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Journal Articles

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes

Jasper Hsu, Andreea Reilly, Brian J. Hayes, Courtnee A. Clough, Eric Q. Konnick, Beverly Torok-Storb, Suleyman Gulsuner, David Wu, Pamela S. Becker, Siobán B. Keel, Janis L. Abkowitz, Sergei Doulatov

Blood (2019) 134 (2): 186–198.

https://doi.org/10.1182/blood.2018884338

Published: 2019

Includes: Supplemental data

Journal Articles

The Role of PPM1D Mutations in Lenalidomide Resistance and Progression in Patients with MDS and Deletion of Chromosome 5q

Blood (2018) 132 (Supplement 1): 4360.

https://doi.org/10.1182/blood-2018-99-114026

Published: 2018

Journal Articles

5q+ MDS Patients with Low RPS14 Expression Are Candidates to Immune-Modulating Drugs

María Linares, PhD, Inmaculada Rapado, Yanira Ruiz-Heredia, Maria Teresa Cedena, Keina Quiroz, Santiago Barrio, PhD, Rosa Ayala, Joaquín Martínez

Blood (2017) 130 (Supplement 1): 5303.

https://doi.org/10.1182/blood.V130.Suppl_1.5303.5303

Published: 2017

Journal Articles

PPM1D Mutations in MDS Patients with Deletion of Chromosome 5q

Blood (2017) 130 (Supplement 1): 4275.

https://doi.org/10.1182/blood.V130.Suppl_1.4275.4275

Published: 2017

Journal Articles

Haploinsufficiency of Multiple Genes on Del(5q) Cooperate to Induce B Cell Abnormalities in Mice

Tanzir Ahmed, PhD, Tuoen Liu, MD PhD, Kilannin Krysiak, PhD, Matthew Ndonwi, PhD, Matthew J. Walter, MD

Blood (2017) 130 (Supplement 1): 2947.

https://doi.org/10.1182/blood.V130.Suppl_1.2947.2947

Published: 2017

Journal Articles

Tifab , a Del(5q) MDS/AML Gene, Regulates USP15 Activity and p53

Madeline Niederkorn, BS, Melinda Varney, PhDBS, Molly A Smith, BS, Ruhikanta A. Meetei, PhD, Daniel T Starczynowski, PhD

Blood (2016) 128 (22): 1130.

https://doi.org/10.1182/blood.V128.22.1130.1130

Published: 2016

Journal Articles

Application of a Short Tandem Repeat Based PCR Assay for Chronological Monitoring of Myelodysplastic Syndrome (MDS) Patients with Deletion of Chromosome 5q Following Lenalidomide Treatment

Blood (2015) 126 (23): 2891.

https://doi.org/10.1182/blood.V126.23.2891.2891

Published: 2015

Journal Articles

Clinical Characteristics, Treatment and Outcomes for Patients with Myelodysplastic Syndromes and Chromosome 5q Abnormalities in the Republic of Ireland

Su Wai Maung, MBBS, MRCP(UK), Cian McEllistrim, MRCPI, Amjad Hayat, MBBS, MRCP, FRCPath, PhD, Margaret Murray, FRCPath, Michael O'Dwyer, MD, Patrick Thornton, FRCPath, Emma Groarke, MRCPI, Denis O'Keeffe, MD MRCPath, Maeve Leahy, MD MRCPath, Aine Burke, MRCP,MD, Peter O'Gorman, Carmel Weldon, M.Sc, MRCPI, Gerard Crotty, MD FRCPath, Meegahage Ratnakanthi Perera, MDMRCPath,MBBS, Cathie Burke, RN, Johnny McHugh, FRCPath, Helen Enright, MD FRCPI, FRCPath, Ronan Desmond, MD FRCPath

Blood (2015) 126 (23): 5258.

https://doi.org/10.1182/blood.V126.23.5258.5258

Published: 2015

Journal Articles

Haploinsufficiency and Deletions of G3BP1 on Chromosome 5q Result in Induction of TP53

Naoko Hosono, MDPhD, Mahfouz Reda, MDPhD, Bartlomiej P Przychodzen, Chantana Polprasert, MD, Latifa Zekri, PhD, Michael J. Clemente, Jamal Tazi, Yogen Saunthararajah, MD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD, Hideki Makishima, MD PhD

