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Journal Articles

Heat stress activates the coagulation cascade through Z-DNA-binding protein 1-dependent necroptosis

Fanglin Li, Jinxiu Li, Jian Shi, Xinyu Yang, Ting Zhang, Hao Liu, Fengjie Wang, Xiao Yan, Qiuli He, Long Wu, Yong Zou, Yiting Tang, Erhua Wang, Yanjun Zhong

Blood blood.2025030764.

https://doi.org/10.1182/blood.2025030764

Published: 2026

Includes: Supplemental data

Journal Articles

Title: Hacs1 is a myeloma immunosuppressor driving pro-tumorigenic myelopoiesis and myeloid cell differentiation through MS4A3/IL3/GM-CSF signaling

DingYan Wang, Xiao-Yan Wen, Jamie Li, Raymond Qu, Wiiliam JiaYi Wu, Xinmiao Andrew Yang, Derek Shiqi Xu, Jingdong Wu, Leqi Shen, Jeremy Dai, Yuan Gao, Jinyi Zhang, Anthony Gramolini Gramolini, Xiaoyuan Liu, Katherine Siminovitch, Keith Stewart

Blood (2025) 146 (Supplement 1): 7480.

https://doi.org/10.1182/blood-2025-7480

Published: 2025

Journal Articles

Normal B Cells in MBL follow divergent maturation pathways that correlate with the IGHV mutation status of the pre-leukemic clone

Gonzalo Blanco, Xiao Yan, Anita Kar Yun Ng, Andrew Shih, Jacqueline Aldridge, Anna Puiggros, Lindybeth Sarmiento, Jonathan Kolitz, Steven Allen, Kanti Rai, Douglas Stewart, Blanca Espinet, Gerald Marti, Neil Caporaso, Marcelo Navarrete, Nicholas Chiorazzi

Blood (2025) 146 (Supplement 1): 3910.

https://doi.org/10.1182/blood-2025-3910

Published: 2025

Journal Articles

ICAM-2 mediates adhesion of acute myeloid leukemia cells to bone marrow microenvironment and promotes chemoresistance

Xinqi Li, Muheremu Muhetaer, Jin xian Liu, Xiao yan Liu, Fuling Zhou

Blood (2025) 146 (Supplement 1): 1691.

https://doi.org/10.1182/blood-2025-1691

Published: 2025

Journal Articles

Coexisting trisomies of chromosomes 12 and 19 define a cytogenetic subgroup of IgG+ CLL enriched for BIRC3 mutations

Blood (2025) 146 (Supplement 1): 7410.

https://doi.org/10.1182/blood-2025-7410

Published: 2025

Journal Articles

Foreign antigen delivered to CLL B cells via membrane IgD leads to a distinct antigen processing pathway that allows antigen-specific T cell activation that is superior to membrane IgM delivery

Martina Cardillo, Matthew Friedman, Xiao Yan, Anita Kar Yun Ng, Randall Davis, Michael Ryan, Peter Gregersen, Steven Allen, Jonathan Kolitz, Kanti Rai, Paolo Ghia, Nicholas Chiorazzi

Blood (2025) 146 (Supplement 1): 3882.

https://doi.org/10.1182/blood-2025-3882

Published: 2025

Journal Articles

Dynamic crosstalk between CLL cells and lymph node fibroblasts promotes a pro-tumor microenvironment

Yu-Ju Chen, Antonio Ferreira, Kelly Wong, Samantha Stoneking, Angelika Jiang, Anita Kar Yun Ng, Martina Cardillo, Gonzalo Blanco, Xiao Yan, Susan Buhl, Matthew Scharff, Nicholas Chiorazzi, Ivan Maillard, Jon Aster, Shih-Shih Chen

Blood (2025) 146 (Supplement 1): 241.

https://doi.org/10.1182/blood-2025-241

Published: 2025

Journal Articles

The Immune Inhibitory Hematopoietic Adaptor Protein Hacs1(Sly2) Suppresses the Proinflammatory Macrophage Function Contributing to Multiple Myeloma Progression

Ding Yan Wang, Ming Liu, Jamie Li, Raymond Qu, Keva Garg, Yuan Gao, Xinmiao Andrew Yang, Leqi Shen, Jingdong Wu, Xiaoyuan Liu, Derek Shiqi Xu, Cecilia Bonolo De Campos, Jinyi Zhang, Anthony Gramolini, Katherine Siminovitch, Xiao-Yan Wen, A. Keith Stewart

Blood (2024) 144 (Supplement 1): 3271.

