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Journal Articles

Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat

Mark J. McVey, Sarah Weidenfeld, Mazharul Maishan, Chris Spring, Michael Kim, Arata Tabuchi, Victoria Srbely, Alisa Takabe-French, Szandor Simmons, Christoph Arenz, John W. Semple, Wolfgang M. Kuebler

Blood (2021) 137 (5): 690–701.

https://doi.org/10.1182/blood.2020005985

Published: 2021

Includes: Supplemental data

Journal Articles

GDF1 Regulation of Ceramide Metabolism Restores Effective Hematopoiesis in Myelodysplastic Syndrome

Brian Barth, PhD MS, BS, Weiyuan Wang, Emily Sullivan, Vasiliki Papakotsi, Andrea Cote, Paul Toran, PhD, Sarah Walker, PhD, Thomas P Loughran, Jr., MD

Blood (2019) 134 (Supplement_1): 1700.

https://doi.org/10.1182/blood-2019-131623

Published: 2019

Journal Articles

The Exosomal Transfer of Acid Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma

Inge Oudaert, MSc, Sylvia Faict, MSc, Ludovic D'Auria, PhD, Jonas Dehairs, PhD, Ken Maes, Philip Vlummens, MD, Lotte Jacobs, BSc, Kim De Veirman, Elke De Bruyne, PhD, Karel Fostier, MD, Isabelle Vande Broek, MD PhD, Rik Schots, Karin Vanderkerken, PhD, Johannes V. Swinnen, PhD, Eline Menu, PhD

Blood (2019) 134 (Supplement_1): 3058.

https://doi.org/10.1182/blood-2019-122857

Published: 2019

Journal Articles

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Colin D. Crean, BS, Judith L Anderson, BS, G. David Roodman, MD PhD

Blood (2019) 134 (Supplement_1): 4387.

https://doi.org/10.1182/blood-2019-131106

Published: 2019

Journal Articles

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

Weiyuan Wang, Emily Sullivan, Vasiliki Papakotsi, Andrea Cote, Paul Toran, PhD, Thomas P Loughran, Jr., MD, Brian Barth, PhD MS, BS

Blood (2019) 134 (Supplement_1): 1245.

https://doi.org/10.1182/blood-2019-130964

Published: 2019

Journal Articles

The Gfi1-SphK1 Axis Regulates the Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Patrick Mulcrone, PhD, Colin D. Crean, BS, Judith L Anderson, BS, Quanhong Sun, PhD, Deborah Lynn Galson, PhD, G. David Roodman, MD PhD

Blood (2018) 132 (Supplement 1): 5615.

https://doi.org/10.1182/blood-2018-99-119507

Published: 2018

Journal Articles

Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis

Karin von Wnuck Lipinski, Sarah Weske, Petra Keul, Susann Peters, Hideo A. Baba, Gerd Heusch, Markus H. Gräler, Bodo Levkau

Blood (2017) 130 (25): 2786–2798.

https://doi.org/10.1182/blood-2017-03-774356

Published: 2017

Includes: Supplemental data

Journal Articles

The Effect of Bioactive Phospholipids on Normal and Malignant Hematopoiesis—Modulation of Their Effects By Downregulating the Activities of Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS)

Ahmed Abdelbaset-Ismail, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 3803.

https://doi.org/10.1182/blood.V130.Suppl_1.3803.3803

Published: 2017

Journal Articles

Aspariginase-Triggered Hyperglycerimedia: An Analysis on Germline Regulatory Gene Variations in Adult Acute Lymphoblastic Leukemia Patients

Sari Kytölä, MD, Suvi Rantamo, MSc, Matti Jauhiainen, PhD, Kimmo Porkka, MD PhD, Outi Kilpivaara, PhD, Ulla Wartiovaara-Kautto, MD PhD

Blood (2017) 130 (Supplement 1): 1287.

https://doi.org/10.1182/blood.V130.Suppl_1.1287.1287

Published: 2017

Journal Articles

The Role of Sphingomyelin (SM) in Tissue Factor (TF) Encryption: ATP-Induced Activation of Acid Sphingomyelinase in Macrophages Decrypts Tissue Factor By Hydrolysis of SM in the Outer Leaflet

Jue Wang, PhD, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 16.

https://doi.org/10.1182/blood.V128.22.16.16

Published: 2016

Journal Articles

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Mateusz Adamiak, MS, Ahmed Abdelbaset Ismail, PhD, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3342.

https://doi.org/10.1182/blood.V128.22.3342.3342

Published: 2016

Journal Articles

Cannabinoids Derivatives Exert a Potent Antileukemic Effect By Modifying the Pattern of Membrane Sphingolipids

Mayte Medrano, María Victoria Barbado-Gonzalez, Nuria Campillo, Francisco Hidalgo, Teresa Caballero-Velazquez, Olga Perez-Lopez, Maria Sole-Rodriguez, Jose Ignacio Piruat-Palomo, Jose A. Perez-Simon, MD, PhD

Blood (2016) 128 (22): 4718.

https://doi.org/10.1182/blood.V128.22.4718.4718

Published: 2016

Journal Articles

Fighting fat in AML

Shaoguang Li

Blood (2016) 128 (15): 1910–1911.

https://doi.org/10.1182/blood-2016-08-735704

Published: 2016

Journal Articles

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

Mohammed Dany, Salih Gencer, Rose Nganga, Raquela J. Thomas, Natalia Oleinik, Kyla D. Baron, Zdzislaw M. Szulc, Peter Ruvolo, Steven Kornblau, Michael Andreeff, Besim Ogretmen

