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Journal Articles

Zinc Finger Nuclease (ZFN) Targeted Homologous Recombination Assay Detects Elevated Inter Homologous Recombination Activity and Copy Neutral Loss of Heterozygosity (CN-LOH) in Internal Tandem Duplication Mutated FLT3 (FLT3-ITD) Acute Myeloid Leukaemia (AML)

Terry J Gaymes, Ghulam J Mufti

Blood (2015) 126 (23): 1219.

https://doi.org/10.1182/blood.V126.23.1219.1219

Published: 2015

Journal Articles

Mutations in Cohesin Complex As Potential Targets for Therapeutic Intervention By PARP (Poly ADP Ribose Polymerase) Inhibitors in Myelodysplastic Syndrome

Nazia Matto, Terry J Gaymes, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Syed A Mian, BSc, M.Phil, Ghulam J Mufti, FRCP, FRCPath

Blood (2015) 126 (23): 1221.

https://doi.org/10.1182/blood.V126.23.1221.1221

Published: 2015

Journal Articles

Internal Tandem Duplication Mutation of FLT3 (FLT3/ITD) Significantly Increases Inter Chromosomal Homologous Recombination Providing a Direct Link Between Constitutive FLT3-ITD Activity and Propagation of Copy Neutral Loss of Heterozygosity (CN-LOH) in Acute Myeloid Leukaemia

Terry J Gaymes, DPhil, Azim M Mohamedali, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2014) 124 (21): 2185.

https://doi.org/10.1182/blood.V124.21.2185.2185

Published: 2014

Journal Articles

Comprehensive Mutational Screening Of 5-Azacitidne Treated Myelodysplastic Syndrome (MDS) Patients Fails To Identify a Specific Mutational Profile Predicting Response To Therapy

Austin G. Kulasekararaj, Azim M Mohamedali, PhD, Alexander E Smith, PhD, Syed A Mian, Nazia Matto, Terry J Gaymes, DPhil, Nicholas Lea, PhD, Joop Gaken, PhD, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2013) 122 (21): 2792.

https://doi.org/10.1182/blood.V122.21.2792.2792

Published: 2013

Journal Articles

Internal Tandem Duplication Mutation Of FLT3 (FLT3/ITD) Induces Increased Homologous Recombination DNA Repair Activity, Drug Resistance and Sister Chromatid Exchanges In Acute Myeloid Leukaemia (AML)

Terry J Gaymes, DPhil, David C Darling, PhD, Ghulam J. Mufti, MD, PhD

Blood (2013) 122 (21): 1244.

https://doi.org/10.1182/blood.V122.21.1244.1244

Published: 2013

Journal Articles

Microsatellite Instability Induced Mutation in DNA Repair Genes, CTiP and Mre11 Confer Hypersensitivity to PARP Inhibitors in Myeloid Malignancies

Terry J Gaymes, DPhil, Rajani Chelliah, BSc, MSc, Austin G Kulasekararaj, Azim M Mohamedali, PhD, Sydney Shall, DPhil, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 276.

https://doi.org/10.1182/blood.V118.21.276.276

Published: 2011

Journal Articles

Polycomb Complex Group Gene Mutations and Their Prognostic Relevance In 5-Azacitidine Treated Myelodysplastic Syndrome Patients

Blood (2010) 116 (21): 125.

https://doi.org/10.1182/blood.V116.21.125.125

Published: 2010

Journal Articles

Microsatellite Instability (MSI) In High Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukaemia (AML) Cells Promotes Frameshift Mutations In DNA Repair Genes: Indications for PARP Inhibitor Therapy.

