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Journal Articles

Continuous Dose Dasatinib Is Safe and Feasible in Combination with Intensive Chemotherapy in Pediatric Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph + ALL): Children's Oncology Group (COG) Trial AALL0622

Blood (2012) 120 (21): 137.

https://doi.org/10.1182/blood.V120.21.137.137

Published: 2012

Journal Articles

Removal of Normal Competition Increases Proliferation of Pre-Leukemic Cells in a Mouse Model of Pre-B Acute Lymphoblastic Leukemia.

Gregor SD Reid, PhD, David Barrett, MD, PhD, Alix Eden Seif, MD, MPH, Valerie I. Brown, MD, PhD, Stephan A. Grupp, MD, PhD

Blood (2009) 114 (22): 1430.

https://doi.org/10.1182/blood.V114.22.1430.1430

Published: 2009

Journal Articles

Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses

Alix E. Seif, David M. Barrett, Michael Milone, Valerie I. Brown, Stephan A. Grupp, Gregor S. D. Reid

Blood (2009) 114 (12): 2459–2466.

https://doi.org/10.1182/blood-2009-02-203984

Published: 2009

Journal Articles

Inhibiting PIM-1 Is Effective in Vitro and in Vivo against ALL: A Novel Mechanistic and Potentially Clinically Relevant Druggable Target.

Valerie I. Brown, MD, PhD, Cecilia Sheen, Jessica Hulitt, Theresa Ryan, Laura DiNardo, David Barrett, MD, PhD, David T. Teachey, MD, David J. Bearss, PhD, Gregory I. Berk, MD, Stephan A. Grupp, MD, PhD

Blood (2008) 112 (11): 1922.

https://doi.org/10.1182/blood.V112.11.1922.1922

Published: 2008

Journal Articles

Targeting HMG-CoA Reductase in Acute Lymphoblastic Leukemia (ALL): Statins Inhibit Proliferation and Induce Apoptosis in ALL Cells

David Teachey, MD, Cecilia Sheen, Alix Eden Seif, MD, MPH, Valerie I. Brown, MD, PhD, Stephan A. Grupp, MD, PhD

Blood (2008) 112 (11): 2927.

https://doi.org/10.1182/blood.V112.11.2927.2927

Published: 2008

Journal Articles

mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia

David T. Teachey, Cecilia Sheen, Junior Hall, Theresa Ryan, Valerie I. Brown, Jonathan Fish, Gregor S. D. Reid, Alix E. Seif, Robin Norris, Yueh J. Chang, Martin Carroll, Stephan A. Grupp

Blood (2008) 112 (5): 2020–2023.

https://doi.org/10.1182/blood-2008-02-137141

Published: 2008

Includes: Supplemental data

Journal Articles

Targeting Notch signaling in autoimmune and lymphoproliferative disease

David T. Teachey, Alix E. Seif, Valerie I. Brown, Marlo Bruno, Ralph M. Bunte, Yueh J. Chang, John K. Choi, Jonathan D. Fish, Junior Hall, Gregor S. Reid, Theresa Ryan, Cecilia Sheen, Patrick Zweidler-McKay, Stephan A. Grupp

Blood (2008) 111 (2): 705–714.

https://doi.org/10.1182/blood-2007-05-087353

Published: 2008

Journal Articles

CpG Oligonucleotides Induce Anti-Leukemia Activity in a Syngeneic Murine Model of Acute Lymphoblastic Leukemia.

Alix E. Seif, MD, MPH, Marlo D. Bruno, Junior Hall, Valerie I. Brown, MD, PhD, Stephan A. Grupp, MD, PhD, Gregor S.D. Reid, PhD

Blood (2007) 110 (11): 2830.

https://doi.org/10.1182/blood.V110.11.2830.2830

Published: 2007

Journal Articles

A Phase I Trial of Sirolimus (Rapamycin) in Pediatric Patients with Relapsed/Refractory Leukemia.

Susan R. Rheingold, MD, Nancy Sacks, MS, RD, LDN, Yueh J. Chang, PhD, Valerie I. Brown, MD, PhD, David T. Teachey, MD, Beverly J. Lange, MD, Stephan A. Grupp, MD, PhD

Blood (2007) 110 (11): 2834.

https://doi.org/10.1182/blood.V110.11.2834.2834

Published: 2007

Journal Articles

PI3-Kinase Inhibition Decreases the Proliferation of ALL Cells, Potentiates mTOR Inhibition, and Abrogates Growth Factor-Mediated Reversal of mTOR Inhibition.

Jonathan Fish, MD, Jessica Hulitt, Marlo Bruno, Stephan A. Grupp, MD, PhD, Valerie I. Brown, MD, PhD

Blood (2006) 108 (11): 1383.

https://doi.org/10.1182/blood.V108.11.1383.1383

Published: 2006

Journal Articles

In Vivo Control of Acute Lymphoblastic Leukemia by Immunostimulatory CpG Oligonucleotides.

