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Journal Articles

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2516.

https://doi.org/10.1182/blood-2019-129372

Published: 2019

Journal Articles

High Expression of BCAT1 promotes Acute Myeloid Leukemia Progression and Sensitize to PARP Inhibitor

Jie Jin, PhD, Jie Jin, PhD, Jiajia Pan, Yungui Wang, PhD, Shujuan Huang, Shihui Mao, Qing Ling, Jinghan Wang, MD PhD, Chenying Li

Blood (2019) 134 (Supplement_1): 5041.

https://doi.org/10.1182/blood-2019-125221

Published: 2019

Journal Articles

Leucine for the Treatment of Transfusion Dependence in Patients with Diamond Blackfan Anemia

Adrianna Vlachos, MD, Evangelia Atsidaftos, MA, MPH, Ellen Muir, RN, MSN, Zora R. Rogers, MD, Mohammad Lufti Lababidi, MD, Waseem Alhushki, MD, Jason E. Farrar, MD, Bertil Glader, MD, Barbara Gruner, MD, Helge Hartung, MD, Christine M. Knoll, MD, Grzegorz Nalepa, MDPhD, Anupama Narla, MD, Arun Ranjan Panigrahi, MD, Colin A. Sieff, MB, BCh, Kelly J. Walkovich, MD, Jeffrey M Lipton, MD PhD

Blood (2018) 132 (Supplement 1): 755.

https://doi.org/10.1182/blood-2018-99-113570

Published: 2018

Journal Articles

Tryptophan Deprivation Promotes an Adaptive Response and Contributes to Bioenergetics in Multiple Myeloma

Alessandra Romano, MDPhD, Nunziatina Laura Parrinello, Katia Todoerti, PhD, Piera La Cava, Fabrizio Puglisi, Cesarina Giallongo, PhD, Daniele Tibullo, Giuseppina Camiolo, Giuseppe Sapienza, MD, Vittorio Del Fabro, MD, Concetta Conticello, Francesco Piazza, Marilena Carrino, PhD, Giuseppe A. Palumbo, MD, Simone Cenci, MD, Antonino Neri, MD, Francesco Di Raimondo, MD

Blood (2018) 132 (Supplement 1): 4511.

https://doi.org/10.1182/blood-2018-99-116447

Published: 2018

Journal Articles

Characteristic Amino Acid and Energy Metabolism in AML Stem Cells As Revealed By Quantitative Multiplex Proteomics

Simon Raffel, MD, Jenny Hansson, Mattia Falcone, Christoph Lutz, Oliver Bischel, MD, Anthony D Ho, Jeroen Krijgsveld, Andreas Trumpp, Prof, PhD

Blood (2018) 132 (Supplement 1): 2780.

https://doi.org/10.1182/blood-2018-99-117046

Published: 2018

Journal Articles

Targeting the Epigenetic and Metabolic Vulnerabilities of Ezh2-Deficiency-Induced Myeloid Neoplasms

Zhimin Gu, PhD, Yuxuan Liu, PhD, Hui Cao, MS, Mingyi Chen, MD PhD, Yuannyu Zhang, PhD, Le Qi, Xin Liu, PhD, Kailong Li, PhD, Kathryn Dickerson, MD, Feng Cai, PhD, Weina Chen, MD PhD, Min Ni, PhD, Ralph Deberardinis, MD PhD, Jian Xu, PhD

Blood (2017) 130 (Supplement 1): 380.

https://doi.org/10.1182/blood.V130.Suppl_1.380.380

Published: 2017

Journal Articles

A Zebrafish Model of Diamond-Blackfan Anemia Results in Bone Marrow Failure and Demonstrates Defective Translation in Erythroid Cells By Ribosome Footprinting

Jasmine Rowell, BS, MS, Gregorz Pietka, PhD, Maria Virgilio, Oscar Pena, BS, MSc, Catherine Hockings, MBBChir, MA, FRCPath, MRCP, Elspeth Payne, MDPhDFRCPath

Blood (2017) 130 (Supplement 1): 871.

https://doi.org/10.1182/blood.V130.Suppl_1.871.871

Published: 2017

Journal Articles

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

Blood (2017) 130 (Supplement 1): 472.

