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Journal Articles

Integration of ζ -deficient CARs into the CD3 ζ gene conveys potent cytotoxicity in T and NK cells

Jonas Kath, Clemens Franke, Vanessa Drosdek, Weijie Du, Viktor Glaser, Carla Fuster-Garcia, Maik Stein, Tatiana Zittel, Sarah Schulenberg, Caroline E. Porter, Lena Andersch, Annette Künkele, Joshua Alcaniz, Jens Hoffmann, Hinrich Abken, Mohamed Abou-el-Enein, Axel Pruß, Masataka Suzuki, Toni Cathomen, Renata Stripecke, Hans-Dieter Volk, Petra Reinke, Michael Schmueck-Henneresse, Dimitrios L. Wagner
Journal: Blood
Blood (2024) 143 (25): 2599–2611.
https://doi.org/10.1182/blood.2023020973
Published: 2024
Includes: Supplemental data
Journal Articles

A Universal CRISPR/Cas9n-Mediated Genome Editing Approach for ELANE -Related Severe Congenital Neutropenia

Masoud Nasri, Malte Ulrich Ritter, Perihan Mir, Benjamin Dannenmann, Masako Monika Kaufmann, Yun Xu, Natalia Borbaran-Bravo, Maksim Klimiankou, Claudia Lengerke, Cornelia Zeidler, Toni Cathomen, Karl Welte, Julia Skokowa
Journal: Blood
Blood (2023) 142 (Supplement 1): 932.
https://doi.org/10.1182/blood-2023-181678
Published: 2023
Journal Articles

CRISPR/Cas9 Gene Editing of Immune Checkpoint Receptor NKG2A Improves the Efficacy of Primary CD33-CAR-NK Cells Against AML

Nawid Albinger, Tobias Bexte, Leon Buchinger, Philipp Wendel, Ahmad Al-Ajami, Alec Gessner, Vinzenz Särchen, Jamal Alzubi, Sarah Mertlitz, Olaf Penack, Raj Bhayadia, Jan-Henning Klusmann, Meike Vogler, Nina Möker, Toni Cathomen, Michael A. Rieger, Katharina Imkeller, Evelyn Ullrich
Journal: Blood
Blood (2022) 140 (Supplement 1): 4558–4559.
https://doi.org/10.1182/blood-2022-169758
Published: 2022
Journal Articles

Function-Preserving Single Amino Acid Substitutions Shield Hematopoietic Stem and Progenitor Cells from CD117 Targeted Immunotherapy In Vivo

Romina Marone, Rosalba Lepore, Julia Rositzka, Viviane Dettmer-Monaco, Alessandro dell' Aglio, Giuseppina Capoferri, Julie Brault, Emiel Ten Buren, Thomas Burgold, Anna Camus, Christopher Divsalar, Laura Garcia Prat, Anna Haydn, Felix Hermann, Marcel Heugel, Andreja Knezevic, Frank Michael Lehmann, Valentin Do Sacramento, Alessandro Sinopoli, Lisa C Wellinger, Amélie Wiederkehr, Saniye Yumlu, Toni Cathomen, Thomas Winkler, Tatjana I Cornu, Stefanie Urlinger, Lukas T Jeker
Journal: Blood
Blood (2022) 140 (Supplement 1): 4493–4494.
https://doi.org/10.1182/blood-2022-165274
Published: 2022
Journal Articles

A Highly Efficient and GMP Compliant Protocol to Manufacture CCR5 Edited Cells to Treat HIV Infection

Marianna Romito, PhD, Emily Meyer, MD, Sushmita Poddar, PhD, Helena Heinz, PhD, Julia Rositzka, Markus Hildenbeutel, PhD, Anne-Sophie Gautron, PhD, Brian W Busser, PhD, Yik Lim Kok, PhD, Giandomenico Turchiano, PhD, Simone Haas, Richard Schäfer, MD, Julianne Smith, PhD, Karin J Metzner, MD, Claudio Mussolino, PhD, Philippe Duchateau, Toni Cathomen, PhD, Tatjana I Cornu, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5795.
https://doi.org/10.1182/blood-2018-99-117116
Published: 2018
Journal Articles

Gene Editing with Crispr-Cas9 for Treating Beta-Hemoglobinopathies

Ciaran Lee, PhD, Gang Bao, PhD, Matthew H. Porteus, MD PhD, Tatjana Cornu, PhD, Annarita Miccio, PhD, Thomas Cradick, Toni Cathomen, PhD, Ante Lundberg, MD, Fulvio Mavilio, PhD
Journal: Blood
Blood (2015) 126 (23): 3376.
https://doi.org/10.1182/blood.V126.23.3376.3376
Published: 2015