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Journal Articles

Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway

Michael J. Krisinger, Verena Goebeler, Zhen Lu, Scott C. Meixner, Timothy Myles, Edward L. G. Pryzdial, Edward M. Conway
Journal: Blood
Blood (2012) 120 (8): 1717–1725.
https://doi.org/10.1182/blood-2012-02-412080
Published: 2012
Includes: Supplemental data
Journal Articles

Waveform Analysis Extends the Capabilities of aPTT and PT Clotting Assays for Detecting Factor Deficiency and Monitoring Procoagulant Drug Therapy

Lilley Leong, PhD, MS, Xiaoqiao Jiang, BS, Jill Cifrese, MS, John E. Murphy, PhD, Jesper Haaning, PhD, Timothy Myles, PhD
Journal: Blood
Blood (2011) 118 (21): 1205.
https://doi.org/10.1182/blood.V118.21.1205.1205
Published: 2011
Journal Articles

Prochemerin Is a New Substrate for Thrombin.

Xiaoyan Du, PhD, Timothy Myles, PhD, John Morser, PhD, Lawrence L. Leung, MD
Journal: Blood
Blood (2009) 114 (22): 3591.
https://doi.org/10.1182/blood.V114.22.3591.3591
Published: 2009
Journal Articles

Differentially Cleaved Forms of Osteopontin by Thrombin and Carboxypeptidase B (TAFIa) Regulates Neutrophil Viability and Synoviocyte Binding in Rheumatoid Arthritis

Shadi Sharif, MS, Xiaoyan Du, PhD, Timothy Myles, PhD, Jason Jungsik Song, MD, Elizabeth A Price, MD, MPH, David Lee, MD, PhD, Stuart Goodman, MD, John Morser, PhD, William Robinson, MD, PhD, Lawrence L. Leung, MD
Journal: Blood
Blood (2008) 112 (11): 3562.
https://doi.org/10.1182/blood.V112.11.3562.3562
Published: 2008
Journal Articles

Thrombin-Cleaved Osteopontin Is Regulated by Thrombin-Activatable Carboxypeptidase B in Rheumatoid Arthritis.

Timothy Myles, PhD, Shadi A. Sharif, BS, Xiao-Yan Du, PhD, Jason J. Song, MD, Price Elizabeth, MD, William H. Robinson, MD, Lawrence L. Leung, MD
Journal: Blood
Blood (2007) 110 (11): 1744.
https://doi.org/10.1182/blood.V110.11.1744.1744
Published: 2007
Journal Articles

Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo

Toshihiko Nishimura, Timothy Myles, Adrian M. Piliposky, Peter N. Kao, Gerald J. Berry, Lawrence L. K. Leung
Journal: Blood
Blood (2006) 109 (5): 1992–1997.
https://doi.org/10.1182/blood-2006-03-012567
Published: 2006
Journal Articles

Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Regulates Activated Complement C5a in Vivo.

Toshihiko Nishimura, MD, Timothy Myles, PhD, Mariko Nagashima, PhD, John Morser, PhD, Ronald G. Pearl, MD, Lawrence L.K. Leung, MD
Journal: Blood
Blood (2004) 104 (11): 2973.
https://doi.org/10.1182/blood.V104.11.2973.2973
Published: 2004
Journal Articles

Mechanism of Interaction between the Heavy Chain of Factor VIII and Thrombin.

Keiji Nogami, M.D./Ph. D., Qian Zhou, Hironao Wakabayashi, Ph.D., Timothy Myles, Ph.D., Lawrence L. Leung, M. D., Philip J. Fay, Ph. D.
Journal: Blood
Blood (2004) 104 (11): 1711.
https://doi.org/10.1182/blood.V104.11.1711.1711
Published: 2004
Journal Articles

Essential Thrombin Residues for Inhibition by Plasminogen Activator Inhibitor-1 in the Absence and Presence of Heparin and Vitronectin.

Yolanda M. Fortenberry, Ph.D., Jill C. Rau, Lauren C. Cranford, Timothy Myles, Ph.D., Lawerence L. Leung, M.D., Frank C. Church, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 3986.
https://doi.org/10.1182/blood.V104.11.3986.3986
Published: 2004
Journal Articles

Structural requirements for the activation of human factor VIII by thrombin

Timothy Myles, Thomas H. Yun, Lawrence L. K. Leung
Journal: Blood
Blood (2002) 100 (8): 2820–2826.
https://doi.org/10.1182/blood-2002-03-0843
Published: 2002