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Journal Articles

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

Xuejie Chen, Caihong Li, Da-Yun Jin, Brian Ingram, Zhenyu Hao, Xue Bai, Darrel W. Stafford, Keping Hu, Jian-Ke Tie

Blood (2020) 136 (7): 898–908.

https://doi.org/10.1182/blood.2019004234

Published: 2020

Includes: Supplemental data

Journal Articles

IDH1 Mutant AML Is Susceptible to Targeting De Novo Lipid Synthesis Independent of 2-Hydroxyglutarate and Has a Distinct Metabolic Profile from IDH2 Mutant AML

Daniel Thomas, MD PhD, Yusuke Nakauchi, MD PhD, Manhong Wu, PhD, Ming Zheng, PhD, Subarna Sinha, PhD, David Dill, PhD, Gary Peltz, MD PhD, Ravindra Majeti, MD PhD

Blood (2018) 132 (Supplement 1): 440.

https://doi.org/10.1182/blood-2018-99-115040

Published: 2018

Journal Articles

Platelet-Targeted Hyperfunctional Factor IX (FIX) Gene Therapy for Hemophilia B Mice with Pre-Existing Anti-FIX Immunity

Jocelyn A. Schroeder, Jeremy G Mattson, Paul Edward Monahan, MD, Qizhen Shi, MD

Blood (2018) 132 (Supplement 1): 220.

https://doi.org/10.1182/blood-2018-99-111718

Published: 2018

Journal Articles

Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase

Mark A. Rishavy, Kevin W. Hallgren, Lee Wilson, Savita Singh, Kurt W. Runge, Kathleen L. Berkner

Blood (2018) 131 (25): 2826–2835.

https://doi.org/10.1182/blood-2017-09-804666

Published: 2018

Includes: Supplemental data

Journal Articles

Isocitrate Dehydrogenase 1 Mutant Cancers Are Metabolically Vulnerable to Inhibition of Acetyl CoA Carboxylase Via a 2-Hydroxyglutarate Independent Mechanism

Daniel Thomas, MD PhD, Subarna Sinha, PhD, Steven M. Chan, MD PhD, Manhong Wu, Damoun Torabi, Gary Peltz, MD PhD, Yang Gao, David L Dill, PhD, Ravi Majeti, MD PhD

Blood (2016) 128 (22): 1054.

https://doi.org/10.1182/blood.V128.22.1054.1054

Published: 2016

Journal Articles

Novel Sites of Gamma Carboxylation in Human Factor VII

Emily M Wilkerson, Barbara Bates, Kraig T Kumfer, Nicholas M Riley, Brad S Schwartz, Joshua J Coon

Blood (2016) 128 (22): 3759.

https://doi.org/10.1182/blood.V128.22.3759.3759

Published: 2016

Journal Articles

Characterization of vitamin K–dependent carboxylase mutations that cause bleeding and nonbleeding disorders

Jian-Ke Tie, Jorge D. A. Carneiro, Da-Yun Jin, Ciro D. Martinhago, Cees Vermeer, Darrel W. Stafford

Blood (2016) 127 (15): 1847–1855.

https://doi.org/10.1182/blood-2015-10-677633

Published: 2016

Includes: Supplemental data

Journal Articles

Deeper understanding of carboxylase

James H. Morrissey

Blood (2016) 127 (15): 1841–1842.

https://doi.org/10.1182/blood-2016-02-694927

Published: 2016

Journal Articles

Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

Lindsey A. Greene, MD, Nabil K. Thalji, BS, Harlan Bradford, BA, Sriram Krishnaswamy, PhD MD, Rodney M. Camire, PhD

Blood (2015) 126 (23): 124.

https://doi.org/10.1182/blood.V126.23.124.124

Published: 2015

Journal Articles

Zymogen-like FXa Variant As a Short-Acting Warfarin Reversal Agent: Pre-Clinical Evaluation and Mechanism of Action

Lindsey A. Greene, MD, Nabil K. Thalji, BS, Leslie J. Raffini, MD, Rodney M. Camire, PhD

Blood (2014) 124 (21): 4262.

https://doi.org/10.1182/blood.V124.21.4262.4262

Published: 2014

Journal Articles

VKORc1 Is Under-Expressed in Skeletal Muscle of Humans, Dogs and Mice: Potential Implications for Ectopic Coagulation Factor Expression in Pre-Clinical and Therapeutic Applications

Courtney T Connolly, Armida Faella, Timothy C. Nichols, MD, Katherine A. High, MD, Valder R. Arruda, MD, PhD, Paris Margaritis, DPhil

Blood (2014) 124 (21): 1477.

https://doi.org/10.1182/blood.V124.21.1477.1477

Published: 2014

Journal Articles

A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites

Jamil A. Haque, Matthew G. McDonald, John D. Kulman, Allan E. Rettie

Blood (2014) 123 (4): 582–589.

https://doi.org/10.1182/blood-2013-05-505123

Published: 2014

Includes: Supplemental data

Journal Articles

Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias

Polina Matre, PhD, Ismael Samudio, PhD, Rodrigo Jacamo, PhD, Ying Wang, Jing Wang, R Eric Davis, Xiaohua Su, Sonja Schindela, Rachel Newman, Jianhua Hu, Torsten Haferlach, MD, Michael Andreeff, MD, PhD, Elsa R. Flores, Aaron Schimmer, PhD, MD, Marina Konopleva, MD, PhD