https://doi.org/10.1182/blood.V130.Suppl_1.472.472

Published: 2017

Journal Articles

Arginine Deprivation and Autophagy Sustain Bioenergetics in Multiple Myeloma

Alessandra Romano, MDPhD, Laura Oliva, PhD, Jose Manuel Manteiga, Todoerti Katia, Lorenzo Canziani, Matteo Trudu, Francesca Fontana, Michela Ghizzinardi, Ugo Orfanelli, Magda Marcatti, MD, Fabio Ciceri, MD, Giovanni Tonon, MD PhD, Antonino Neri, MD, Claudio Cerichione, MD PhD, Francesco Di Raimondo, MD, Simone Cenci, MD

Blood (2017) 130 (Supplement 1): 3051.

https://doi.org/10.1182/blood.V130.Suppl_1.3051.3051

Published: 2017

Journal Articles

Small Molecule Inhibition of SIRT Activity: A Novel Therapeutic Approach for Refractory Multiple Myeloma

Steffan T. Nawrocki, PhD, Claudia M. Espitia, Valeria Visconte, PhD, Yingchun Han, MD, Kevin R. Kelly, MD PhD, Jennifer S. Carew, PhD

Blood (2015) 126 (23): 1807.

https://doi.org/10.1182/blood.V126.23.1807.1807

Published: 2015

Journal Articles

Activation of the mTOR Signaling Pathway by L-Leucine in RPS14-Deficient Erythroid Cells

Bon Ham Yip, Chaitanya Vuppusetty, Andrea Pellagatti, Aristoteles Giagounidis, MD, Ulrich Germing, Abigail A Lamikanra, David J Roberts, Marta Fernandez-Mercado, Emma-Jane McDonald, Cristina Mecucci, Sally Killick, James S Wainscoat, Jacqueline Boultwood, MD

Blood (2012) 120 (21): 171.

https://doi.org/10.1182/blood.V120.21.171.171

Published: 2012

Journal Articles

L-Leucine Improves the Anemia of the 5q- Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway

Maria Virgilio, Elspeth Payne, MB, ChB, Ph.D, Anupama Narla, MD, Hong Sun, MD, Barry H. Paw, M.D., Ph.D., Thomas Look, MD, Benjamin L. Ebert, MD, D.Phil, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2011) 118 (21): 970.

https://doi.org/10.1182/blood.V118.21.970.970

Published: 2011

Journal Articles

Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway?

Maria Virgilio, Elspeth Payne, MBChB, Anupama Narla, MD, Hong Sun, MD, Barry Paw, M.D., Ph.D., A. Thomas Look, MD, Benjamin L. Ebert, MD, DPhil, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2010) 116 (21): 195.

https://doi.org/10.1182/blood.V116.21.195.195

Published: 2010

Journal Articles

Intermediaries of Branched-Chain Amino Acid Metabolism Can Increase Fetal Hemoglobin In Vitro and In Vivo .

Himanshu Bhatia, MD, Jaimie Higgs, BA, Sonja Hess, PhD, Cynthia Tifft, MD, PhD, Jane Little, MD

Blood (2007) 110 (11): 3834.

https://doi.org/10.1182/blood.V110.11.3834.3834

Published: 2007

NARROW

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

High Expression of BCAT1 promotes Acute Myeloid Leukemia Progression and Sensitize to PARP Inhibitor

Leucine for the Treatment of Transfusion Dependence in Patients with Diamond Blackfan Anemia

Tryptophan Deprivation Promotes an Adaptive Response and Contributes to Bioenergetics in Multiple Myeloma

Characteristic Amino Acid and Energy Metabolism in AML Stem Cells As Revealed By Quantitative Multiplex Proteomics

Targeting the Epigenetic and Metabolic Vulnerabilities of Ezh2-Deficiency-Induced Myeloid Neoplasms

A Zebrafish Model of Diamond-Blackfan Anemia Results in Bone Marrow Failure and Demonstrates Defective Translation in Erythroid Cells By Ribosome Footprinting

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

Arginine Deprivation and Autophagy Sustain Bioenergetics in Multiple Myeloma

Small Molecule Inhibition of SIRT Activity: A Novel Therapeutic Approach for Refractory Multiple Myeloma

Activation of the mTOR Signaling Pathway by L-Leucine in RPS14-Deficient Erythroid Cells

L-Leucine Improves the Anemia of the 5q- Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway

Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway?

Intermediaries of Branched-Chain Amino Acid Metabolism Can Increase Fetal Hemoglobin In Vitro and In Vivo .

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American Society of Hematology

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ASH Publications

American Society of Hematology

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