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Journal Articles

FF-10101 Retains Potent Inhibitory Activities Against Resistant Mutations to FLT3 Inhibitors, Newly Identified in Random Mutagenesis Screens

Yuichi Ishikawa, MD PhD, Koichi Saito, PhD, Naomi Kawashima, MD PhD, Michie Morimoto, Hidetoshi Murao, PhD, Daisuke Terada, Takeshi Yamaura, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2672.
https://doi.org/10.1182/blood-2019-124632
Published: 2019
Journal Articles

Kinetic Catalytic Inhibition and Cell-Based Analysis, Not Just Target Binding, Are Required to Assess Kinase Selectivity of Covalent Inhibitors: Comparable BTK vs TEC Selectivity Profile for Ibrutinib and Acalabrutinib

Melissa Hopper, MS, Tarikere Gururaja, PhD, Taisei Kinoshita, PhD, James P. Dean, Ronald Hill, PhD, Ann Mongan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3498.
https://doi.org/10.1182/blood-2018-99-110849
Published: 2018
Journal Articles

Plasma FXIII Mediated Crosslinking Is Necessary for Thrombin Generation and Clot Retraction

Prajeeda M Nair, PhD, Crystal B Lafleur, B.S., Adrienne Wells, PhD, Bin Liu, BS, Anand K. Ramasubramanian, PhD, Xiaowu Wu, MD MSc, Andrew P. Cap, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3664.
https://doi.org/10.1182/blood.V130.Suppl_1.3664.3664
Published: 2017
Journal Articles

Biochemical Characterization of GS-4059 As a Potent and Selective Covalent Irreversible Inhibitor of Bruton's Tyrosine Kinase

Albert Liclican, Weimei Xing, Loredana Serafini, Ting Wang, Kathy Brendza, Justin Lutz, Adrian S. Ray, Brian Schultz, Roman Sakowicz, Joy Y. Feng
Journal: Blood
Blood (2016) 128 (22): 1594.
https://doi.org/10.1182/blood.V128.22.1594.1594
Published: 2016
Journal Articles

Targeted Inhibition of Activated Protein C Anticoagulant Activity By Monoclonal Antibody HAPC1573 for Treatment of Hemophilia

Xiao-Yan Zhao, PhD, Subramanian Yegneswaran, PhD, Maxine Bauzon, Derek Sim, Chandra Patel, PhD, Doug Schneider, Kirk McLean, Ying Zhu, MD, Xiaoqiao Jiang, Vince Evans, Jian-Ming Gu, PhD, Inge Ivens, PhD, Jun Xu, PhD, Peter Wolfgang Bringmann, PhD, Katalin Kauser, Charles Esmon, PhD
Journal: Blood
Blood (2016) 128 (22): 80.
https://doi.org/10.1182/blood.V128.22.80.80
Published: 2016
Journal Articles

Rviii-Singlechain in Surgical Prophylaxis: Efficacy and Safety of Continuous and Bolus Infusion

Claudia Djambas Khayat, MD BS, Johnny N. Mahlangu, MD, Ross I Baker, MD, Cindy A. Leissinger, MD, Elena Santagostino, MD PhD, Debra M. Bensen-Kennedy, MD, Katie St. Ledger, MS, Alex Veldman, MD, Ingrid Pabinger, MD
Journal: Blood
Blood (2015) 126 (23): 3525.
https://doi.org/10.1182/blood.V126.23.3525.3525
Published: 2015
Journal Articles

Clinical Development of AVL-292; A Potent, Selective Covalent Btk Inhibitor for the Treatment of B Cell Malignancies,

Erica Evans, PhD, Richland Tester, PhD, Sharon Aslanian, Prasoon Chaturvedi, PhD, Hormoz Mazdiyasni, Sabine Ponader, PhD, Bethany Tesar, Michael Sheets, Mariana Nacht, PhD, Kathryn Stiede, Steve Witowski, PhD, Heather Lounsbury, Russell Petter, PhD, Jennifer R. Brown, MD, PhD, Jan A. Burger, MD, PhD, Juswinder Singh, PhD, William F. Westlin, PhD
Journal: Blood
Blood (2011) 118 (21): 3485.
https://doi.org/10.1182/blood.V118.21.3485.3485
Published: 2011
Journal Articles

Design, Synthesis and Biological Evaluation of A Boron Containing Retinoid As a Novel Therapeutic Agent for Acute Promyelocytic Leukemia

Carolina D. Schinke, MD, Bhaskar C Das, Swati Goel, Tushar Bhagat, Sangeeta Nischal, Ph.D., Saverio Minucci, George Kabalka, B.S, PhD, Robert E. Gallagher, MD, Todd Evans, PhD, Leonidas C Platanias, MD, PhD, Amit Verma, MD
Journal: Blood
Blood (2011) 118 (21): 5008.
https://doi.org/10.1182/blood.V118.21.5008.5008
Published: 2011
Journal Articles

A Protease Resistant Factor VIII Analog for Blockade of Inhibitory Antibodies

Stephanie Planque, Ph.D., Miguel Antonio Escobar, MD, Yasuhiro Nishiyama, Ph.D., Sudhir Paul, Ph.D.
Journal: Blood
Blood (2010) 116 (21): 3361.
https://doi.org/10.1182/blood.V116.21.3361.3361
Published: 2010
Journal Articles

Increasing Hydrophobicity and Disulfide Bridging Between A1 and C2 Subunits Improves Factor VIII Stability.

Hironao Wakabayashi, MD, PhD, Amy E Griffiths, MS, Philip Fay, PhD
Journal: Blood
Blood (2009) 114 (22): 3176.
https://doi.org/10.1182/blood.V114.22.3176.3176
Published: 2009
Journal Articles

PEG Modified rVWF Prolongs the Survival of Native rFVIII in Hemophilia A Knock-Out Mice.

Peter L. Turecek, PhD, Friedrich Scheiflinger, PhD, Herbert Gritsch, PhD, Bernhard Baumgartner, DVM, Katalin Váradi, PhD, H. Peter Matthiessen, PhD, Juergen Siekmann, PhD, Eva-Maria Muchitsch, DVM, Hans Peter Schwarz, MD
Journal: Blood
Blood (2006) 108 (11): 1002.
https://doi.org/10.1182/blood.V108.11.1002.1002
Published: 2006
Journal Articles

The IL-2 Induced De-Ubiquitinating Enzyme, DUB-2, Is a Nuclear-Cytoplasmic Shuttle Which Requires Catalytic Activity for Nuclear Localization.

Paul J. Galardy, MD, Alan D. D’Andrea, M.D., Hidde L. Ploegh, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 868.
https://doi.org/10.1182/blood.V108.11.868.868
Published: 2006
Journal Articles

Endothelial Microparticles (EMP) Bind and Complex with Unusually-Large Multimers of Von Willebrand Factor (ULvWf) and Act as Potent Inducers of Platelet Adhesion and Aggregation.

Wenche Jy, PhD, Joaquin J. Jimenez, MD, Pengyu Cheng, Lucia M. Mauro, BS, Lawrence L. Horstman, BS, Eugene R. Ahn, MD, Carlos J. Bidot, MD, Yeon S. Ahn, MD
Journal: Blood
Blood (2004) 104 (11): 3667.
https://doi.org/10.1182/blood.V104.11.3667.3667
Published: 2004