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Journal Articles

TET2-Mediated Dysregulation of Heterochromatin in Age-Related Clonal Hematopoiesis

Tingting Hong, Jia Li, Lei Guo, Maryn Cavalier, Tianlu Wang, Shaohai Fang, Anna Guzman, Katharina Wohlan, Chiraag Kapadia, Yaling Yang, C. Cameron Yin, Shaoying Li, M. James You, Xiaodong Cheng, Yubin Zhou, Margaret Goodell, Yun Nancy Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 5606.
https://doi.org/10.1182/blood-2023-178792
Published: 2023
Journal Articles

DNMT3A Regulates Megakaryocyte-Primed HSC Lineage Fate Decisions

Sarah Waldvogel, Rachel E. Rau, Virginia Camacho, Ashlyn G. Laidman, Anna Guzman, Alejandra G Martell, Kellie Machlus, Margaret Goodell
Journal: Blood
Blood (2023) 142 (Supplement 1): 1303.
https://doi.org/10.1182/blood-2023-187363
Published: 2023
Journal Articles

Combination of the Kdm-Family Inhibitor, Jib-04, Improves Response to Acute Myeloid Leukemia Cells to Venetoclax

Katharina Wohlan, Dandan Fan, Anna Guzman, Jianzhong Su, Margaret A. Goodell, Rachel E. Rau
Journal: Blood
Blood (2022) 140 (Supplement 1): 5953–5954.
https://doi.org/10.1182/blood-2022-160199
Published: 2022
Journal Articles

Clonal Competition: Cisplatin Treatment Drives Dominance of TP53- over Tet2-Mutant Stem Cell Clones

Katharina Wohlan, Lorenzo Brunetti, Joanne I. Hsu, Katie A. Matatall, Rebecca L. Murdaugh, Linda Zhang, Anna Guzman, Jack Toups, Daniel Hormaechea-Agulla, Carina Rosas, Meghan Kisiel, Ayumi Kitano, Tianyuan Hu, Yu-Jung Tseng, Bailee N. Kain, Sara Biesiadny, Jonathan Tiessen, Minhua Li, Marcus Florez, Sarah Waldvogel, Kristen Kurtz, Mira Jeong, Duy Le, Daniel E. Morales-Mantilla, Hannah Yan, Alejandra Garcia Martell, Chiraag D. Kapadia, Yung-Hsin Huang, Shannon E. Conneely, Rogelio Aguilar, Xiangguo Shi, Tianpeng Gu, Hyojeong Han, Yajian Jiang, Jason Rogers, Taishi Yonezawa, Apoorva Thatavarty, Ruoqiong Cao, Trisha K. Wathan, Nesa Mercer, Daniel Kennedy, Ayala Tovy, Jaime M. Reyes, Marek Kimmel, Yun Huang, Daisuke Nakada, Katherine Y. King, Margaret A. Goodell
Journal: Blood
Blood (2022) 140 (Supplement 1): 8590–8591.
https://doi.org/10.1182/blood-2022-164858
Published: 2022
Journal Articles

Tet2 Deficiency Rejuvenates Hematopoietic Stem and Progenitor Cells during Ageing

Tingting Hong, Shengli Li, PhD, Shaohai Fang, MS, Anna Guzman, Wei Han, MS, Yubin Zhou, PhD, Leng Han, PhD, Margaret Goodell, PhD, Yun Huang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37.
https://doi.org/10.1182/blood-2020-141705
Published: 2020
Journal Articles

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis

Xiaotian Zhang, Xinyu Wang, Xue Qing David Wang, Jianzhong Su, Nagireddy Putluri, Ting Zhou, Ying Qu, Mira Jeong, Anna Guzman, Carina Rosas, Yun Huang, Arun Sreekumar, Wei Li, Margaret A. Goodell
Journal: Blood
Blood (2020) 135 (11): 845–856.
https://doi.org/10.1182/blood.2019003330
Published: 2020
Includes: Supplemental data
Journal Articles

A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells

Lei Guo, PhD, Jia Li, PhD, Hongxiang Zeng, PhD, Anna Guzman, Tingting Li, MD, Minjung Lee, MS, Yubin Zhou, PhD, Clifford Stephan, Peter J.A Davies, Margaret Goodell, PhD, Deqiang Sun, PhD, Mark A. Dawson, PhD MBBS, Yun Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5053.
https://doi.org/10.1182/blood-2019-130586
Published: 2019
Journal Articles

Antibiotics Treatment Ameliorates TET2 Loss of Function Associated Hematological Malignancies

Hongxiang Zeng, PhD, Hailan He, MS, Jia Li, PhD, Wei Han, MS, Anna Guzman, Deqiang Sun, PhD, Katherine Y. King, MD PhD, Margaret A. Goodell, PhD, Yun Huang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2610.
https://doi.org/10.1182/blood-2018-99-116424
Published: 2018
Journal Articles

Nearly a Third of Clonal Hematopoiesis-Associated DNMT3A Mutations Reduce Protein Stability and May be Associated with Poorer Prognosis

Yung-Hsin Huang, Ayala Tovy, PhD, Venkatasubramaniam Sundaramurthy, Jianzhong Su, Joanne Hsu, BS, Lian He, Anna Guzman, Yubin Zhou, Alexander Meissner, PhD, Wei Li, Margaret A. Goodell, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1315.
https://doi.org/10.1182/blood-2018-99-115275
Published: 2018
Journal Articles

Mosaic DNMT3A Germline Mutation As a Model for Mutant DNMT3A Competitive Advantage in the Blood Lineage

Ayala Tovy, PhD, Hyun Jung Park, PhD, Jaime M. Reyes, BS, Anna Guzman, Rachel E. Rau, MD, Aaron Jeffries, PhD, Mill Jonnathan, PhD, Emma Baple, PhD, Andrew Crosby, MD, Mia Petljak, Henry Lee-Six, PhD, Heng Wang, MD PhD, Xin Baozhong, MD PhD, Mathijs A. Sanders, PhD, Peter J. Campbell, PhD, Michael Stratton, Wei Li, Margaret Goodell, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 173.
https://doi.org/10.1182/blood-2018-173
Published: 2018
Journal Articles

Loss of De Novo DNA Methyltransferase DNMT3A Impacts Alternative Splicing in Hematopoietic Stem Cells

Raghav Ramabadran, BS, Jarey Wang, Anna Guzman, Sean Michael Cullen, MD PhD, Lorenzo Brunetti, MD, Michael Gundry, Sunny Chan, PhD, Michael Kyba, PhD, Thomas Westbrook, PhD, Margaret Goodell, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1.
https://doi.org/10.1182/blood.V130.Suppl_1.1.1
Published: 2017
Journal Articles

Acute Myeloid Leukemia with Mutated NPM1 Is Dependent on the Cytoplasmic Localization of NPM1c

Lorenzo Brunetti, MD, Michael Gundry, Anna Guzman, Ilaria Gionfriddo, PhD, Federica Mezzasoma, PhD, Francesca Milano, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Margaret Goodell, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 877.
https://doi.org/10.1182/blood.V130.Suppl_1.877.877
Published: 2017