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Journal Articles

Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizumab, in Subjects with Newly Diagnosed Acute Graft Versus Host Disease

Blood (2019) 134 (Supplement_1): 4516.

https://doi.org/10.1182/blood-2019-127325

Published: 2019

Journal Articles

Anti-CD6 Monoclonal Antibody Itolizumab Efficiently Inhibits T Cell Proliferation after in Vitro TCR Stimulation in the Setting of Acute Graft Versus Host Disease

Benedetta Rambaldi, MD, Carol Reynolds, PhD, Sharmila Chamling Rai, BSc, Takeru Asano, MD PhD, Yohei Arihara, MD PhD, Mahasweta Gooptu, MD, John Koreth, MBBS, DPhil, Corey Cutler, MD MPH, FRCPC, Sarah Nikiforow, MD PhD, Vincent T. Ho, MD, Edwin P. Alyea, III, MD, Joseph H. Antin, MD, Rizwan Romee, MD PhD, Robert J. Soiffer, MD, Domenico Russo, MD, Jeanette Ampudia, BSc, Cherie Tracy Ng, PhD MPH, Stephen Connelly, PhD MBA, Jerome Ritz, MD

Blood (2019) 134 (Supplement_1): 4517.

https://doi.org/10.1182/blood-2019-125721

Published: 2019

Journal Articles

Itolizumab As a Potential Therapeutic for the Prevention and Treatment of Graft Vs Host Disease

Cherie Tracy Ng, PhD MPH, Jeanette Ampudia, BSc, Robert J. Soiffer, MD, Jerome Ritz, MD, Stephen Connelly, PhD MBA

Blood (2019) 134 (Supplement_1): 5603.

https://doi.org/10.1182/blood-2019-122787

Published: 2019

Journal Articles

Activated Leukocyte Cell Adhesion Molecule (ALCAM) Regulate Myeloma Cancer Stem Cell Mediated Myelomagenesis and Chemoresistance

Yuhuan Zheng, Hongmei Luo, Dan Zhang, Fangfang Wang

Blood (2018) 132 (Supplement 1): 3190.

https://doi.org/10.1182/blood-2018-99-111740

Published: 2018

Journal Articles

Single-Cell Gene Expression Analysis Identifies Alcam As a Novel Candidate Therapeutic Target in AML

Arika Shimura-Nukina, MD PhD, Yosuke Masamoto, MD PhD, Yuki Kagoya, MD PhD, Shunya Arai, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2016) 128 (22): 3915.

https://doi.org/10.1182/blood.V128.22.3915.3915

Published: 2016

Journal Articles

Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance

Blood (2016) 127 (15): 1896–1906.

https://doi.org/10.1182/blood-2015-08-665679

Published: 2016

Includes: Supplemental data

Journal Articles

The Myeloma Cells Escape from Bone Marrow to Skin Extramedullary Localization upon Bortezomib Resistance: Role of CXCR4

Valentina Marchica, Fabrizio Accardi, MD, Paola Storti, PhD, Cristina Mancini, MD, Eugenia Martella, MD, Marina Bolzoni, PhD, Katia Todoerti, Chiara Schifano, Sabrina Bonomini, Benedetta Dalla Palma, MD, Magda Marcatti, MD, Maurilio Ponzoni, MD, Antonino Neri, MD, Franco Aversa, MD, Nicola Giuliani, MD PhD

Blood (2015) 126 (23): 5315.

https://doi.org/10.1182/blood.V126.23.5315.5315

Published: 2015

Journal Articles

Neutrophils Modulate Osteoblastic Niche for Hematopoietic Progenitors Via Prostaglandin E2 Production Triggered By Sympathetic Nervous System

Yuko Kawano, MD, Chie Fukui, Kanako Wakahashi, MD, Shinichi Ishii, MD, Tomohide Suzuki, MD, Mari Sato, DDS,PhD, Noboru Asada, MDPhD, Hiroki Kawano, MD PhD, Kentaro Minagawa, MD PhD, Akiko Sada, MD PhD, Satoshi Uematsu, MDPhD, Shizuo Akira, MD PhD, Toshimitsu Uede, MD PhD, Shuh Narumiya, MDPhD, Toshimitsu Matsui, MD PhD, Yoshio Katayama, MD PhD