Blood (2014) 124 (21): 784.

https://doi.org/10.1182/blood.V124.21.784.784

Published: 2014

Journal Articles

Reduced Protein Synthesis and p53 Activation in Late-Stage Erythroblasts Mediate the Erythroid Differentiation Defect in Mice with Ribosomal Protein S14 Haploinsufficiency

Rebekka K. Schneider, MD, Marie E. McConkey, PhD, Lisa P. Chu, Benjamin L. Ebert, MDPhD

Blood (2014) 124 (21): 1892.

https://doi.org/10.1182/blood.V124.21.1892.1892

Published: 2014

Journal Articles

Casein Kinase 1A1 (CSNK1A1) Is Recurrently Mutated in MDS Patients with Deletion of Chromosome 5q

Blood (2014) 124 (21): 4643.

https://doi.org/10.1182/blood.V124.21.4643.4643

Published: 2014

Journal Articles

Loss of MiR-143 and MiR-145 Inhibits Hematopoietic Stem Cell Self-Renewal through Dysregulated TGFβ Signaling

Jeffrey C Lam, BSc, Joanna Wegrzyn-Woltosz, PhD, Rawa Ibrahim, BSc, Kate Slowski, BSc, Patricia Umlandt, BSc, Megan Fuller, BSc, Aly Karsan, MD

Blood (2014) 124 (21): 527.

https://doi.org/10.1182/blood.V124.21.527.527

Published: 2014

Journal Articles

DNA Methylation Changes In Aging Human CD34+ Cells Coincide With Hotspots Of Disordered Methylation In AML At Imprinted and Allelically Methylated Regions

Tim Triche, Jr, Ph.D, Stephen Capone, B.S, Akil Merchant, MD, Preet Chaudhary, MD, PhD, Giridharan Ramsingh, M.D

Blood (2013) 122 (21): 1193.

https://doi.org/10.1182/blood.V122.21.1193.1193

Published: 2013

Journal Articles

Deletion Of Tifab, a Novel Candidate Gene On Chromosome 5q, Results In Hematopoietic Defects By Changing The Dynamic Range Of Innate Immune Pathway Activation

Melinda Varney, PhD, Susanne Christie, Madeline Niederkorn, Jing Fang, MD, PhD, Andres Jerez, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD, FACP, Jun-ichiro Inoue, PhD, Daniel T Starczynowski, PhD

Blood (2013) 122 (21): 102.

https://doi.org/10.1182/blood.V122.21.102.102

Published: 2013

Journal Articles

Whole Exome Sequencing (“mutatome”) Of Deletion 5q

Naoko Hosono, MD, PhD, Hideki Makishima, MD, PhD, Bartlomiej P Przychodzen, PhD, Andres Jerez, MD, Chantana Polprasert, MD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Satoru Miyano, PhD, Kenichi Yoshida, MD, Masashi Sanada, MD, PhD, Jacqueline Boultwood, PhD, Alan List, MD, Mikkael A. Sekeres, MD, MS, Seishi Ogawa, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2013) 122 (21): 656.

https://doi.org/10.1182/blood.V122.21.656.656

Published: 2013

Journal Articles

SQSTM1/p62 Is a Necessary Cofactor In MDS/AML With Deletion Of Mir-146a

Jing Fang, MD/PhD, Brenden Barker, BSc, Lyndsey Bolanos, BSc, Xiaona Liu, BSc, Andres Jerez, MD, PhD, Hideki Makishima, MD, PhD, Dinesh S. Rao, M.D., James C. Mulloy, PhD, Jaroslaw P. Maciejewski, MD, PhD, Jose A. Cancelas, M.D. PhD., Daniel T Starczynowski, PhD

Blood (2013) 122 (21): 747.

https://doi.org/10.1182/blood.V122.21.747.747

Published: 2013

Journal Articles

Initial experience with l-leucine therapy in myelodysplastic syndromes with associated chromosome 5q deletion

David P. Steensma, Benjamin L. Ebert

Blood (2013) 121 (21): 4428.

https://doi.org/10.1182/blood-2013-03-493809

Published: 2013

Journal Articles

Haploinsufficiency of Mir-146a in High-Risk Del(5q) MDS/AML Requires an Intrachromosomal Gene Network Involving p62/TRAF6/NF-κB

Jing Fang, MD/PhD, Andres Jerez, MD, PhD, Christopher Rasch, BSc, Lyndsey Bolanos, BSc, Jaroslaw P. Maciejewski, MD, PhD, Daniel T Starczynowski, PhD

Blood (2012) 120 (21): 557.

https://doi.org/10.1182/blood.V120.21.557.557

Published: 2012

Journal Articles

Tifab, a Novel Candidate Gene in Deletion Chromosome 5q, Contributes to Deregulation of NF-κB Signaling in MDS/AML.

