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Journal Articles

Therapeutic Applications of a Unique Calcium Channel Blocker to Target SF3B1 MDS

Sunisa Kongkiatkamon, Anand Tiwari, Vera Adema, PhD, Cassandra M Kerr, MS, Bartlomiej Przychodzen, Hassan Awada, Jibran Durrani, Yvonne Parker, Drew Adams, Yuriy Fedorov, Hetty E. Carraway, MD MBA, Chao-Yie Yang, Mikkael A. Sekeres, MD MS, Daniel J. Lindner, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD

Blood (2019) 134 (Supplement_1): 881.

https://doi.org/10.1182/blood-2019-128671

Published: 2019

Journal Articles

Calpain-1 Contributes to Pain and Organ Damage in Sickle Cell Disease

Stacy B Kiven, BS, Jianxun Lei, PhD, Varun Sagi, BS, Huy Tran, BS, Ying Wang, PhD, Piyusha P Pagare, PhD, Jennifer O Nwankwo, PhD, Nils Lambrecht, MD PhD, Kalpna Gupta, PhD

Blood (2019) 134 (Supplement_1): 76.

https://doi.org/10.1182/blood-2019-127761

Published: 2019

Journal Articles

HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway

Jung Kwon Lee, SungMyung Kang, Xidi Wang, Jesusa L. Rosales, Xu Gao, Hee-Guk Byun, Yan Jin, Songbin Fu, Jinghua Wang, Ki-Young Lee

Blood (2019) 133 (20): 2222–2232.

https://doi.org/10.1182/blood-2018-12-890236

Published: 2019

Includes: Supplemental data

Journal Articles

Growth Arrest-Specific 2 Promotes the Growth of T-Cell Acute Lymphoblastic Leukemia Cells Via Its Regulation of CXCR4

Wenjuan Ma, Yan Wan, Haixia Zhou, MD PhD, Li Zhu, MD PhD, Yun Zhao, PhD

Blood (2018) 132 (Supplement 1): 4081.

https://doi.org/10.1182/blood-2018-99-114354

Published: 2018

Journal Articles

Fatal Dysfunction and Fragmentation of Thrombin-Stimulated Platelets

Oleg V. Kim, PhD, Tatiana A. Nevzorova, PhD, Elmira R. Mordakhanova, Izabella A. Andrianova, Giang Le Minh, Mark S. Alber, PhD, Olga Vagin, PhD, Rustem I. Litvinov, MD PhD, John W. Weisel, PhD

Blood (2018) 132 (Supplement 1): 521.

https://doi.org/10.1182/blood-2018-99-112703

Published: 2018

Journal Articles

Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton

Rustem I. Litvinov, Karen Pei Yi Fong, PhD BS, Oleg V. Kim, PhD, Kathleen I. Molnar, PhD, Paul C. Billings, PhD, Alex Sternisha, BS, James A. Wells, PhD, John W. Weisel, PhD, William F. DeGrado, PhD, Joel S. Bennett, MD

Blood (2018) 132 (Supplement 1): 1128.

https://doi.org/10.1182/blood-2018-99-113063

Published: 2018

Journal Articles

Calcium Mobilization in Unfavorable-Prognosis Chronic Lymphocytic Leukemia Patients Mediates Focal Adhesion Kinase (FAK) Cleavage, Thereby Its Activation

Federica Frezzato, PhD, Veronica Martini, PhD MSc, Filippo Severin, PhD MSc, Flavia Raggi, Marco Piccoli, Andrea Visentin, Edoardo Scomazzon, MD, Stefano Pravato, MD, Silvia Imbergamo, MD, Francesco Piazza, Monica Facco, Gianpietro Semenzato, Livio Trentin, MD

Blood (2018) 132 (Supplement 1): 5537.

https://doi.org/10.1182/blood-2018-99-114492

Published: 2018

Journal Articles

Botanical Alkyl Hydroquinone Derivative HQ17(3) Induces Calcium-Associated Mitochondrial Damage and Mitophagy to Exert Ctotoxicity to Philadelphila Chromosome(+) ALL Cells

Yin-Chen Chou, MS, Chia-Wei Chen, MS, Yuan-Yeh Kuo, PhD, Liang-In Lin, PhD, Chung-Yi Hu, PhD

Blood (2018) 132 (Supplement 1): 5800.

