Articles

The Investigation of HMGA2 Dysregulation and Promoter Mutations in PIG-M in the Molecular Pathogenesis of Paroxysmal Nocturnal Haemoglobinuria (PNH).

Richard J. Kelly, MD, Reuben M. Tooze, PhD, Gina M. Doody, PhD, Stephen J. Richards, PhD, Peter Hillmen, PhD

Blood (2007) 110 (11): 3671.

https://doi.org/10.1182/blood.V110.11.3671.3671

Published: 2007

Journal Articles

Monoclonal B-Cell Lymphocytosis (MBL) Is a Precursor State for Chronic Lymphocytic Leukemia (CLL) with 1% Progression Per Year.

Andy C. Rawstron, Fiona L. Bennet, Sheila J.M. O’Connor, Marwan Kwok, James A.L. Fenton, Marieth Plummer, Ruth M. de Tute, Roger G. Owen, Stephen J. Richards, Andrew S. Jack, Peter Hillmen

Blood (2007) 110 (11): 749.

https://doi.org/10.1182/blood.V110.11.749.749

Published: 2007

Journal Articles

Abortive Plasma Cell Differentiation with Loss of Mature B-Cell Phenotype in a Subset of Patients with De Novo Diffuse Large B-Cell Lymphoma and Transformed Follicular Lymphoma: Relevance of cMYC Rearrangements.

Matthew J. Cullen, MSc, Sharon L. Barrans, PhD, Stephen J. Richards, PhD, Andy C. Rawstron, PhD, Sheila J.M. O’Connor, PhD, Reuben M. Tooze, PhD, Roger G. Owen, MD, Andrew Jack, MD

Blood (2006) 108 (11): 4643.

https://doi.org/10.1182/blood.V108.11.4643.4643

Published: 2006

Journal Articles

The Incidence and Prevalence of Paroxysmal Nocturnal Hemoglobinuria (PNH) and Survival of Patients in Yorkshire.

Anita Hill, MD, Philip J. Platts, MRes, Alex Smith, PhD, Stephen J. Richards, PhD, Matthew J. Cullen, MSc, Quentin A. Hill, MD, Eve Roman, PhD, Peter Hillmen, PhD

Blood (2006) 108 (11): 985.

https://doi.org/10.1182/blood.V108.11.985.985

Published: 2006

Journal Articles

Blockade of Intravascular Hemolysis in PNH with the Terminal Complement Inhibitor Eculizumab Unmasks Low-Level Hemolysis Potentially Occurring through C3 Opsonization.

Anita Hill, MD, Russell P. Rother, PhD, Antonio M. Risitano, PhD, Duncan S. Cole, PhD, Matthew J. Cullen, MSc, Stephen J. Richards, PhD, Carmine Selleri, MD, Patrizia Ricci, BSc, Bruno Rotoli, MD, Lucio Luzzatto, PhD, Peter Hillmen, PhD

Blood (2006) 108 (11): 972.

https://doi.org/10.1182/blood.V108.11.972.972

Published: 2006

Journal Articles

Protection of erythrocytes from human complement–mediated lysis by membrane-targeted recombinant soluble CD59: a new approach to PNH therapy

Anita Hill, Simon H. Ridley, Dirk Esser, Rodney G. Oldroyd, Matthew J. Cullen, Paula Kareclas, Seán Gallagher, Geoffrey P. Smith, Stephen J. Richards, Jennifer White, Richard A. G. Smith, Peter Hillmen

Blood (2006) 107 (5): 2131–2137.

https://doi.org/10.1182/blood-2005-02-0782

Published: 2006

Journal Articles

Nitric Oxide Consumption and Pulmonary Hypertension in Patients with Paroxysmal Nocturnal Hemoglobinuria.

Anita Hill, MD, Xunde Wang, PhD, Robert J. Sapsford, MD, Rother P. Russell, PhD, Alison L. Farrell, PGDip, Hilary A. Jessop, Gina M. McGawley, MSc, David L. Oxborough, BHSc, Paul Pleasants, BSc, Stephen J. Richards, PhD, Louise M. Arnold, BSc, David M. Buchanan, MA, Sara Rollinson, PhD, Mark T. Gladwin, MD, Peter Hillmen, PhD

Blood (2005) 106 (11): 1046.

https://doi.org/10.1182/blood.V106.11.1046.1046

Published: 2005

Journal Articles

The Effect of Eculizumab Therapy on Red Cell Response Kinetics in Patients with Paroxysmal Nocturnal Hemoglobinuria.

Stephen J. Richards, PhD, Matthew J. Cullen, MSc, Anita J. Dickinson, MSc, Anita Hill, MD, David Buchanon, MA, Louise Arnold, BSc, Modupe Elebute, MD, Russell P. Rother, PhD, Peter Hillmen, PhD

Blood (2005) 106 (11): 1047.

https://doi.org/10.1182/blood.V106.11.1047.1047

Published: 2005

Journal Articles

Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria

Anita Hill, Peter Hillmen, Stephen J. Richards, Dupe Elebute, Judith C. Marsh, Jason Chan, Christopher F. Mojcik, Russell P. Rother

Blood (2005) 106 (7): 2559–2565.

https://doi.org/10.1182/blood-2005-02-0564

Published: 2005

Journal Articles

Differential Clearance Kinetics and Phenotypic Alterations of Leukaemic Blast Cells during Induction Therapy for Hyperdiploid and t(12;21) Childhood ALL: Implications for Minimal Residual Disease Detection by Flow Cytometry and Clinical Outcome.

