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Jeffrey J Molldrem
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Journal Articles

High-Throughput Identification of Graft-Vs-Leukemia TCRs in AML Patient Samples after Allogeneic Stem Cell Transplantation

Noah J Tubo, Duncheng Wang, Qiuming He, Yibin Chen, Ho Ngai, Yanqing Huang, Celine Kerros, Xizeng Mao, Shoudan Liang, Sachet Shukla, Arnau Peris Cuesta, Pavan Bachireddy, Julio Alcantara Montiel, Gheath Alatrash, Priya Koppikar, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 7168.
https://doi.org/10.1182/blood-2023-190330
Published: 2023
Journal Articles

ASXL1 Truncating Mutations Drive Leukemic Resistance to T Cell Attack

Dustin McCurry, Zhongqi Ge, Jaehyun Lee, Pranaya Raparla, Thomas Koehnke, Rishi Pasumarthi, Xiaohong Leng, Oren Pasvolsky, Vinhkhang Nguyen, Katie Maurer, Shuqiang Li, Kenneth J. Livak, Elham Azizi, Robert J. Soiffer, Sachet Shukla, Ravindra Majeti, Jerome Ritz, Catherine J Wu, Jeffrey J. Molldrem, Pavan Bachireddy
Journal: Blood
Blood (2023) 142 (Supplement 1): 364.
https://doi.org/10.1182/blood-2023-189177
Published: 2023
Journal Articles

AML Immunotherapy Using a Novel Tcrm-Based Bispecific Antibody That Targets a Leader Sequence Peptide Derived from Cathepsin G

Chunhua Shi, Ze Tian, Jun Yan, Mao Zhang, Pariya Sukhumalchandra, Edward Chang, Guojun Yang, Junping You, Meng Cui, Qing Shi, Anne Philips, Na Qiao, Anna Sergeeva, Lisa St. John, Hong He, Dongxing Zha, Jeffrey J. Molldrem, Gheath Alatrash
Journal: Blood
Blood (2023) 142 (Supplement 1): 1415.
https://doi.org/10.1182/blood-2023-189514
Published: 2023
Journal Articles

Phase I Study of the T-Cell Receptor-like Antibody, Hu8F4 in Patients with Relapsed and Refractory Myeloid Malignancies

Tapan M. Kadia, Hagop Kantarjian, Gheath Alatrash, Anna Sergeeva, Hong He, Lisa St. John, Priya Koppikar, Celine Kerros, Karen Clise-Dwyer, Kathryn Ruissard, Abhishek Maiti, Courtney D. DiNardo, Elias Jabbour, Srdan Verstovsek, Naveen Pemmaraju, Nitin Jain, Ghayas C. Issa, Guillermo Garcia-Manero, Guillermo Montalban-Bravo, Aditi Shastri, Daniel R. Couriel, Maria Rhona Pinsoy, Sapna Parshottham, Richard E. Champlin, Jorge Cortes, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 1545.
https://doi.org/10.1182/blood-2023-189966
Published: 2023
Journal Articles

A Public Neoantigen Produced By the SF3B1 K700E Mutation Is a Bona Fide T Cell Target in AML/MDS

Noah J Tubo, Duncheng Wang, Qiuming He, Yibin Chen, Ho Ngai, Yanqing Huang, Celine Kerros, Xizeng Mao, Shoudan Liang, Hong He, Gheath Alatrash, Priya Koppikar, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 6816.
https://doi.org/10.1182/blood-2023-190199
Published: 2023
Journal Articles

CD47 Blockade Enhances Phagocytic Activity of the TCR-Mimic Antibody Hu8F4 Against HLA-A2+ AML

Anna Sergeeva, Hong He, Lisa St. John, Ling Yu, Rong Cai, Kathryn Ruissard, Karen Clise-Dwyer, Rolando Vedia, Dan Li, Qing Ma, Celine Kerros, Mithil Chokshi, Vanshika Jhonsa, Gang Bao, Gheath Alatrash, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 4176.
https://doi.org/10.1182/blood-2023-190099
Published: 2023
Journal Articles

LRP1-Deficient T Cells Protect Against Acute Graft Versus Host Disease in MHC-Mismatched Mice

Olga Sizova, Dan Li, Qing Ma, Lisa St John, Karen Clise-Dwyer, Abel Trujillo-Ocampo, Jeffrey J. Molldrem
Journal: Blood
Blood (2022) 140 (Supplement 1): 4483–4484.
https://doi.org/10.1182/blood-2022-167517
Published: 2022
Journal Articles

A Novel Approach to Reduce Toxicity and Preserve Efficacy of Chimeric Antigen Receptor T Cells for Adoptive Transfer

Rolando A. Vedia, Sijie Lu, Anne Philip, Anna Sergeeva, Lisa St John, Karen Clise-Dwyer, Jeffrey J. Molldrem
Journal: Blood
Blood (2022) 140 (Supplement 1): 10269–10270.
https://doi.org/10.1182/blood-2022-158603
Published: 2022
Journal Articles

Cord Derived 8F4CAR-iNKT Cells to Prevent Acute Myeloid Leukemia Relapse and Graft Vs. Host Disease after Allogeneic Stem Cell Transplantation

