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Journal Articles

Preclinical Activity of the MPS1 Inhibitor S81694 in Acute Lymphoblastic Leukemia (ALL)

Anna Kaci, PhD, Emilie Adiceam, Melanie Dupont, Marine Garrido, Jeannig Berrou, Hanane Djamai, Andre Baruchel, Mike Burbridge, Claude Gardin, Herve Dombret, MD PhD, Thorsten Braun, MD

Blood (2019) 134 (Supplement_1): 2631.

https://doi.org/10.1182/blood-2019-125641

Published: 2019

Journal Articles

DIS3 Mutation in RUNX1-Mutated AML1 Confers a Highly Dismal Prognosis in AML By Repressing Sister Chromatid Cohesion

Christophe Desterke, PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2019) 134 (Supplement_1): 1454.

https://doi.org/10.1182/blood-2019-123352

Published: 2019

Journal Articles

Targeted Disruption of the Cohesin Subunit STAG2 Leads to Loss of Insulation and Inappropriate Gene Activation in Response to Differentiation Signals

Jisha Antony, PhD, Gregory Giminez, PhD, Umaima Khatoon, BSc (Hons), Robert Day, PhD, Ian Morison, PhD, FRCPA, MBBS, Julia Horsfield, PhD

Blood (2018) 132 (Supplement 1): 878.

https://doi.org/10.1182/blood-2018-99-117965

Published: 2018

Journal Articles

Novel Roles of Separase in Hematopoiesis

Samridhdi Paudyal, PhD, Praveen Kumar, PhD, Nakamura Lanelle, MDPhD, Mira Jeong, PhD, Jessica Tao Li, PhD, Nenggang Zhang, PhD, Margaret Goodell, PhD, Debananda Pati, PhD

Blood (2017) 130 (Supplement 1): 3768.

https://doi.org/10.1182/blood.V130.Suppl_1.3768.3768

Published: 2017

Journal Articles

Constitutional Ring Chromosome 21 Predisposes to Acute Lymphoblastic Leukaemia (ALL) with iAMP21

Claire Schwab, Eigil Kjeldsen, MD DMSc, Nyla A. Heerema, PhD, Andrew Carroll, PhD, Matthew Bashton, PhD, Sarra Ryan, PhD, Anthony V. Moorman, PhD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Henrik Hasle, MD PhD, Christine J Harrison, PhD FRCPath

Blood (2017) 130 (Supplement 1): 3978.

https://doi.org/10.1182/blood.V130.Suppl_1.3978.3978

Published: 2017

Journal Articles

Stag2 regulates Hematopoietic Differentiation and Self-Renewal

Yotaro Ochi, MD, Ayana Kon, MD PhD, Kenichi Yoshida, MD PhD, Keisuke Kataoka, Masahiro Marshall Nakagawa, Hideki Makishima, MD,PhD,FACP., Manabu Nakayama, Haruhiko Koseki, Akifumi Takaori-Kondo, MD PhD, Seishi Ogawa, MD PhD

Blood (2017) 130 (Supplement 1): 790.

https://doi.org/10.1182/blood.V130.Suppl_1.790.790

Published: 2017

Journal Articles

Genetic Heterogeneity of t(8;21)(q22;q22.1) Acute Myeloid Leukemia Revealed By High-Throughput Targeted Sequencing

Blood (2017) 130 (Supplement 1): 2688.

https://doi.org/10.1182/blood.V130.Suppl_1.2688.2688

Published: 2017

Journal Articles

Dot1l Reverses the Abnormal Self-Renewal Conferred on HSPCs through Cohesin Haploinsufficiency By Diminishing Expression of Hoxa7 and Hoxa9

Joseph B Fisher, PhD, Cary Stelloh, Emily Kristine Phillips, BS, Katelyn Heimbruch, BS, Alison E Meyer, PhD, Kirthi Pulakanti, Maureen McNulty, BS, Aaron D Viny, MDMS, Ross L. Levine, MD, John D. Crispino, PhD, Sridhar Rao, MD PhD

