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Journal Articles

Evaluation of GBT021601 As a Therapeutic Agent to Restore Bone Marrow Health and Effective Erythropoiesis in a Sickle Mouse Model

Britney Hernandez, Anupama Priyadarshini, Zachary Kostamo, Yankai Zhang, Ashwin P Patel, Michael A Pendergast, Madhulika Jupelli, Heli Huang, Annie Nguyen Dang, Mira Patel Pochron, Kobina Dufu, Vivien A Sheehan

Blood (2023) 142 (Supplement 1): 16.

https://doi.org/10.1182/blood-2023-175022

Published: 2023

Journal Articles

Evaluation of the Impact of a Naturally Occurring Beta Hemoglobin Variant, Hb G-Makassar, on Mature Red Blood Cell Function and Pathology in a Sickle Cell Disease Mouse Model

Zachary Kostamo, Jawa Darazim, Britney Hernandez, Alex Pendergast, Jordan Zgodny, Erica N Evans, Yankai Zhang, Ashwin P Patel, Celeste K. Kanne, Elizabeth Budak, Rebecca Jenkins, Daniel Haupt, Valerie Winton, Bo Yan, Adam Hartigan, Haihua Chu, Giuseppe Ciaramella, Vivien A. Sheehan

Blood (2023) 142 (Supplement 1): 2251.

https://doi.org/10.1182/blood-2023-186237

Published: 2023

Journal Articles

A Miniaturized, Rapid Technique for Measuring Red Blood Cell-Mediated Microcapillary Occlusion in HbAS, HbSC, and HbSS Sickle Cell Disease Genotypes

Solomon Oshabaheebwa, Christopher A. Delianides, Zoe Sekyonda, Yusang M. Bejarano Ley, Calvin Abonga, Vivien A Sheehan, Michael A. Suster, Pedram Mohseni, Umut A. Gurkan

Blood (2023) 142 (Supplement 1): 5022.

https://doi.org/10.1182/blood-2023-187259

Published: 2023

Journal Articles

Red Cell Rheology and Blood Viscosity in Pediatric Individuals Having Received Allogenic Hematopoietic Stem Cell Transplantation or Ex Vivo Autologous Gene Therapy for Sickle Cell Disease

Ashwin P. Patel, Celeste K. Kanne, Elizabeth O Stenger, Tami D. John, Vivien A. Sheehan

Blood (2023) 142 (Supplement 1): 1076.

https://doi.org/10.1182/blood-2023-188045

Published: 2023

Journal Articles

Impact of Vaso-Occlusive Crises on the Transcriptomes of Patients with Sickle Cell Disease

Varsha Bhat, Alka A Potdar, Ashwin P Patel, Gregory Gibson, G. Karen Yu, Vivien A Sheehan

Blood (2023) 142 (Supplement 1): 1116.

https://doi.org/10.1182/blood-2023-179366

Published: 2023

Journal Articles

A Phase 2, Open-Label Study to Assess the Pharmacokinetics, Pharmacodynamics and Safety of Orally Administered Epeleuton in Patients with Sickle Cell Disease

Biree Andemariam, Vivien A. Sheehan, Moayed Hamza, Kirsty Kelly, John Climax

Blood (2023) 142 (Supplement 1): 1159.

https://doi.org/10.1182/blood-2023-188727

Published: 2023

Journal Articles

Rheological Characteristics of Elderly Individuals with Sickle Cell Disease Compared with an Adult Sickle Cell Population

Justin J Yoo, Jordan Zgodny, Britney Hernandez, Jawa Darazim, Ashwin P Patel, Fuad El Rassi, G. Karen Yu, Alka A Potdar, Vivien A. Sheehan

Blood (2023) 142 (Supplement 1): 926.

https://doi.org/10.1182/blood-2023-177791

Published: 2023

Journal Articles

Radchip: A Laminin-Lined Red Blood Cell (RBC) Adhesion Device for Functional Characterization and Clinical Evaluation of Sickle RBCs at Steady-State

Erica N Evans, Evelyn K Williams, Celeste K. Kanne, Kirby A Fibben, Ashwin P. Patel, Lindsey Abel, Meredith Ellen Fay, Akshay A Patwardhan, Jawa Darazim, Zachary Kostamo, Wilbur Lam, Vivien A. Sheehan

