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Journal Articles

AML Immunotherapy Using a Novel Tcrm-Based Bispecific Antibody That Targets a Leader Sequence Peptide Derived from Cathepsin G

Chunhua Shi, Ze Tian, Jun Yan, Mao Zhang, Pariya Sukhumalchandra, Edward Chang, Guojun Yang, Junping You, Meng Cui, Qing Shi, Anne Philips, Na Qiao, Anna Sergeeva, Lisa St. John, Hong He, Dongxing Zha, Jeffrey J. Molldrem, Gheath Alatrash
Journal: Blood
Blood (2023) 142 (Supplement 1): 1415.
https://doi.org/10.1182/blood-2023-189514
Published: 2023
Journal Articles

Phase I Study of the T-Cell Receptor-like Antibody, Hu8F4 in Patients with Relapsed and Refractory Myeloid Malignancies

Tapan M. Kadia, Hagop Kantarjian, Gheath Alatrash, Anna Sergeeva, Hong He, Lisa St. John, Priya Koppikar, Celine Kerros, Karen Clise-Dwyer, Kathryn Ruissard, Abhishek Maiti, Courtney D. DiNardo, Elias Jabbour, Srdan Verstovsek, Naveen Pemmaraju, Nitin Jain, Ghayas C. Issa, Guillermo Garcia-Manero, Guillermo Montalban-Bravo, Aditi Shastri, Daniel R. Couriel, Maria Rhona Pinsoy, Sapna Parshottham, Richard E. Champlin, Jorge Cortes, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 1545.
https://doi.org/10.1182/blood-2023-189966
Published: 2023
Journal Articles

A Public Neoantigen Produced By the SF3B1 K700E Mutation Is a Bona Fide T Cell Target in AML/MDS

Noah J Tubo, Duncheng Wang, Qiuming He, Yibin Chen, Ho Ngai, Yanqing Huang, Celine Kerros, Xizeng Mao, Shoudan Liang, Hong He, Gheath Alatrash, Priya Koppikar, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 6816.
https://doi.org/10.1182/blood-2023-190199
Published: 2023
Journal Articles

CD47 Blockade Enhances Phagocytic Activity of the TCR-Mimic Antibody Hu8F4 Against HLA-A2+ AML

Anna Sergeeva, Hong He, Lisa St. John, Ling Yu, Rong Cai, Kathryn Ruissard, Karen Clise-Dwyer, Rolando Vedia, Dan Li, Qing Ma, Celine Kerros, Mithil Chokshi, Vanshika Jhonsa, Gang Bao, Gheath Alatrash, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 4176.
https://doi.org/10.1182/blood-2023-190099
Published: 2023
Journal Articles

Cord Derived 8F4CAR-iNKT Cells to Prevent Acute Myeloid Leukemia Relapse and Graft Vs. Host Disease after Allogeneic Stem Cell Transplantation

Maison Grefe, Abel Trujillo-Ocampo, Drew Boagni, Jelita Clinton, Hong He, Karen Clise-Dwyer, Hyunwoo Cho, Elizabeth J Shpall, Jeffrey J. Molldrem, Jin S. Im
Journal: Blood
Blood (2022) 140 (Supplement 1): 4517–4518.
https://doi.org/10.1182/blood-2022-167166
Published: 2022
Journal Articles

Targeting Myeloid Leukemia Using Novel TCR-like Chimeric Antigen Receptor-T Cells Against Cathepsin G

Jun Yan, Ze Tian, Chunhua Shi, Mao Zhang, Pariya Sukhumalchandra, Guojan Yang, Qing Edward Chang, Junping You, Meng Cui, Qing Shi, Anne Philip, Na Qiao, Anna Sergeeva, Lisa St John, Hong He, Dongxing Zha, Jeffrey J. Molldrem, Gheath Alatrash
Journal: Blood
Blood (2022) 140 (Supplement 1): 7392–7393.
https://doi.org/10.1182/blood-2022-166488
Published: 2022
Journal Articles

Humanized T Cell Receptor-like Antibody Hu8F4 Reduces Leukemia By Fc-Mediated Mechanism

Anna Sergeeva, Hong He, Lisa St John, Celine Kerros, Ling Yu, Rolando A. Vedia, Valeria Rodriguez Gonzalez, Sijie Lu, Gheath Alatrash, Kathryn Cox, Karen Clise-Dwyer, Shao-Ping Yang, Gregory Lizee, Long Vien, Laura Bover, Qing Ma, Mithil Chokshi, Gang Bao, M. James You, Jeffrey J. Molldrem
Journal: Blood
Blood (2022) 140 (Supplement 1): 9061–9062.
https://doi.org/10.1182/blood-2022-162593
Published: 2022
Journal Articles