https://doi.org/10.1182/blood-2018-99-120307

Published: 2018

Journal Articles

Platelet Activation and Shear- dependent Changes in Filamin a Conformation Downstream of Ligand Binding to αIIbβ3, GPIb and α2β1 Are Reversible in Time, but Those Downstream of Fibrin Binding to αIIbβ3 Are Not

Barry S. Coller, MD, Claudia Buitrago, PhD

Blood (2017) 130 (Supplement 1): 1028.

https://doi.org/10.1182/blood.V130.Suppl_1.1028.1028

Published: 2017

Journal Articles

Blocking of Transient Receptor Potential Vanilloid1 (TRPV1) Promotes Lysosomal Destabilization and Enhances Bortezomib-Induced ER Stress and Cell Death Via HSP70 and LAMP3 Down-Regulation: Novel Therapeutic Target for Multiple Myeloma

Katia Beider, Valeria Voevoda, Hanna Bitner, Evgenia Rosenberg, Yaarit Sirovsky, Hila Magen, MD, Olga Ostrovsky, PhD, Avichai Shimoni, MD, Zohar Bromberg, PhD, Amnon Peled, Arnon Nagler, MD

Blood (2017) 130 (Supplement 1): 804.

https://doi.org/10.1182/blood.V130.Suppl_1.804.804

Published: 2017

Journal Articles

Twinfilin 2a regulates platelet reactivity and turnover in mice

Simon Stritt, Sarah Beck, Isabelle C. Becker, Timo Vögtle, Markku Hakala, Katrin G. Heinze, Xiaoping Du, Markus Bender, Attila Braun, Pekka Lappalainen, Bernhard Nieswandt

Blood (2017) 130 (15): 1746–1756.

https://doi.org/10.1182/blood-2017-02-770768

Published: 2017

Includes: Multimedia, Supplemental data

Journal Articles

Hemopoietic Progenitor Cells from the Bone Marrow of Serpinb3A-/- Mice Are Radioresistant

Stephanie Thermozier, Michael W. Epperly, PhD, Darcy Franicola, Xichen Zhang, Renee Fisher, Donna Shields, Hong Wang, John A. Willis, Cliff Luke, Gary A. Silverman, Joel S. Greenberger, MD

Blood (2016) 128 (22): 2680.

https://doi.org/10.1182/blood.V128.22.2680.2680

Published: 2016

Journal Articles

Calcium Independent Events Trigger VWF-Dependent Shear-Induced Procoagulant Platelet Formation

Andaleb Kholmukhamedov, MD, Ann An, Fang Liu, PhD, Rae Janecke, Shawn M Jobe, MD PhD

Blood (2016) 128 (22): 1354.

https://doi.org/10.1182/blood.V128.22.1354.1354

Published: 2016

Journal Articles

Factor XIII Contributes to Clot Formation and Thrombin Generation

M Rick Rollins, Emily A Larson, Hillary J Larson, Jason A Taylor, MD PhD

Blood (2016) 128 (22): 208.

https://doi.org/10.1182/blood.V128.22.208.208

Published: 2016

Journal Articles

Identification of Kinase-Dependent Signaling Pathways Regulated By Rap1b in Murine Platelets

Luis Paniagua, Xiaogang Wu, PhD, Michael Pereckas, Kathleen Noon, Gilbert White, II, MD

Blood (2016) 128 (22): 3717.

https://doi.org/10.1182/blood.V128.22.3717.3717

Published: 2016

Journal Articles

An IGF2BP3-Cdk9 Pathway Governs the Human Fetal-Adult Megakaryocyte Transition

Kamaleldin E Elagib, MBBS, PhD, Chih-Huan Lu, BS, Goar Mosoyan, Ewelina Zasadzińska, MS, Daniel R Foltz, PhD, Peter Balogh, Els Verhoeyen, Miriam Sansó, PhD, Robert P Fisher, MD PhD, Camelia Iancu-Rubin, PhD, Adam N Goldfarb, MD

Blood (2016) 128 (22): 886.

https://doi.org/10.1182/blood.V128.22.886.886

Published: 2016

Journal Articles

Filanesib Primarily Initiates the Apoptotic Program By Activating Bax through a Calpain-Dependent Mechanism

Susana Hernández-García, Lorena González-Méndez, Irena Misiewicz-Krzeminska, Esperanza Macarena Algarín, Ana Alicia López-Iglesias, Laura San-Segundo, Montserrat Martín-Sánchez, Teresa Paíno, Norma C Gutierrez, Mercedes Garayoa, Brian Tunquist, Maria-Victoria Mateos, Enrique M Ocio

