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Journal Articles

3D Genomics of Acute Meyloid Leukemia Reveals the Imbalance between DNA Methylation Canyon Interactions and Leukemic Specific Enhancer Network Interactions

Xiaotian Zhang, PhD, Xue Qing David Wang, PhD, Haley Gore, MS, Pamela Himadewi, BSc, Fan Feng, Jie Liu, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45.
https://doi.org/10.1182/blood-2020-141708
Published: 2020
Journal Articles

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis

Xiaotian Zhang, Xinyu Wang, Xue Qing David Wang, Jianzhong Su, Nagireddy Putluri, Ting Zhou, Ying Qu, Mira Jeong, Anna Guzman, Carina Rosas, Yun Huang, Arun Sreekumar, Wei Li, Margaret A. Goodell
Journal: Blood
Blood (2020) 135 (11): 845–856.
https://doi.org/10.1182/blood.2019003330
Published: 2020
Includes: Supplemental data
Journal Articles

Chromosomal Loop Editing Reveals New Epigenomic Landscape in the β-Globin Locus with Implications for Hemoglobinopathy Therapies

Pamela Himadewi, BSc, Xiaotian Zhang, PhDBS, Haley Gore, MS, Xue Qing David Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 813.
https://doi.org/10.1182/blood-2019-125020
Published: 2019
Journal Articles

A Gene Depleted DNA Methylation Canyon Maintains Hematopoietic Stem Cell Self-Renewal and NPM1c+ Leukemia By Regulating the Gene Expression of HOXA Cluster

Xiaotian Zhang, PhDBS, Margaret Goodell, PhD, Mira Jeong, PhD, Haley Gore, Wanding Zhou
Journal: Blood
Blood (2018) 132 (Supplement 1): 649.
https://doi.org/10.1182/blood-2018-99-112962
Published: 2018
Journal Articles

Large DNA Methylation Canyons Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Mira Jeong, PhD, Xiangfan Huang, Xiaotian Zhang, PhDBS, Jianzhong Su, Muhammad S Shamim, Ivan D Bochkov, Jaime M. Reyes, BS, Haiyoung Jung, Emily Beth Heikamp, MD PhD MSc, Aviva P Aiden, Wei Li, Erez Lieberman Aiden, Margaret A. Goodell, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 534.
https://doi.org/10.1182/blood-2018-99-119485
Published: 2018
Journal Articles

High Order Chromatin Structure Regulates Gene Expression in Hematopoietic Stem Cell Self-Renewal and Erythroid Differentiation

Xiaotian Zhang, BS, Mira Jeong, PhD, Ivan Bochkov, Muhammad Saad Shamim, Erez Lieberman Aiden, Margaret Goodell, PhD
Journal: Blood
Blood (2016) 128 (22): 1033.
https://doi.org/10.1182/blood.V128.22.1033.1033
Published: 2016
Journal Articles

DNA Epigenome Editing Using Crispr-Cas Suntag-Directed DNMT3A

Yung-Hsin Huang, BS, Su Jianzhong, PhD, Yong Lei, PhD, Michael C Gundry, BS, Xiaotian Zhang, BS, Mira Jeong, PhD, Wei Li, PhD, Margaret A Goodell, PhD
Journal: Blood
Blood (2016) 128 (22): 2707.
https://doi.org/10.1182/blood.V128.22.2707.2707
Published: 2016
Journal Articles

Dnmt3a and Tet2 interact to Repress differentiation lineage-specific transcriptional factors in Hematopoietic Stem Cells By the Regulation of Epigenome

Xiaotian Zhang, BS, Mira Jeong, PhD, Jianzhong Su, Myung Gon Ko, PhD, Yun Huang, PhD, Hyun Jung Park, Anjana Rao, PhD, Wei Li, PhD, Margaret A. Goodell, PhD
Journal: Blood
Blood (2014) 124 (21): 242.
https://doi.org/10.1182/blood.V124.21.242.242
Published: 2014
Journal Articles

Large Conserved Domains Of Low DNA Methylation Maintained By 5-Hydroxymethycytosine and Dnmt3a

Mira Jeong, Ph.D., Deqiang Sun, Min Luo, Ph.D., Yun Huang, PhD, Myunggon Ko, PhD, Lucas Chavez, Grant A Challen, PhD, Benjamin Rodriguez, Xiaotian Zhang, B.S, Liubin Yang, Hui Wang, Ph.D., Rui Chen, Ph.D., Rebecca Hannah, Ph.D., Sang-Bae Kim, Ju-Seog Lee, Berthold Gottgens, Ph.D., Preethi Gunaratne, Lucy A Godley, Gretchen Darlington, Ph.D., Anjana Rao, PhD, Wei Li, Ph.D., Margaret A. Goodell, PhD
Journal: Blood
Blood (2013) 122 (21): 2406.
https://doi.org/10.1182/blood.V122.21.2406.2406
Published: 2013
Journal Articles

Dnmt3a-Deletion Accelerates FLT3-ITD Malignancies In Mice By Hypomethylation Of Enhancer Sites and Activating Stem Cell Programs; Implications For Therapy

Liubin Yang, Benjamin Rodriguez, Min Luo, Ph.D., Mira Jeong, Ph.D., David Ruau, Choladda V. Curry, MD, Xiaotian Zhang, B.S, Grant A Challen, PhD, Rachel E. Rau, MD, Berthold Gottgens, Ph.D., Wei Li, Ph.D., Margaret A. Goodell, PhD
Journal: Blood
Blood (2013) 122 (21): 595.
https://doi.org/10.1182/blood.V122.21.595.595
Published: 2013
Journal Articles

Combined Effect Of Dnmt3a Loss-Of-Function and Idh2 neomorphic mutation Promotes Hematopoietic Malignancy

Xiaotian Zhang, B.S, Ting Zhou, M.D., Putluri Nagireddy, PhD, George Michailidis, PhD, Mira Jeong, Ph.D., Arun Sreekumar, PhD, Vivienne I. Rebel, MD, PhD, Margaret A. Goodell, PhD
Journal: Blood
Blood (2013) 122 (21): 884.
https://doi.org/10.1182/blood.V122.21.884.884
Published: 2013