Blood (2013) 122 (21): 606.

https://doi.org/10.1182/blood.V122.21.606.606

Published: 2013

Journal Articles

Involvement of Lipid Rafts and Caveolae in gas6-Axl Signaling in Endothelial Cells

Sandrine Laurance, Catherine A Lemarie, Mark Blostein

Blood (2011) 118 (21): 2211.

https://doi.org/10.1182/blood.V118.21.2211.2211

Published: 2011

Journal Articles

Functional study of the vitamin K cycle in mammalian cells

Jian-Ke Tie, Da-Yun Jin, David L. Straight, Darrel W. Stafford

Blood (2011) 117 (10): 2967–2974.

https://doi.org/10.1182/blood-2010-08-304303

Published: 2011

Journal Articles

Mutational Analysis for IDH1 and IDH2 In Pediatric Leukemia

Mitsuteru Hiwatari, MD, PhD, Kentaro Oki, MD, Jyunko Takita, MD, PhD, Riki Nishimura, MD, Masashi Sanada, MD, PhD, Jun Okubo, MD, Masatoki Adachi, MD, Manabu Sotomatsu, MD, Akira Kikuchi, MD, PhD, Takashi Igarashi, MD, PhD, Yasuhide Hayashi, MD, PhD, Seishi Ogawa, MD, PhD

Blood (2010) 116 (21): 5106.

https://doi.org/10.1182/blood.V116.21.5106.5106

Published: 2010

Journal Articles

IDH1 and IDH2 Mutations In Pediatric Acute Myeloid Leukemia

Anna Andersson, PhD, David Miller, John Lynch, PhD, Andrew Lemoff, Zhongling Cai, Stanley Pounds, PhD, Ina Radtke, MD, PhD, Yan Bing, PhD, Schuetz John, PhD, Rubnitz Jeffrey, MD, PhD, Raul Ribeiro, MD, Susana C. Raimondi, PhD, Jinghui Zhang, PhD, Sheila Shurtleff, PhD, Brenda Schulman, PhD, James Downing, MD

Blood (2010) 116 (21): 1699.

https://doi.org/10.1182/blood.V116.21.1699.1699

Published: 2010

Journal Articles

Pre-Clinical Characterization and Analysis of Long Lasting Recombinant Factor IXFc

John V Amari, PhD, Qi Lu, PhD, Mark Slein, BS, Robert Peters, PhD

Blood (2010) 116 (21): 4415.

https://doi.org/10.1182/blood.V116.21.4415.4415

Published: 2010

Journal Articles

Prolonged Coagulopathy Secondary to Superwarfarin Brodifacoum Rodenticide Ingestion

Abhinav B. Chandra, MD, MSc, Nanda K. Methuku, MD, MPH, Yiwu Huang, MD, PhD

Blood (2010) 116 (21): 4425.

https://doi.org/10.1182/blood.V116.21.4425.4425

Published: 2010

Journal Articles

Hepatoma Cell Line HuH-7 : a Promising New Cellular System for Recombinant FIX Production.

Nathalie Enjolras, PhD, Yesim Dargaud, MD, PhD, Jean-Luc Plantier, PhD, Heli Simpson, Florine Guillaume, Claude Negrier, MD

Blood (2009) 114 (22): 4202.

https://doi.org/10.1182/blood.V114.22.4202.4202

Published: 2009

NARROW

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

IDH1 Mutant AML Is Susceptible to Targeting De Novo Lipid Synthesis Independent of 2-Hydroxyglutarate and Has a Distinct Metabolic Profile from IDH2 Mutant AML

Platelet-Targeted Hyperfunctional Factor IX (FIX) Gene Therapy for Hemophilia B Mice with Pre-Existing Anti-FIX Immunity

Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase

Isocitrate Dehydrogenase 1 Mutant Cancers Are Metabolically Vulnerable to Inhibition of Acetyl CoA Carboxylase Via a 2-Hydroxyglutarate Independent Mechanism

Novel Sites of Gamma Carboxylation in Human Factor VII

Characterization of vitamin K–dependent carboxylase mutations that cause bleeding and nonbleeding disorders

Deeper understanding of carboxylase

Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

Zymogen-like FXa Variant As a Short-Acting Warfarin Reversal Agent: Pre-Clinical Evaluation and Mechanism of Action

VKORc1 Is Under-Expressed in Skeletal Muscle of Humans, Dogs and Mice: Potential Implications for Ectopic Coagulation Factor Expression in Pre-Clinical and Therapeutic Applications

A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites

Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias

Involvement of Lipid Rafts and Caveolae in gas6-Axl Signaling in Endothelial Cells

Functional study of the vitamin K cycle in mammalian cells

Mutational Analysis for IDH1 and IDH2 In Pediatric Leukemia

IDH1 and IDH2 Mutations In Pediatric Acute Myeloid Leukemia

Pre-Clinical Characterization and Analysis of Long Lasting Recombinant Factor IXFc

Prolonged Coagulopathy Secondary to Superwarfarin Brodifacoum Rodenticide Ingestion

Hepatoma Cell Line HuH-7 : a Promising New Cellular System for Recombinant FIX Production.

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American Society of Hematology

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American Society of Hematology

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