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Journal Articles

Cladribine Combined with Idarubicin and High-Dose AraC (CLIA2) As a Frontline and Salvage Treatment for Young Patients (≤65 yrs) with Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 4039.

https://doi.org/10.1182/blood-2018-99-119271

Published: 2018

Journal Articles

Outcome at Two Years after a Response-Adapted Approach with Azacitidine and Intensive Chemotherapy in Patients > 60 Years with Newly Diagnosed AML Treated within the DRKS00004519 Trial of the East German Study Group (OSHO)

Nadia Jaekel, MD, Karolin Hubert, Mathias Hänel, MD, Georg Maschmeyer, MD, Regina Herbst, MD, Susann Schulze, MD, Song-Yau Wang, MD, Christoph Kahl, MD, Maxi Wass, MD, Herbert G. Sayer, MD PhD, Oana Brosteanu, PhD, Dietger Niederwieser, MD, Haifa Kathrin Al-Ali

Blood (2018) 132 (Supplement 1): 83.

https://doi.org/10.1182/blood-2018-99-115790

Published: 2018

Journal Articles

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Victoria Y Ling, MBBS, William Godfrey, Sebastien Jacquelin, PhD, Jasmin Straube, PhD, Leanne T Cooper, Claudia Bruedigam, PhD, Siok-Keen Tey, MBBS PhDFRACP FRCPA, Lars Bullinger, MD, Marco J Herold, Megan Bywater, PhD, Steven W. Lane, MD PhD

Blood (2018) 132 (Supplement 1): 2771.

https://doi.org/10.1182/blood-2018-99-115729

Published: 2018

Journal Articles

Protides of 5-Fluorotroxacitabine Display Potent Anti-Proliferative Properties and Circumvent Deoxycytidine Kinase-Mediated Resistance Associated with Cytotoxic Cytidine Analogues; A Novel Approach for Acute Myeloid Leukemia

Pedro Pinho, PhD, Helen Kylefjord, BSc, Vilma Rraklli, PhD, Christina Rydergård, BSc, Biljana Rizoska, PhD, Anders Eneroth, PhD, Johan Bylund, PhD, Sara Moses, PhD, Stefan Norin, MD PhD, Richard Bethell, PhD, Aniket Bankar, MBBS, MD DM, Thirushi Piyumika Siriwardena, Mark D. Minden, MD PhD, Aaron D Schimmer, MD PhD, Mark Albertella, PhD, Paul Targett-Adams, PhD BSc

Blood (2018) 132 (Supplement 1): 3497.

https://doi.org/10.1182/blood-2018-99-114440

Published: 2018

Journal Articles

Cladribine Combined with Idarubicin and Ara-C (CLIA) As a Frontline and Salvage Treatment for Young Patients (≤65 yrs) with Acute Myeloid Leukemia

Blood (2016) 128 (22): 1639.

https://doi.org/10.1182/blood.V128.22.1639.1639

Published: 2016

Journal Articles

Resistance to Cytarabine in Mantle Cell Lymphoma Is Mediated By Down-Regulation of Deoxycytidine Kinase at the Protein Level

Catja Freiburghaus, PhD, Venera Kuci Emruli, PhD, Angelica Johansson, Roger Olsson, PhD, Fredrik Ek, PhD, Christian H Geisler, Mats Jerkeman, Sara Ek, PhD

Blood (2016) 128 (22): 1769.

https://doi.org/10.1182/blood.V128.22.1769.1769

Published: 2016

Journal Articles

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Sanduni U. Liyanage, Hon. B. Sc., Rose Hurren, Veronique Voisin, Wang Xiaoming, Gaëlle Bridon, Changjiang Xu, Neil MacLean, Thirushi Siriwardena, Aisha Shamas-Din, PhD, Shrivani Sriskanthadevan, Mark D. Minden, MD PhD, Gary D Bader, Rebecca Laposa, Aaron D. Schimmer, MD PhD

Blood (2016) 128 (22): 1573.

https://doi.org/10.1182/blood.V128.22.1573.1573

Published: 2016

Journal Articles

Dose-Escalation Study of Azacitidine Followed By High-Dose Cytarabine (HiDAC) and Mitoxantrone (Mito) for Remission Induction in High-Risk Acute Myeloid Leukemia (AML)

Yasmin H Karimi, MD, Nitin Jain, MD, Margaret Green, Lucy A Godley, MD, PhD, Howie Lawrence Weiner, Gregory Malnassy, Noreen Fulton, Andrew Artz, MD MS, Hongtao Liu, MDPhD, Michael J. Thirman, MD, Michael Daunov, Richard A. Larson, MD, Wendy Stock, MD, Olatoyosi Odenike, MD

Blood (2015) 126 (23): 3777.

https://doi.org/10.1182/blood.V126.23.3777.3777

Published: 2015

Journal Articles

Phase II Study of Cladribine, Idarubicin, and Cytarabine (araC) in Patients with Acute Myeloid Leukemia (AML)

Blood (2015) 126 (23): 2541.