Terry J Gaymes, DPhil, Azim Mohamedali, PHD, Austin G Kulasekararaj, Sydney Shall, DPhil, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2010) 116 (21): 1194.

https://doi.org/10.1182/blood.V116.21.1194.1194

Published: 2010

Journal Articles

Poly ADP Ribose Polymerase (PARP) Inhibitors Induce Apoptosis Alone or Synergistically with Histone Deacetylase Inhibitors in Primary Acute Myeloid Leukemic Patient Cells

Terry J Gaymes, DPhil, Sydney Shall, Dphil, Farzin Farzaneh, DPhil, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath

Blood (2008) 112 (11): 2974.

https://doi.org/10.1182/blood.V112.11.2974.2974

Published: 2008

Journal Articles

Inhibition of Poly ADP Ribose Polymerase (PARP) Activity Exerts Cytotoxic Effects on Chromosomal Instability Syndrome and Leukaemic Cell Lines: Potential for Anti-Leukaemia Therapy.

Terry J. Gaymes, DPhil, S. Shall, DM,FRCP,FRPath, Farzin Farzaneh, DPhil, Ghulam J. Mufti

Blood (2006) 108 (11): 2647.

https://doi.org/10.1182/blood.V108.11.2647.2647

Published: 2006

Journal Articles

Increased DNA Damage and Error-Prone Repair in MPD/MDS Mice with Disease Progression: Key Indicators for Increased Genomic Instability.

Feyruz V. Rassool, PhD, Terry J. Gaymes, PhD, Nicola Brady, PhD, Nicholas Lea, PhD, Marika Pla, PhD, Thi Hai Phan, PhD, Scott Kogan, MD, Christine Chomienne, MDPhD, Nicholas S. Thomas, PhD, Ghulam J. Mafti, MD, Rose Ann Padua, PhD

Blood (2004) 104 (11): 200.

https://doi.org/10.1182/blood.V104.11.200.200

Published: 2004

NARROW

Zinc Finger Nuclease (ZFN) Targeted Homologous Recombination Assay Detects Elevated Inter Homologous Recombination Activity and Copy Neutral Loss of Heterozygosity (CN-LOH) in Internal Tandem Duplication Mutated FLT3 (FLT3-ITD) Acute Myeloid Leukaemia (AML)

Mutations in Cohesin Complex As Potential Targets for Therapeutic Intervention By PARP (Poly ADP Ribose Polymerase) Inhibitors in Myelodysplastic Syndrome

Internal Tandem Duplication Mutation of FLT3 (FLT3/ITD) Significantly Increases Inter Chromosomal Homologous Recombination Providing a Direct Link Between Constitutive FLT3-ITD Activity and Propagation of Copy Neutral Loss of Heterozygosity (CN-LOH) in Acute Myeloid Leukaemia

Comprehensive Mutational Screening Of 5-Azacitidne Treated Myelodysplastic Syndrome (MDS) Patients Fails To Identify a Specific Mutational Profile Predicting Response To Therapy

Internal Tandem Duplication Mutation Of FLT3 (FLT3/ITD) Induces Increased Homologous Recombination DNA Repair Activity, Drug Resistance and Sister Chromatid Exchanges In Acute Myeloid Leukaemia (AML)

Microsatellite Instability Induced Mutation in DNA Repair Genes, CTiP and Mre11 Confer Hypersensitivity to PARP Inhibitors in Myeloid Malignancies

Polycomb Complex Group Gene Mutations and Their Prognostic Relevance In 5-Azacitidine Treated Myelodysplastic Syndrome Patients

Microsatellite Instability (MSI) In High Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukaemia (AML) Cells Promotes Frameshift Mutations In DNA Repair Genes: Indications for PARP Inhibitor Therapy.

Poly ADP Ribose Polymerase (PARP) Inhibitors Induce Apoptosis Alone or Synergistically with Histone Deacetylase Inhibitors in Primary Acute Myeloid Leukemic Patient Cells

Inhibition of Poly ADP Ribose Polymerase (PARP) Activity Exerts Cytotoxic Effects on Chromosomal Instability Syndrome and Leukaemic Cell Lines: Potential for Anti-Leukaemia Therapy.

Increased DNA Damage and Error-Prone Repair in MPD/MDS Mice with Disease Progression: Key Indicators for Increased Genomic Instability.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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