Melinda Varney, PhD, Andres Jerez, MD, PhD, Jing Fang, MD/PhD, David Miller, Lyndsey Bolanos, BSc, Aly Karsan, MD, Jaroslaw P. Maciejewski, MD, PhD, Daniel T Starczynowski, PhD

Blood (2012) 120 (21): 2812.

https://doi.org/10.1182/blood.V120.21.2812.2812

Published: 2012

Journal Articles

Treatment of Higher-Risk Myelodysplastic Syndrome (MDS) by American Hematology-Oncology Providers (AHOP's): Changes in 1st-Line Treatment Preferences Over Time in Relation to Cytogenetics & Survival Data From Randomized Studies (2006–2010),

James M. Foran, MD, FRCPC, Michael G. Heckman, MS, Michael E. Williams, MD, Joanne Willey, RN, Mark R. Green, MD

Blood (2011) 118 (21): 3816.

https://doi.org/10.1182/blood.V118.21.3816.3816

Published: 2011

NARROW

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes

The Role of PPM1D Mutations in Lenalidomide Resistance and Progression in Patients with MDS and Deletion of Chromosome 5q

5q+ MDS Patients with Low RPS14 Expression Are Candidates to Immune-Modulating Drugs

PPM1D Mutations in MDS Patients with Deletion of Chromosome 5q

Haploinsufficiency of Multiple Genes on Del(5q) Cooperate to Induce B Cell Abnormalities in Mice

Tifab , a Del(5q) MDS/AML Gene, Regulates USP15 Activity and p53

Application of a Short Tandem Repeat Based PCR Assay for Chronological Monitoring of Myelodysplastic Syndrome (MDS) Patients with Deletion of Chromosome 5q Following Lenalidomide Treatment

Clinical Characteristics, Treatment and Outcomes for Patients with Myelodysplastic Syndromes and Chromosome 5q Abnormalities in the Republic of Ireland

Haploinsufficiency and Deletions of G3BP1 on Chromosome 5q Result in Induction of TP53

Reduced Protein Synthesis and p53 Activation in Late-Stage Erythroblasts Mediate the Erythroid Differentiation Defect in Mice with Ribosomal Protein S14 Haploinsufficiency

Casein Kinase 1A1 (CSNK1A1) Is Recurrently Mutated in MDS Patients with Deletion of Chromosome 5q

Loss of MiR-143 and MiR-145 Inhibits Hematopoietic Stem Cell Self-Renewal through Dysregulated TGFβ Signaling

DNA Methylation Changes In Aging Human CD34+ Cells Coincide With Hotspots Of Disordered Methylation In AML At Imprinted and Allelically Methylated Regions

Deletion Of Tifab, a Novel Candidate Gene On Chromosome 5q, Results In Hematopoietic Defects By Changing The Dynamic Range Of Innate Immune Pathway Activation

Whole Exome Sequencing (“mutatome”) Of Deletion 5q

SQSTM1/p62 Is a Necessary Cofactor In MDS/AML With Deletion Of Mir-146a

Initial experience with l-leucine therapy in myelodysplastic syndromes with associated chromosome 5q deletion

Haploinsufficiency of Mir-146a in High-Risk Del(5q) MDS/AML Requires an Intrachromosomal Gene Network Involving p62/TRAF6/NF-κB

Tifab, a Novel Candidate Gene in Deletion Chromosome 5q, Contributes to Deregulation of NF-κB Signaling in MDS/AML.

Treatment of Higher-Risk Myelodysplastic Syndrome (MDS) by American Hematology-Oncology Providers (AHOP's): Changes in 1st-Line Treatment Preferences Over Time in Relation to Cytogenetics & Survival Data From Randomized Studies (2006–2010),

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