Blood (2014) 124 (21): 769.

https://doi.org/10.1182/blood.V124.21.769.769

Published: 2014

Journal Articles

Plerixafor Successfully Rescues Poor Mobilizers Resulting in Adequate CD34 Cell Numbers However Stem Cell Products Yield Lower Numbers of CFU/CD34 and Delayed Neutrophil Engraftment

David Szwajcer, MD FRCPC, Anna Blankstein, Miranda M. Charette, MD, Qingdong Guan, MD PhD, Donna A. Wall, MD

Blood (2014) 124 (21): 2450.

https://doi.org/10.1182/blood.V124.21.2450.2450

Published: 2014

Journal Articles

CD166+CD34+ Cells Exhibit Marked Functional Differences During Fetal and Adult Life

Saloomeh Mokhtari, Zanetta S. Lamar, MD, Chris Booth, Frank Marini, III, PhD, Christopher D Porada, PhD, Graca Almeida-Porada, MD, PhD

Blood (2013) 122 (21): 2435.

https://doi.org/10.1182/blood.V122.21.2435.2435

Published: 2013

Journal Articles

Deletion Of Core Binding Factors Runx1 and Runx2 Leads To Perturbed Hematopoiesis In Multiple Lineages

John Anto Pulikkan, PhD, Xue Liting, Rachel Gerstein, PhD, Merav Socolovsky, PhD, Lucio H. Castilla, PhD

Blood (2013) 122 (21): 46.

https://doi.org/10.1182/blood.V122.21.46.46

Published: 2013

Journal Articles

Prostaglandin E 2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Yoshiko Matsumoto Ikushima, Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Keiyo Takubo, Tomoyuki Furuyashiki, Shuh Narumiya, Toshio Suda

Blood (2013) 121 (11): 1995–2007.

https://doi.org/10.1182/blood-2012-06-437889

Published: 2013

Includes: Supplemental data

Journal Articles

Sinusoidal Endothelial CD26 Cleavage of Neuropeptide Y Regulates Transendothelial Migration and Mobilization of Hematopoietic Stem and Progenitor Cells in Response to G-CSF.

Pratibha Singh, PhD, Jonathan Hoggatt, Ph.D., Peirong Hu, PhD, Louis M. Pelus, PhD

Blood (2012) 120 (21): 2347.

https://doi.org/10.1182/blood.V120.21.2347.2347

Published: 2012

Journal Articles

Effects of G-CSF On Acute Lymphoblastic Leukemia.

Jordan Basnett, BSc(Hons), Adam Cisterne, BSc(Hons), Kenneth F Bradstock, MB, PhD, FRACP, FRCPA, Linda J Bendall, BSc, PhD

Blood (2012) 120 (21): 2564.

https://doi.org/10.1182/blood.V120.21.2564.2564

Published: 2012

Journal Articles

Origin and Characterization of CD166+ Cells During Human Marrow Ontogeny

Saloomeh Mokhtari, BS, Evan Colletti, PhD, Christopher D Porada, PhD, Graca Almeida-Porada, MD, PhD

Blood (2012) 120 (21): 1252.

https://doi.org/10.1182/blood.V120.21.1252.1252

Published: 2012

Journal Articles

Hierarchical Organization of Osteoblast Reveals the Significant Role of CD166 in Hematopoietic Stem Cell Maintenance and Function

Brahmananda Reddy Chitteti, PhD, Yinghua Cheng, M.D., Melissa A. Kacena, PhD, Edward F. Srour, Ph.D.

Blood (2012) 120 (21): 215.

https://doi.org/10.1182/blood.V120.21.215.215

Published: 2012

Journal Articles

CD166 (ALCAM): A Functional Marker of Primitive Murine and Human Hematopoietic Stem Cells and Cellular Elements of Their Niche

Brahmananda Reddy Chitteti, PhD, MIchihiro Kobayashi, M.D., Ph.D., Yinghua Cheng, M.D., Peirong Hu, PhD, Bradley Poteat, Hal E. Broxmeyer, Ph.D., Louis M. Pelus, PhD, Melissa A. Kacena, PhD, Edward F. Srour, Ph.D.

