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Journal Articles

Addition of the PARP Inhibitor, Talazoparib, to Gemtuzumab Ozogamicin Significantly Enhances Anti-Leukemic Activity in Human CD33+ Acute Myeloid Leukemia

Scott M. Portwood, MBA, MS, Marianna C Cantella, BE, Tara L. Cronin, BA, Eunice S. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1371.
https://doi.org/10.1182/blood-2019-130427
Published: 2019
Journal Articles

Preclinical Evaluation of Gilteritinib on NPM1-ALK Driven Anaplastic Large Cell Lymphoma Cells

Sudhakiranmayi Kuravi, M.S., Janice Cheng, MD, Kishore Polireddy, PhD, Gabrielle Fangman, B.S., Roy A Jensen, MD, Tara L. Lin, MD, Siddhartha Ganguly, MD, Joseph P. McGuirk, DO, Ramesh Balusu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2865.
https://doi.org/10.1182/blood-2019-130633
Published: 2019
Journal Articles

Targeting DNA Damage and Repair in Acute Myeloid Leukemia Carrying Internal Tandem Duplication of Fms-like Tyrosine Kinase 3 (FLT3-ITD) - a Mechanistic Study

Ka Lam Nelson Ng, PhD, Claire Lynn, Thomas Wing Yan Leung, Eric Chi Wai So, PhD, Anskar Yu Hung Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1261.
https://doi.org/10.1182/blood-2019-129472
Published: 2019
Journal Articles

Dual Inhibition of MCL1 and BCL2 in Lymphoma Using Tumor Targeted Nanoparticles

Neeta Bala Bala, PhD, Mandana Taghizadeh Manzari, PhD, Mariana Da Silva Ferreira, MSc, Zahra Asgari, Connor Hagen, Venkatraman Seshan, PhD, Elisa de Stanchina, Katia Manova-Todorova, Daniel Heller, Anas Younes, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 305.
https://doi.org/10.1182/blood-2019-130571
Published: 2019
Journal Articles

Characterization of Monoclonal Gammopathy of Undetermined Significance Progression to Multiple Myeloma through Meta-Analysis of GEO Data

Jihad Aljabban, MMSc, BA, David Chen, BS, Francesca Cottini, MD, Saad Syed, BS, Nabeal Aljabban, BS, Sharjeel Syed, BS, Tiffany Hughes, PhD, David Feldman, BS, Dexter Hadley, MD PhD, Don M. Benson, Jr., MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4395.
https://doi.org/10.1182/blood-2019-129699
Published: 2019
Journal Articles

DNA Methyltransferase Inhibitors Promote Homologous Recombination Deficiency through Induction of Immune Signaling, Sensitizing Acute Myeloid Leukemia Cells to PARP Inhibitors

Aksinija A Kogan, BS, MS, Lena J Mclaughlin, BS, Maria R. Baer, MD, Stephen Baylin, MD, Michael Topper, BS, Feyruz V. Rassool, BSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3763.
https://doi.org/10.1182/blood-2019-129535
Published: 2019
Journal Articles

Anti-Leukemic Efficacy of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies

Vanessa Kohl, MSc, Susanne Brendel, MTA, Johanna Flach, PhD, Helga Kleiner, MTA, Christel Weiss, PhD, Wolfgang Seifarth, PhD, Daniel Nowak, MD, Wolf-Karsten Hofmann, MD PhD, Alice Fabarius, PhD, Henning D. Popp
Journal: Blood
Blood (2019) 134 (Supplement_1): 5056.
https://doi.org/10.1182/blood-2019-122672
Published: 2019
Journal Articles

NK Cells Lacking CD38 Are Resistant to Oxidative Stress-Induced Death

Frank Cichocki, PhD, Karrune Woan, MD PhD, Cheng-Ying Wu, Bruce R. Blazar, MD, Ryan Bjordahl, PhD, Bahram Valamehr, PhD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3215.
https://doi.org/10.1182/blood-2019-124490
Published: 2019
Journal Articles

Integrated Multi-Level Omics to Characterize Bortezomib Resistance in Multiple Myeloma

David C. Koomen, BS, Mark B. Meads, PhD, Dario M. Magaletti, Joy D. Guingab, PhD, Paula S. Oliveira, Bin Fang, PhD, Victoria Izumi, MS, Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria Silva, Raghunandanreddy Alugubelli, MS, Gabe De Avilla, Alex Tungeskiv, Eric A. Welsh, PhD, Laurel E. Meke, Wei Zhang, PhD, Steven A. Eschrich, PhD, Timothy J. Garrett, PhD, Ariosto Siqueira Silva, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5534.
https://doi.org/10.1182/blood-2019-132001
Published: 2019
Journal Articles

A Critical Role of Growth Arrest-Specific Gene 6-Mer Axis in the Pathogenesis of Endothelial Damage Contributing to Thrombotic Microangiopathy Associated with Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Miki Furukawa, MD PhD, Wang Xintao, MD PhD, Hiroshi Ohkawara, MD PhD, Masahiko Fukatsu, MD, Lobna Alkebsi, PhD, Hideyoshi Noji, MD PhD, Kazuei Ogawa, MD PhD, Takayuki Ikezoe, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4520.
https://doi.org/10.1182/blood-2018-99-112816
Published: 2018
Journal Articles

A Study of Haemostatic Parameters in Patients with Philadelphia-Negative Myeloproliferative Neoplasms. Correlation with, Clinical, Laboratory, Molecular, and Treatment Characteristics