Blood (2016) 128 (15): 1944–1958.

https://doi.org/10.1182/blood-2016-04-708750

Published: 2016

Includes: Supplemental data

Journal Articles

Transient Ex Vivo Inhibition of Heme Oxygenase 1 (HO-1) in Hematopoietic Stem/Progenitor Cells (HSPCs) By Small-Molecule Inhibitors Enhances Their Migratory Responsiveness to Bone Marrow (BM)-Secreted Chemoattractants a Novel and Simple Strategy to Improve Homing of HSPCs

Mateusz Adamiak, MS, Joseph B Moore IV, PhD, John Zhao, BS, Ahmed Abdelbaset-Ismail, PhD, Marcin Wysoczynski, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2015) 126 (23): 4272.

https://doi.org/10.1182/blood.V126.23.4272.4272

Published: 2015

Journal Articles

Long-Term Hematologic Response to Eliglustat in Patients with Gaucher Disease Type 1: Results from a Phase 2 and Two Phase 3 Trials

Neal J. Weinreb, MD FACP, Timothy M Cox, MD, Elena Lukina, MD, Pramod Mistry, MD PhD FRCP, Jennifer Angell, Sebastiaan Gaemers, MD, M. Judith Peterschmitt, MD

Blood (2015) 126 (23): 884.

https://doi.org/10.1182/blood.V126.23.884.884

Published: 2015

Journal Articles

Acid Ceramidase Inhibition Impairs Tumor Progression in a Rat Model of LGL Leukemia

Su-Fern Tan, PhD, Xin Liu, MD PhD, Kathleen Broeg, B.S., Todd E. Fox, PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD

Blood (2015) 126 (23): 1246.

https://doi.org/10.1182/blood.V126.23.1246.1246

Published: 2015

Journal Articles

FTY720 (Fingolimod) Targets the Sphingolipid Pathway and Induces Autophagy-Related Apoptosis in Human Natural Killer Large Granular Lymphocyte Leukemia

Francis Roland LeBlanc, B.S., Hong-Gang Wang, MD PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD

Blood (2015) 126 (23): 1288.

https://doi.org/10.1182/blood.V126.23.1288.1288

Published: 2015

Journal Articles

Engage - a Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Investigate the Efficacy and Safety of Eliglustat in Adults with Gaucher Disease Type 1: Results after 18 Months

Dominick J Amato, MD, Majed Dasouki, MD, Seymour Packman, MD PhD, Gregory M. Pastores, MD, Sarit Assouline, MD MSc, Manisha Balwani, MD MS, Pramod Mistry, MD PhD FRCP, Andres Ortega, MD, Suma Shankar, MD PhD, Maria Helena Solano, MD, Leorah H. Ross, MD PhD, Jennifer Angell, ScM, Judith Peterschmitt, MD

Blood (2014) 124 (21): 2732.

https://doi.org/10.1182/blood.V124.21.2732.2732

Published: 2014

Journal Articles

Evidence for Induction of a Tumor-Metastasis-Receptive Microenvironment in Bone Marrow and Other Organs As an Unwanted and Underestimated Side Effect of Chemotherapy/Radiotherapy

Pranesh Gunjal, MS, Gabriela Schneider, PhD, Sham Kakar, PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2014) 124 (21): 2925.

https://doi.org/10.1182/blood.V124.21.2925.2925

Published: 2014

NARROW

Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat

GDF1 Regulation of Ceramide Metabolism Restores Effective Hematopoiesis in Myelodysplastic Syndrome

The Exosomal Transfer of Acid Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

The Gfi1-SphK1 Axis Regulates the Growth and Survival of Myeloma Cells

Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis

The Effect of Bioactive Phospholipids on Normal and Malignant Hematopoiesis—Modulation of Their Effects By Downregulating the Activities of Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS)

Aspariginase-Triggered Hyperglycerimedia: An Analysis on Germline Regulatory Gene Variations in Adult Acute Lymphoblastic Leukemia Patients

The Role of Sphingomyelin (SM) in Tissue Factor (TF) Encryption: ATP-Induced Activation of Acid Sphingomyelinase in Macrophages Decrypts Tissue Factor By Hydrolysis of SM in the Outer Leaflet

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Cannabinoids Derivatives Exert a Potent Antileukemic Effect By Modifying the Pattern of Membrane Sphingolipids

Fighting fat in AML

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

Transient Ex Vivo Inhibition of Heme Oxygenase 1 (HO-1) in Hematopoietic Stem/Progenitor Cells (HSPCs) By Small-Molecule Inhibitors Enhances Their Migratory Responsiveness to Bone Marrow (BM)-Secreted Chemoattractants a Novel and Simple Strategy to Improve Homing of HSPCs

Long-Term Hematologic Response to Eliglustat in Patients with Gaucher Disease Type 1: Results from a Phase 2 and Two Phase 3 Trials

Acid Ceramidase Inhibition Impairs Tumor Progression in a Rat Model of LGL Leukemia

FTY720 (Fingolimod) Targets the Sphingolipid Pathway and Induces Autophagy-Related Apoptosis in Human Natural Killer Large Granular Lymphocyte Leukemia

Engage - a Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Investigate the Efficacy and Safety of Eliglustat in Adults with Gaucher Disease Type 1: Results after 18 Months

Evidence for Induction of a Tumor-Metastasis-Receptive Microenvironment in Bone Marrow and Other Organs As an Unwanted and Underestimated Side Effect of Chemotherapy/Radiotherapy

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American Society of Hematology

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ASH Publications

American Society of Hematology

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