Blood (2017) 130 (Supplement 1): 246.

https://doi.org/10.1182/blood.V130.Suppl_1.246.246

Published: 2017

Journal Articles

Loss of Function Cohesin Complex Gene Mutations Create Neomorphic Cell States Advantageous to Oncogenesis

James S Smith, BSc (Hons), Kienan I Savage, PhD, Alexander Thompson, PhD, Ken I Mills, PhD, FRCPath

Blood (2016) 128 (22): 1564.

https://doi.org/10.1182/blood.V128.22.1564.1564

Published: 2016

Journal Articles

The Cohesin Subunit Rad21 Is a Negative Regulator of Hematopoietic Self-Renewal through Epigenetic Repression of HoxA7 and HoxA9

Joseph B. Fisher, PhD, Jonathan Peterson, B.S., Michael Reimer, Jr., B.S., Cary Stelloh, BA, Kirthi Pulakanti, MS, Zachary Gerbec, BS, Alex M Abel, MS, Jennifer Strouse, MD, Christopher Strouse, MD, Maureen McNulty, BS, Subramaniam Malarkannan, PhD, John Crispino, PhD MBA, Samuel Milanovich, MD, Sridhar Rao, MD PhD

Blood (2016) 128 (22): 1708.

https://doi.org/10.1182/blood.V128.22.1708.1708

Published: 2016

Journal Articles

STAG2 Mutations Are an Independent Prognostic Factor in Patients with Myelodysplastic Syndromes

Blood (2016) 128 (22): 3182.

https://doi.org/10.1182/blood.V128.22.3182.3182

Published: 2016

Journal Articles

A Double Strand Break during Telophase Is Repaired with Homologous Recombination Despite the Absence of an Available Sister Chromatid

Amit Patel, MBBS, PhD MRCP, MRCS, FRCPath, Luis Alcaide Aragon, PhD

Blood (2015) 126 (23): 2421.

https://doi.org/10.1182/blood.V126.23.2421.2421

Published: 2015

Journal Articles

Dose-Dependent Role of the Cohesin Complex in Normal and Malignant Hematopoiesis

Aaron D. Viny, MD MS, Christopher J. Ott, PhD, Barbara Spitzer, MD, Martin A Rivas, PhD, Cem Meydan, Efthymia Papalexi, Dana Yelin, MD, Kaitlyn Shank, BS, Jaime Reyes, April Chiu, MD, Swapna Thota, MD, Jaroslaw P Maciejewski, MD PhD FACP, Ari Melnick, MD, James E. Bradner, MD, Ross L. Levine, MD

Blood (2015) 126 (23): 435.

https://doi.org/10.1182/blood.V126.23.435.435

Published: 2015

Journal Articles

Elevated APEX1 Disrupts G2/M Checkpoint, Contributing to Evolution and Survival of Myeloma Cells

Subodh Kumar, PhD, Srikanth Talluri, PhD, Mariateresa Fulciniti, Masood A Shammas, PhD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 2997.

https://doi.org/10.1182/blood.V126.23.2997.2997

Published: 2015

Journal Articles

Cohesin Complex Mutations Impair Differentiation of Human Hematopoietic Stem and Progenitor Cells

Claire Mazumdar, Rui Li, Jason Buenrostro, Howard Y. Chang, MD PhD, Ravi Majeti, MD PhD

Blood (2014) 124 (21): 4785.

https://doi.org/10.1182/blood.V124.21.4785.4785

Published: 2014

Journal Articles

Cohesin Complex Plays Distinct Roles in Normal Versus Malignant Hematopoiesis

Samuel Milanovich, Jonathan Peterson, Sridhar Rao

Blood (2014) 124 (21): 3556.

https://doi.org/10.1182/blood.V124.21.3556.3556

Published: 2014

Journal Articles

Cohesin Genes Are Negative Regulators of HSC Renewal

Roman Galeev, PhDstudent, Aurelie Baudet, PhD, Anders Kvist, PhD, Therese Törngren, PhDstudent, Shamit Soneji, PhD, Åke Borg, PhD, Jonas Larsson, MD PhD