https://doi.org/10.1182/blood-2024-209501

Published: 2024

Journal Articles

Development and Validation of a Specific and Sensitive Anti-Drug Antibody Assay for Abelacimab That Avoids False Positive Results Due to Factor XI Interference

Connie Cullen, Xiao-Yan Cai, Cansu Dernek, Debra Freedholm

Blood (2021) 138 (Supplement 1): 4274.

https://doi.org/10.1182/blood-2021-153363

Published: 2021

Journal Articles

Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

Tiancheng Fang, Yurun Zhang, Vivian Y. Chang, Martina Roos, Christina M. Termini, Lia Signaevskaia, Mamle Quarmyne, Paulina K. Lin, Amara Pang, Jenny Kan, Xiao Yan, Anna Javier, Katherine Pohl, Liman Zhao, Peter Scott, Heather A. Himburg, John P. Chute

Blood (2020) 136 (4): 441–454.

https://doi.org/10.1182/blood.2020005895

Published: 2020

Includes: Supplemental data

Journal Articles

P-Gemox Regimen(Pegaspargase, Gemcitabine, oxaliplatin) for Extranodal Natural Killer Cell Lymphoma: 10 Years' Real-World Clinical Experience from China

Gao Yan, Hui-qiang Huang, MD PhD, Wang Xiaoxiao, Bai Bing, Pengfei Li, Hui Zhou, Zhi-gang Peng, Xiao-yan Ke, Kai-yang Ding, Yu Yang, MD, Sha-dong Min, Yue-rong Shuang, Li Zhiming, Cai Qingqing, Bingzong Li, MDPhD, Wenqi Jiang

Blood (2018)

https://doi.org/10.1182/blood-2018-99-116551

Published: 2018

Journal Articles

Set7 Is Highly Expressed in B-Lineage Acute Lymphoblastic Leukemia Cells and Overexpression of Set7 Exhibits Antileukemia Effect

Xiao-Tong Ma, PhD, Ya-Kun Mou, MD, Yang-Yang Zhao, PhD, Nan Wang, PhD, Xiao-Yan Liu, Jing Yin, Yan-Ping Ma, Dan Guo, PhD

Blood (2016) 128 (22): 5088.

https://doi.org/10.1182/blood.V128.22.5088.5088

Published: 2016

Journal Articles

The Combination Effect of Homoharringtonine and Ibrutinib on FLT3-ITD Mutant Acute Myeloid Leukemia

Xia Li, PhD, Xiufeng Yin, PhD, Huafeng Wang, Jiansong Huang, PhD, Mengxia Yu, PhD, Zhixin Ma, PhD, Chenying Li, Yile Zhou, Xiao Yan, Shujuan Huang, Jie Jin, MD PhD

Blood (2016) 128 (22): 5225.

https://doi.org/10.1182/blood.V128.22.5225.5225

Published: 2016

Journal Articles

A Small Molecule Inhibitor of Protein Tyrosine Phosphatase-Sigma (PTPσ) Promotes Hematopoietic Stem Cell (HSC) Regeneration

Yurun Zhang, Mamle Quarmyne, PhD, Heather A Himburg, PhD, Xiao Yan, William McBride, PhD, Michael Jung, PhD, John P. Chute, MD

Blood (2016) 128 (22): 822.

https://doi.org/10.1182/blood.V128.22.822.822

Published: 2016

Journal Articles

Targeted Inhibition of Activated Protein C Anticoagulant Activity By Monoclonal Antibody HAPC1573 for Treatment of Hemophilia

Xiao-Yan Zhao, PhD, Subramanian Yegneswaran, PhD, Maxine Bauzon, Derek Sim, Chandra Patel, PhD, Doug Schneider, Kirk McLean, Ying Zhu, MD, Xiaoqiao Jiang, Vince Evans, Jian-Ming Gu, PhD, Inge Ivens, PhD, Jun Xu, PhD, Peter Wolfgang Bringmann, PhD, Katalin Kauser, Charles Esmon, PhD

Blood (2016) 128 (22): 80.

https://doi.org/10.1182/blood.V128.22.80.80

Published: 2016

Journal Articles

Dickkopf 1 (Dkk1) Regulates Hematopoietic Stem Cell Regeneration

Heather A Himburg, PhD, Phuong L Doan, MD, Xiao Yan, Mamle Quarmyne, PhD, Liman Zhao, Evelyn Tran, Nelson J. Chao, MD, Jeffrey Harris, PhD, John P Chute, MD

Blood (2015) 126 (23): 1200.

https://doi.org/10.1182/blood.V126.23.1200.1200

Published: 2015

Journal Articles

Growth Factor Receptor-Bound Protein 10 (Grb10) Regulates Hematopoietic Stem Cell (HSC) Self-Renewal Via Control of mTOR Signaling

