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Thomas M. Ryan
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Journal Articles

An HPFH Mutation in the γ-Globin Gene Promoter of Humanized Cooley's Anemia Mice Rescues Them from Perinatal Lethality and Renders Them Transfusion Independent

Suean Daimia Fontenard, BS, Yongliang Huo, PhD, Shanrun Liu, MD PhD, Jonathan Lockhart, BS, Michael Berlett, BS, Thomas M Ryan, PhD
Journal: Blood
Blood (2016) 128 (22): 1290.
https://doi.org/10.1182/blood.V128.22.1290.1290
Published: 2016
Journal Articles

In Vivo Efficacy of Bcl11a Erythroid-Enhancer Deletion in Humanized Mouse Models of Anemia

Thomas M Ryan, PhD, Suean Daimia Fontenard, BS, Shanrun Liu, MD PhD, Jonathan Lockhart, BS, Michael Berlett, BS
Journal: Blood
Blood (2016) 128 (22): 2465.
https://doi.org/10.1182/blood.V128.22.2465.2465
Published: 2016
Journal Articles

Rescue of a Humanized Mouse Model of β-Thalassemia Major By Allogeneic Bone Marrow Transplantation in the Absence of Cytoreductive Conditioning

Jonathan Lockhart, BS, Yongliang Huo, PhD, Shanrun Liu, MD PhD, Suean Daimia Fontenard, BS, Michael Berlett, BS, Thomas M Ryan, PhD
Journal: Blood
Blood (2016) 128 (22): 2155.
https://doi.org/10.1182/blood.V128.22.2155.2155
Published: 2016
Journal Articles

Preclinical transfusion-dependent humanized mouse model of β thalassemia major

Yongliang Huo, Sean C. McConnell, Thomas M. Ryan
Journal: Blood
Blood (2009) 113 (19): 4763–4770.
https://doi.org/10.1182/blood-2008-12-197012
Published: 2009
Includes: Supplemental data
Journal Articles

Lentiviral Insertion Site Analysis of Corrected Mouse Model of β Thalassemia Following Lentiviral Transduction of Embryonic Stem Cells.

Rui Yang, Sean C. McConnell, Yongliang Huo, Clayton Ulrey, Shan-Run Liu, Ting-Ting Zhang, Thomas M. Ryan
Journal: Blood
Blood (2007) 110 (11): 2592.
https://doi.org/10.1182/blood.V110.11.2592.2592
Published: 2007
Journal Articles

Human Gamma Globin Gene Regulation in Knock-In Mouse Models of Anemia.

Sean C. McConnell, Yongliang Huo, Shan-Run Liu, Ting-Ting Zhang, Clayton L. Ulrey, Thomas M. Ryan
Journal: Blood
Blood (2007) 110 (11): 1779.
https://doi.org/10.1182/blood.V110.11.1779.1779
Published: 2007
Journal Articles

A Humanized Cooley’s Anemia Mouse Model.

Yongliang Huo, Sean C. McConnell, Clayton L. Ulrey, Ting-Ting Zhang, Rui Yang, Shan-Run Liu, Thomas M. Ryan, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 1784.
https://doi.org/10.1182/blood.V110.11.1784.1784
Published: 2007
Journal Articles

Efficient Clonal Gene Delivery into Human Embryonic Stem Cells Via Active Transgenesis Using PiggyBac Transposition.

Ting-Ting Zhang, Clayton L. Ulrey, Shan-Run Liu, Rui Yang, Sean C. McConnell, Yongliang Huo, Thomas M. Ryan
Journal: Blood
Blood (2007) 110 (11): 5149.
https://doi.org/10.1182/blood.V110.11.5149.5149
Published: 2007
Journal Articles

Erythroid Development in the Absence of Hemoglobin.

Shan-Run Liu, Sean C. McConnell, Yongliang Huo, Ting-Ting Zhang, Rui Yang, Clayton L. Ulrey, Thomas M. Ryan
Journal: Blood
Blood (2007) 110 (11): 1262.
https://doi.org/10.1182/blood.V110.11.1262.1262
Published: 2007
Journal Articles

Correction of sickle cell disease by homologous recombination in embryonic stem cells

Li-Chen Wu, Chiao-Wang Sun, Thomas M. Ryan, Kevin M. Pawlik, Jinxiang Ren, Tim M. Townes
Journal: Blood
Blood (2006) 108 (4): 1183–1188.
https://doi.org/10.1182/blood-2006-02-004812
Published: 2006
Journal Articles

Generation of a Novel Mouse Model of Cooley’s Anemia.

Yongliang Huo, Sean McConnell, Chiao-Wang Sun, PhD, Li-Chen Wu, Thomas M. Ryan, PhD
Journal: Blood
Blood (2005) 106 (11): 3654.
https://doi.org/10.1182/blood.V106.11.3654.3654
Published: 2005
Journal Articles

Correction of β Thalassemia by Homologous Recombination in Embryonic Stem Cells.

Thomas M. Ryan, Ph.D., Chiao-Wang Sun, Ph.D., Li-Chen Wu, Jin-Xiang Ren, Tim M. Townes, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 373.
https://doi.org/10.1182/blood.V104.11.373.373
Published: 2004
Journal Articles

Global ENU Mutagenesis Screen for Genetic Modifiers in Sickle Cell Disease Mice.

Thomas M. Ryan, Ph.D., Yongliang Huo, Sean McConnell
Journal: Blood
Blood (2004) 104 (11): 3733.
https://doi.org/10.1182/blood.V104.11.3733.3733
Published: 2004
Journal Articles

Correction of a mouse model of sickle cell disease: lentiviral/antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells

Dana N. Levasseur, Thomas M. Ryan, Kevin M. Pawlik, Tim M. Townes
Journal: Blood
Blood (2003) 102 (13): 4312–4319.
https://doi.org/10.1182/blood-2003-04-1251
Published: 2003
Includes: Supplemental data
Journal Articles

Distinguishable live erythroid and myeloid cells in β-globin ECFP x lysozyme EGFP mice

Brief Report
Susanne Heck, Olga Ermakova, Hiromi Iwasaki, Koichi Akashi, Chiao-Wang Sun, Thomas M. Ryan, Tim Townes, Thomas Graf
Journal: Blood
Blood (2003) 101 (3): 903–906.
https://doi.org/10.1182/blood-2002-06-1861
Published: 2003