Maison Grefe, Abel Trujillo-Ocampo, Drew Boagni, Jelita Clinton, Hong He, Karen Clise-Dwyer, Hyunwoo Cho, Elizabeth J Shpall, Jeffrey J. Molldrem, Jin S. Im
Journal: Blood
Blood (2022) 140 (Supplement 1): 4517–4518.
https://doi.org/10.1182/blood-2022-167166
Published: 2022
Journal Articles

Targeting Myeloid Leukemia Using Novel TCR-like Chimeric Antigen Receptor-T Cells Against Cathepsin G

Jun Yan, Ze Tian, Chunhua Shi, Mao Zhang, Pariya Sukhumalchandra, Guojan Yang, Qing Edward Chang, Junping You, Meng Cui, Qing Shi, Anne Philip, Na Qiao, Anna Sergeeva, Lisa St John, Hong He, Dongxing Zha, Jeffrey J. Molldrem, Gheath Alatrash
Journal: Blood
Blood (2022) 140 (Supplement 1): 7392–7393.
https://doi.org/10.1182/blood-2022-166488
Published: 2022
Journal Articles

Humanized T Cell Receptor-like Antibody Hu8F4 Reduces Leukemia By Fc-Mediated Mechanism

Anna Sergeeva, Hong He, Lisa St John, Celine Kerros, Ling Yu, Rolando A. Vedia, Valeria Rodriguez Gonzalez, Sijie Lu, Gheath Alatrash, Kathryn Cox, Karen Clise-Dwyer, Shao-Ping Yang, Gregory Lizee, Long Vien, Laura Bover, Qing Ma, Mithil Chokshi, Gang Bao, M. James You, Jeffrey J. Molldrem
Journal: Blood
Blood (2022) 140 (Supplement 1): 9061–9062.
https://doi.org/10.1182/blood-2022-162593
Published: 2022
Journal Articles

Pembrolizumab in Combination with Antigen-Specific Cytotoxic T Lymphocytes Enhances Killing of Acute Myeloid Leukemia

Amber Gibson, Mao Zhang, Pariya Sukhumalchandra, Anne V. Philips, Na Qiao, Alexander A. Perakis, Celine Kerros, Lisa St. John, Karen Clise-Dwyer, Sijie Lu, Qing Ma, Jeffrey J. Molldrem, Gheath Alatrash
Journal: Blood
Blood (2021) 138 (Supplement 1): 2775.
https://doi.org/10.1182/blood-2021-149318
Published: 2021
Journal Articles

Immunologic Predictors for Clinical Responses in Patients with Myelodysplastic Syndromes Treated with Immune Checkpoint Blockade

Sung-Eun Lee, MD PhD, Feng Wang, PhD, Abel Trujillo-Ocampo, PhDMS, Wilfredo Ruiz Vazquez, Hyun-Woo Cho, Koichi Takahashi, MD PhD, Gheath Alatrash, Jeffrey J. Molldrem, Richard E. Champlin, MD, Naval Daver, MD, Hagop M. Kantarjian, MD, P. Andrew Futreal, Guillermo Garcia-Manero, MD, Jin S. Im
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-136963
Published: 2020
Journal Articles

Myeloablative Fractionated Busulfan Conditioning Regimen in Older Patients: Results of a Phase II Study

Uday Popat, MD, Rohtesh S. Mehta, MD, Roland Bassett, Amanda L. Olson, MD, Julianne Chen, Christina Ganesh, BSN, RN, Amin M. Alousi, MD, Paolo Anderlini, Gheath Alatrash, DO, PhD, Qaiser Bashir, MBBS, Stefan O. Ciurea, MD, Chitra Hosing, MD, Jin S Im, MD PhD, Partow Kebriaei, MD, Issa F. Khouri, MD, David Marin, MD, Yago Nieto, MD PhD, Betul Oran, MDMS, Neeraj Saini, MD, Samer Srour, Katayoun Rezvani, MD PhD, Muzaffar Qazilbash, Jeffrey J. Molldrem, Elizabeth J. Shpall, MD, Borje S Andersson, MD PhD, Richard E Champlin
Journal: Blood
Blood (2019) 134 (Supplement_1): 256.
https://doi.org/10.1182/blood-2019-122124
Published: 2019
Journal Articles

Nonmyeloablative Allogeneic Transplantation (NMAT) Confers an Overall Survival Benefit with Similar Non-Relapse Mortality When Compared to Autologous Stem Transplantation (ASCT) for Patients (pts) with Relapsed Follicular Lymphoma (FL)

Issa F. Khouri, MD, Denái R. Milton, Celina Ledesma, Loretta J. Nastoupil, MD MSc, Elias Jabbour, MD, Paolo Anderlini, Qaiser Bashir, MBBS, Stefan O. Ciurea, MD, May Daher, MD, Luis E. Fayad, MD, Jin S Im, MD PhD, Swaminathan P. Iyer, MD, David Marin, MD, Rohtesh S. Mehta, MD, Jeffrey J. Molldrem, Amanda L. Olson, MD, Betul Oran, MDMS, Uday Popat, MD, Muzaffar Qazilbash, Samer Srour, Felipe Samaniego, MD, Gabriela Rondon, MD, L. Jeffrey Medeiros, MD, Alison Gulbis, Richard E Champlin
Journal: Blood
Blood (2019) 134 (Supplement_1): 322.
https://doi.org/10.1182/blood-2019-124590
Published: 2019
Journal Articles