Xiao Yan, Heather A Himburg, PhD, Phuong L Doan, MD, Mamle Quarmyne, PhD, Evelyn Tran, Liman Zhao, Nelson J. Chao, MD, John P Chute, MD

Blood (2015) 126 (23): 1160.

https://doi.org/10.1182/blood.V126.23.1160.1160

Published: 2015

Journal Articles

Protein Tyrosine Phosphatase-Sigma (PTPσ) Regulates Hematopoietic Stem Cell Repopulating Capacity

Mamle Quarmyne, Phuong L. Doan, MD, Heather A. Himburg, PhD, Xiao Yan, Liman Zhao, Nelson J. Chao, MD, John P. Chute, MD

Blood (2014) 124 (21): 4309.

https://doi.org/10.1182/blood.V124.21.4309.4309

Published: 2014

Journal Articles

WBC More Than 300 *10 9 /L Confers an Adverse Outcome in Pediatric Acute Lymphoblastic Leukemia Patients Treated By Protocol(CCLG-2008 )

Shaoyan Hu, MD PhD, Xiao-yan Yang, Hai-long He, MD, Jun LU, Yi WANG, Wenli Zhao, Peifang Xiao, Yi-huan Chai

Blood (2014) 124 (21): 5244.

https://doi.org/10.1182/blood.V124.21.5244.5244

Published: 2014

Journal Articles

Growth Factor Receptor-Bound Protein 10 (Grb10) Regulates Hematopoietic Stem Cell Renewal

Xiao Yan, Heather A. Himburg, PhD, Phuong L. Doan, MD, Mamle Quarmyne, Nelson J. Chao, MD, John P. Chute, MD

Blood (2014) 124 (21): 248.

https://doi.org/10.1182/blood.V124.21.248.248

Published: 2014

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Heat stress activates the coagulation cascade through Z-DNA-binding protein 1-dependent necroptosis

Title: Hacs1 is a myeloma immunosuppressor driving pro-tumorigenic myelopoiesis and myeloid cell differentiation through MS4A3/IL3/GM-CSF signaling

Normal B Cells in MBL follow divergent maturation pathways that correlate with the IGHV mutation status of the pre-leukemic clone

ICAM-2 mediates adhesion of acute myeloid leukemia cells to bone marrow microenvironment and promotes chemoresistance

Coexisting trisomies of chromosomes 12 and 19 define a cytogenetic subgroup of IgG+ CLL enriched for BIRC3 mutations

Foreign antigen delivered to CLL B cells via membrane IgD leads to a distinct antigen processing pathway that allows antigen-specific T cell activation that is superior to membrane IgM delivery

Dynamic crosstalk between CLL cells and lymph node fibroblasts promotes a pro-tumor microenvironment

The Immune Inhibitory Hematopoietic Adaptor Protein Hacs1(Sly2) Suppresses the Proinflammatory Macrophage Function Contributing to Multiple Myeloma Progression

Development and Validation of a Specific and Sensitive Anti-Drug Antibody Assay for Abelacimab That Avoids False Positive Results Due to Factor XI Interference

Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

P-Gemox Regimen(Pegaspargase, Gemcitabine, oxaliplatin) for Extranodal Natural Killer Cell Lymphoma: 10 Years' Real-World Clinical Experience from China

Set7 Is Highly Expressed in B-Lineage Acute Lymphoblastic Leukemia Cells and Overexpression of Set7 Exhibits Antileukemia Effect

The Combination Effect of Homoharringtonine and Ibrutinib on FLT3-ITD Mutant Acute Myeloid Leukemia

A Small Molecule Inhibitor of Protein Tyrosine Phosphatase-Sigma (PTPσ) Promotes Hematopoietic Stem Cell (HSC) Regeneration

Targeted Inhibition of Activated Protein C Anticoagulant Activity By Monoclonal Antibody HAPC1573 for Treatment of Hemophilia

Dickkopf 1 (Dkk1) Regulates Hematopoietic Stem Cell Regeneration

Growth Factor Receptor-Bound Protein 10 (Grb10) Regulates Hematopoietic Stem Cell (HSC) Self-Renewal Via Control of mTOR Signaling

Protein Tyrosine Phosphatase-Sigma (PTPσ) Regulates Hematopoietic Stem Cell Repopulating Capacity

WBC More Than 300 *10 9 /L Confers an Adverse Outcome in Pediatric Acute Lymphoblastic Leukemia Patients Treated By Protocol(CCLG-2008 )

Growth Factor Receptor-Bound Protein 10 (Grb10) Regulates Hematopoietic Stem Cell Renewal

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