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Journal Articles

Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors

Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Edward Simpson, PhD, Judith L Anderson, BS, Xiang-Qun Xie, PhDMD,MBA, Yunlong Liu, PhD, John Chirgwin, PhD, G. David Roodman, MD PhD

Blood (2019) 134 (Supplement_1): 4391.

https://doi.org/10.1182/blood-2019-131865

Published: 2019

Journal Articles

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Mykel D Green, Mitchell Schaffler, PhD, Gilda A Barabino, PhD

Blood (2019) 134 (Supplement_1): 3561.

https://doi.org/10.1182/blood-2019-128950

Published: 2019

Journal Articles

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

Denise Toscani, PhD, Martina Chiu, PhD, Giuseppe Taurino, MS, Emanuela Vicario, MS, Valentina Marchica, MS, Fabrizio Accardi, MD, Anna Benedetta Dalla Palma, MD, Paola Storti, PhD, Gaetano Donofrio, PhD, Franco Aversa, MD, Ovidio Bussolati, MD PhD, Nicola Giuliani, MD PhD

Blood (2018) 132 (Supplement 1): 4481.

https://doi.org/10.1182/blood-2018-99-111337

Published: 2018

Journal Articles

The Pleiotropic Immunosuppressive Role of Osteoclasts in Multiple Myeloma

Kenta Mukaihara, MD PhD, Ka Tat Siu, PhD, Cristina Panaroni, PhD, Keertik Fulzele, PhD, Rosemary Soucy, Cherrie Huang, Shrikanta Chattopadhyay, MBBS, Noopur Raje, MD

Blood (2018) 132 (Supplement 1): 4447.

https://doi.org/10.1182/blood-2018-99-114922

Published: 2018

Journal Articles

Defective Notch Activation in Mesenchymal Cells Contributes to Myeloproliferative Neoplasm in Aged Mice

Young-Woong Kim, PhD, Sonia Rodriguez, PhD, Lin Wang, PhD, Guido Marcucci, MD, Amy Zollman, Nadia Carlesso, MD PhD

Blood (2017) 130 (Supplement 1): 134.

https://doi.org/10.1182/blood.V130.Suppl_1.134.134

Published: 2017

Journal Articles

New Bone Cell Type Identified As Driver of Drug Resistance in Multiple Myeloma: The Bone Marrow Adipocyte

Carolyne Falank, PhD, Heather Fairfield, MS, Mariah Farrell, BS, Michaela Reagan, PhD

Blood (2017) 130 (Supplement 1): 122.

https://doi.org/10.1182/blood.V130.Suppl_1.122.122

Published: 2017

Journal Articles

Maternal Embryonic Leucine Zipper Kinase Inhibitor OTSSP167 Inhibits Osteoclast Activity and Restores Osteoblast Activity in a Murine Model of Multiple Myeloma Bone Disease

Josephine Muller, Arnold Bolomsky, PhD, Kathrin Schonfelder, Frederic Baron, Yves Beguin, MD PhD, Heinz Ludwig, MD, Jo Caers, MD, Roy Heusschen, PhD

Blood (2017) 130 (Supplement 1): 4416.

https://doi.org/10.1182/blood.V130.Suppl_1.4416.4416

Published: 2017

Journal Articles

Aplidin (Plitidepsin) Regulates Viability and Function of Myeloma Cells and Bone Cells in Combination with Other Anti-MM Drugs

Jesus Delgado-Calle, PhD, Emily G Atkinson, Jessica Nelson, Noriyoshi Kurihara, DDS, PhD, Carlos Galmarini, David David Roodman, MD PhD, Teresita Bellido

Blood (2017) 130 (Supplement 1): 3065.

https://doi.org/10.1182/blood.V130.Suppl_1.3065.3065

Published: 2017

Journal Articles

Myeloma-Associated Adipocytes Exhibit Reduced Adipogenic Gene Expression and Delipidation

Heather Fairfield, MS, Elizabeth J Harris, Carolyne Falank, PhD, Michaela Reagan, PhD

Blood (2017) 130 (Supplement 1): 1768.

https://doi.org/10.1182/blood.V130.Suppl_1.1768.1768

Published: 2017

Journal Articles

Low Intensity Vibration Treatment Reduces Myeloma Cell-Induced Osteoclast Formation By Inhibiting IL-6 and GFI-1 Production By MM Cells