Humanized Anti-PR1/HLA-A2 T Cell Receptor-like Monoclonal Antibody, h8F4, Has Multiple Effector Mechanisms

Anna Sergeeva, PhD, Hong He, MD, Kathryn Cox, Lisa St John, PhD, Mei Sang, Celine Kerros, PhD, Qiaochuan Li, PhD MD, Amanda Herrmann, Karen Clise-Dwyer, PhD, Qing Ma, PhD, Gregory Lizee, PhD, Gheath Alatrash, DO, PhD, Jeffrey J. Molldrem, MD
Journal: Blood
Blood (2016) 128 (22): 4061.
https://doi.org/10.1182/blood.V128.22.4061.4061
Published: 2016
Journal Articles

Cathepsin G Is Broadly Expressed By AML and Is an Effective Immunotherapeutic Target Against AML in Vivo

Gheath Alatrash, DO, PhD, Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Yihua Qiu, MD, Amjad H. Talukder, PhD, Vladimir Senyukov, PhD, Lisa S. St. John, PhD, Hong He, MD, Anna Sergeeva, PhD, Jason Roszik, PhD, Karen Clise-Dwyer, PhD, Sijie Lu, PhD, Qing Ma, PhD, Elizabeth A. Mittendorf, MD PhD, Dean A. Lee, MD PhD, David H Hawke, PhD, Lizee Gregory, PhD, Jeffrey J. Molldrem, Steven M. Kornblau, MD
Journal: Blood
Blood (2014) 124 (21): 3761.
https://doi.org/10.1182/blood.V124.21.3761.3761
Published: 2014
Journal Articles

Treatment with 8F4, An Anti-PR1/HLA-A2 T Cell Receptor-Like Antibody, Reduces Established Acute Myeloid Leukemia and Eliminates Leukemia Stem Cells in Mice

Anna Sergeeva, PhD, Hong He, MD, PhD, Kathryn Ruisaard, MS, Karen Clise-Dwyer, PhD, Lisa S St. John, PhD, Rebecca Patenia, Pariya Sukhumalchandra, BS, Gheath Alatrash, DO, PhD, William K Decker, PhD, Elizabeth J Shpall, MD, M. James You, MD, PhD, Qing Ma, PhD, Jeffrey J. Molldrem, MD
Journal: Blood
Blood (2011) 118 (21): 766.
https://doi.org/10.1182/blood.V118.21.766.766
Published: 2011
Journal Articles

An anti–PR1/HLA-A2 T-cell receptor–like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells

Anna Sergeeva, Gheath Alatrash, Hong He, Kathryn Ruisaard, Sijie Lu, James Wygant, Bradley W. McIntyre, Qing Ma, Dan Li, Lisa St John, Karen Clise-Dwyer, Jeffrey J. Molldrem
Journal: Blood
Blood (2011) 117 (16): 4262–4272.
https://doi.org/10.1182/blood-2010-07-299248
Published: 2011
Includes: Supplemental data
Journal Articles

Peripheral Tolerance to PR1 Is Maintained After Uptake of Soluble Proteinas-3 and Neutrophil Elastase

Gheath Alatrash, DO, PhD, Yoko Ono, MD, Anna Sergeeva, PhD, Pariya Sukhumalchandra, BS, Mao Zhang, MPH, Kathryn Quintanilla, MS, Paul Armistead, MD, PhD, Hong He, MD, Tania Rodriguez-Cruz, BS, Karen Clise-Dwyer, PhD, Eric Wieder, PhD, Greg Lizee, PhD, Sijie Lu, PhD, Jeffrey J. Molldrem, MD
Journal: Blood
Blood (2010) 116 (21): 4301.
https://doi.org/10.1182/blood.V116.21.4301.4301
Published: 2010
Journal Articles

Semi-Solid Decalcification and Research System: a Novel Method to Study Fluorescence Protein Gene Modified Stem Cells In Bone.

Qian-li Jiang, Shan Jiang, Fei-li Chen, Li-qiong Zhu, Pei-ran Zhao, Hao-jia Huang, Xiao-hong He, Chang-xin Yin, Fan Yi Meng, MD
Journal: Blood
Blood (2010) 116 (21): 2625.
https://doi.org/10.1182/blood.V116.21.2625.2625
Published: 2010
Journal Articles

T-Cell Immunity to Two HLA-A2-Restricted Self-Determinants of Cyclin E May Contribute to Remission After Stem Cell Transplantation.

Hong He, M.D., Ph.D., Ken Ishiyama, M.D., Ph.D., Gheath Alatrash, D.O., Ph.D., Yukio Kondo, M.D., Ph.D., Sijie Lu, Ph.D., Jeffrey J. Molldrem, M.D.
Journal: Blood
Blood (2009) 114 (22): 686.
https://doi.org/10.1182/blood.V114.22.686.686
Published: 2009