https://doi.org/10.1182/blood.V126.23.2541.2541

Published: 2015

Journal Articles

Population Pharmacokinetics of Fludarabine and Treosulfan in Patients with Thalassemia Undergoing Hematopoietic Stem Cell Transplantation

Ezhil Pavai Mohanan, MSc, John C Panetta, PhD, Shareen Stella Backia Royan, BSc, Ajay Abraham, MSc, Eunice Sindhuvi Edison, PhD, Kavitha M Lakshmi, MSc, Fouzia Nambiathayil Abubacker, DM, Anu Korula, MD DM, Aby Abraham, MD DM, Auro Viswabandya, MD DM, Biju George, DM, Alok Srivastava, MD FRACP, Vikram Mathews, DM, Poonkuzhali Balasubramanian, PhD

Blood (2015) 126 (23): 3120.

https://doi.org/10.1182/blood.V126.23.3120.3120

Published: 2015

Journal Articles

The Novel Phospholipid Gemcitabine Conjugate KPC34 Has Activity In Acute Leukemia

Timothy Pardee, MD, PhD, Peter Alexander, BA, Kristin Stadelman, MS, Greg Kucera, PhD

Blood (2013) 122 (21): 1425.

https://doi.org/10.1182/blood.V122.21.1425.1425

Published: 2013

Journal Articles

NPM1 Mutated AML Is Associated With Lower Expression Of Poor Prognostic Markers BAALC, ERG and MN1 In Adult Patients With Acute Myeloid Leukaemia

Poonkuzhali Balasubramanian, Ph.D, Ashok kumar Jayavelu, M.Sc, Ajay Abraham, M.Sc, Savitha Varatharajan, M.Sc, Sreeja Karathedath, M.Sc, Senthamizhselvi Anandan, M.Sc, Vivi Srivastava, MD, Aby Abraham, MD, Auro Viswabandya, MD, Alok Srivastava, MD, Vikram Mathews, MD, DM

Blood (2013) 122 (21): 4945.

https://doi.org/10.1182/blood.V122.21.4945.4945

Published: 2013

Journal Articles

Phase II Trial Of Cladribine and Low-Dose AraC (LDAC) Alternating With Decitabine In Older Patients With Acute Myeloid Leukemia (AML)

Tapan M. Kadia, MD, Gautam Borthakur, MD, Alessandra Ferrajoli, MD, Preetesh Jain, MD, DM, PhD, Elias Jabbour, MD, Srdan Verstovsek, MD, PhD, Naveen Pemmaraju, MD, Stefan Faderl, MD, Farhad Ravandi, MD, Marina Konopleva, MD, PhD, Carla Tuttle, RN, Mark Brandt, Xuemei Wang, MS, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Jorge E. Cortes, MD

Blood (2013) 122 (21): 5011.

https://doi.org/10.1182/blood.V122.21.5011.5011

Published: 2013

Journal Articles

FLT3 Is Involved In Ara-C Transport By Human Equilibrative Nucleoside Transporter (hENT1) In Pediatric Acute Leukemia

Albert Català, MarÇal Pastor-Anglada, Roberta Malatesta, Susana Rives, Montserrat Torrebadell, Teresa Toll, Ruben Berrueco, Jesús Estella, Mireia Camós, Paula Fernández-Calotti

Blood (2013) 122 (21): 3844.

https://doi.org/10.1182/blood.V122.21.3844.3844

Published: 2013

Journal Articles

Human Equilibrative Nucleoside Transporter 1 (hENT1) Expression Level Is a Potential Predictive Tool For Response To Decitabine In Patients With Myelodysplastic Syndrome

Lingyun Wu, Xiao Li, MD, PhD, Chunkang Chang, Feng Xu, Qi He, Dong Wu, Jiying Su

Blood (2013) 122 (21): 2790.

https://doi.org/10.1182/blood.V122.21.2790.2790

Published: 2013

Journal Articles

Downregulation Of Deoxycytidine Kinase In Cytarabine-Resistant Mantle Cell Lymphoma Cells Confers Cross-Resistance To Nucleoside Analogs Fludarabine, Gemcitabine and Cladribine, But Not To Other Classes Of Anti-Lymphoma Agents

Magdalena Klanova, Lucie Lorkova, MSc, Ondrej Vit, MSc, Bokang Maswabi, MD, Jan Molinsky, MD, Jana Pospisilova, MSc, Cory Mavis, BSc, MSc, Francisco Hernandez, MD, Martin Vokurka, MD, PhD, Jiri Petrak, MSc, PhD, Pavel Klener, Jr., MD, PhD

Blood (2013) 122 (21): 3835.

https://doi.org/10.1182/blood.V122.21.3835.3835

Published: 2013

Journal Articles

Establishment of Novel Leukemic Cell Lines Resistant to Clofarabine by Dual Mechanisms of Decreased Active Metabolite and Increased Antiapoptotic Factor

Hiroko Shigemi, MD, Takahiro Yamauchi, MD, PhD, Takanori Ueda, MD, PhD

Blood (2012) 120 (21): 1356.