Blood (2015) 126 (23): 5353.

https://doi.org/10.1182/blood.V126.23.5353.5353

Published: 2015

Journal Articles

The Hybrid Molecule, Edo-S101, Impairs Double Strand Breaks Repair in Multiple Myeloma and Synergizes with Bortezomib and Dexamethasone

Ana Alicia López-Iglesias, Ana Belen Herrero, Laura San-Segundo, Susana Hernández-García, Lorena González-Méndez, Montserrat Martín-Sánchez, Esperanza M Algarín, Teresa Paino, Mercedes Garayoa, Thomas Mehrling, MD PhD, Norma C Gutierrez, Jesús F. San-Miguel, MD, Maria-Victoria Mateos, Enrique M. Ocio, MD PhD

Blood (2015) 126 (23): 5354.

https://doi.org/10.1182/blood.V126.23.5354.5354

Published: 2015

Journal Articles

Hypoxia Reoxygenation Treatment Induces Platelet Hyperactivity and Relieves Calpain-1-Mediated Inhibition of Platelet Aggregation in a Mouse Model of Severe Sickle Cell Disease

Jennifer O. Nwankwo, BS, Rod R. Warburton, BA, Thomas Gremmel, MD, Anja J. Gerrits, PhD, Lauren J. Richey, DVM, PhD, Nicholas S. Hill, MD, Alicia Rivera, Joseph A. Jakubowski, PhD, Andrew L. Frelinger, III, PhD, Athar H. Chishti, PhD

Blood (2015) 126 (23): 413.

https://doi.org/10.1182/blood.V126.23.413.413

Published: 2015

Journal Articles

Regulation of Platelet Procoagulant Activity

Johan Heemskerk, PhD

Blood (2015) 126 (23): SCI-33.

https://doi.org/10.1182/blood.V126.23.SCI-33.SCI-33

Published: 2015

NARROW

Therapeutic Applications of a Unique Calcium Channel Blocker to Target SF3B1 MDS

Calpain-1 Contributes to Pain and Organ Damage in Sickle Cell Disease

HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway

Growth Arrest-Specific 2 Promotes the Growth of T-Cell Acute Lymphoblastic Leukemia Cells Via Its Regulation of CXCR4

Fatal Dysfunction and Fragmentation of Thrombin-Stimulated Platelets

Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton

Calcium Mobilization in Unfavorable-Prognosis Chronic Lymphocytic Leukemia Patients Mediates Focal Adhesion Kinase (FAK) Cleavage, Thereby Its Activation

Botanical Alkyl Hydroquinone Derivative HQ17(3) Induces Calcium-Associated Mitochondrial Damage and Mitophagy to Exert Ctotoxicity to Philadelphila Chromosome(+) ALL Cells

Platelet Activation and Shear- dependent Changes in Filamin a Conformation Downstream of Ligand Binding to αIIbβ3, GPIb and α2β1 Are Reversible in Time, but Those Downstream of Fibrin Binding to αIIbβ3 Are Not

Blocking of Transient Receptor Potential Vanilloid1 (TRPV1) Promotes Lysosomal Destabilization and Enhances Bortezomib-Induced ER Stress and Cell Death Via HSP70 and LAMP3 Down-Regulation: Novel Therapeutic Target for Multiple Myeloma

Twinfilin 2a regulates platelet reactivity and turnover in mice

Hemopoietic Progenitor Cells from the Bone Marrow of Serpinb3A-/- Mice Are Radioresistant

Calcium Independent Events Trigger VWF-Dependent Shear-Induced Procoagulant Platelet Formation

Factor XIII Contributes to Clot Formation and Thrombin Generation

Identification of Kinase-Dependent Signaling Pathways Regulated By Rap1b in Murine Platelets

An IGF2BP3-Cdk9 Pathway Governs the Human Fetal-Adult Megakaryocyte Transition

Filanesib Primarily Initiates the Apoptotic Program By Activating Bax through a Calpain-Dependent Mechanism

The Hybrid Molecule, Edo-S101, Impairs Double Strand Breaks Repair in Multiple Myeloma and Synergizes with Bortezomib and Dexamethasone

Hypoxia Reoxygenation Treatment Induces Platelet Hyperactivity and Relieves Calpain-1-Mediated Inhibition of Platelet Aggregation in a Mouse Model of Severe Sickle Cell Disease

Regulation of Platelet Procoagulant Activity

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American Society of Hematology

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American Society of Hematology

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