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Journal Articles

Leukemia-Associated Primary Granule Proteins (PGPs) Elastase-2 and Proteinase-3 Are Aberrantly Expressed in Solid Tumors: A Potential Therapeutic Target for PR1-Directed Immunotherapy

Gheath Alatrash, Luis M Vence, Wendy Woodward, Naoto T Ueno, Jeffrey J Molldrem

Blood (2008) 112 (11): 5440.

https://doi.org/10.1182/blood.V112.11.5440.5440

Published: 2008

Journal Articles

Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis

David S. Grenda, Mark Murakami, Jhuma Ghatak, Jun Xia, Laurence A. Boxer, David Dale, Mary C. Dinauer, Daniel C. Link

Blood (2007) 110 (13): 4179–4187.

https://doi.org/10.1182/blood-2006-11-057299

Published: 2007

Includes: Supplemental data

Journal Articles

Identification of Two Novel Homozygous HAX1 Mutations in an Autosomal Recessive Jewish and Two Unrelated Sporadic British Families with Severe Congenital Neutropenia.

Bradley N. Smith, PhD, Phil J. Ancliff, MRCPath, David C. Linch, FRCPath, Rosemary E. Gale, PhD

Blood (2007) 110 (11): 3309.

https://doi.org/10.1182/blood.V110.11.3309.3309

Published: 2007

Journal Articles

PR1-Specific T Cell Responses in the First Months Following T-Cell Depleted Allogeneic Stem Cell Transplantation Occur in Both Myeloid and Non-Myeloid Malignancies but Are Only Associated with a GVL Effect in Myeloid Leukemias.

Katayoun Rezvani, MD, PhD, Yong Agnes, MD, PhD, Rhoda B. Eniafe, Stephan Mielke, MD, Bipin N. Savani, MD, David A. Price, MD, PhD, Emma Gostick, Daniel C. Douek, MD, PhD, John M. Goldman, MD, A. John Barrett, MD

Blood (2006) 108 (11): 5195.

https://doi.org/10.1182/blood.V108.11.5195.5195

Published: 2006

Journal Articles

Increased Unfolded Protein Response in Hematopoietic Cells from Cyclic Hematopoietic Dogs.

Ronghua Meng, David Upchurch, Glenn P. Niemeyer, PhD, Clinton D. Lothrop, DVM PhD

Blood (2006) 108 (11): 4185.

https://doi.org/10.1182/blood.V108.11.4185.4185

Published: 2006

Journal Articles

Mutations of the ELA2 Gene Found in Patients with Severe Congenital Neutropenia Induce the Unfolded Protein Response and Cellular Apoptosis.

Mark A. Murakami, BA, David S. Grenda, BA, Jhuma Ghatak, PhD, Laurence A. Boxer, MD, David C. Dale, MD, Mary C. Dinauer, MD, PhD, Audrey Anna Bolyard, RN, BS, Daniel C. Link, MD

Blood (2006) 108 (11): 499.

https://doi.org/10.1182/blood.V108.11.499.499

Published: 2006

Journal Articles

Developmental and Differential Changes of Gene Expression in Erythroid Progenitor Cells.

Vladan P. Cokic, MD, Bhaskar Bhattacharya, PhD, Raj K. Puri, MD, Alan N. Schechter, MD

Blood (2005) 106 (11): 3648.

https://doi.org/10.1182/blood.V106.11.3648.3648

Published: 2005

Journal Articles

Mutations in the ELA2 Gene Encoding Neutrophil Elastase Induce the Unfolded Protein Response and May Contribute to Neutropenia through the UPR-Dependent Apoptosis of Granulocytic Precursors.

David S. Grenda, Daniel C. Link, MD

Blood (2005) 106 (11): 91.

https://doi.org/10.1182/blood.V106.11.91.91

Published: 2005

Journal Articles

Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes

Pam Massullo, Lawrence J. Druhan, Bruce A. Bunnell, Melissa G. Hunter, John M. Robinson, Clay B. Marsh, Belinda R. Avalos

Blood (2005) 105 (9): 3397–3404.

https://doi.org/10.1182/blood-2004-07-2618

Published: 2005

Journal Articles

Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register

Christine Bellanné-Chantelot, Séverine Clauin, Thierry Leblanc, Bruno Cassinat, Fernando Rodrigues-Lima, Sandrine Beaufils, Christelle Vaury, Mohamed Barkaoui, Odile Fenneteau, Micheline Maier-Redelsperger, Christine Chomienne, Jean Donadieu

Blood (2004) 103 (11): 4119–4125.

https://doi.org/10.1182/blood-2003-10-3518

Published: 2004

Journal Articles

Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease

Phil J. Ancliff, Rosemary E. Gale, Ri Liesner, Ian M. Hann, David C. Linch

Blood (2001) 98 (9): 2645–2650.

https://doi.org/10.1182/blood.V98.9.2645

Published: 2001

NARROW

Leukemia-Associated Primary Granule Proteins (PGPs) Elastase-2 and Proteinase-3 Are Aberrantly Expressed in Solid Tumors: A Potential Therapeutic Target for PR1-Directed Immunotherapy

Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis

Identification of Two Novel Homozygous HAX1 Mutations in an Autosomal Recessive Jewish and Two Unrelated Sporadic British Families with Severe Congenital Neutropenia.

PR1-Specific T Cell Responses in the First Months Following T-Cell Depleted Allogeneic Stem Cell Transplantation Occur in Both Myeloid and Non-Myeloid Malignancies but Are Only Associated with a GVL Effect in Myeloid Leukemias.

Increased Unfolded Protein Response in Hematopoietic Cells from Cyclic Hematopoietic Dogs.

Mutations of the ELA2 Gene Found in Patients with Severe Congenital Neutropenia Induce the Unfolded Protein Response and Cellular Apoptosis.

Developmental and Differential Changes of Gene Expression in Erythroid Progenitor Cells.

Mutations in the ELA2 Gene Encoding Neutrophil Elastase Induce the Unfolded Protein Response and May Contribute to Neutropenia through the UPR-Dependent Apoptosis of Granulocytic Precursors.

Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes

Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register

Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease

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American Society of Hematology

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American Society of Hematology

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