https://doi.org/10.1182/blood.V120.21.1356.1356

Published: 2012

Journal Articles

Quantification of the Active Decitabine-Triphosphate (DAC-TP) Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia (AML)

Hongyan Wang, Ping Chen, Ph.D., Jiang Wang, Ramasamy Santhanam, Ph.D, Josephine Aimiuwu, Vijayasaradhi UV, Zhongfa Liu, Sebastian Schwind, MD, Alice S. Mims, MD, Rebecca B Klisovic, MD, Alison Walker, MD, Michael R. Grever, MD, Miguel Villalona-Calero, MD, John C. Byrd, MD, Ramiro Garzon, MD, William Blum, MD, Kenneth K. Chan, Ph.D, Guido Marcucci, MD

Blood (2012) 120 (21): 3578.

https://doi.org/10.1182/blood.V120.21.3578.3578

Published: 2012

Journal Articles

Association of Polymorphisms of Cytosine Arabinoside- Metabolizing Enzyme Gene with Therapy Efficacy for Acute Myeloid Leukemia

Peipei Xu, Baoan Chen, Ran Liu, Jifeng Feng, Lu Cheng, Guohua Xia, Yufeng Li, Jun Qian, Jiahua Ding, Han Zhu, Zuhong Lu

Blood (2012) 120 (21): 4328.

https://doi.org/10.1182/blood.V120.21.4328.4328

Published: 2012

Journal Articles

Detection of SNPs of Dck and Cda Genes in Five Hematological Malignant Tumor Cell Lines

Zhang Xiaoping, Ziying Jian, Bao-An Chen, Peipei Xu, Miaoxin Peng, Guohua Xia, Lu Cheng, Zuhong Lu

Blood (2012) 120 (21): 5129.

https://doi.org/10.1182/blood.V120.21.5129.5129

Published: 2012

NARROW

Cladribine Combined with Idarubicin and High-Dose AraC (CLIA2) As a Frontline and Salvage Treatment for Young Patients (≤65 yrs) with Acute Myeloid Leukemia

Outcome at Two Years after a Response-Adapted Approach with Azacitidine and Intensive Chemotherapy in Patients > 60 Years with Newly Diagnosed AML Treated within the DRKS00004519 Trial of the East German Study Group (OSHO)

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Protides of 5-Fluorotroxacitabine Display Potent Anti-Proliferative Properties and Circumvent Deoxycytidine Kinase-Mediated Resistance Associated with Cytotoxic Cytidine Analogues; A Novel Approach for Acute Myeloid Leukemia

Cladribine Combined with Idarubicin and Ara-C (CLIA) As a Frontline and Salvage Treatment for Young Patients (≤65 yrs) with Acute Myeloid Leukemia

Resistance to Cytarabine in Mantle Cell Lymphoma Is Mediated By Down-Regulation of Deoxycytidine Kinase at the Protein Level

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Dose-Escalation Study of Azacitidine Followed By High-Dose Cytarabine (HiDAC) and Mitoxantrone (Mito) for Remission Induction in High-Risk Acute Myeloid Leukemia (AML)

Phase II Study of Cladribine, Idarubicin, and Cytarabine (araC) in Patients with Acute Myeloid Leukemia (AML)

Population Pharmacokinetics of Fludarabine and Treosulfan in Patients with Thalassemia Undergoing Hematopoietic Stem Cell Transplantation

The Novel Phospholipid Gemcitabine Conjugate KPC34 Has Activity In Acute Leukemia

NPM1 Mutated AML Is Associated With Lower Expression Of Poor Prognostic Markers BAALC, ERG and MN1 In Adult Patients With Acute Myeloid Leukaemia

Phase II Trial Of Cladribine and Low-Dose AraC (LDAC) Alternating With Decitabine In Older Patients With Acute Myeloid Leukemia (AML)

FLT3 Is Involved In Ara-C Transport By Human Equilibrative Nucleoside Transporter (hENT1) In Pediatric Acute Leukemia

Human Equilibrative Nucleoside Transporter 1 (hENT1) Expression Level Is a Potential Predictive Tool For Response To Decitabine In Patients With Myelodysplastic Syndrome

Downregulation Of Deoxycytidine Kinase In Cytarabine-Resistant Mantle Cell Lymphoma Cells Confers Cross-Resistance To Nucleoside Analogs Fludarabine, Gemcitabine and Cladribine, But Not To Other Classes Of Anti-Lymphoma Agents

Establishment of Novel Leukemic Cell Lines Resistant to Clofarabine by Dual Mechanisms of Decreased Active Metabolite and Increased Antiapoptotic Factor

Quantification of the Active Decitabine-Triphosphate (DAC-TP) Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia (AML)

Association of Polymorphisms of Cytosine Arabinoside- Metabolizing Enzyme Gene with Therapy Efficacy for Acute Myeloid Leukemia

Detection of SNPs of Dck and Cda Genes in Five Hematological Malignant Tumor Cell Lines

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American Society of Hematology

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