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Yu-hung Leung
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Journal Articles

Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML

Cheuk-Him Man, Wing Lam, Chee-Chean Dang, Xiao-yuan Zeng, Li-Chuan Zheng, Natalie Nok-Man Chan, Ka-Lam Ng, Koon-Chuen Chan, Tsz-Ho Kwok, Timothy Chi-Chun Ng, Wing-Yan Leung, Michael Shing-Yan Huen, Carmen Chak-Lui Wong, Chi Wai Eric So, Zhixun Dou, Susumu Goyama, Mark Robert Bray, Tak Wah Mak, Anskar Yu-Hung Leung
Journal: Blood
Blood (2023) 142 (23): 2002–2015.
https://doi.org/10.1182/blood.2023019782
Published: 2023
Journal Articles

Inhibition of Polo-like Kinase 4 Induced Both Cell Intrinsic and Non-Cell Intrinsic Anti-Leukemia Effects on TP53 -Mutated Acute Myeloid Leukemia

Chee Chean Dang, Ka Lam Nelson Ng, Wing Lam, Xiao Yuan Zeng, Li Chuan Zheng, Koon Chuen Chan, Timothy Chi Chun Ng, Tsz Ho Kwok, Wing Yan Leung, Michael Shing Yan Huen, Carmen Chak Lui Wong, Zhi Xun Dou, Tak Wah Mak, Cheuk Him Man, Anskar Yu Hung Leung
Journal: Blood
Blood (2022) 140 (Supplement 1): 3099.
https://doi.org/10.1182/blood-2022-165205
Published: 2022
Journal Articles

A Phase II Single-Arm Open-Labeled Study Evaluating Combination of Quizartinib and Omacetaxine Mepesuccinate (QUIZOM) in Newly Diagnosed or Relapsed/Refractory AML Carrying FlT3-ITD

Chunxiao Zhang, Garret MK Leung, MBBS, Sze Pui Tsui, MSc, Ho-Wan Ip, MBBS,FRCPA, Edmond S. K. Ma, MD, Chun Hang Au, PhD, Chris T.L. Chan, PhD, Ka Lam Nelson Ng, PhD, Sze Fai Yip, MD, Bonnie Kho, MD, Harold K K Lee, MD, Qing LIU, Thomas Wing Yan Leung, Yok Lam Kwong, MD FRCP, Anskar Yu Hung Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3825.
https://doi.org/10.1182/blood-2019-126510
Published: 2019
Journal Articles

Targeting DNA Damage and Repair in Acute Myeloid Leukemia Carrying Internal Tandem Duplication of Fms-like Tyrosine Kinase 3 (FLT3-ITD) - a Mechanistic Study

Ka Lam Nelson Ng, PhD, Claire Lynn, Thomas Wing Yan Leung, Eric Chi Wai So, PhD, Anskar Yu Hung Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1261.
https://doi.org/10.1182/blood-2019-129472
Published: 2019
Journal Articles

A Mutation Pentad Defined Outcome of De Novo and Cytogenetically Normal Acute Myeloid Leukaemia in Young Adults

Sze Pui Tsui, MSc, Ip HW Alvin, Chunxiao Zhang, Tommy W.F. Tang, CH Lin, Arthur Cheung, Grace Cheng, Jason Chi Chiu So, FRCPath,MBBS, S.Y. Leung, Tommy CH Au, Edmond S. K. Ma, MD, Chris T.L. Chan, PhD, Margaret Ng, Kelvin CK Cheng, Kit Fai Wong, MBBS, MD FRCP, FRCPath, Lisa L.P. Siu, Sze Fai Yip, MD, S.Y. Lin, Szeman June Lau, T.H. Luk, Harold K K Lee, MD, Chi Kuen Lau, FRCP, Bonnie Kho, MD, Yok Lam Kwong, MD FRCP, Asif Javed, Anskar Yu Hung Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1400.
https://doi.org/10.1182/blood-2019-130810
Published: 2019
Journal Articles

Single Cell Sequencing Reveals Evolution of Tumor Heterogeneity of Acute Myeloid Leukemia on Quizartinib

Cheryl A Cohler Peretz, MD, Lisa H F McGary, Tanya F Kumar, J Hunter Jackson, Jose Jacob, Robert Durruthy-Durruthy, PhD, Chunxiao Zhang, Mark J. Levis, MD, Alexander E. Perl, MD, Anskar Yu Hung Leung, MD PhD, Catherine C. Smith, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1440.
https://doi.org/10.1182/blood-2019-132105
Published: 2019
Journal Articles

Antioxidant N-acetyl-l-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice

e-blood
Linping Hu, Hui Cheng, Yingdai Gao, Ming Shi, Yanfeng Liu, Zheng Hu, Jing Xu, Lugui Qiu, Weiping Yuan, Anskar Yu-Hung Leung, Yong-Guang Yang, Tao Cheng
Journal: Blood
Blood (2014) 124 (20): e45–e48.
https://doi.org/10.1182/blood-2014-03-559369
Published: 2014
Includes: Supplemental data
Journal Articles

A long-term follow-up study on hepatitis B surface antigen–positive patients undergoing allogeneic hematopoietic stem cell transplantation

Clinical Trials & Observations
Chee-kin Hui, Albert Lie, Wing-yan Au, Yu-hung Leung, Shing-yan Ma, Winnie W. W. Cheung, Hai-ying Zhang, Chor-sum Chim, Yok-lam Kwong, Raymond Liang, George K. K. Lau
Journal: Blood
Blood (2005) 106 (2): 464–469.
https://doi.org/10.1182/blood-2005-02-0698
Published: 2005
Journal Articles

High hepatitis B virus (HBV) DNA viral load as the most important risk factor for HBV reactivation in patients positive for HBV surface antigen undergoing autologous hematopoietic cell transplantation

Clinical Trials & Observations
George K. K. Lau, Yu-hung Leung, Daniel Y. T. Fong, Wing-yan Au, Yok-lam Kwong, Albert Lie, Ji-lin Hou, Yu-mei Wen, Amin Nanj, Raymond Liang
Journal: Blood
Blood (2002) 99 (7): 2324–2330.
https://doi.org/10.1182/blood.V99.7.2324
Published: 2002