Blood (2023) 142 (Supplement 1): 3657.

https://doi.org/10.1182/blood-2023-186769

Published: 2023

Journal Articles

Using Human Genetics to Develop Strategies to Increase Erythropoietic Output from Genome-Edited Hematopoietic Stem and Progenitor Cells

Sofia E Luna, Joab Camarena, Jessica P Hampton, Kiran R Majeti, Carsten T Charlesworth, Eric Soupene, Vivien A. Sheehan, Kyle Cromer, Matthew Porteus

Blood (2023) 142 (Supplement 1): 5003.

https://doi.org/10.1182/blood-2023-174170

Published: 2023

Journal Articles

Comparison of Devices That Measure Sickle Red Cell Deformability

Akshay A Patwardhan, Solomon Oshabaheebwa, Christopher A. Delianides, Zoe Sekyonda, Ashwin P Patel, Erica N Evans, Justin J Yoo, Lindsey Abel, Michael A. Suster, Pedram Mohseni, Umut A. Gurkan, Vivien A Sheehan

Blood (2023) 142 (Supplement 1): 3669.

https://doi.org/10.1182/blood-2023-187557

Published: 2023

Journal Articles

Reduction in Opioid Use and Clinical Complications in Vitamin D Deficient Pediatric SCD Patients Following Vitamin D Replacement

Ashwin Patel, Dorothy Kim Waller, Luis Leon Novelo, Jonathan M. Flanagan, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 8266–8267.

https://doi.org/10.1182/blood-2022-164989

Published: 2022

Journal Articles

Functionality of a Peripheral Blood Derived Microglia-like Cell System for Drug Discovery to Treat Sickle Cell Related Chronic Pain

Yankai Zhang, Celeste K. Kanne, Britney N. Hernandez, Michael J. Lacagnina, Peter M. Grace, Mark J. Burish, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 2498–2499.

https://doi.org/10.1182/blood-2022-169831

Published: 2022

Journal Articles

GBT021601 Increases Hemoglobin and Improves Red Blood Cell Deformability without Rebound Hyperviscosity upon Drug Clearance in a Sickle Mouse Model

Celeste K. Kanne, Christina Liu, Britney N. Hernandez, Erica N. Evans, Mira P. Pochron, Kobina Dufu, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 5393–5394.

https://doi.org/10.1182/blood-2022-169599

Published: 2022

Journal Articles

Development of a High-Throughput Drug Screening System Based on Human Peripheral Blood Derived Microglia-like Cells from Sickle Cell Patients with Chronic Pain

Yankai Zhang, Celeste K. Kanne, Michael J. Lacagnina, Peter M. Grace, Mark J. Burish, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 10678–10679.

https://doi.org/10.1182/blood-2022-167510

Published: 2022

Journal Articles

Characterization of Hemoglobin Variants Due to in-Frame Deletions in the β-Globin Gene from CRISPR/Cas9 Gene Correction for Sickle Cell Disease

Alex Alex Pendergast, So Hyun Park, Loren A. Binns, Celeste K. Kanne, Cecile Karsenty, Britney N. Hernandez, Byoungyong Yoo, Yankai Zhang, Gang Bao, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 7793–7794.

https://doi.org/10.1182/blood-2022-166931

Published: 2022

Journal Articles

Optimization of an Adherent Microfluidic Device for Use in Sickle Cell Disease

Erica N Evans, Celeste K. Kanne, Evelyn Kendall Williams, Kirby S. Fibben, Meredith A Fay, Wilbur A. Lam, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 13011–13012.

https://doi.org/10.1182/blood-2022-167137

Published: 2022

Journal Articles

S. Aureus Cas9 Leads to Higher Sickle Mutation Correction Compared to S. Pyogenes Cas9 in Patient Hematopoietic Stem and Progenitor Cells

Byoungyong Yoo, So Hyun Julie Park Park, Yankai Zhang, Vivien A. Sheehan, Gang Bao

Blood (2021) 138 (Supplement 1): 1861.

https://doi.org/10.1182/blood-2021-150830

Published: 2021

Journal Articles

CRISPR/Cas9 Editing Induces High Rates of Unintended Large Gene Modifications in HSPCs from Patients with Sickle Cell Disease

So Hyun Julie Park Park, Mingming Cao, Yankai Zhang, Vivien A. Sheehan, Gang Bao

Blood (2021) 138 (Supplement 1): 3969.