Matthew J. Cullen, MSc, Anita J. Dickinson, MSc, Helen Dickinson, BSc, Michael A. Short, BSc, Paul A.S. Evans, PhD, Sally E. Kinsey, MD, Mike Richards, MD, Stephen J. Richards, PhD

Blood (2004) 104 (11): 991.

https://doi.org/10.1182/blood.V104.11.991.991

Published: 2004

Journal Articles

IgH Rearrangements and Mutational Status in Class-Switched IgG B-CLL.

James A.L. Fenton, DPhil, David Gonzalez, PhD, Andy C. Rawstron, PhD, Gareth J. Morgan, MS, BCh, PhD, Andrew S. Jack, MB ChB PhD, Stephen J. Richards, PhD, Peter Hillmen, MB ChB PhD

Blood (2004) 104 (11): 2793.

https://doi.org/10.1182/blood.V104.11.2793.2793

Published: 2004

Journal Articles

Sustained Control of Hemolysis and Symptoms and Reduced Transfusion Requirements over a Period of 2 Years in Paroxysmal Nocturnal Hemoglobinuria (PNH) with Eculizumab Therapy.

Anita Hill, MD, Dupe Elebute, MD, Judith C. Marsh, MD, Stephen J. Richards, PhD, Bruce McNutt, MD, Beth E. Petro, BS, Russell P. Rother, PhD, Peter Hillmen, PhD

Blood (2004) 104 (11): 2823.

https://doi.org/10.1182/blood.V104.11.2823.2823

Published: 2004

Journal Articles

Evolution of GPI-Deficient Clones Predicts Clinical Course in Paroxysmal Nocturnal Haemoglobinuria.

Stephen J. Richards, PhD, Matthew J. Cullen, MSc, Anita J. Dickinson, MSc, Claire Hall, MD, Anita Hill, MD, Peter Hillmen, PhD

Blood (2004) 104 (11): 172.

https://doi.org/10.1182/blood.V104.11.172.172

Published: 2004

Journal Articles

Early prediction of outcome and response to alemtuzumab therapy in chronic lymphocytic leukemia

Andy C. Rawstron, Ben Kennedy, Paul Moreton, Anita J. Dickinson, Matthew J. Cullen, Stephen J. Richards, Andrew S. Jack, Peter Hillmen

Blood (2004) 103 (6): 2027–2031.

https://doi.org/10.1182/blood-2002-10-3270

Published: 2004

Journal Articles

Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion

Andy C. Rawstron, Martin R. Yuille, Julie Fuller, Matthew Cullen, Ben Kennedy, Stephen J. Richards, Andrew S. Jack, Estella Matutes, Daniel Catovsky, Peter Hillmen, Richard S. Houlston

Blood (2002) 100 (7): 2289–2290.

https://doi.org/10.1182/blood-2002-03-0892

Published: 2002

NARROW

Improved Outcomes of Budd-Chiari Syndrome in Paroxysmal Nocturnal Hemoglobinuria with Eculizumab Therapy

Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival

A “pathogenetic” role for CMV in CD4 + LGL proliferations

Successful Pregnancy Outcomes in Paroxysmal Nocturnal Hemoglobinuria with Long-Term Eculizumab Treatment

Eculizumab Reduces Pulmonary Hypertension through Inhibition of Hemolysis-Associated Nitric Oxide Consumption in Patients with Paroxysmal Nocturnal Hemoglobinuria

The Investigation of HMGA2 Dysregulation and Promoter Mutations in PIG-M in the Molecular Pathogenesis of Paroxysmal Nocturnal Haemoglobinuria (PNH).

Monoclonal B-Cell Lymphocytosis (MBL) Is a Precursor State for Chronic Lymphocytic Leukemia (CLL) with 1% Progression Per Year.

Abortive Plasma Cell Differentiation with Loss of Mature B-Cell Phenotype in a Subset of Patients with De Novo Diffuse Large B-Cell Lymphoma and Transformed Follicular Lymphoma: Relevance of cMYC Rearrangements.

The Incidence and Prevalence of Paroxysmal Nocturnal Hemoglobinuria (PNH) and Survival of Patients in Yorkshire.

Blockade of Intravascular Hemolysis in PNH with the Terminal Complement Inhibitor Eculizumab Unmasks Low-Level Hemolysis Potentially Occurring through C3 Opsonization.

Protection of erythrocytes from human complement–mediated lysis by membrane-targeted recombinant soluble CD59: a new approach to PNH therapy

Nitric Oxide Consumption and Pulmonary Hypertension in Patients with Paroxysmal Nocturnal Hemoglobinuria.

The Effect of Eculizumab Therapy on Red Cell Response Kinetics in Patients with Paroxysmal Nocturnal Hemoglobinuria.

Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria

Differential Clearance Kinetics and Phenotypic Alterations of Leukaemic Blast Cells during Induction Therapy for Hyperdiploid and t(12;21) Childhood ALL: Implications for Minimal Residual Disease Detection by Flow Cytometry and Clinical Outcome.

IgH Rearrangements and Mutational Status in Class-Switched IgG B-CLL.

Sustained Control of Hemolysis and Symptoms and Reduced Transfusion Requirements over a Period of 2 Years in Paroxysmal Nocturnal Hemoglobinuria (PNH) with Eculizumab Therapy.

Evolution of GPI-Deficient Clones Predicts Clinical Course in Paroxysmal Nocturnal Haemoglobinuria.

Early prediction of outcome and response to alemtuzumab therapy in chronic lymphocytic leukemia

Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion

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American Society of Hematology

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American Society of Hematology

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