Gabriel M. Pagnotti, PhD, Noriyoshi Kurihara, DDS, PhD, G David Roodman, MD PhD

Blood (2017) 130 (Supplement 1): 1775.

https://doi.org/10.1182/blood.V130.Suppl_1.1775.1775

Published: 2017

Journal Articles

Distinct Stress Responses of Bone Marrow Stromal Cell Subgroups Defined by Unbiased Single-Cell Mass-Cytometry Analysis

Nicolas Severe, PhD, Murat Karabacak, PhD, Ninib Baryawno, PhD, Karin Gustafsson, PhD, Youmna Sami Kfoury, PhD, Mehmet Toner, PhD, David T. Scadden, MD

Blood (2016) 128 (22): 430.

https://doi.org/10.1182/blood.V128.22.430.430

Published: 2016

Journal Articles

The Crosstalk Between Leptin Receptor Activation and iNKT Mediated Anti-Tumor Immunity in Multiple Myeloma

Mérédis Favreau, PhDstudent, Eline Menu, PhD, Karin Vanderkerken, PhD, Sylvia Faict, MD, Ken Maes, PhD, Els Van Valckenborgh, PhD, Elke De Bruyne, PhD, Srinath Govindarajan, PhDstudent, Michael Drennan, PhD, Xavier Leleu, Lennart Zabeau, PhD, Jan Tavernier, PhD, Koen Venken, PhD, Dirk Elewaut, MD PhD

Blood (2016) 128 (22): 2075.

https://doi.org/10.1182/blood.V128.22.2075.2075

Published: 2016

Journal Articles

Effect of the Wnt-Signaling Inhibitor Sclerostin and Bone Marrow Adipocytes on Multiple Myeloma

Cristina Panaroni, PhD, Ka Tat Siu, PhD, Keertik S Fulzele, PhD, Janani Ramachandran, MA, Noopur Raje, MD

Blood (2016) 128 (22): 2077.

https://doi.org/10.1182/blood.V128.22.2077.2077

Published: 2016

Journal Articles

Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D

Attaya Suvannasankha, MD, Colin D Crean, Douglas R Tompkins, Jesus Delgado-Calle, PhD, Teresita M Bellido, PhD, G. David Roodman, MD PhD, John M Chirgwin, PhD

Blood (2016) 128 (22): 4439.

https://doi.org/10.1182/blood.V128.22.4439.4439

Published: 2016

Journal Articles

Bidirectional Notch Signaling Between Multiple Myeloma (MM) Cells and Osteocytes As a Potential Target to Inhibit Tumor Growth and Osteoclast Recruitment in MM

Jesus Delgado-Calle, PhD, Judith Anderson, Meloney D. Cregor, Nadia Carlesso, MD PhD, Khalid S. Mohammad, MD PhD, Lilian I. Plotkin, PhD, Teresita M. Bellido, PhD, G. David Roodman, MD PhD

Blood (2015) 126 (23): 2977.

https://doi.org/10.1182/blood.V126.23.2977.2977

Published: 2015

Journal Articles

Notch- and TNFα-Activated Signaling Pathways Mediate Osteocyte Apoptosis Triggered By Multiple Myeloma Cells

Jesus Delgado-Calle, PhD, Judith Anderson, Lilian I. Plotkin, PhD, Teresita Bellido, PhD, G. David Roodman, MD PhD

Blood (2014) 124 (21): 3354.

https://doi.org/10.1182/blood.V124.21.3354.3354

Published: 2014

Journal Articles

Erythropoietin Stimulates Bone Resorption Via Direct Activation of the Monocytic Lineage and Via Increased RANKL Production By B Cells and Osteoblasts

Sahar Hiram-Bab, PhD, Naamit Deshet, M.Sc., Tamar Liron, PhD, Moshe Mittelman, MD, Max Gassmann, DVM, Martina Rauner, PhD, Kristin Franke, Ben Wielockx, PhD, Yankel Gabet, DMD, PhD, Drorit Neumann, PhD

Blood (2014) 124 (21): 247.

