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Journal Articles

Collection and Processing of Bone Marrow at 3% Oxygen Significantly Alters the Manifestation of Aged Mouse Hematopoietic Stem Cell Phenotype

Maegan L. Capitano, PhD, Scott Cooper, M.S., Bin Guo, PhD, Xinxin Huang, PhD, Carol Sampson, MS, Safa Mohamad, Edward F. Srour, PhD, Christie M. Orschell, PhD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1202.
https://doi.org/10.1182/blood-2019-128642
Published: 2019
Journal Articles

Chromatin Remodeling Subunit Brm Regulates Hematopoietic Stem Cell Self-Renewal By Limiting Intracellular Valine Levels

Samisubbu R Naidu, PhD, Maegan L. Capitano, PhD, Scott Cooper, MS, Xinxin Huang, PhD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3702.
https://doi.org/10.1182/blood-2019-128867
Published: 2019
Journal Articles

CD166 Engagement Augments Mouse and Human Hematopoietic Stem and Progenitor Function Via Activation of Stem Cell-Associated and Cell Cycle Pathways

Joydeep Ghosh, PhD, Jing Zhang, PhD, Chi Zhang, PhD, Xinxin Huang, PhD, Safa F. Mohamad, MS, Maegan L. Capitano, PhD, Andrea M. Gunawan, Scott Cooper, MS, Bin Guo, PhD, Qingchun Cai, PhD, Hal E. Broxmeyer, PhD, Edward F. Srour, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1282.
https://doi.org/10.1182/blood-2018-99-119251
Published: 2018
Journal Articles

Nitric Oxide Promotes Human Hematopoietic Stem Cell Homing and Engraftment Via cGMP-Pkg Signaling

Xinxin Huang, PhD, Bin Guo, PhD, Maegan L. Capitano, PhD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 807.
https://doi.org/10.1182/blood-2018-99-112993
Published: 2018
Journal Articles

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

Maegan Capitano, Liang Zhao, Scott Cooper, Chelsea Thorsheim, Aae Suzuki, Xinxin Huang, Alexander L. Dent, Michael S. Marks, Charles S. Abrams, Hal E. Broxmeyer
Journal: Blood
Blood (2018) 132 (10): 1027–1038.
https://doi.org/10.1182/blood-2017-09-806257
Published: 2018
Includes: Supplemental data
Journal Articles

Patient-Tailored Mouse Genome Editing Recapitulates Hematopoietic and Systemic Manifestations of Barth Syndrome

Donna Edwards, PhD, Elizabeth Sierra Potchanant, PhD, Xinxin Huang, PhD, Zejin Sun, PhD, Maegan Capitano, PhD, Caroline Miller, Ying He, Hal E. Broxmeyer, PhD, Grzegorz Nalepa, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 775.
https://doi.org/10.1182/blood.V130.Suppl_1.775.775
Published: 2017
Journal Articles

Antagonizing PPARγ Expands Human Hematopoietic Stem and Progenitor Cells By Switching on FBP1-Repressed Glycolysis and Preventing Differentiation

Bin Guo, PhD, Xinxin Huang, PhD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 709.
https://doi.org/10.1182/blood.V130.Suppl_1.709.709
Published: 2017
Journal Articles

Mitigating Detrimental Influences of Ambient Air Collection of Bone Marrow By Hypoxic Collection Results in Detection of Functionally Enhanced Aged Mouse Hematopoiesis: Reflecting Stem Cell Expression Levels of CXCR4, CCR5 and ROS

Maegan Capitano, PhD, Scott Cooper, MS, Bin Guo, PhD, Jing Zhang, PhD, Xinxin Huang, PhD, Qingchun Cai, PhD, Heather A. O'Leary, PhD, Hui Lin Chua, PhD, Artur Plett, PhD, Christie M. Orschell, PhD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2420.
https://doi.org/10.1182/blood.V130.Suppl_1.2420.2420
Published: 2017
Journal Articles

Human Hematopoietic Stem Cell Homing and Engraftment Promoted By Glucocorticoid Induced Chromatin Remodeling

Bin Guo, PhD, Xinxin Huang, PhD, Scott Cooper, MAS, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2016) 128 (22): 494.
https://doi.org/10.1182/blood.V128.22.494.494
Published: 2016
Journal Articles

Inhibition of HDAC5-Mediated p65 Deacetylation Enhances Human Cord Blood Hematopoietic Stem Cell Homing and Engraftment in NSG Mice

Xinxin Huang, PhD, Bin Guo, PhD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2016) 128 (22): 884.
https://doi.org/10.1182/blood.V128.22.884.884
Published: 2016
Journal Articles

Activation of OCT4 Enhances Ex Vivo Expansion of Phenotypically Defined and Functionally Engraftable Human Cord Blood Hematopoietic Stem and Progenitor Cells By Regulating HOXB4 Expression

Xinxin Huang, PhD, Scott Cooper, BS, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2014) 124 (21): 4332.
https://doi.org/10.1182/blood.V124.21.4332.4332
Published: 2014
Journal Articles

Mitigation of a Newly Discovered Phenomenon, Extra Physiologic Oxygen Shock/Stress (EPHOSS), Mediated By the Mitochondria Permeability Transition Pore, Greatly Improves Stem Cell Collection and Transplantation

Charlie Mantel, Heather A. O'Leary, PhD, Brahmananda Reddy Chitteti, PhD, Xinxin Huang, PhD, Scott Cooper, BS, Giao Hangoc, DVM, PhD, Nickolay Brustovetsky, PhD, Edward F. Srour, PhD, Man Ryul Lee, PhD, Steven Messina-Graham, Nadia Falah, MD, Reuben Kapur, PhD, Louis M. Pelus, PhD, Mircea Ivan, MD, PhD, Kye-Seong Kim, PhD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2014) 124 (21): 2905.
https://doi.org/10.1182/blood.V124.21.2905.2905
Published: 2014