https://doi.org/10.1182/blood-2021-150739

Published: 2021

Journal Articles

Identification of Biomarkers That Are Associated with Clinical Complications of Hemoglobin SC Disease and Sickle Cell Anemia

Minke A.E. Rab, Celeste K. Kanne, Mitchel C. Berrevoets, Jennifer Bos, Brigitte A. van Oirschot, Erik Teske, Roger E.G. Schutgens, Gerard Pasterkamp, Richard van Wijk, Eduard J. Van Beers, Vivien A. Sheehan

Blood (2021) 138 (Supplement 1): 962.

https://doi.org/10.1182/blood-2021-145376

Published: 2021

Journal Articles

Use of Red Blood Cell Phenotypes for Second Line Therapy Selection in Sickle Cell Disease

Celeste K. Kanne, Ashwin P Patel, Minke A.E. Rab, Brigitte A. van Oirschot, Jennifer Bos, Evelyn Kendall Williams, Meredith E. Fay, Kirby S. Fibben, Wilbur A. Lam, Richard van Wijk, Vivien A. Sheehan

Blood (2021) 138 (Supplement 1): 2053.

https://doi.org/10.1182/blood-2021-153919

Published: 2021

NARROW

Evaluation of GBT021601 As a Therapeutic Agent to Restore Bone Marrow Health and Effective Erythropoiesis in a Sickle Mouse Model

Evaluation of the Impact of a Naturally Occurring Beta Hemoglobin Variant, Hb G-Makassar, on Mature Red Blood Cell Function and Pathology in a Sickle Cell Disease Mouse Model

A Miniaturized, Rapid Technique for Measuring Red Blood Cell-Mediated Microcapillary Occlusion in HbAS, HbSC, and HbSS Sickle Cell Disease Genotypes

Red Cell Rheology and Blood Viscosity in Pediatric Individuals Having Received Allogenic Hematopoietic Stem Cell Transplantation or Ex Vivo Autologous Gene Therapy for Sickle Cell Disease

Impact of Vaso-Occlusive Crises on the Transcriptomes of Patients with Sickle Cell Disease

A Phase 2, Open-Label Study to Assess the Pharmacokinetics, Pharmacodynamics and Safety of Orally Administered Epeleuton in Patients with Sickle Cell Disease

Rheological Characteristics of Elderly Individuals with Sickle Cell Disease Compared with an Adult Sickle Cell Population

Radchip: A Laminin-Lined Red Blood Cell (RBC) Adhesion Device for Functional Characterization and Clinical Evaluation of Sickle RBCs at Steady-State

Using Human Genetics to Develop Strategies to Increase Erythropoietic Output from Genome-Edited Hematopoietic Stem and Progenitor Cells

Comparison of Devices That Measure Sickle Red Cell Deformability

Reduction in Opioid Use and Clinical Complications in Vitamin D Deficient Pediatric SCD Patients Following Vitamin D Replacement

Functionality of a Peripheral Blood Derived Microglia-like Cell System for Drug Discovery to Treat Sickle Cell Related Chronic Pain

GBT021601 Increases Hemoglobin and Improves Red Blood Cell Deformability without Rebound Hyperviscosity upon Drug Clearance in a Sickle Mouse Model

Development of a High-Throughput Drug Screening System Based on Human Peripheral Blood Derived Microglia-like Cells from Sickle Cell Patients with Chronic Pain

Characterization of Hemoglobin Variants Due to in-Frame Deletions in the β-Globin Gene from CRISPR/Cas9 Gene Correction for Sickle Cell Disease

Optimization of an Adherent Microfluidic Device for Use in Sickle Cell Disease

S. Aureus Cas9 Leads to Higher Sickle Mutation Correction Compared to S. Pyogenes Cas9 in Patient Hematopoietic Stem and Progenitor Cells

CRISPR/Cas9 Editing Induces High Rates of Unintended Large Gene Modifications in HSPCs from Patients with Sickle Cell Disease

Identification of Biomarkers That Are Associated with Clinical Complications of Hemoglobin SC Disease and Sickle Cell Anemia

Use of Red Blood Cell Phenotypes for Second Line Therapy Selection in Sickle Cell Disease

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American Society of Hematology

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ASH Publications

American Society of Hematology

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