https://doi.org/10.1182/blood.V124.21.247.247

Published: 2014

Journal Articles

High Bone Turnover Is Present in Patients with Primary Systemic (AL) Amyloidosis and Increased Osteoprotegerin Identifies Patients with Poor Survival within Mayo Stage 1 Disease

Efstathios Kastritis, MD, Maria Gavriatopoulou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Maria Roussou, Constantinos Pamboucas, Savvas Th. Toumanidis, Evangelos Terpos, Meletios A. Dimopoulos

Blood (2014) 124 (21): 2028.

https://doi.org/10.1182/blood.V124.21.2028.2028

Published: 2014

Journal Articles

Direct Cell-To-Cell Interactions Between Osteocytes and Multiple Myeloma (MM) Cells Upregulate Sost and Downregulate OPG Expression In Osteocytes: Evidence For Osteocytic Contributions To MM-Induced Bone Disease

Jesus Delgado Calle, PhD, Teresita Bellido, PhD, G. David David Roodman, MD, PhD

Blood (2013) 122 (21): 3140.

https://doi.org/10.1182/blood.V122.21.3140.3140

Published: 2013

Journal Articles

The Zinc Finger Transcription Factor Growth Factor Independence 1b (Gfi1b) Regulates The Wnt/Beta-Catenin Signaling Pathway In Hematopoietic Stem Cells Through Interaction With Inhibitory Proteins

Peiman Shooshtarizadeh, PhD, Ryan Chen, PhD, Tarik Moroy, Ph.D.

Blood (2013) 122 (21): 2417.

https://doi.org/10.1182/blood.V122.21.2417.2417

Published: 2013

NARROW

Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

The Pleiotropic Immunosuppressive Role of Osteoclasts in Multiple Myeloma

Defective Notch Activation in Mesenchymal Cells Contributes to Myeloproliferative Neoplasm in Aged Mice

New Bone Cell Type Identified As Driver of Drug Resistance in Multiple Myeloma: The Bone Marrow Adipocyte

Maternal Embryonic Leucine Zipper Kinase Inhibitor OTSSP167 Inhibits Osteoclast Activity and Restores Osteoblast Activity in a Murine Model of Multiple Myeloma Bone Disease

Aplidin (Plitidepsin) Regulates Viability and Function of Myeloma Cells and Bone Cells in Combination with Other Anti-MM Drugs

Myeloma-Associated Adipocytes Exhibit Reduced Adipogenic Gene Expression and Delipidation

Low Intensity Vibration Treatment Reduces Myeloma Cell-Induced Osteoclast Formation By Inhibiting IL-6 and GFI-1 Production By MM Cells

Distinct Stress Responses of Bone Marrow Stromal Cell Subgroups Defined by Unbiased Single-Cell Mass-Cytometry Analysis

The Crosstalk Between Leptin Receptor Activation and iNKT Mediated Anti-Tumor Immunity in Multiple Myeloma

Effect of the Wnt-Signaling Inhibitor Sclerostin and Bone Marrow Adipocytes on Multiple Myeloma

Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D

Bidirectional Notch Signaling Between Multiple Myeloma (MM) Cells and Osteocytes As a Potential Target to Inhibit Tumor Growth and Osteoclast Recruitment in MM

Notch- and TNFα-Activated Signaling Pathways Mediate Osteocyte Apoptosis Triggered By Multiple Myeloma Cells

Erythropoietin Stimulates Bone Resorption Via Direct Activation of the Monocytic Lineage and Via Increased RANKL Production By B Cells and Osteoblasts

High Bone Turnover Is Present in Patients with Primary Systemic (AL) Amyloidosis and Increased Osteoprotegerin Identifies Patients with Poor Survival within Mayo Stage 1 Disease

Direct Cell-To-Cell Interactions Between Osteocytes and Multiple Myeloma (MM) Cells Upregulate Sost and Downregulate OPG Expression In Osteocytes: Evidence For Osteocytic Contributions To MM-Induced Bone Disease

The Zinc Finger Transcription Factor Growth Factor Independence 1b (Gfi1b) Regulates The Wnt/Beta-Catenin Signaling Pathway In Hematopoietic Stem Cells Through Interaction With Inhibitory Proteins

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American Society of Hematology

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American Society of Hematology

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