Characterization of Changes in the T-Cell Receptor Repertoire in Patients with Acute Myeloid Leukemia with Durable Remission Following Allogeneic Stem Cell Transplant

Ronald M. Paranal, MD, Hagop M. Kantarjian, MD, Alexandre Reuben, PhD, Celine Kerros, PhD, Priya Koppikar, PhD, Latasha Little, BS, Curtis Gumbs, Nicholas J. Short, MD, Jorge E. Cortes, MD, Elias Jabbour, MD, Jeffrey J. Molldrem, P. Andrew Futreal, PhD, Ghayas C. Issa, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5186.
https://doi.org/10.1182/blood-2019-129911
Published: 2019
Journal Articles

Reduced Severe aGVHD and Improved Survival Using Post Transplant Cyclophosphamide/Tacrolimus/Methotrexate Graft Versus Host Disease Prophylaxis in AML Patients Receiving Myeloablative Fractionated Busulfan Conditioning Regimen

Uday Popat, MD, Rima M. Saliba, PhD, Rohtesh S. Mehta, MD, Amanda L. Olson, MD, Julianne Chen, Christina Ganesh, BSN, RN, Gabriela Rondon, MD, Glenda Woodworth, BSN, OCN, RN, Becky McMullin, Amin M. Alousi, MD, Paolo Anderlini, Gheath Alatrash, DO, PhD, Qaiser Bashir, MBBS, Stefan O. Ciurea, MD, Chitra Hosing, MD, Jin S Im, MD PhD, Partow Kebriaei, MD, Issa F. Khouri, MD, David Marin, MD, Yago Nieto, MD PhD, Betul Oran, MDMS, Neeraj Saini, MD, Samer Srour, Katayoun Rezvani, MD PhD, Muzaffar H. Qazilbash, MD, Jeffrey J. Molldrem, Elizabeth J. Shpall, MD, Borje S Andersson, MD PhD, Richard E. Champlin, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3296.
https://doi.org/10.1182/blood-2019-125996
Published: 2019
Journal Articles

Clinical Relevance of MYC/BCL2 and Cell of Origin in Patients with Relapsed Diffuse Large B-Cell Lymphoma Treated with Autologous Stem Cell Transplantation

Yingjun Wang, Ken H. Young, MD PhD, Denái R. Milton, Celina Ledesma, Elias Jabbour, MD, Zijun Yidan Xu-Monette, PhD, Jeffrey J. Molldrem, Paolo Anderlini, Amin M. Alousi, MD, Qaiser Bashir, MBBS, May Daher, MD, Luis E. Fayad, MD, Swaminathan P. Iyer, MD, Partow Kebriaei, MD, David Marin, MD, Rohtesh S. Mehta, MD, Amanda L. Olson, MD, Uday Popat, MD, Felipe Samaniego, MD, Jason R. Westin, MD, Muzaffar H. Qazilbash, MD, Jin S Im, MD PhD, Gabriela Rondon, MD, Alison Gulbis, Richard E. Champlin, MD, Issa F. Khouri, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2021.
https://doi.org/10.1182/blood-2019-126719
Published: 2019
Journal Articles

Pembrolizumab Enhances the Anti-Leukemia Activity of Antigen Specific Cytotoxic T Lymphocytes

Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Anne V. Philips, PhD, Na Qiao, PhD, Celine Kerros, PhD, Lisa St. John, PhD, Alexander A. Perakis, BS, Karen Clise-Dwyer, PhD, Elizabeth Mittendorf, MD PhD, Naval G. Daver, MD, Jeffrey J. Molldrem, MD, Qing Ma, PhD, Gheath Alatrash, DO, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4542.
https://doi.org/10.1182/blood-2018-99-114864
Published: 2018
Journal Articles

Influence of the Intensity of the Conditioning Regimens on the Risks of Gvhd in Patients Receiving Rituximab Prophylaxis during Allogeneic Stem Cell Transplantation (alloSCT)

Issa F. Khouri, Denái R. Milton, Celina Ledesma, Elias J. Jabbour, MD, Gheath Alatrash, DO, PhD, Paolo Anderlini, MD, Amin M. Alousi, MD, Qaiser Bashir, MD MBBS, Stefan O. Ciurea, Sharon Hymes, BS, MD, David Marin, MD, Jeffrey J. Molldrem, MD, Amanda L. Olson, MD, Betul Oran, MDMS, Uday Popat, MD, Muzaffar H. Qazilbash, MD, Gabriela Rondon, MD, Richard E Champlin, MD, Alison Gulbis
Journal: Blood
Blood (2018) 132 (Supplement 1): 4584.
https://doi.org/10.1182/blood-2018-99-112990
Published: 2018