Blood (2012) 120 (21): 640.

https://doi.org/10.1182/blood.V120.21.640.640

Published: 2012

Journal Articles

Alcam Mediated Interaction Regulates Normal Hematopoietic Stem Cell Function and Cbfβ-SMMHC Induced Leukemogenesis

Robin Jeannet, PhD, Qi Cai, PhD, Hongjun Liu, Hieu Vu, Ya-Huei Kuo, PhD

Blood (2012) 120 (21): 4091.

https://doi.org/10.1182/blood.V120.21.4091.4091

Published: 2012

Journal Articles

Cripto Regulates Hematopoietic Stem Cells As a Hypoxic Niche Related Factor Through the Cell Surface Receptor GRP78

Kenichi Miharada, Göran Karlsson, Matilda Rehn, Emma Rörby, Kavitha Siva, JÃ¶rg Cammenga, Stefan Karlsson, M.D., Ph.D., Prof.

Blood (2011) 118 (21): 2332.

https://doi.org/10.1182/blood.V118.21.2332.2332

Published: 2011

Journal Articles

Alcam Mediated Cellular Interaction Regulates Hematopoietic Stem Cell Repopulation and Self-Renewal

Robin Jeannet, PhD, Qi Cai, PhD, Hongjun Liu, Hieu Vu, Ya-Huei Kuo, PhD

Blood (2011) 118 (21): 1291.

https://doi.org/10.1182/blood.V118.21.1291.1291

Published: 2011

NARROW

Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizumab, in Subjects with Newly Diagnosed Acute Graft Versus Host Disease

Anti-CD6 Monoclonal Antibody Itolizumab Efficiently Inhibits T Cell Proliferation after in Vitro TCR Stimulation in the Setting of Acute Graft Versus Host Disease

Itolizumab As a Potential Therapeutic for the Prevention and Treatment of Graft Vs Host Disease

Activated Leukocyte Cell Adhesion Molecule (ALCAM) Regulate Myeloma Cancer Stem Cell Mediated Myelomagenesis and Chemoresistance

Single-Cell Gene Expression Analysis Identifies Alcam As a Novel Candidate Therapeutic Target in AML

Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance

The Myeloma Cells Escape from Bone Marrow to Skin Extramedullary Localization upon Bortezomib Resistance: Role of CXCR4

Neutrophils Modulate Osteoblastic Niche for Hematopoietic Progenitors Via Prostaglandin E2 Production Triggered By Sympathetic Nervous System

Plerixafor Successfully Rescues Poor Mobilizers Resulting in Adequate CD34 Cell Numbers However Stem Cell Products Yield Lower Numbers of CFU/CD34 and Delayed Neutrophil Engraftment

CD166+CD34+ Cells Exhibit Marked Functional Differences During Fetal and Adult Life

Deletion Of Core Binding Factors Runx1 and Runx2 Leads To Perturbed Hematopoiesis In Multiple Lineages

Prostaglandin E 2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Sinusoidal Endothelial CD26 Cleavage of Neuropeptide Y Regulates Transendothelial Migration and Mobilization of Hematopoietic Stem and Progenitor Cells in Response to G-CSF.

Effects of G-CSF On Acute Lymphoblastic Leukemia.

Origin and Characterization of CD166+ Cells During Human Marrow Ontogeny

Hierarchical Organization of Osteoblast Reveals the Significant Role of CD166 in Hematopoietic Stem Cell Maintenance and Function

CD166 (ALCAM): A Functional Marker of Primitive Murine and Human Hematopoietic Stem Cells and Cellular Elements of Their Niche

Alcam Mediated Interaction Regulates Normal Hematopoietic Stem Cell Function and Cbfβ-SMMHC Induced Leukemogenesis

Cripto Regulates Hematopoietic Stem Cells As a Hypoxic Niche Related Factor Through the Cell Surface Receptor GRP78

Alcam Mediated Cellular Interaction Regulates Hematopoietic Stem Cell Repopulation and Self-Renewal

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American Society of Hematology

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American Society of Hematology

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