Gregor S.D. Reid, PhD, Hisaki Fujii, MD, Jacqueline Trudeau, PhD, Junior Hall, Jonathan D. Fish, MD, David T. Teachey, MD, Valerie I. Brown, MD, PhD, Kirk R. Schultz, MD, Stephan A. Grupp, MD, PhD

Blood (2006) 108 (11): 1868.

https://doi.org/10.1182/blood.V108.11.1868.1868

Published: 2006

Journal Articles

Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

David T. Teachey, Dana A. Obzut, Kelly Axsom, John K. Choi, Kelly C. Goldsmith, Junior Hall, Jessica Hulitt, Catherine S. Manno, John M. Maris, Nicholas Rhodin, Kathleen E. Sullivan, Valerie I. Brown, Stephan A. Grupp

Blood (2006) 108 (6): 1965–1971.

https://doi.org/10.1182/blood-2006-01-010124

Published: 2006

Includes: Supplemental data

Journal Articles

The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

David T. Teachey, Dana A. Obzut, Jonathan Cooperman, Junjie Fang, Martin Carroll, John K. Choi, Peter J. Houghton, Valerie I. Brown, Stephan A. Grupp

Blood (2006) 107 (3): 1149–1155.

https://doi.org/10.1182/blood-2005-05-1935

Published: 2006

Journal Articles

Murine Ultrasonography Confirms That Rapamycin Is Effective Against Autoimmune Lymphoproliferative Syndrome (ALPS).

David T. Teachey, MD, Kelly Axsom, Valerie I. Brown, MD, PhD, Dana Obzut, MD, Stephan A. Grupp, MD, PhD

Blood (2005) 106 (11): 2386.

https://doi.org/10.1182/blood.V106.11.2386.2386

Published: 2005

Journal Articles

mTOR Inhibitors Induce Apoptosis and Inhibit Growth of Primary Adult Human ALL in Xenograft and Tissue Culture Models.

David T. Teachey, MD, Valerie I. Brown, MD, PhD, Junior Hall, Jonathan Cooperman, Dana Obzut, MD, Martin Carroll, MD, John K. Choi, MD, Stephan A. Grupp, MD, PhD

Blood (2004) 104 (11): 2748.

https://doi.org/10.1182/blood.V104.11.2748.2748

Published: 2004

Journal Articles

IL-7 and Thymic Stromal Lymphopoietin (TSLP) Stimulate Proliferation of All Cells and Reverse mTOR Inhibitor-Induced Growth Inhibition, Suggesting a Role for IL-7Rα Signaling in All.

Valerie I. Brown, MD, PhD, David Teachey, MD, Junjie Fang, MD, Stephan A. Grupp, MD, PhD

Blood (2004) 104 (11): 1893.

https://doi.org/10.1182/blood.V104.11.1893.1893

Published: 2004

NARROW

Continuous Dose Dasatinib Is Safe and Feasible in Combination with Intensive Chemotherapy in Pediatric Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph + ALL): Children's Oncology Group (COG) Trial AALL0622

Removal of Normal Competition Increases Proliferation of Pre-Leukemic Cells in a Mouse Model of Pre-B Acute Lymphoblastic Leukemia.

Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses

Inhibiting PIM-1 Is Effective in Vitro and in Vivo against ALL: A Novel Mechanistic and Potentially Clinically Relevant Druggable Target.

Targeting HMG-CoA Reductase in Acute Lymphoblastic Leukemia (ALL): Statins Inhibit Proliferation and Induce Apoptosis in ALL Cells

mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia

Targeting Notch signaling in autoimmune and lymphoproliferative disease

CpG Oligonucleotides Induce Anti-Leukemia Activity in a Syngeneic Murine Model of Acute Lymphoblastic Leukemia.

A Phase I Trial of Sirolimus (Rapamycin) in Pediatric Patients with Relapsed/Refractory Leukemia.

PI3-Kinase Inhibition Decreases the Proliferation of ALL Cells, Potentiates mTOR Inhibition, and Abrogates Growth Factor-Mediated Reversal of mTOR Inhibition.

In Vivo Control of Acute Lymphoblastic Leukemia by Immunostimulatory CpG Oligonucleotides.

Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

Murine Ultrasonography Confirms That Rapamycin Is Effective Against Autoimmune Lymphoproliferative Syndrome (ALPS).

mTOR Inhibitors Induce Apoptosis and Inhibit Growth of Primary Adult Human ALL in Xenograft and Tissue Culture Models.

IL-7 and Thymic Stromal Lymphopoietin (TSLP) Stimulate Proliferation of All Cells and Reverse mTOR Inhibitor-Induced Growth Inhibition, Suggesting a Role for IL-7Rα Signaling in All.

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American Society of Hematology

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American Society of Hematology

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