Nefeli Giannakopoulou, Marianna Politou, MD, Panagiotis Theodorou Diamantopoulos, MD PhD, Dimitris Korakakis, Maria Efstathopoulou, Theodora Kassi, Christina-Nefeli Kontandreopoulou, Katerina Zoi, PhD, Andreas Giannopoulos, BSc, MSc, Maria Dimou, Panayiotis Panayiotidis, MD PhD, Nora-Athina Viniou, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4304.
https://doi.org/10.1182/blood-2018-99-116660
Published: 2018
Journal Articles

Targeting Insulin-like Growth Factor in Multiple Myeloma: Novel Strategies in the Treatment of Proteasome Inhibitor Resistant Cells

Yuko Tanaka, Seiichi Okabe, MD PhD, Tetsuzo Tauchi, MD PhD, Yoshikazu Ito, MD PhD, Kazuma Ohyashiki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5155.
https://doi.org/10.1182/blood-2018-99-114750
Published: 2018
Journal Articles

PARP Inhibitor Veliparib and Busulfan in a Xenograft Model of Myeloproliferative Neoplasm

Pritesh Patel, MD, Vitalyi Senyuk, PhD, Natalie S. Rodriguez, MS, Dolores Mahmud, PhD, Annie Lee Oh, MD, Nadim Mahmud, MBBS, PhD, Giovanni Barosi, MD, Damiano Rondelli, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3319.
https://doi.org/10.1182/blood-2018-99-119497
Published: 2018
Journal Articles

PIKfyve Inhibitors for the Treatment of Multiple Myeloma

Cecilia Bonolo De Campos, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Laura Ann Bruins, BS, Joachim L Petit, PhD, Alysia N Polito, BS, Meaghen E Sharik, BS, Caleb K Stein, MS, Gregory J Ahmann, BS, Ilsel D Lopez Armenta, BS, Nikolai Sepetov, PhD, Sergei Romanov, PhD, P. Leif Bergsagel, MD, Marta Chesi, PhD, Nathalie Meurice, PhD, A. Keith Stewart, MBChB, MBA
Journal: Blood
Blood (2017) 130 (Supplement 1): 4423.
https://doi.org/10.1182/blood.V130.Suppl_1.4423.4423
Published: 2017
Journal Articles

Enhanced In Vivo Persistence and Proliferation of NK Cells Expanded in Culture with the Small Molecule Nicotinamide: Development of a Clinical-Applicable Method for NK Expansion

Tony Peled, Guy Brachya, Nurit Persi, Chana Lador, Esti Olesinski, Efrat Landau, Einat Galamidi, Amnon Peled, Jeffrey S. Miller, MD, Veronika Bachanova, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 657.
https://doi.org/10.1182/blood.V130.Suppl_1.657.657
Published: 2017
Journal Articles

CDC37 As a Novel Target for the Treatment of NPM1-ALK Expressing Anaplastic Large Cell Lymphomas

Sudhakiranmayi Kuravi, M.S., Elizabeth Parrott, M.A., Siddhartha Ganguly, MD, Anusha Vallurupalli, MD, Yogenthiran Saunthararajah, MD, Brian S Blagg, PhD, Jensen Roy, MD, Joseph P. McGuirk, DO, Ramesh Balusu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2758.
https://doi.org/10.1182/blood.V130.Suppl_1.2758.2758
Published: 2017
Journal Articles

The Proto-Oncogene Mer Is a Novel Therapeutic Target in Mantle Cell Lymphoma

Cunzhen Shi, Xiaogan Wang, MD, Ning Ding, MD, Lingyan Ping, Yuqin Song, MD, Jun Zhu, BS
Journal: Blood
Blood (2017) 130 (Supplement 1): 5138.
https://doi.org/10.1182/blood.V130.Suppl_1.5138.5138
Published: 2017
Journal Articles

Peroxisome Proliferator-Activated Receptors: Targets for the Treatment of Philadelphia Chromosome-Positive Leukemia Cells

Seiichi Okabe, MD PhD, Tetsuzo Tauchi, MD, Yuko Tanaka, MD PhD, Kazuma Ohyashiki, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5241.
https://doi.org/10.1182/blood.V130.Suppl_1.5241.5241
Published: 2017
Journal Articles

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Acute Myeloid Leukemia Quiescent and Proliferative Cells to PARP Inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Marcin M Machnicki, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Stoklosa, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, MD, Peter Valent, MD, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2635.
https://doi.org/10.1182/blood.V130.Suppl_1.2635.2635
Published: 2017
Journal Articles

Bone Marrow Levels of PARP1 mRNA Predict Response to Treatment with 5-Azacytidine in Patients with Myelodysplastic Syndrome

Panagiotis Theodorou Diamantopoulos, MD PhD, Elina Kodandreopoulou, Argiris S. Symeonidis, Ioannis Kotsianidis, MDPhD, Vassiliki Pappa, MDPhD, Athanasios Galanopoulos, MD PhD, Maria Dimou, Georgia Christopoulou, Konstantinos Zervakis, Elena E. Solomou, MD PhD, Marie-Christine Kyrtsonis, MD PhD, Niki Rougala, Marina Siakantaris, MD, Theodoros Vassilakopoulos, MDPhD, Panayiotis Panayiotidis, MDPhD, Nora-Athina Viniou
Journal: Blood
Blood (2017) 130 (Supplement 1): 161.
https://doi.org/10.1182/blood.V130.Suppl_1.161.161
Published: 2017