Blood (2014) 124 (21): 605.

https://doi.org/10.1182/blood.V124.21.605.605

Published: 2014

Journal Articles

FANCA Controls Mitotic Phosphosignaling Networks To Ensure Genome Stability During Cell Division

Rikki Enzor, Zahi Abdul Sater, Donna Cerabona, Zejin Sun, MD, PhD, Su-jung Park, PhD, Helmut Hanenberg, MD, D. Wade Clapp, MD, Grzegorz Nalepa, MD, PhD

Blood (2013) 122 (21): 801.

https://doi.org/10.1182/blood.V122.21.801.801

Published: 2013

Journal Articles

Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells

Thibaut Brugat, Florence Nguyen-Khac, Aurore Grelier, Hélène Merle-Béral, Jozo Delic

Blood (2010) 116 (2): 239–249.

https://doi.org/10.1182/blood-2009-12-257618

Published: 2010

Journal Articles

A Novel Function of MLL in the S Phase Checkpoint: MLL Is Phosphorylated by ATR Upon DNA Damage, Which Blocks Its Degradation by the SCF skp2 Proteasome, Leading to Its Accumulation That Directly Inhibits DNA Replication.

Han Liu, Shugaku Takeda, Rakesh Kumar, Todd Westergard, Tej Pandita, Emily Cheng, MD, PhD, James J.-D. Hsieh, MD, PhD

Blood (2009) 114 (22): 450.

https://doi.org/10.1182/blood.V114.22.450.450

Published: 2009

NARROW

Preclinical Activity of the MPS1 Inhibitor S81694 in Acute Lymphoblastic Leukemia (ALL)

DIS3 Mutation in RUNX1-Mutated AML1 Confers a Highly Dismal Prognosis in AML By Repressing Sister Chromatid Cohesion

Targeted Disruption of the Cohesin Subunit STAG2 Leads to Loss of Insulation and Inappropriate Gene Activation in Response to Differentiation Signals

Novel Roles of Separase in Hematopoiesis

Constitutional Ring Chromosome 21 Predisposes to Acute Lymphoblastic Leukaemia (ALL) with iAMP21

Stag2 regulates Hematopoietic Differentiation and Self-Renewal

Genetic Heterogeneity of t(8;21)(q22;q22.1) Acute Myeloid Leukemia Revealed By High-Throughput Targeted Sequencing

Dot1l Reverses the Abnormal Self-Renewal Conferred on HSPCs through Cohesin Haploinsufficiency By Diminishing Expression of Hoxa7 and Hoxa9

Loss of Function Cohesin Complex Gene Mutations Create Neomorphic Cell States Advantageous to Oncogenesis

The Cohesin Subunit Rad21 Is a Negative Regulator of Hematopoietic Self-Renewal through Epigenetic Repression of HoxA7 and HoxA9

STAG2 Mutations Are an Independent Prognostic Factor in Patients with Myelodysplastic Syndromes

A Double Strand Break during Telophase Is Repaired with Homologous Recombination Despite the Absence of an Available Sister Chromatid

Dose-Dependent Role of the Cohesin Complex in Normal and Malignant Hematopoiesis

Elevated APEX1 Disrupts G2/M Checkpoint, Contributing to Evolution and Survival of Myeloma Cells

Cohesin Complex Mutations Impair Differentiation of Human Hematopoietic Stem and Progenitor Cells

Cohesin Complex Plays Distinct Roles in Normal Versus Malignant Hematopoiesis

Cohesin Genes Are Negative Regulators of HSC Renewal

FANCA Controls Mitotic Phosphosignaling Networks To Ensure Genome Stability During Cell Division

Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells

A Novel Function of MLL in the S Phase Checkpoint: MLL Is Phosphorylated by ATR Upon DNA Damage, Which Blocks Its Degradation by the SCF skp2 Proteasome, Leading to Its Accumulation That Directly Inhibits DNA Replication.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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